{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:00:21Z","timestamp":1787677221126,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.yebeh.2018.12.021","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T11:53:31Z","timestamp":1547553211000},"page":"140-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Comparison of optic coherence tomography results in patients with diagnosed epilepsy: Findings in favor of neurodegeneration"],"prefix":"10.1016","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3783-184X","authenticated-orcid":false,"given":"Ali Zeynal Abidin","family":"Tak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u0131ld\u0131zhan","family":"\u015eeng\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Ekmek\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Sevgi","family":"Karada\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2018.12.021_bb0005","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.2147\/NDT.S142032","article-title":"Genetic and epigenetic mechanisms of epilepsy: a review","volume":"13","author":"Chen","year":"2017","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0010","series-title":"Handbook of epilepsy","author":"Browne","year":"2008"},{"issue":"9848","key":"10.1016\/j.yebeh.2018.12.021_bb0015","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0140-6736(12)61381-6","article-title":"Epilepsy in poor regions of the world","volume":"380","author":"Newton","year":"2012","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.yebeh.2018.12.021_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112365","article-title":"Metabolic dysfunction and oxidative stress in epilepsy","volume":"18","author":"Pearson-Smith","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0025","doi-asserted-by":"crossref","first-page":"43276","DOI":"10.1038\/srep43276","article-title":"Abnormal capillary Vasodynamics contribute to Ictal Neurodegeneration in epilepsy","volume":"7","author":"Leal-Campanario","year":"2017","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.yebeh.2018.12.021_bb0030","first-page":"BC05","article-title":"Oxidative stress in the development of genetic generalised epilepsy: an observational study in southern Indian population","volume":"11","author":"Prasad","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0035","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fneur.2017.00603","article-title":"resveratrol for easing status epilepticus induced brain injury, inflammation, epileptogenesis, and cognitive and memory dysfunction \u2014 are we there yet?","volume":"8","author":"Castro","year":"2017","journal-title":"Front Neurol"},{"issue":"5035","key":"10.1016\/j.yebeh.2018.12.021_bb0040","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical coherence tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0045","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/bjo.85.6.673","article-title":"The Humphrey optical coherence tomography scanner: quantitative analysis and reproducibility study of the normal human retinal nerve fibre layer","volume":"85","author":"Jones","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0050","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1055\/s-0035-1563579","article-title":"Optical coherence tomography for the neurologist","volume":"35","author":"Nolan","year":"2015","journal-title":"Semin Neurol"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0055","first-page":"105","article-title":"The use of optical coherence tomography in neurology","volume":"6","author":"Lamirel","year":"2009","journal-title":"Rev Neurol Dis"},{"issue":"2","key":"10.1016\/j.yebeh.2018.12.021_bb0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s13760-017-0852-1","article-title":"Evaluation of thickness of retinal nerve fiber layer, ganglion cell layer, and choroidal thickness in essential tremor: can eyes be a clue for neurodegeneration?","volume":"118","author":"Tak","year":"2018","journal-title":"Acta Neurol Belg"},{"issue":"3","key":"10.1016\/j.yebeh.2018.12.021_bb0065","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10072-017-3234-9","article-title":"Evaluation of white matter hyperintensities and retinal fiber layer, ganglion cell layer, inner-plexiform layer, and choroidal layer in migraine patients","volume":"39","author":"Tak","year":"2018","journal-title":"Neurol Sci"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0070","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/S0161-6420(00)00341-9","article-title":"Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography","volume":"107","author":"Blumenthal","year":"2000","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.yebeh.2018.12.021_bb0075","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1167\/iovs.03-0514","article-title":"Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using stratus OCT","volume":"45","author":"Paunescu","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0080","article-title":"Temporal lobe epilepsy-induced neurodegeneration and cognitive deficits: implications for aging","volume":"19","author":"Vrinda","year":"2018","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0085","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/978-3-319-57193-5_12","article-title":"Neurodegeneration and pathology in epilepsy: clinical and basic perspectives","volume":"15","author":"Farrell","year":"2017","journal-title":"Adv Neurobiol"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0090","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1468-1331.2006.01213.x","article-title":"Color vision and macular recovery time in epileptic