{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:57:41Z","timestamp":1789408661304,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.yebeh.2016.10.006","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T03:20:46Z","timestamp":1481772046000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Effectiveness and tolerability of antiepileptic drugs in 104 girls with Rett syndrome"],"prefix":"10.1016","volume":"66","author":[{"given":"Aglaia","family":"Vignoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Nella","family":"Savini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sonia","family":"Nowbut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Peron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"La Briola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Canevini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.yebeh.2016.10.006_bb0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pediatrneurol.2006.10.003","article-title":"Rett syndrome: clinical and electrophysiologic aspects","volume":"36","author":"SJ","year":"2007","journal-title":"Pediatr Neurol"},{"issue":"Suppl 1","key":"10.1016\/j.yebeh.2016.10.006_bb0010","first-page":"5","article-title":"Rett syndrome: epidemiology and geographical variability","volume":"6","author":"Hagberg","year":"1997","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"6","key":"10.1016\/j.yebeh.2016.10.006_bb0015","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/ana.22124","article-title":"Rett syndrome: revised diagnostic criteria and nomenclature","volume":"68","author":"Neul","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2016.10.006_bb0020","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2147\/TCRM.S55896","article-title":"Management of epilepsy in patients with Rett syndrome: perspectives and considerations","volume":"11","author":"Krajnc","year":"2015","journal-title":"Ther Clin Risk Manag"},{"issue":"1","key":"10.1016\/j.yebeh.2016.10.006_bb0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ajmg.a.34367","article-title":"Medical care of adolescents and women with Rett syndrome: an Italian study","volume":"158A","author":"Vignoli","year":"2012","journal-title":"Am J Med Genet A"},{"issue":"11","key":"10.1016\/j.yebeh.2016.10.006_bb0030","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1212\/WNL.0b013e3181d6b852","article-title":"Epilepsy and the natural history of Rett syndrome","volume":"74","author":"Glaze","year":"2010","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.yebeh.2016.10.006_bb0035","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.clinph.2008.08.015","article-title":"Drug-resistant epilepsy and epileptic phenotype-EEG association in MECP2 mutated Rett syndrome","volume":"119","author":"Buoni","year":"2008","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.yebeh.2016.10.006_bb0040","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/epi.12941","article-title":"Epilepsy in Rett syndrome\u2014lessons from the Rett networked database","volume":"56","author":"Nissenkorn","year":"2015","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2016.10.006_bb0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.pediatrneurol.2012.11.001","article-title":"Rett syndrome and epilepsy: an update for child neurologists","volume":"48","author":"Dolce","year":"2013","journal-title":"Pediatr Neurol"},{"issue":"4","key":"10.1016\/j.yebeh.2016.10.006_bb0050","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","article-title":"Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology, 2005\u20142009","volume":"51","author":"Berg","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.10.006_bb0055","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.yebeh.2016.10.006_bb0060","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ejpn.2015.02.007","article-title":"Antiepilptic drugs in Rett syndrome","volume":"19","author":"Pintaudi","year":"2015","journal-title":"Eur J Paediatr Neurol"},{"issue":"2","key":"10.1016\/j.yebeh.2016.10.006_bb0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ajmg.a.32491","article-title":"Rett syndrome and long-term disorder profile","volume":"149A","author":"Smeets","year":"2009","journal-title":"Am J Med Genet A"},{"issue":"12","key":"10.1016\/j.yebeh.2016.10.006_bb0070","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1111\/j.1528-1167.2012.03656.x","article-title":"Epilepsy in Rett syndrome, and CDKL5- and FOXG1-gene-related encephalopathies","volume":"53","author":"Guerrini","year":"2012","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2016.10.006_bb0075","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejpn.2006.09.003","article-title":"Treatment of epilepsy in Rett syndrome","volume":"11","author":"Huppke","year":"2007","journal-title":"Eur J Paediatr Neurol"},{"issue":"2","key":"10.1016\/j.yebeh.2016.10.006_bb0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ajmg.a.36864","article-title":"Angelman syndrome in adulthood","volume":"167A","author":"Larson","year":"2015","journal-title":"Am J Med Genet A"},{"issue":"4 Suppl 1","key":"10.1016\/j.yebeh.2016.10.006_bb0085","first-page":"S42","article-title":"Epilepsy in women: the science of why it is special","volume":"53","author":"Morrell","year":"1999","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.yebeh.2016.10.006_bb0090","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0022-510X(97)00223-2","article-title":"Decrease in benzodiazepine receptor binding in the brains of adult patients with Rett syndrome","volume":"154","author":"Yamashita","year":"1998","journal-title":"J Neurol Sci"},{"issue":"2","key":"10.1016\/j.yebeh.2016.10.006_bb0095","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ejhg.2014.81","article-title":"GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells","volume":"23","author":"Livide","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"11","key":"10.1016\/j.yebeh.2016.10.006_bb0100","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1177\/0883073811408422","article-title":"Epilepsy treatment in Rett syndrome","volume":"26","author":"Krajnc","year":"2011","journal-title":"J Child Neurol"},{"issue":"6","key":"10.1016\/j.yebeh.2016.10.006_bb0105","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/dmcn.12093","article-title":"Using a large international sample to investigate epilepsy in Rett syndrome","volume":"55","author":"Bao","year":"2013","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.yebeh.2016.10.006_bb0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.seizure.2015.02.022","article-title":"Interactions between antiepileptic drugs and hormones","volume":"28","author":"Svalheim","year":"2015","journal-title":"Seizure"},{"issue":"6","key":"10.1016\/j.yebeh.2016.10.006_bb0115","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/adc.2008.148932","article-title":"Valproate and risk of fracture in Rett syndrome","volume":"95","author":"Leonard","year":"2010","journal-title":"Arch Dis Child"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016303146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016303146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T20:56:13Z","timestamp":1536180973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505016303146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":23,"alternative-id":["S1525505016303146"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2016.10.006","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness and tolerability of antiepileptic drugs in 104 girls with Rett syndrome","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2016.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}