{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:34:55Z","timestamp":1787495695152,"version":"build-2736575974"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PO681\/9-1"],"award-info":[{"award-number":["PO681\/9-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.yebeh.2018.11.034","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:45:24Z","timestamp":1546476324000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Impact of repeated kindled seizures on heart rate rhythms, heart rate variability, and locomotor activity in rats"],"prefix":"10.1016","volume":"92","author":[{"given":"Christina","family":"M\u00f6ller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roelof Maarten","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Keck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Sch\u00f6nhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Bierling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidrun","family":"Potschka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2018.11.034_bb0005","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.smrv.2009.01.002","article-title":"The circadian rhythm and its interaction with human epilepsy: a review of literature","volume":"13","author":"Hofstra","year":"2009","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fncel.2012.00055","article-title":"Molecular mechanism of circadian rhythmicity of seizures in temporal lobe epilepsy","volume":"6","author":"Cho","year":"2012","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0015","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00415-012-6675-3","article-title":"Clinical evolution of seizures: distribution across time of day and sleep\/wakefulness cycle","volume":"260","author":"Sanchez Fernandez","year":"2013","journal-title":"J Neurol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0020","first-page":"1117","article-title":"Comorbid sleep disturbances in neurologic disorders","volume":"23","author":"Ju","year":"2017","journal-title":"Continuum (Minneap Minn)"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0025","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1111\/j.1528-1167.2009.02044.x","article-title":"Temporal distribution of clinical seizures over the 24-h day: a retrospective observational study in a tertiary epilepsy clinic","volume":"50","author":"Hofstra","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0030","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.yebeh.2009.01.020","article-title":"Diurnal rhythms in seizures detected by intracranial electrocorticographic monitoring: an observational study","volume":"14","author":"Hofstra","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0035","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ejpn.2016.04.004","article-title":"Sleep\u2013wake distribution and circadian patterns of epileptic seizures in children","volume":"20","author":"Gurkas","year":"2016","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0040","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.eplepsyres.2011.01.015","article-title":"Timing of temporal and frontal seizures in relation to the circadian phase: a prospective pilot study","volume":"94","author":"Hofstra","year":"2011","journal-title":"Epilepsy Res"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2018.11.034_bb0045","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1528-1167.2006.00707.x","article-title":"Circadian rhythm and personality profile in juvenile myoclonic epilepsy","volume":"47","author":"Pung","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0050","doi-asserted-by":"crossref","first-page":"941354","DOI":"10.1155\/2015\/941354","article-title":"Chronotypes in patients with epilepsy: does the type of epilepsy make a difference?","volume":"2015","author":"Kendis","year":"2015","journal-title":"Behav Neurol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yebeh.2015.05.031","article-title":"Chronotype in patients with epilepsy: a controlled study in 60 subjects with late-onset focal epilepsy","volume":"50","author":"Manni","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0060","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3109\/07420528.2010.497234","article-title":"Chronotypes and subjective sleep parameters in epilepsy patients: a large questionnaire study","volume":"27","author":"Hofstra","year":"2010","journal-title":"Chronobiol Int"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0065","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00004691-200103000-00003","article-title":"Interactions between sleep and epilepsy","volume":"18","author":"Mendez","year":"2001","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0070","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1136\/jnnp.2004.053777","article-title":"Suppressed circadian heart rate dynamics in temporal lobe epilepsy","volume":"76","author":"Ronkainen","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/jnnp.72.1.26","article-title":"Heart rate dynamics in refractory and well controlled temporal lobe epilepsy","volume":"72","author":"Ansakorpi","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0080","first-page":"670682","article-title":"Epilepsy, antiseizure therapy, and sleep cycle parameters","volume":"2013","author":"Shvarts","year":"2013","journal-title":"Epilepsy Res Treat"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0085","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1525-5050(03)00006-4","article-title":"Temporal lobe seizures alter the amplitude and timing of rat behavioral rhythms","volume":"4","author":"Stewart","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0090","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.yebeh.2006.08.019","article-title":"Daily rhythms of seizure activity and behavior in a model of atypical absence epilepsy","volume":"9","author":"Stewart","year":"2006","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yebeh.2009.11.001","article-title":"Diurnal