{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:29:26Z","timestamp":1772987366856,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.yebeh.2019.01.033","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T18:00:16Z","timestamp":1551463216000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Prevalence and incidence of new-onset seizures and epilepsy in patients with human immunodeficiency virus (HIV): Systematic review and meta-analysis"],"prefix":"10.1016","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-5731","authenticated-orcid":false,"given":"Paddy","family":"Ssentongo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2019.01.033_bb0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.seizure.2007.05.017","article-title":"Frequency of seizures and epilepsy in neurological HIV-infected patients","volume":"17","author":"Kellinghaus","year":"2008","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0010","first-page":"146","article-title":"Metabolic abnormalities and new-onset seizures in human immunodeficiency virus-seropositive patients","volume":"36","author":"Van Paesschen","year":"1995"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0015","first-page":"573","article-title":"Seizures in patients with human immunodeficiency virus infection","volume":"48","author":"Chadha","year":"2000","journal-title":"J Assoc Physicians India"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0020","first-page":"59","article-title":"Prospective analysis of seizures occurring in human immunodeficiency virus type-1 infection","volume":"1","author":"Dore","year":"1997","journal-title":"J NeuroAIDS"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0025","series-title":"Epilepsy seizures in HIV infection. 52 cases","first-page":"2135","volume":"20","author":"Bartolomei","year":"1991"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0030","first-page":"173","article-title":"New-onset seizures associated with \\human immunodeficiency virus infection: causation and clinical features in 100 cases","volume":"87","author":"Holtzman","year":"1989"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0035","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/QAI.0000000000000563","article-title":"Early antiretroviral therapy is protective against epilepsy in children with human immunodeficiency virus infection in Botswana","volume":"69","author":"Bearden","year":"2015","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0040","first-page":"694","article-title":"Clinical features of seizures in patients with human immunodeficiency virus infection","volume":"30","author":"Kim","year":"2015"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0045","first-page":"905","article-title":"New-onset generalized seizures in patients with aids presenting to an emergency department","volume":"5","author":"Pesola","year":"1998"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0050","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1001\/archneur.1990.00530060048015","article-title":"Seizures in human immunodeficiency virus infection","volume":"47","author":"Wong","year":"1990","journal-title":"Arch Neurol"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0055","first-page":"477","article-title":"New-onset seizure in HIV-infected adult Zambians: a search for causes and consequences","volume":"88","author":"Siddiqi","year":"2017"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/0883073812446161","article-title":"Prevalence of seizures in children infected with human immunodeficiency virus","volume":"28","author":"Samia","year":"2012","journal-title":"J Child Neurol"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ebcr.2018.02.006","article-title":"Seizures in HIV: the case for special consideration","volume":"10","author":"Zaporojan","year":"2018","journal-title":"Epilepsy Behav Case Rep"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0070","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/archneur.56.5.609","article-title":"Prospective study of new-onset seizures in patients with human immunodeficiency virus infection: etiologic and clinical aspects","volume":"56","author":"Pascual-Sedano","year":"1999","journal-title":"Arch Neurol"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.eplepsyres.2012.07.009","article-title":"The impact of enzyme-inducing antiepileptic drugs on antiretroviral drug levels: a case\u2013control study","volume":"103","author":"Okulicz","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0080","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1212\/WNL.55.10.1558","article-title":"New-onset seizures associated with HIV infection","volume":"55","author":"Modi","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0085","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0002-9343(89)80693-X","article-title":"New-onset seizures associated with human immunodeficiency virus infection: causation and clinical features in 100 cases","volume":"87","author":"Holtzman","year":"1989","journal-title":"Am J Med"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0090","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.0013-9580.2005.30604.x","article-title":"Estimating prevalence, incidence, and disease-related mortality for patients with epilepsy in managed care organizations","volume":"46","author":"Holden","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0095","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1528-1157.1991.tb04675.x","article-title":"Prevalence of epilepsy in Rochester, Minnesota: 