{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:26:53Z","timestamp":1761514013968},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.yebeh.2017.04.017","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T09:48:48Z","timestamp":1496224128000},"page":"51-57","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Lacosamide and concomitant use of antiepileptic and other medications in a US population \u2014 A retrospective cohort study"],"prefix":"10.1016","volume":"72","author":[{"given":"Linda","family":"Kalilani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bosny","family":"Pierre-Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2017.04.017_bb0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.yebeh.2005.04.012","article-title":"Psychiatric comorbidity in epilepsy","volume":"7","author":"Swinkels","year":"2005","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0010","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1111\/j.0013-9580.2004.17504.x","article-title":"The epidemiology of the comorbidity of epilepsy in the general population","volume":"45","author":"Gaitatzis","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0015","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1212\/01.wnl.0000341789.77291.8d","article-title":"Assessment of potential drug interactions in patients with epilepsy: impact of age and sex","volume":"72","author":"Gidal","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0020","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S1474-4422(11)70047-3","article-title":"The pharmacological treatment of epilepsy in adults","volume":"10","author":"Perucca","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1528-1157.2002.13001.x","article-title":"The importance of drug interactions in epilepsy therapy","volume":"43","author":"Patsalos","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0030","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yebeh.2015.09.006","article-title":"Safety and tolerability of lacosamide as adjunctive therapy for adults with partial-onset seizures: analysis of data pooled from three randomized, double-blind, placebo-controlled clinical trials","volume":"52","author":"Biton","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0035","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/S0140-6736(98)04512-7","article-title":"Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy","volume":"352","author":"Wallace","year":"1998","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0040","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00415-005-0735-x","article-title":"Medical therapy of epilepsy: when to initiate treatment and when to combine?","volume":"252","author":"Brodie","year":"2005","journal-title":"J Neurol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0045","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S1474-4422(09)70240-6","article-title":"Epilepsy in later life","volume":"8","author":"Brodie","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0050","first-page":"443","article-title":"Diseases and syndromes associated with intractable epilepsy","volume":"97","author":"Whiting","year":"2006","journal-title":"Adv Neurol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0055","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1474-4422(04)00906-8","article-title":"Chronic epilepsy and cognition","volume":"3","author":"Elger","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0060","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1093\/brain\/awh597","article-title":"Greater functional recovery after temporal lobe epilepsy surgery in children","volume":"128","author":"Gleissner","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s40261-014-0255-5","article-title":"Early add-on lacosamide in a real-life setting: results of the REALLY study","volume":"35","author":"Villanueva","year":"2015","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0070","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.seizure.2012.05.005","article-title":"Clinical experience with oral lacosamide as adjunctive therapy in adult patients with uncontrolled epilepsy: a multicentre study in epilepsy clinics in the United Kingdom (UK)","volume":"21","author":"Flores","year":"2012","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.seizure.2015.06.016","article-title":"Choice of the first anti-epileptic drug in elderly patients with newly diagnosed epilepsy: a Finnish retrospective study","volume":"31","author":"Bruun","year":"2015","journal-title":"Seizure"},{"issue":"Suppl. 8","key":"10.1016\/j.yebeh.2017.04.017_bb0080","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1528-1167.2009.02235.x","article-title":"Should enzyme-inducing antiepileptic drugs be considered first-line agents?","volume":"50","author":"Mintzer","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0085","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1474-4422(03)00483-6","article-title":"Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs","volume":"2","author":"Patsalos","year":"2003","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1474-4422(03)00409-5","article-title":"Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs","volume":"2","author":"Patsalos","year":"2003","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0095","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2165\/00002512-200320020-00005","article-title":"Drug treatment of epilepsy in elderly people: focus on valproic acid","volume":"20","author":"Stephen","year":"2003","journal-title":"Drugs Aging"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0100","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2165\/11587550-000000000-00000","article-title":"A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs","volume":"24","author":"Sake","year":"2010","journal-title":"CNS