rhythms of spontaneous recurrent seizures and behavioral alterations of Wistar and spontaneously hypertensive rats in the kainate model of epilepsy","volume":"17","author":"Tchekalarova","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.eplepsyres.2016.02.014","article-title":"Insomnia in epilepsy is associated with continuing seizures and worse quality of life","volume":"122","author":"Quigg","year":"2016","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0105","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.0013-9580.2004.46703.x","article-title":"Subjective sleep disturbance in patients with partial epilepsy: a questionnaire-based study on prevalence and impact on quality of life","volume":"45","author":"de Weerd","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jneumeth.2015.09.007","article-title":"Opportunities for improving animal welfare in rodent models of epilepsy and seizures","volume":"260","author":"Lidster","year":"2016","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.vascn.2012.09.001","article-title":"Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy","volume":"67","author":"Wolfensohn","year":"2013","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0120","first-page":"437","article-title":"Animal care practices in experiments on biological rhythms and sleep: report of the Joint Task Force of the Society for Research on Biological Rhythms and the Sleep Research Society","volume":"52","author":"Bittman","year":"2013","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0125","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF02345274","article-title":"Circadian rhythm changes in heart rate variability during chronic sound stress","volume":"39","author":"Takeuchi","year":"2001","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0130","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1037\/0735-7044.113.6.1283","article-title":"Long-lasting consequences of a social conflict in rats: behavior during the interaction predicts subsequent changes in daily rhythms of heart rate, temperature, and activity","volume":"113","author":"Meerlo","year":"1999","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0135","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/10253890.2016.1174852","article-title":"Wheel running improves REM sleep and attenuates stress-induced flattening of diurnal rhythms in F344 rats","volume":"19","author":"Thompson","year":"2016","journal-title":"Stress"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0140","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnbeh.2014.00082","article-title":"Day and night: diurnal phase influences the response to chronic mild stress","volume":"8","author":"Aslani","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/102538902900012387","article-title":"Intermittent exposure to social defeat and open-field test in rats: acute and long-term effects on ECG, body temperature and physical activity","volume":"5","author":"Sgoifo","year":"2002","journal-title":"Stress"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0920-1211(02)00073-6","article-title":"Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy","volume":"50","author":"Loscher","year":"2002","journal-title":"Epilepsy Res"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2018.11.034_bb0155","first-page":"S33","article-title":"Kindling as a model of human epilepsy","volume":"36","author":"McIntyre","year":"2009","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0160","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1684\/epd.2012.0532","article-title":"Animal models of drug-resistant epilepsy","volume":"14","author":"Potschka","year":"2012","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0165","first-page":"55","article-title":"The rat grimace scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions","volume":"7","author":"Sotocinal","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-662-46943-9_4","article-title":"CNS adverse effects: from functional observation battery\/Irwin tests to electrophysiology","volume":"229","author":"Fonck","year":"2015","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0175","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbi.2015.12.007","article-title":"Proteomic profiling of epileptogenesis in a rat model: focus on inflammation","volume":"53","author":"Walker","year":"2016","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0180","series-title":"The rat brain in stereotactic coordinates","author":"Paxinos","year":"2005"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0185","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/epi.13328","article-title":"Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy","volume":"57","author":"Russmann","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation .2. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0195","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1258\/00236770460734353","article-title":"The importance of learning young: the use of nesting material in laboratory rats","volume":"38","author":"Van Loo","year":"2004","journal-title":"Lab Anim"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0200","series-title":"R: a language and environment for statistical computing","author":"R-Core-Team","year":"2017"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0205","series-title":"Ggplot2: elegant graphics for data analysis","author":"Wickham","year":"2009"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0210","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/epi.14028","article-title":"Toward evidence-based severity assessment in rat models with repeated seizures: I. Electrical kindling","volume":"59","author":"Moller","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0215","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2015.12.002","article-title":"Minocycline