1940\u20131980","volume":"32","author":"Hauser","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000110245","article-title":"Antiepileptic drugs as \u2018tracers\u2019 of disease","volume":"10","author":"Beghi","year":"1991","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0105","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1046\/j.1528-1157.2002.t01-1-26901.x","article-title":"Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures","volume":"43","author":"Kotsopoulos","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1742-6405-8-18","article-title":"Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control study","volume":"8","author":"Okulicz","year":"2011","journal-title":"Aids Res Ther"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0115","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2125.2005.02529.x","article-title":"Clinically relevant drug interactions with antiepileptic drugs","volume":"61","author":"Perucca","year":"2006","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0120","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1742-6405-8-18","article-title":"The infectious disease clinical research program HIVWG. Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control study","volume":"8","author":"Okulicz","year":"2011","journal-title":"Aids Res Ther"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0125","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1517\/17425255.3.4.583","article-title":"The role of cytochrome P450 in antiretroviral drug interactions","volume":"3","author":"Walubo","year":"2007","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0130","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1212\/WNL.0b013e31823efcf8","article-title":"Evidence-based guideline: antiepileptic drug selection for people with HIV\/AIDS","volume":"78","author":"Birbeck","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1528-1167.2008.01754.x","article-title":"Seizures in HIV-seropositive individuals: NIMHANS experience and review","volume":"49","author":"Satishchandra","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0140","first-page":"30","article-title":"Provisional WHO\/UNAIDS Secretariat Recommendations on the use of cotrimoxazole prophylaxis in adults and children living with HIV\/AIDS in Africa","volume":"1","author":"Organization Wh","year":"2000","journal-title":"Afr Health Sci"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0145","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(99)03465-0","article-title":"Efficacy of trimethoprim-sulphamethoxazole prophylaxis to decrease morbidity and mortality in HIV-1-infected patients with tuberculosis in Abidjan, C\u00f4te D'ivoire: a randomised controlled trial","volume":"353","author":"Wiktor","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0150","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/S0140-6736(04)17225-5","article-title":"Effect of co-trimoxazole prophylaxis on morbidity, mortality, Cd4-cell count, and viral load in HIV infection in rural Uganda","volume":"364","author":"Mermin","year":"2004","journal-title":"The Lancet"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0155","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/S0140-6736(04)17442-4","article-title":"Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (chap): a double-blind randomised placebo-controlled trial","volume":"364","author":"Chintu","year":"2004","journal-title":"The Lancet"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0160","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0140-6736(98)07399-1","article-title":"Early chemoprophylaxis with trimethoprim-sulphamethoxazole for HIV-1-infected adults in Abidjan, C\u00f4te D'ivoire: a randomised trial","volume":"353","author":"Anglaret","year":"1999","journal-title":"The Lancet"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0165","series-title":"Models of seizures and epilepsy","author":"Pitk\u00e4nen","year":"2017"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/srep43652","article-title":"A murine model to study epilepsy and SUDEP induced by malaria infection","volume":"7","author":"Ssentongo","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0175","doi-asserted-by":"crossref","first-page":"8473","DOI":"10.1523\/JNEUROSCI.1130-18.2018","article-title":"A brain\u2013heart biomarker for epileptogenesis","volume":"38","author":"Bahari","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0180","first-page":"2011","article-title":"Prevalence of human immunodeficiency virus and its sociodemographic, knowledge and behavioral predictors among women: a cross-sectional population-based survey in Ivory Coast","volume":"6","author":"Ba","year":"2018","journal-title":"J Prev Treat Hiv\/Aids"},{"key":"10.1016\/j.yebeh.2019.01.033_bb0185","first-page":"29","article-title":"New-onset seizures among HIV infected drug na\u00efve patients from south India","volume":"10","author":"Sinha","year":"2005"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018310370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505018310370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:24:48Z","timestamp":1761503088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505018310370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":37,"alternative-id":["S1525505018310370"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2019.01.033","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and incidence of new-onset seizures and epilepsy in patients with human immunodeficiency virus (HIV): Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2019.01.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}