{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:45:25Z","timestamp":1779399925253,"version":"3.53.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.yebeh.2018.04.025","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T11:20:45Z","timestamp":1526037645000},"page":"93-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Intravenous lacosamide (LCM) in status epilepticus (SE): Weight-adjusted dose and efficacy"],"prefix":"10.1016","volume":"84","author":[{"given":"Estevo","family":"Santamarina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Gonz\u00e1lez-Cuevas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Becerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Qu\u00edlez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Suller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Marinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier Salas","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.yebeh.2018.04.025_bb0005","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1528-1167.2007.01317.x","article-title":"Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures","volume":"49","author":"Biton","year":"2008","journal-title":"Epilepsia"},{"issue":"1\u20132","key":"10.1016\/j.yebeh.2018.04.025_bb0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000339077","article-title":"Bioequivalence of intravenous and oral formulations of the antiepileptic drug lacosamide","volume":"90","author":"Cawello","year":"2012","journal-title":"Pharmacology"},{"issue":"1","key":"10.1016\/j.yebeh.2018.04.025_bb0015","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1528-1167.2012.03543.x","article-title":"Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-naive patients with partial-onset seizures","volume":"54","author":"Fountain","year":"2013","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.yebeh.2018.04.025_bb0020","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/epi.13716","article-title":"Lacosamide in status epilepticus: systematic review of current evidence","volume":"58","author":"Strzelczyk","year":"2017","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.yebeh.2018.04.025_bb0025","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s12028-013-9882-6","article-title":"Intravenous lacosamide in refractory seizure clusters and status epilepticus: comparison of 200 and 400\u202fmg loading doses","volume":"20","author":"Legros","year":"2014","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.yebeh.2018.04.025_bb0030","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yebeh.2014.05.015","article-title":"Factors influencing response to intravenous lacosamide in emergency situations: LACO-IV study","volume":"36","author":"Garc\u00e9s","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"2","key":"10.1016\/j.yebeh.2018.04.025_bb0035","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejpn.2015.12.013","article-title":"Clinical experience of intravenous lacosamide in infants and young children","volume":"20","author":"Arkilo","year":"2016","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.yebeh.2018.04.025_bb0040","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pediatrneurol.2016.03.021","article-title":"Intravenous lacosamide in pediatric status epilepticus: an open-label efficacy and safety study","volume":"61","author":"Poddar","year":"2016","journal-title":"Pediatr Neurol"},{"issue":"5","key":"10.1016\/j.yebeh.2018.04.025_bb0045","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejpn.2014.04.013","article-title":"Lacosamide in children with refractory status epilepticus. A multicenter Italian experience","volume":"18","author":"Grosso","year":"2014","journal-title":"Eur J Paediatr Neurol"},{"issue":"4","key":"10.1016\/j.yebeh.2018.04.025_bb0050","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1528-1167.2012.03419.x","article-title":"Treatment of refractory tonic status epilepticus with intravenous lacosamide","volume":"53","author":"Jain","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.04.025_bb0055","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.yebeh.2015.06.032","article-title":"Safety & pK of IV loading dose of lacosamide in the ICU","volume":"49","author":"Ramsay","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"10","key":"10.1016\/j.yebeh.2018.04.025_bb0060","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus\u2014report of the ILAE Task Force on Classification of Status Epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2018.04.025_bb0065","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/jnnp.2005.080887","article-title":"Prognosis of status epilepticus: role of aetiology, age, and consciousness impairment at presentation","volume":"77","author":"Rossetti","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"10","key":"10.1016\/j.yebeh.2018.04.025_bb0070","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/ene.13073","article-title":"A new clinical score for the prognosis of status epilepticus in adults","volume":"23","author":"Gonz\u00e1lez-Cuevas","year":"2016","journal-title":"Eur J Neurol"},{"issue":"Pt A","key":"10.1016\/j.yebeh.2018.04.025_bb0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yebeh.2017.03.018","article-title":"The efficacy of different kinds of intravenously applied antiepileptic drugs in the treatment of status epilepticus. How can it be determined?","volume":"71","author":"Redecker","year":"2017","journal-title":"Epilepsy Behav"},{"issue":"12","key":"10.1016\/j.yebeh.2018.04.025_bb0080","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1007\/s00415-013-7133-6","article-title":"Usefulness of intravenous lacosamide in status epilepticus","volume":"260","author":"Santamarina","year":"2013","journal-title":"J Neurol"},{"issue":"4","key":"10.1016\/j.yebeh.2018.04.025_bb0085","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/FTD.0000000000000051","article-title":"Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs","volume":"36","author":"Markoula","year":"2014","journal-title":"Ther Drug Monit"},{"issue":"6","key":"10.1016\/j.yebeh.2018.04.025_bb0090","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/FTD.0b013e318290eacc","article-title":"Lacosamide therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs","volume":"35","author":"Contin","year":"2013","journal-title":"Ther Drug Monit"},{"issue":"11","key":"10.1016\/j.yebeh.2018.04.025_bb0095","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1177\/0091270011426875","article-title":"No pharmacokinetic interaction between lacosamide and valproic acid in healthy volunteers","volume":"52","author":"Cawello","year":"2012","journal-title":"J Clin Pharmacol"},{"issue":"7","key":"10.1016\/j.yebeh.2018.04.025_bb0100","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/epi.12237","article-title":"Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice","volume":"54","author":"Shandra","year":"2013","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.yebeh.2018.04.025_bb0105","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrneurol.2013.154","article-title":"Outcome predictors for status epilepticus\u2014what really counts","volume":"9","author":"Sutter","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"1\u20132","key":"10.1016\/j.yebeh.2018.04.025_bb0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.eplepsyres.2010.12.014","article-title":"The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus","volume":"94","author":"Wasterlain","year":"2011","journal-title":"Epilepsy Res"},{"issue":"2\u20133","key":"10.1016\/j.yebeh.2018.04.025_bb0115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.eplepsyres.2007.03.004","article-title":"Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy","volume":"74","author":"St\u00f6hr","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2018.04.025_bb0120","series-title":"Antiepileptic drug interactions: a clinical guide","author":"Patsalos","year":"2013"},{"key":"10.1016\/j.yebeh.2018.04.025_bb0125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.eplepsyres.2017.05.007","article-title":"Intravenous lacosamide in status epilepticus: correlation between loading dose, serum levels, and clinical response","volume":"135","author":"Perrenoud","year":"2017","journal-title":"Epilepsy Res"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018302026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018302026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T13:45:37Z","timestamp":1564494337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505018302026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":25,"alternative-id":["S1525505018302026"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.04.025","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous lacosamide (LCM) in status epilepticus (SE): Weight-adjusted dose and efficacy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}