fails to exert antiepileptogenic effects in a rat status epilepticus model","volume":"771","author":"Russmann","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0220","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1111\/j.1528-1167.2011.03302.x","article-title":"The erythropoietin-derived peptide mimetic pHBSP affects cellular and cognitive consequences in a rat post-status epilepticus model","volume":"52","author":"Seeger","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0225","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0014-4886(02)00056-0","article-title":"The effect of kindled seizures on the locomotory behavior of Long-Evans rats","volume":"180","author":"Murphy","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0230","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yebeh.2016.08.022","article-title":"Neuroanatomical differences in FAST and SLOW rat strains with differential vulnerability to kindling and behavioral comorbidities","volume":"65","author":"Sharma","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0235","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.physbeh.2006.01.037","article-title":"Low amplitude entrainment of mice and the impact of circadian phase on behavior tests","volume":"87","author":"Beeler","year":"2006","journal-title":"Physiol Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0240","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0031-9384(00)00388-7","article-title":"Influence of circadian phase and test illumination on pre-clinical models of anxiety","volume":"72","author":"Jones","year":"2001","journal-title":"Physiol Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0245","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0006-8993(01)02780-9","article-title":"Seizures induce phase shifts of rat circadian rhythms","volume":"913","author":"Quigg","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0250","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1528-1157.2000.tb00202.x","article-title":"Effects of circadian regulation and rest-activity state on spontaneous seizures in a rat model of limbic epilepsy","volume":"41","author":"Quigg","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0255","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jsmc.2015.10.008","article-title":"Sleep and epilepsy","volume":"11","author":"Kataria","year":"2016","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0260","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1097\/01.nrl.0000340790.15295.59","article-title":"The relationship between sleep and epilepsy","volume":"14","author":"Rocamora","year":"2008","journal-title":"Neurologist"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0265","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.sleep.2014.09.021","article-title":"Sleep disorders and circadian rhythm in epilepsy revisited: a prospective controlled study","volume":"16","author":"Unterberger","year":"2015","journal-title":"Sleep Med"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0270","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.yebeh.2011.07.034","article-title":"Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats","volume":"22","author":"Pansani","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0275","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/bcpt.12556","article-title":"Cardiovascular alterations during the Interictal period in awake and pithed amygdala-kindled rats","volume":"119","author":"Ruiz-Salinas","year":"2016","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0280","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0920-1211(95)00018-6","article-title":"The effect of amygdaloid kindling on heart period and heart period variability","volume":"21","author":"Healy","year":"1995","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0285","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1528-1167.2009.02479.x","article-title":"Autonomic alterations and cardiac changes in epilepsy","volume":"51","author":"Sevcencu","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0290","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.seizure.2010.07.008","article-title":"Cardiac changes in epilepsy","volume":"19","author":"Jansen","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0295","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.eplepsyres.2005.02.001","article-title":"Time and frequency domain analyses of heart rate variability in patients with epilepsy","volume":"63","author":"Evrengul","year":"2005","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.seizure.2008.05.013","article-title":"Heart rate variability in patients with frontal lobe epilepsy","volume":"18","author":"Harnod","year":"2009","journal-title":"Seizure"},{"issue":"Suppl. 1","key":"10.1016\/j.yebeh.2018.11.034_bb0305","first-page":"69","article-title":"A study of interictal cardiac autonomic functions in patients with refractory complex partial epilepsy secondary to medial temporal lobe pathology: before and after surgery","volume":"12","author":"Shobha","year":"2007","journal-title":"Neurol Asia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0310","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1990.tb06096.x","article-title":"Kindled seizures elevate blood pressure and induce cardiac arrhythmias","volume":"31","author":"Goodman","year":"1990","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0315","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.yebeh.2010.08.019","article-title":"Tachycardias and sudden unexpected death in epilepsy: a gold rush by an experimental route","volume":"19","author":"Pansani","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0320","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuroscience.2014.10.055","article-title":"Amygdalar neuronal activity mediates the cardiovascular responses evoked from the dorsolateral