{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:28:47Z","timestamp":1790263727119,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.yebeh.2017.02.019","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T14:15:49Z","timestamp":1491920149000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"PA","title":["VEGF treatment during status epilepticus attenuates long-term seizure-associated alterations in astrocyte morphology"],"prefix":"10.1016","volume":"70","author":[{"given":"Janice R.","family":"Lenzer-Fanara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa A.","family":"Salerni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firmause","family":"Payen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Croll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2017.02.019_bb0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0306-4522(01)00154-3","article-title":"Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor","volume":"108","author":"Jin","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/scdb.2001.0290","article-title":"Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders","volume":"13","author":"Carmeliet","year":"2001","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0015","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuroscience.2007.09.083","article-title":"Vascular endothelial growth factor is upregulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus","volume":"151","author":"Nicoletti","year":"2008","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.yebeh.2017.02.019_bb0020","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.yebeh.2010.07.011","article-title":"Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats","volume":"19","author":"Nicoletti","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0025","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nrn1870","article-title":"Astrocyte dysfunction in neurological disorders: a molecular perspective","volume":"7","author":"Seifert","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"Suppl. 6","key":"10.1016\/j.yebeh.2017.02.019_bb0030","first-page":"S181","article-title":"Functional and molecular properties of human astrocytes in acute hippocampal slices obtained from patients with temporal lobe epilepsy","author":"Schroder","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0035","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuron.2008.04.002","article-title":"Astrocytes in the epileptic brain","volume":"58","author":"Wetherington","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0040","doi-asserted-by":"crossref","first-page":"10588","DOI":"10.1523\/JNEUROSCI.2323-09.2009","article-title":"Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?","volume":"29","author":"David","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0045","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/1073858405278321","article-title":"Reactive astrocytes in neural repair and protection","volume":"5","author":"Sofroniew","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0050","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/path.1645","article-title":"Astrocyte intermediate filaments in CNS pathologies and regeneration","volume":"204","author":"Pekny","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0055","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0060","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nm1277","article-title":"An astrocytic basis of epilepsy","volume":"11","author":"Tian","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0065","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1523\/JNEUROSCI.4980-07.2008","article-title":"Loss of astrocytic domain organization in the epileptic brain","volume":"28","author":"Oberheim","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0070","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0306-4522(01)00615-7","article-title":"Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain","volume":"110","author":"Krum","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0075","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/3684","article-title":"Astrocyte-mediated potentiation of inhibitory synaptic transmission","volume":"1","author":"Kang","year":"1998","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0080","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1982"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0085","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1006\/exnr.1997.6737","article-title":"Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective","volume":"149","author":"Rudge","year":"1998","journal-title":"Exp Neurol"},{"issue":"4","key":"10.1016\/j.yebeh.2017.02.019_bb0090","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0306-4522(99)00296-1","article-title":"Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex","volume":"93","author":"Croll","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0095","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0196-9781(86)90076-8","article-title":"Use of cryoprotectant to maintain long term peptide immunoreactivity and tissue morphology","volume":"7","author":"Watson","year":"1986","journal-title":"Peptides"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0896-6273(00)80781-3","article-title":"Leukocyte infiltration, neuronal degeneration and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice","volume":"23","author":"Bush","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.expneurol.2011.08.024","article-title":"Neuron-astrocyte signaling and epilepsy","volume":"244","author":"Seifert","year":"2011","journal-title":"Exp Neurol"},{"issue":"7","key":"10.1016\/j.yebeh.2017.02.019_bb0115","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.neuint.2012.12.008","article-title":"Contributions of astrocytes to epileptogenesis following status epilepticus: opportunities for preventive therapy?","volume":"63","author":"Gibbons","year":"2013","journal-title":"Neurochem Int"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0120","series-title":"Astrocytes in pathophysiology of the nervous system","author":"Parpura","year":"2009"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S1740925X04000031","article-title":"Astrocytic connectivity in the hippocampus","volume":"1","author":"Sul","year":"2004","journal-title":"Neuron Glia Biol"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0074-7742(07)82005-8","article-title":"The role of astrocytes and complement system in neural plasticity","volume":"82","author":"Pekny","year":"2007","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0135","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1523\/JNEUROSCI.2577-05.2005","article-title":"Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures","volume":"25","author":"McCloskey","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/emmm.201302878","article-title":"Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinson's","author":"Prochel","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0145","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1523\/JNEUROSCI.21-10-03392.2001","article-title":"Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord","volume":"21","author":"McTigue","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0150","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.neuron.2010.09.009","article-title":"NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration","volume":"68","author":"Kang","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.yebeh.2017.02.019_bb0155","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1101\/gad.188326.112","article-title":"Astrocytes and disease: a neurodevelopmental perspective","volume":"26","author":"Molofsky","year":"2012","journal-title":"Genes Dev"},{"issue":"5","key":"10.1016\/j.yebeh.2017.02.019_bb0160","first-page":"11","article-title":"Astrocytes promote or impair the survival and function of embryonic ventral mesencephalon co-grafts: effects of astrocyte age and expression of recombinant brain-derived neurotrophic factor","volume":"145","author":"Kolbert","year":"1997","journal-title":"Exp Neurol"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016306527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016306527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:25:14Z","timestamp":1761503114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505016306527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":32,"alternative-id":["S1525505016306527"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2017.02.019","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VEGF treatment during status epilepticus attenuates long-term seizure-associated alterations in astrocyte morphology","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2017.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}