{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:54:14Z","timestamp":1773302054046,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["220365"],"award-info":[{"award-number":["220365"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["380140"],"award-info":[{"award-number":["380140"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.yebeh.2018.06.021","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T10:56:42Z","timestamp":1534157802000},"page":"200-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Sodium cromoglycate reduces short- and long-term consequences of status epilepticus in rats"],"prefix":"10.1016","volume":"87","author":[{"given":"Mar\u00eda Guadalupe","family":"Valle-Dorado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar Emmanuel","family":"Santana-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Adela","family":"Orozco-Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2018.06.021_bb0005","doi-asserted-by":"crossref","first-page":"68S","DOI":"10.1378\/chest.87.1.68S","article-title":"Cromolyn sodium","volume":"87","author":"Bernstein","year":"1985","journal-title":"Chest"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0010","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0022-3565(24)39140-2","article-title":"Cloning and cellular localization of the rat mast cell 78-kDa protein phosphorylated in response to the mast cell \u201cstabilizer\u201d cromolyn","volume":"294","author":"Theoharides","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0015","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/cea.12043","article-title":"Ion channels regulating mast cell biology","volume":"43","author":"Ashmole","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0020","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000105478","article-title":"Mast cell stabilization limits hypoxic\u2013ischemic brain damage in the immature rat","volume":"29","author":"Jin","year":"2007","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0025","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1161\/STROKEAHA.109.549691","article-title":"Mast cells are early responders after hypoxia\u2013ischemia in immature rat brain","volume":"40","author":"Jin","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0030","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.jcbfm.9600387","article-title":"Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage","volume":"27","author":"Strbian","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0035","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000452528","article-title":"Cerebral mast cells participate in postoperative cognitive dysfunction by promoting astrocyte activation","volume":"40","author":"Zhang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0041-008X(73)90268-8","article-title":"The absorption, metabolism and excretion of disodium cromoglycate in nine animal species","volume":"26","author":"Ashton","year":"1973","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0045","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0041-008X(70)90043-8","article-title":"Distribution and metabolism of disodium cromoglycate in rats","volume":"17","author":"Moss","year":"1970","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0006-8993(96)00203-X","article-title":"The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus","volume":"725","author":"Fujikawa","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0055","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1590\/S0004-282X2002000400011","article-title":"The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy","volume":"60","author":"Scorza","year":"2002","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yebeh.2013.03.025","article-title":"Activation and involvement of the lateral-posterior nucleus of the thalamus after a single generalized tonic\u2013clonic seizure","volume":"28","author":"Sonoda","year":"2013","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0065","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.eplepsyres.2015.11.005","article-title":"Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups","volume":"120","author":"Torolira","year":"2016","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0070","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1528-1157.1991.tb05533.x","article-title":"Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous I recurrent seizures","volume":"32","author":"Cavalheiro","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0075","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuropharm.2014.12.032","article-title":"The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus","volume":"92","author":"Valle-Dorado","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0080","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-015-0347-z","article-title":"Increased CCL2, CCL3, CCL5, and IL-1\u03b2 cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures","volume":"12","author":"Arisi","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0085","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuroscience.2015.11.061","article-title":"Structural alterations in the rat brain and behavioral impairment after status epilepticus: an MRI study","volume":"315","author":"Suleymanova","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0090","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0306-4522(90)90234-U","article-title":"Histochemical and ultrastructural characteristics of rat brain perivascular mast cells stimulated with compound 48\/80 and carbachol","volume":"39","author":"Dimitriadou","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0095","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbi.2017.05.003","article-title":"Thalamic mast cell activity is associated with sign-tracking behavior in rats","volume":"65","author":"Fitzpatrick","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2005.07.026","article-title":"Mast cells modulate maintained neuronal activity in the thalamus in vivo","volume":"171","author":"Kov\u00e1cs","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0105","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1528-1157.1998.tb01288.x","article-title":"Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: a qualitative study","volume":"39","author":"Scorza","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0110","doi-asserted-by":"crossref","first-page":"H518","DOI":"10.1152\/ajpheart.00218.2000","article-title":"Cause and effect relationship between myocardial mast cell number and matrix metalloproteinase activity","volume":"283","author":"Brower","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/FJC.0000000000000385","article-title":"Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in middle-aged, ovariectomized Fischer 344\u202f\u00d7\u202fBrown Norway rats","volume":"68","author":"Wang","year":"2016","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0120","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/labinvest.2014.129","article-title":"Inhibition of mast cell-derived histamine secretion by cromolyn sodium treatment decreases biliary hyperplasia in cholestatic rodents","volume":"94","author":"Kennedy","year":"2014","journal-title":"Lab Invest"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131705","article-title":"Immediate