{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:58:56Z","timestamp":1770069536302,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Instituto de Investigaci\u00f3n Sanitaria la Fe","award":["2014\/00412\/EO"],"award-info":[{"award-number":["2014\/00412\/EO"]}]},{"DOI":"10.13039\/501100007775","name":"UCB","doi-asserted-by":"publisher","award":["VIM12881014"],"award-info":[{"award-number":["VIM12881014"]}],"id":[{"id":"10.13039\/501100007775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.yebeh.2016.09.033","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T13:10:32Z","timestamp":1479301832000},"page":"25-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["NEOPLASM study: Real-life use of lacosamide in patients with brain tumor-related epilepsy"],"prefix":"10.1016","volume":"65","author":[{"given":"Vicente","family":"Villanueva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana","family":"Saiz-Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Piera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Angel","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jes\u00fas","family":"Rodriguez-Uranga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asier","family":"G\u00f3mez-Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Garc\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Gonz\u00e1lez de la Aleja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiana","family":"Rodr\u00edguez-Osorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Palao-Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ascensi\u00f3n","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macarena","family":"Bonet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Ruiz-Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Palau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Arcediano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2016.09.033_bb0005","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1634\/theoncologist.2014-0060","article-title":"Seizure prognosis in brain tumors: new insights and evidence-based management","volume":"19","author":"Vecht","year":"2014","journal-title":"Oncologist"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0010","doi-asserted-by":"crossref","first-page":"e375","DOI":"10.1016\/S1470-2045(12)70266-8","article-title":"Epilepsy meets cancer: when, why, and what to do about it?","volume":"13","author":"Weller","year":"2012","journal-title":"Lancet Oncol"},{"issue":"Suppl. 9","key":"10.1016\/j.yebeh.2016.09.033_bb0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/epi.12452","article-title":"Optimizing antiepileptic drug treatment in tumoral epilepsy","volume":"54","author":"Perucca","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0140-6736(00)02503-4","article-title":"Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia","volume":"356","author":"Relling","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0025","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1200\/JCO.1997.15.9.3121","article-title":"Preirradiation paclitaxel in glioblastoma multiforme: efficacy, pharmacology, and drug interactions. New approaches to brain tumor therapy central nervous system consortium","volume":"15","author":"Fetell","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0030","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2174\/157015909788848929","article-title":"Truly \u201crational\u201d polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects","volume":"7","author":"St Louis","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0035","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s40262-013-0088-z","article-title":"Drug interactions with the newer antiepileptic drugs (AEDs)\u2014part 2: pharmacokinetic and pharmacodynamic interactions between AEDs and drugs used to treat non-epilepsy disorders","volume":"52","author":"Patsalos","year":"2013","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0040","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S1474-4422(09)70204-2","article-title":"Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up","volume":"8","author":"Douw","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0045","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s00415-010-5637-x","article-title":"Rash in four patients with brain tumor-related epilepsy in monotherapy with oxcarbazepine, during radiotherapy","volume":"257","author":"Maschio","year":"2010","journal-title":"J Neurol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/mol.107.039867","article-title":"The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels","volume":"73","author":"Errington","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0055","author":"European Medicines Agency"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0060","author":"UCB Inc."},{"key":"10.1016\/j.yebeh.2016.09.033_bb0065","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1528-1167.2007.01188.x","article-title":"Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures","volume":"48","author":"Ben-Menachem","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0070","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1528-1167.2009.02496.x","article-title":"Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial","volume":"51","author":"Chung","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0075","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1528-1167.2008.01951.x","article-title":"Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial","volume":"50","author":"Halasz","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0080","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/epi.12681","article-title":"Conversion to lacosamide monotherapy in the treatment of focal epilepsy: results from a historical-controlled, multicenter, double-blind study","volume":"55","author":"Wechsler","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0085","first-page":"1","article-title":"Lacosamide has low potential for drug\u2013drug interaction (abstract p562)","volume":"47","author":"Thomas","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0090","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/epi.12085","article-title":"Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers","volume":"54","author":"Cawello","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0095","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/epi.12192","article-title":"Lack of effect of lacosamide on the pharmacokinetic and pharmacodynamic profiles of warfarin","volume":"54","author":"Stockis","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yebeh.2013.11.016","article-title":"Prospective audits with newer antiepileptic drugs in focal epilepsy: insights into population responses?","volume":"31","author":"Brodie","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s40261-014-0255-5","article-title":"Early add-on lacosamide in a real-life setting: results of the REALLY study","volume":"35","author":"Villanueva","year":"2015","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0110","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1007\/s00415-011-6132-8","article-title":"Lacosamide as add-on in brain tumor-related epilepsy: preliminary report on efficacy and tolerability","volume":"258","author":"Maschio","year":"2011","journal-title":"J Neurol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0115","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3171\/2013.1.JNS12397","article-title":"Retrospective analysis of the tolerability and activity of lacosamide in patients with brain tumors: clinical article","volume":"118","author":"Saria","year":"2013","journal-title":"J Neurosurg"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0120","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","volume":"22","year":"1981","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0125","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/neuonc\/nou304","article-title":"Medical management of brain tumors and the sequelae of treatment","volume":"17","author":"Schiff","year":"2015","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0130","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10143-014-0538-6","article-title":"Treatment of epileptic seizures in brain tumors: a critical review","volume":"37","author":"Bauer","year":"2014","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0135","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/neuonc\/not170","article-title":"Levetiracetam and pregabalin for antiepileptic monotherapy in patients with primary brain tumors. A phase II randomized study","volume":"16","author":"Rossetti","year":"2014","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0140","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1684\/epd.2012.0542","article-title":"Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study","volume":"14","author":"Maschio","year":"2012","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11060-010-0460-x","article-title":"Levetiracetam monotherapy in patients with brain tumor-related epilepsy: seizure control, safety, and quality of life","volume":"104","author":"Maschio","year":"2011","journal-title":"J Neurooncol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0150","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fonc.2012.00098","article-title":"The strategy for enhancing temozolomide against malignant glioma","volume":"2","author":"Nakada","year":"2012","journal-title":"Front Oncol"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0155","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1212\/WNL.0b013e31822f02e1","article-title":"Prolonged survival with valproic acid use in the EORTC\/NCIC temozolomide trial for glioblastoma","volume":"77","author":"Weller","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0160","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s40263-013-0094-6","article-title":"Levetiracetam compared with valproic acid for the prevention of postoperative seizures after supratentorial tumor surgery: a retrospective chart review","volume":"27","author":"Lee","year":"2013","journal-title":"CNS Drugs"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0165","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.eplepsyres.2011.03.018","article-title":"Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients","volume":"95","author":"Hu","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0170","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.seizure.2008.01.006","article-title":"Adult-onset epilepsy associated with dysembryoplastic neuroepithelial tumors","volume":"17","author":"Burneo","year":"2008","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0175","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2165\/11587550-000000000-00000","article-title":"A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs","volume":"24","author":"Sake","year":"2010","journal-title":"CNS Drugs"},{"key":"10.1016\/j.yebeh.2016.09.033_bb0180","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.yebeh.2011.11.026","article-title":"Rational polytherapy with lacosamide in clinical practice: results of a Spanish cohort analysis RELACOVA","volume":"23","author":"Villanueva","year":"2012","journal-title":"Epilepsy Behav"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016301585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016301585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T09:32:49Z","timestamp":1601199169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505016301585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":36,"alternative-id":["S1525505016301585"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2016.09.033","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NEOPLASM study: Real-life use of lacosamide in patients with brain tumor-related epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2016.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}