adolescents treated with valproate and carbamazepine","volume":"13","author":"Verrotti","year":"2006","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0095","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1528-1167.2006.00505.x","article-title":"Retinal nerve fiber layer and macular thickness in adolescents with epilepsy treated with valproate and carbamazepine","volume":"47","author":"Lobefalo","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0100","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.seizure.2009.02.003","article-title":"Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat","volume":"18","author":"Aktas\u00b8","year":"2009","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0105","first-page":"1","article-title":"Ciliary body toxicities of sys- temic oxcarbazepine and valproic acid treatments: electron microscopic study","volume":"28","author":"G\u00f6ktas\u00b8","year":"2014","journal-title":"Cutan Ocul Toxicol"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0110","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/bjo.84.5.499","article-title":"A controlled study of vigabatrin and visual abnormalities","volume":"84","author":"Manuchehri","year":"2000","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"10.1016\/j.yebeh.2018.12.021_bb0115","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/A:1014643528474","article-title":"Vigabatrin; its effect on the electrophysiology of vision","volume":"104","author":"Harding","year":"2000","journal-title":"Doc Ophthalmol"},{"issue":"3","key":"10.1016\/j.yebeh.2018.12.021_bb0120","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1167\/iovs.05-0854","article-title":"Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer","volume":"47","author":"Wild","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.yebeh.2018.12.021_bb0125","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ophtha.2008.09.047","article-title":"Nasal retinal nerve fiber layer attenuation: a biomarker for vigabatrin toxicity","volume":"116","author":"Lawthom","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0130","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1177\/112067211002000419","article-title":"Detecting retinal vigabatrin toxicity in patients with partial symptomatic or cryptogenic epilepsy","volume":"20","author":"Ak\u00e7akaya","year":"2010","journal-title":"Eur J Ophthalmol"},{"issue":"5","key":"10.1016\/j.yebeh.2018.12.021_bb0135","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.22266","article-title":"Retinal nerve fiber layer thickness in vigabatrin-exposed patients","volume":"69","author":"Clayton","year":"2011","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1016\/j.yebeh.2018.12.021_bb0140","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/aos.12030","article-title":"Attenuation of the retinal nerve fibre layer and reduced retinal function assessed by optical coherence tomography and full-field electroretinography in patients exposed to vigabatrin medication","volume":"92","author":"Kjellstr\u00f6m","year":"2014","journal-title":"Acta Ophthalmol"},{"issue":"5","key":"10.1016\/j.yebeh.2018.12.021_bb0145","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1755-3768.2010.02077.x","article-title":"Retinal nerve fibre layer attenuation: clinical indicator for vigabatrin toxicity","volume":"89","author":"Moseng","year":"2011","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0150","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s10072-017-2971-0","article-title":"Evaluation of inner retinal layers with\u00a0optic\u00a0coherence\u00a0tomography\u00a0in\u00a0vigabatrin-exposed patients","volume":"38","author":"Tu\u011fcu","year":"2017","journal-title":"Neurol Sci"},{"key":"10.1016\/j.yebeh.2018.12.021_bb0155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.seizure.2015.12.014","article-title":"Optical coherence tomography parameters in patients with photosensitive juvenile myoclonic epilepsy","volume":"35","author":"Gomceli","year":"2016","journal-title":"Seizure"},{"issue":"8","key":"10.1016\/j.yebeh.2018.12.021_bb0160","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s10072-017-2971-0","article-title":"Evaluation of inner retinal layers with optic coherence tomography in vigabatrin-exposed patients","volume":"38","author":"Tu\u011fcu","year":"2017","journal-title":"Neurol Sci"},{"issue":"2","key":"10.1016\/j.yebeh.2018.12.021_bb0165","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5935\/0004-2749.20160024","article-title":"Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine","volume":"79","author":"Colak","year":"2016","journal-title":"Arq Bras Oftalmol"},{"issue":"2","key":"10.1016\/j.yebeh.2018.12.021_bb0170","first-page":"137","article-title":"Subfoveal choroidal thickness in normal eyes measurement using optical coherence tomography","volume":"22","author":"Tuncer","year":"2014","journal-title":"Ret Vit"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550501830934X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550501830934X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T06:04:21Z","timestamp":1553321061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152550501830934X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":34,"alternative-id":["S152550501830934X"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.12.021","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of optic coherence tomography results in patients with diagnosed epilepsy: Findings in favor of neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2018.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}