Drugs"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0105","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.yebeh.2011.11.026","article-title":"Rational polytherapy with lacosamide in clinical practice: results of a Spanish cohort analysis RELACOVA","volume":"23","author":"Villanueva","year":"2012","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-0404.2012.01704.x","article-title":"Clinical experience with using lacosamide for the treatment of epilepsy in a tertiary centre","volume":"127","author":"Kamel","year":"2013","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0115","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.eplepsyres.2014.06.018","article-title":"Adjunctive lacosamide\u20145years' clinical experience","volume":"108","author":"Stephen","year":"2014","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0120","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.eplepsyres.2014.11.021","article-title":"Current understanding of the mechanism of action of the antiepileptic drug lacosamide","volume":"110","author":"Rogawski","year":"2015","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0125","series-title":"A Noninterventional Study Evaluating the Effectiveness and Safety of Lacosamide Added to Monotherapy in Patients With Epilepsy With Partial-onset Seizures in Daily Clinical Practice: The VITOBA Study","author":"Runge","year":"2015"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yebeh.2014.08.131","article-title":"Diagnoses, procedures, drug utilization, comorbidities, and cost of health care for people with epilepsy in 2012","volume":"41","author":"Wilner","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0135","first-page":"849","volume":"62","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.spen.2016.01.012","article-title":"The comorbidity of migraine and epilepsy in children and adolescents","volume":"23","author":"Sowell","year":"2016","journal-title":"Semin Pediatr Neurol"},{"issue":"Suppl. 1","key":"10.1016\/j.yebeh.2017.04.017_bb0145","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.eplepsyres.2005.07.017","article-title":"Pharmacological and clinical aspects of antiepileptic drug use in the elderly","volume":"68","author":"Perucca","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0150","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1517\/17425255.2014.956081","article-title":"Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants","volume":"10","author":"Italiano","year":"2014","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0160","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1177\/0091270011426875","article-title":"No pharmacokinetic interaction between lacosamide and valproic acid in healthy volunteers","volume":"52","author":"Cawello","year":"2012","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s40261-014-0180-7","article-title":"Effect of lacosamide on the steady-state pharmacokinetics of digoxin: results from a phase I, multiple-dose, double-blind, randomised, placebo-controlled, crossover trial","volume":"34","author":"Cawello","year":"2014","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0170","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s40261-014-0177-2","article-title":"Pharmacokinetics of lacosamide and omeprazole coadministration in healthy volunteers: results from a phase I, randomized, crossover trial","volume":"34","author":"Cawello","year":"2014","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0175","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0091270009347675","article-title":"No pharmacokinetic interaction between lacosamide and carbamazepine in healthy volunteers","volume":"50","author":"Cawello","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0180","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/epi.12085","article-title":"Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers","volume":"54","author":"Cawello","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0185","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/epi.12192","article-title":"Lack of effect of lacosamide on the pharmacokinetic and pharmacodynamic profiles of warfarin","volume":"54","author":"Stockis","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0190","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.seizure.2011.08.005","article-title":"Early clinical experience with lacosamide as adjunctive therapy in patients with refractory focal epilepsy and nocturnal seizures","volume":"20","author":"Garcia-Morales","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0195","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.eplepsyres.2011.09.010","article-title":"Initial post marketing experience with lacosamide in adult patients with epilepsy","volume":"98","author":"Harden","year":"2012","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.04.017_bb0200","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1007\/s00415-011-6132-8","article-title":"Lacosamide as add-on in brain tumor-related epilepsy: preliminary report on efficacy and tolerability","volume":"258","author":"Maschio","year":"2011","journal-title":"J Neurol"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016306758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016306758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T04:58:07Z","timestamp":1535777887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505016306758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":39,"alternative-id":["S1525505016306758"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2017.04.017","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lacosamide and concomitant use of antiepileptic and other medications in a US population \u2014 A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2017.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}