epileptogenesis after kainate-induced status epilepticus in C57BL\/6J mice: evidence from long term continuous video-EEG telemetry","volume":"10","author":"Puttachary","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0013-4694(72)90176-9","article-title":"Modification of seizure activity by electrical stimulation: I. after-discharge threshold","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(96)01387-X","article-title":"Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration","volume":"751","author":"Schmued","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0140","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0197-4580(93)90112-O","article-title":"New stereological methods for counting neurons","volume":"14","author":"West","year":"1993","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0145","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1161\/STROKEAHA.111.632224","article-title":"Cerebral mast cells mediate blood\u2013brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation","volume":"42","author":"Mattila","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0150","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2796.2011.02431.x","article-title":"Interleukin-1 type 1 receptor\/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group","author":"Maroso","year":"2011","journal-title":"J Intern Med"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0155","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003","article-title":"Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases","volume":"23","author":"Viviani","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0160","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/epi.12219","article-title":"A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus","volume":"54","author":"Faure","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0165","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-4886(87)90293-7","article-title":"Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats","volume":"97","author":"Morrisett","year":"1987","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0170","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0014-4886(88)90010-6","article-title":"Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam","volume":"101","author":"Walton","year":"1988","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0175","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.eplepsyres.2006.07.014","article-title":"The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy","volume":"72","author":"Fran\u00e7ois","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0180","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuro.2017.01.009","article-title":"Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats","volume":"59","author":"Santana-G\u00f3mez","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0185","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0162-3109(99)00046-6","article-title":"Inhibition of mouse mast cell proliferation and proinflammatory mediator release by benzodiazepines","volume":"43","author":"Bidri","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0190","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejphar.2012.12.003","article-title":"Inhibitory effects of benzodiazepines on the adenosine A2B receptor mediated secretion of interleukin-8 in human mast cells","volume":"700","author":"Hoffmann","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0195","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.neuropharm.2011.05.027","article-title":"Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures","volume":"61","author":"Luna-Munguia","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0200","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/0140-6736(93)90754-5","article-title":"Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain","volume":"341","author":"During","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0205","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bbi.2008.03.009","article-title":"The role of cytokines in the pathophysiology of epilepsy","volume":"22","author":"Vezzani","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1535-7511.2007.00165.x","article-title":"New roles for interleukin-1 beta in the mechanisms of epilepsy","volume":"7","author":"Vezzani","year":"2007","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0215","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1111\/j.1528-1157.2000.tb01578.x","article-title":"Functional and molecular properties of human astrocytes in acute hippocampal slices obtained from patients with temporal lobe epilepsy","volume":"41","author":"Schroder","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0220","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/glia.20380","article-title":"Epileptogenic roles of astroglial death and regeneration in the dentate gyrus of experimental temporal lobe epilepsy","volume":"54","author":"Kang","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0225","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0920-1211(96)00058-7","article-title":"Chronic epilepsy with damage restricted to the hippocampus: possible mechanisms","volume":"26","author":"Wasterlain","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0230","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/BF01990130","article-title":"Cholinomimetics produce seizures and brain damage in rats","volume":"39","author":"Turski","year":"1983","journal-title":"Experientia"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0235","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1111\/j.1471-4159.1985.tb07191.x","article-title":"Rat brain mast cells: contribution to brain histamine levels","volume":"44","author":"Goldschmidt","year":"1985","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0240","first-page":"151","article-title":"Migration of mast cells in the developing rat","volume":"56","author":"Lambracht-hall","year":"1990","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0245","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1002\/jnr.23911","article-title":"Contribution of mast cells to injury mechanisms in a mouse model of pediatric traumatic brain injury","volume":"94","author":"Moretti","year":"2016","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.yebeh.2018.06.021_bb0250","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-8993(00)03026-2","article-title":"Acute stress increases permeability of the blood\u2013brain barrier through activation of brain mast cells","volume":"888","author":"Esposito","year":"2001","journal-title":"Brain Res"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018300180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018300180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:28:50Z","timestamp":1761503330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505018300180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":50,"alternative-id":["S1525505018300180"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.06.021","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium cromoglycate reduces short- and long-term consequences of status epilepticus in rats","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}