periaqueductal gray in conscious rats","volume":"284","author":"de Abreu","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0325","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.nlm.2012.12.011","article-title":"Inactivation of the central nucleus of the amygdala blocks classical conditioning but not conditioning-specific reflex modification of rabbit heart rate","volume":"100","author":"Burhans","year":"2013","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0330","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1212\/WNL.0000000000005733","article-title":"Relating structural and functional brainstem connectivity to disease measures in epilepsy","volume":"91","author":"Englot","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0335","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.nicl.2014.06.010","article-title":"Evidence for brainstem network disruption in temporal lobe epilepsy and sudden unexplained death in epilepsy","volume":"5","author":"Mueller","year":"2014","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0340","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/WNP.0000000000000138","article-title":"Seizure-related autonomic changes in children","volume":"32","author":"Moseley","year":"2015","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0345","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1528-1167.2006.00467.x","article-title":"Cardiac autonomic control in patients with refractory epilepsy before and during vagus nerve stimulation treatment: a one-year follow-up study","volume":"47","author":"Ronkainen","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0350","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1528-1167.2011.03361.x","article-title":"A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs","volume":"53","author":"Lotufo","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0355","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.yebeh.2017.04.018","article-title":"Analysis of heart rate variability and risk factors for SUDEP in patients with drug-resistant epilepsy","volume":"71","author":"Baysal-Kirac","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0360","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.seizure.2007.03.010","article-title":"Heart rate variability in patients with untreated epilepsy","volume":"16","author":"Persson","year":"2007","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0365","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1528-1157.1996.tb00536.x","article-title":"The ictal bradycardia syndrome","volume":"37","author":"Reeves","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0370","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.acvd.2009.02.014","article-title":"Recurrent unexplained syncope may have a cerebral origin: report of 10 cases of arrhythmogenic epilepsy","volume":"102","author":"Kouakam","year":"2009","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0375","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(04)17594-6","article-title":"Cardiac arrhythmias in focal epilepsy: a prospective long-term study","volume":"364","author":"Rugg-Gunn","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0380","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0896-6974(95)00061-5","article-title":"Monitoring heart period variability changes during seizures. II. Diversity and trends","volume":"9","author":"Vaughn","year":"1996","journal-title":"J Epilepsy"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0385","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1093\/brain\/124.12.2361","article-title":"Ictal bradycardia in partial epileptic seizures: autonomic investigation in three cases and literature review","volume":"124","author":"Tinuper","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0390","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1528-1167.2007.01330.x","article-title":"Ictal asystole: a benign condition?","volume":"49","author":"Schuele","year":"2008","journal-title":"Epilepsia"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2018.11.034_bb0395","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1528-1167.2007.01068.x","article-title":"The relevance of kindling for human epilepsy","volume":"48","author":"Bertram","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0400","article-title":"Implantation of radiotelemetry transmitters yielding data on ECG, heart rate, core body temperature and activity in free-moving laboratory mice","volume":"57","author":"Cesarovic","year":"2011","journal-title":"J Vis Exp"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0405","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1258\/la.2008.007156","article-title":"Automated analysis of postoperative behaviour: assessment of HomeCageScan as a novel method to rapidly identify pain and analgesic effects in mice","volume":"43","author":"Roughan","year":"2009","journal-title":"Lab Anim"},{"key":"10.1016\/j.yebeh.2018.11.034_bb0410","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00000542-200407000-00030","article-title":"Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain","volume":"101","author":"Martin","year":"2004","journal-title":"Anesthesiology"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018307467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018307467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T07:36:20Z","timestamp":1605944180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505018307467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":82,"alternative-id":["S1525505018307467"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.11.034","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of repeated kindled seizures on heart rate rhythms, heart rate variability, and locomotor activity in rats","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.11.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}