{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:28:31Z","timestamp":1761503311744,"version":"build-2065373602"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.yebeh.2017.10.022","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T11:47:04Z","timestamp":1511264824000},"page":"14-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The effects of felbamate on appetitive and aversive instrumental learning in adult rats"],"prefix":"10.1016","volume":"78","author":[{"given":"John J.","family":"Orczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preston E.","family":"Garraghty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2017.10.022_bb0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1528-1157.1982.tb05439.x","article-title":"Anticonvulsant drugs and cognitive functions","volume":"23","author":"Thompson","year":"1982","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0010","first-page":"81-66","article-title":"Effects of phenytoin and carbamazepine on cognitive functions in newly diagnosed epileptic patients","volume":"89","author":"Pulliainen","year":"1994","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0015","first-page":"819","article-title":"Sodium valproate and cognitive functioning in normal volunteers. Brit","volume":"12","author":"Thompson","year":"1981","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0020","first-page":"27","article-title":"Anticonvulsant effects on the memory performance of epileptics","volume":"20","author":"Butlin","year":"1983","journal-title":"Clin Exp Neurol"},{"issue":"s2","key":"10.1016\/j.yebeh.2017.10.022_bb0025","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1111\/j.1528-1157.1995.tb05999.x","article-title":"Cognitive and behavioral effects of antiepileptic drugs","volume":"36","author":"Devinsky","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0920-1211(95)00047-X","article-title":"Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25years of research","volume":"22","author":"Vermeulen","year":"1995","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0035","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.47.3.626","article-title":"Reversible parkinsonism and cognitive impairment with chronic valproate use","volume":"47","author":"Armon","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0040","doi-asserted-by":"crossref","first-page":"SS1","DOI":"10.1006\/ebeh.2001.0235","article-title":"Cognitive and behavioral effects of antiepileptic drugs","volume":"2","author":"Meador","year":"2001","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1525-5069(02)00502-9","article-title":"Cognitive and behavioral effects of antiepileptic drugs","volume":"3","author":"Drane","year":"2002","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/ebeh.2000.0071","article-title":"Side effect profiles and behavioral consequences of antiepileptic medications","volume":"1","author":"Gates","year":"2000","journal-title":"Epilepsy Behav"},{"issue":"Suppl. 8","key":"10.1016\/j.yebeh.2017.10.022_bb0055","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1528-1157.42.s8.8.x","article-title":"Cognitive and behavioral effects of epilepsy treatment","volume":"42","author":"Loring","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0060","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.yebeh.2003.11.008","article-title":"Cognitive side effects of antiepileptic drugs","volume":"5","author":"Ortinski","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0065","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/0091-3057(86)90489-2","article-title":"Chronic effects of clonazepam, phenytoin, ethosuximide, and valproic acid on learning in pigeons as assayed by a repeated acquisition procedure","volume":"24","author":"Poling","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ddr.430240106","article-title":"Pharmacological studies of a rat spatial delayed nonmatch-to-sample task as an animal model of dementia","volume":"24","author":"Deacon","year":"1991","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuroscience.2009.11.073","article-title":"Valproic acid reduces spatial working memory and cell proliferation in the hippocampus","volume":"166","author":"Umka","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0080","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0031-6989(84)80048-X","article-title":"Effects of valproic acid derivatives on the acquisition of active avoidance behavior in the rat","volume":"16","author":"Continella","year":"1984","journal-title":"Pharmacol Res Commun"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0085","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1471-4159.2001.00411.x","article-title":"Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe","volume":"78","author":"Murphy","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0090","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0091-3057(99)00019-2","article-title":"The effects of phenytoin on instrumental appetitive-to-aversive transfer in rats","volume":"63","author":"Banks","year":"1999","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0095","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0278-5846(00)00175-5","article-title":"The effects of carbamazepine on an appetitive-to-aversive transfer task: comparison to untreated and phenytoin","volume":"25","author":"Banks","year":"2001","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2014.00113","article-title":"The effects of valproic acid on appetitive and aversive instrumental learning in adult rats","volume":"8","author":"Orczyk","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0105","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1037\/0735-7044.107.6.941","article-title":"Using signaled bar-pressing tasks to study the neural substrates of appetitive and aversive learning in rats: behavioral manipulations and cerebellar lesions","volume":"107","author":"Steinmetz","year":"1993","journal-title":"Behav Neurosci"},{"year":"1994","series-title":"An examination of the role of the hippocampus in the acquisition and timing of a signaled barpress in appetitive and aversive conditioning [dissertation]","author":"Logue","key":"10.1016\/j.yebeh.2017.10.022_bb0110"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF02734169","article-title":"Discrete and contextual cue alterations eliminate the instrumental appetitive-to-aversive transfer impairment in phenytoin-treated rats","volume":"39","author":"McDowell","year":"2004","journal-title":"Integr Physiol Behav Sci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0120","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijdevneu.2008.03.005","article-title":"Chronic developmental exposure to phenytoin has long-term behavioral consequences","volume":"26","author":"Mowery","year":"2008","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF02688857","article-title":"Lesions of the rat nucleus basalis magnocellularis disrupt appetitive-to-aversive transfer learning","volume":"38","author":"Butt","year":"2003","journal-title":"Integr Physiol Behav Sci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0130","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/BF02734439","article-title":"The effects of estradiol on avoidance learning in ovariectomized adult rats","volume":"39","author":"Goodman","year":"2004","journal-title":"Integr Physiol Behav Sci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0135","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/893126","article-title":"The effects of sex and chronic restraint on instrumental learning in rats","author":"McDowell","year":"2013","journal-title":"Neurosci J"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0140","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/697659","article-title":"Sex differences and the impact of chronic stress and recovery from on instrumental learning","author":"McDowell","year":"2015","journal-title":"Neurosci