{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:37:08Z","timestamp":1771472228820,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012504","name":"Royal Melbourne Hospital Neuroscience Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.yebeh.2017.10.027","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T15:03:56Z","timestamp":1513955036000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["IDH1 and IDH2 mutations in postoperative diffuse glioma-associated epilepsy"],"prefix":"10.1016","volume":"78","author":[{"given":"Andrew","family":"Neal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence John","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Buckland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Morokoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2017.10.027_bb0005","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3171\/2009.2.JNS081132","article-title":"Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article","volume":"111","author":"Chaichana","year":"2009","journal-title":"J Neurosurg"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3171\/JNS\/2008\/108\/2\/0227","article-title":"Seizure characteristics and control following resection in 332 patients with low-grade gliomas","volume":"108","author":"Chang","year":"2008","journal-title":"J Neurosurg"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0015","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ana.10712","article-title":"Epilepsy in low-grade gliomas: the impact on cognitive function and quality of life","volume":"54","author":"Klein","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0020","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1111\/epi.13562","article-title":"Postoperative seizure control in patients with tumor-associated epilepsy","volume":"57","author":"Neal","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0025","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJMoa0808710","article-title":"IDH1 and IDH2 mutations in gliomas","volume":"360","author":"Yan","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0030","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrneurol.2016.26","article-title":"Seizures and gliomas \u2014 towards a single therapeutic approach","volume":"12","author":"Huberfeld","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0035","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10014-014-0197-x","article-title":"IDH1\/2 mutation detection in gliomas","volume":"32","author":"Arita","year":"2015","journal-title":"Brain Tumor Pathol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0040","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2353\/ajpath.2009.080958","article-title":"IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas","volume":"174","author":"Watanabe","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0045","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nature08617","article-title":"Cancer-associated IDH1 mutations produce 2-hydroxyglutarate","volume":"462","author":"Dang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0050","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0055","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1158\/2159-8290.CD-13-0083","article-title":"Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities","volume":"3","author":"Cairns","year":"2013","journal-title":"Cancer Discov"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1460-9568.2002.02055.x","article-title":"NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria","volume":"16","author":"Kolker","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0065","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1212\/WNL.0000000000003911","article-title":"Mutant IDH1 and seizures in patients with glioma","volume":"88","author":"Chen","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0070","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10545-012-9462-5","article-title":"Progress in understanding 2-hydroxyglutaric acidurias","volume":"35","author":"Kranendijk","year":"2012","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/humu.21197","article-title":"An overview of l-2-hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype-phenotype study","volume":"31","author":"Steenweg","year":"2010","journal-title":"Hum Mutat"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.clineuro.2016.07.003","article-title":"Relationship between IDH1 mutation and preoperative seizure in low-grade gliomas: a meta-analysis","volume":"148","author":"Wang","year":"2016","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0085","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1111\/epi.12662","article-title":"IDH1 mutation is associated with seizures and protoplasmic subtype in patients with low-grade gliomas","volume":"55","author":"Liubinas","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0090","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.seizure.2011.12.007","article-title":"IDH1\/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom","volume":"21","author":"Stockhammer","year":"2012","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0095","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/ana.24522","article-title":"Predictors of preoperative and early postoperative seizures in patients with intra-axial primary and metastatic brain tumors: a retrospective observational single center study","volume":"78","author":"Skardelly","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2016.12.013","article-title":"Epileptic features and survival in glioblastomas presenting with seizures","volume":"130","author":"Toledo","year":"2017","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jocn.2015.11.030","article-title":"An analysis of 170 glioma patients and systematic review to investigate the association between IDH-1 mutations and preoperative glioma-related epilepsy","volume":"31","author":"Yang","year":"2016","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0110","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.eplepsyres.2014.09.012","article-title":"IDH1\/2 mutation is associated with seizure as an initial symptom in low-grade glioma: a report of 311 Chinese adult glioma patients","volume":"109","author":"Zhong","year":"2015","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0115","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1236062","article-title":"An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells","volume":"340","author":"Rohle","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0120","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11060-016-2169-y","article-title":"Peritumoural glutamate correlates with post-operative seizures in supratentorial gliomas","volume":"129","author":"Neal","year":"2016","journal-title":"J Neurooncol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0125","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0130","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/humu.21437","article-title":"BioGrid Australia facilitates collaborative medical and bioinformatics research across hospitals and medical research institutes by linking data from diverse disease and data types","volume":"32","author":"Merriel","year":"2011","journal-title":"Hum Mutat"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0135","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/neuonc\/not057","article-title":"Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme","volume":"15","author":"Kerkhof","year":"2013","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0140","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/nbm.3095","article-title":"Glutamate quantification in patients with supratentorial gliomas using chemical shift imaging","volume":"27","author":"Liubinas","year":"2014","journal-title":"NMR Biomed"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0145","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00401-014-1353-4","article-title":"Oligoastrocytomas: throwing the baby out with the bathwater?","volume":"129","author":"Wilcox","year":"2015","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0150","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1007\/s13277-013-0934-5","article-title":"IDH1 mutation is associated with improved overall survival in patients with glioblastoma: a meta-analysis","volume":"34","author":"Cheng","year":"2013","journal-title":"Tumour Biol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0155","series-title":"AAN. Boston: Neurology","article-title":"Intractable seizures and IDH mutation in low grade gliomas","author":"Avila","year":"2017"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0160","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1073\/pnas.1019393108","article-title":"Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome","volume":"108","author":"Reitman","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0165","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/annonc\/mdw013","article-title":"IDH mutations in cancer and progress toward development of targeted therapeutics","volume":"27","author":"Dang","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0170","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/jmri.25221","article-title":"MR spectroscopy for in vivo assessment of the oncometabolite 2-hydroxyglutarate and its effects on cellular metabolism in human brain gliomas at 9.4T","volume":"44","author":"Bisdas","year":"2016","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.yebeh.2017.10.027_bb0175","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/neuonc\/now190","article-title":"Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials","volume":"19","author":"Avila","year":"2017","journal-title":"Neuro Oncol"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505017307527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505017307527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:26:31Z","timestamp":1761503191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505017307527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":35,"alternative-id":["S1525505017307527"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2017.10.027","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IDH1 and IDH2 mutations in postoperative diffuse glioma-associated epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2017.10.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}