{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:32:03Z","timestamp":1761514323443,"version":"3.40.5"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.yebeh.2018.12.002","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T16:39:21Z","timestamp":1546274361000},"page":"26-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Trends in valproate use in patients in Germany between 2009 and 2017"],"prefix":"10.1016","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-1239","authenticated-orcid":false,"given":"Louis","family":"Jacob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Bohlken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Kostev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2018.12.002_bb0005","article-title":"Weighing the risks of valproate in women who could become pregnant","volume":"361","author":"Angus-Leppan","year":"2018","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.yebeh.2018.12.002_bb0010","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1474-4422(15)00398-1","article-title":"The remarkable story of valproic acid","volume":"15","author":"Tomson","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2018.12.002_bb0015","article-title":"Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data","volume":"6","author":"Nevitt","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.yebeh.2018.12.002_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/bdi.12025","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013","volume":"15","author":"Yatham","year":"2013","journal-title":"Bipolar Disord"},{"issue":"4","key":"10.1016\/j.yebeh.2018.12.002_bb0025","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1526-4610.2006.00413.x","article-title":"Comparison of the effect of topiramate and sodium valporate in migraine prevention: a randomized blinded crossover study","volume":"46","author":"Shaygannejad","year":"2006","journal-title":"Headache"},{"key":"10.1016\/j.yebeh.2018.12.002_bb0030","article-title":"Dangers of valproate in pregnancy","volume":"361","author":"Wieck","year":"2018","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.yebeh.2018.12.002_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2008.04.022","article-title":"Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts","volume":"81","author":"Meador","year":"2008","journal-title":"Epilepsy Res"},{"issue":"7","key":"10.1016\/j.yebeh.2018.12.002_bb0040","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-017248","article-title":"Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis","volume":"7","author":"Veroniki","year":"2017","journal-title":"BMJ Open"},{"issue":"8","key":"10.1016\/j.yebeh.2018.12.002_bb0045","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/bdra.23277","article-title":"Novel mechanism for valproate-induced teratogenicity","volume":"100","author":"Fathe","year":"2014","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"6","key":"10.1016\/j.yebeh.2018.12.002_bb0050","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/adc.2008.144386","article-title":"Changing trends in antiepileptic drug prescribing in girls of child-bearing potential","volume":"94","author":"Ackers","year":"2009","journal-title":"Arch Dis Child"},{"issue":"2","key":"10.1016\/j.yebeh.2018.12.002_bb0055","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0404.2009.01260.x","article-title":"Changing patterns of antiepileptic drug use in pregnant Australian women","volume":"121","author":"Vajda","year":"2010","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2018.12.002_bb0060","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.seizure.2016.01.019","article-title":"Prescribing trends for sodium valproate in Ireland","volume":"36","author":"Murphy","year":"2016","journal-title":"Seizure"},{"issue":"6","key":"10.1016\/j.yebeh.2018.12.002_bb0065","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/ene.13610","article-title":"Declining trend in valproate use in Finland among females of childbearing age in 2012\u20132016 \u2014 a nationwide registry-based outpatient study","volume":"25","author":"Virta","year":"2018","journal-title":"Eur J Neurol"},{"issue":"8","key":"10.1016\/j.yebeh.2018.12.002_bb0070","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/s00103-018-2768-1","article-title":"Prescribing valproate to girls and women of childbearing age in Germany: analysis of trends based on claims data","volume":"61","author":"Wentzell","year":"2018","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"issue":"11","key":"10.1016\/j.yebeh.2018.12.002_bb0075","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1007\/s00415-012-6509-3","article-title":"Prevalence, utilization, and costs of antiepileptic drugs for epilepsy in Germany\u2014a nationwide population-based study in children and adults","volume":"259","author":"Hamer","year":"2012","journal-title":"J Neurol"},{"issue":"10","key":"10.1016\/j.yebeh.2018.12.002_bb0080","doi-asserted-by":"crossref","first-page":"459","DOI":"10.5414\/CP203320","article-title":"Basic characteristics and representativeness of the German Disease Analyzer database","volume":"56","author":"Rathmann","year":"2018","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.yebeh.2018.12.002_bb0085","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.yebeh.2017.06.008","article-title":"Persistence with antiepileptic drugs in epilepsy patients treated in neurological practices in Germany","volume":"73","author":"Jacob","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2018.12.002_bb0090","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yebeh.2017.07.001","article-title":"Adherence to antiepileptic drugs in children and adolescents: a retrospective study in primary care settings in Germany","volume":"75","author":"Jacob","year":"2017","journal-title":"Epilepsy Behav"},{"issue":"6","key":"10.1016\/j.yebeh.2018.12.002_bb0095","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/ana.25353","article-title":"Switching the manufacturer of anti-epileptic drugs is associated with higher risk of seizures","volume":"84","author":"Lang","year":"2018","journal-title":"Ann Neurol"},{"issue":"6","key":"10.1016\/j.yebeh.2018.12.002_bb0100","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.seizure.2012.04.014","article-title":"Trends in antiepileptic drug utilisation in UK primary care 1993\u20132008: cohort study using the General Practice Research Database","volume":"21","author":"Nicholas","year":"2012","journal-title":"Seizure"},{"issue":"11","key":"10.1016\/j.yebeh.2018.12.002_bb0105","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.jocn.2012.11.028","article-title":"Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy","volume":"20","author":"Xiaotian","year":"2013","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.yebeh.2018.12.002_bb0110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.yebeh.2018.04.029","article-title":"Effects of valproate on reproductive endocrine function in male patients with epilepsy: a systematic review and meta-analysis","volume":"85","author":"Zhao","year":"2018","journal-title":"Epilepsy Behav"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018309697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018309697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T08:14:32Z","timestamp":1553156072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505018309697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":22,"alternative-id":["S1525505018309697"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.12.002","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trends in valproate use in patients in Germany between 2009 and 2017","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}