J"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2006.10.008","article-title":"Progress report on new antiepileptic drugs: a summary of the Eighth Eilat Conference (EILAT VIII)","volume":"73","author":"Bialer","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1469-8749.1977.tb08015.x","article-title":"Treatment of generalized epilepsies of childhood and adolescence with sodium valproate (\u2018epilim\u2019)","volume":"19","author":"Jeavons","year":"1977","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0155","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/archneur.55.9.1181","article-title":"New anti-epileptic drugs","volume":"55","author":"Bourgeois","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF02688828","article-title":"Some antiepileptic compounds impair learning by rats in a Morris water maze","volume":"38","author":"Churchill","year":"2003","journal-title":"Integr Physiol Behav Sci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0165","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1528-1157.1998.tb01425.x","article-title":"Phenytoin blocks the reversal of a classically conditioned discriminative eyeblink response in rabbits","volume":"39","author":"Churchill","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF02734185","article-title":"The effects of phenytoin on the performance of rats in a delayed match-to-place task","volume":"40","author":"Samuelson","year":"2005","journal-title":"Integr Physiol Behav Sci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0175","series-title":"Antiepileptic drugs","first-page":"791","article-title":"Felbamate: mechanisms of action","author":"Sofia","year":"1999"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0180","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1528-1157.1997.tb00062.x","article-title":"Evaluation of case reports of aplastic anemia among patients treated with felbamate","volume":"38","author":"Kaufman","year":"1977","journal-title":"Epilepsia"},{"issue":"s5","key":"10.1016\/j.yebeh.2017.10.022_bb0185","doi-asserted-by":"crossref","first-page":"s57","DOI":"10.1111\/j.1528-1157.1999.tb00920.x","article-title":"Felbamate","volume":"40","author":"Pellock","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0190","series-title":"Antiepileptic drugs","first-page":"345","article-title":"Phenytoin: toxicity","author":"Bruni","year":"1995"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0195","series-title":"Antiepileptic drugs","first-page":"641","article-title":"Valproic acid: toxicity","author":"Dreifuss","year":"1995"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0200","series-title":"Antiepileptic drugs","first-page":"567","article-title":"Carbamazepine: toxicity","author":"Holmes","year":"1995"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0205","series-title":"Goodman and Gilman's the pharmalogical basis of therapeutics","first-page":"521","article-title":"Drugs effective in the therapy of the epilepsies","author":"McNamara","year":"2001"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0210","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00008877-199406000-00016","article-title":"Felbamate, a novel antiepileptic agent, does not affect cognition in rodents","volume":"5","author":"Smith","year":"1994","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0215","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0920-1211(95)00089-5","article-title":"Felbamate monotherapy has stimulant-like effects in patients with epilepsy","volume":"23","author":"Ketter","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0220","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/mp.2016.166","article-title":"The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm","volume":"22","author":"LeDoux","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0225","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1523\/JNEUROSCI.08-07-02517.1988","article-title":"Different projections of the central amydaloid nucleus mediate autonomic and behavioral correlates of conditioned fear","volume":"8","author":"LeDoux","year":"1988","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0230","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1037\/0735-7044.107.6.1093","article-title":"Effects of amygdala, hippocampus, and periaquductal gray lesions on short- and long-term contextual fear","volume":"107","author":"Kim","year":"1993","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0235","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/37601","article-title":"Fear conditioning induces associative long-term potentiation in the amygdala","volume":"390","author":"Rogan","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0240","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0896-6273(00)80375-X","article-title":"Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala","volume":"19","author":"Quirk","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0245","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1046\/j.1460-9568.2000.00281.x","article-title":"Auditory fear conditioning increases CS-elicited spike firing in lateral amygdala neurons even after extensive overtraining","volume":"12","author":"Maren","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0250","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/89512","article-title":"Two different lateral amygdala cell populations contribute to theinitiation and storage of memory","volume":"4","author":"Repa","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0255","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1523\/JNEUROSCI.1331-14.2015","article-title":"Active avoidance requires a serial basal amygdala to nucleus accumbens shell circuit","volume":"25","author":"Ramirez","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0260","series-title":"Human memory and amnesia","first-page":"337","article-title":"Multiple dissociations of function in amnesia","author":"Moscovitch","year":"1982"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2015.00249","article-title":"Altered activity of the medial prefrontal cortex and amygdala during acquisition and extinction of an active avoidance task","volume":"9","author":"Jiao","year":"2015","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0270","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/epi.12635","article-title":"The case for assessing cannabidiol in epilepsy","volume":"55","author":"Cilio","year":"2014","journal-title":"Epilepsia"},{"issue":"Part B","key":"10.1016\/j.yebeh.2017.10.022_bb0275","first-page":"277","volume":"70","year":"2017","journal-title":"Epilepsy Behav"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2017.10.022_bb0280","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1528-1167.2006.00684.x","article-title":"Effects of antiepileptic drugs on mood and behavior","volume":"47","author":"Schmitz","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.10.022_bb0285","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1053\/j.seminoncol.2011.03.014","article-title":"An update on cancer- and chemotherapy-related cognitive dysfunction: current status","volume":"38","author":"Janelsins","year":"2011","journal-title":"Semin Oncol"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505017305851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505017305851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:25:33Z","timestamp":1761503133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505017305851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":57,"alternative-id":["S1525505017305851"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2017.10.022","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of felbamate on appetitive and aversive instrumental learning in adult rats","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2017.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}