{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:19:33Z","timestamp":1790000373605,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.yebeh.2019.04.002","type":"journal-article","created":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T05:08:29Z","timestamp":1556428109000},"page":"112-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy"],"prefix":"10.1016","volume":"95","author":[{"given":"Ivana","family":"Kacirova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Grundmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Brozmanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2019.04.002_bb0010","first-page":"23","article-title":"Trend analysis of the utilization of antiepileptic drugs in pregnant women with epilepsy in Moravian-Silesian region of the Czech Republic","volume":"30","author":"Kacirova","year":"2016","journal-title":"Klin Farmakol Farm"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0015","doi-asserted-by":"crossref","first-page":"569","DOI":"10.5507\/bp.2015.055","article-title":"Serum levels of valproic acid during delivery in mothers and in umbilical cord \u2014 correlation with birth length and weight","volume":"159","author":"Kacirova","year":"2015","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0020","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00007691-198409000-00003","article-title":"Valproic acid in breast milk: how much is really there?","volume":"6","author":"von Unruh","year":"1984","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0025","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0022-3476(84)80567-3","article-title":"Valproic acid in the perinatal period: decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and metabolites","volume":"104","author":"Nau","year":"1984","journal-title":"J Pediatr"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0030","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4088\/JCP.v61n0304","article-title":"Serum valproate levels in 6 breastfeeding mother\u2013infant pairs","volume":"61","author":"Piontek","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0035","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0022-3565(25)32875-2","article-title":"Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers","volume":"219","author":"Nau","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0040","series-title":"Advances in epileptology: XIIth epilepsy international symposium","first-page":"581","article-title":"Antiepileptic therapy with carbamazepine and valproic acid during pregnancy and lactation period","author":"Froescher","year":"1981"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0045","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1600-0404.1985.tb00901.x","article-title":"Concentration of valproate during pregnancy, in the newborn and in breast milk","volume":"72","author":"Philbert","year":"1985","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0050","first-page":"1195","article-title":"The perinatal pharmacokinetics of anticonvulsant drugs","volume":"110","author":"Meyer","year":"1988","journal-title":"Zentralbl Gynakol"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0055","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1542\/peds.104.1.e11","article-title":"Serum concentrations of antidepressants and benzodiazepines in nursing infants: a case series","volume":"104","author":"Birnbaum","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0060","first-page":"89","article-title":"Three cases of delivery under sodium valproate\u2014placental transfer, milk transfer and probable teratogenicity of sodium valproate","volume":"42","author":"Tsuru","year":"1988","journal-title":"Jpn J Psychiatry Neurol"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00004714-199804000-00009","article-title":"Serum levels of valproate and carbamazepine in breastfeeding mother\u2013infant pairs","volume":"18","author":"Wisner","year":"1998","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0070","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0022-3476(79)80172-9","article-title":"Transmission of valproic acid (Depakene) across the placenta: half-life of the drug in mother and baby","volume":"94","author":"Dickinson","year":"1979","journal-title":"J Pediatr"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/adc.54.3.240","article-title":"Sodium valproate and pregnancy","volume":"54","author":"Alexander","year":"1979","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0080","series-title":"Epilepsy, pregnancy and the child","first-page":"359","article-title":"Valproic acid and breast-feeding","author":"Bardy","year":"1982"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0085","series-title":"Clinical and pharmacological aspects of sodium valproate in the treatment of epilepsy: proceedings of a symposium","first-page":"145","article-title":"Sodium valproate (Epilim) \u2014 some clinical and pharmacological aspects","author":"Espir","year":"1976"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0090","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0022-3476(97)70292-0","article-title":"Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid","volume":"130","author":"Stahl","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0095","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/jamapediatrics.2014.118","article-title":"Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6\u202fyears","volume":"168","author":"Meador","year":"2014","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0105","series-title":"Antiepileptic drug interactions. A clinical guide","author":"Patsalos","year":"2013"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0110","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.yebeh.2007.08.018","article-title":"Pharmacology of antiepileptic drugs during pregnancy and lactation","volume":"11","author":"Pennell","year":"2007","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.yebeh.2014.02.011","article-title":"Carbamazepine clearance and seizure stability during pregnancy","volume":"33","author":"Johnson","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"7","key":"10.1016\/j.yebeh.2019.04.002_bb0120","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1528-1167.2008.01561.x","article-title":"Antiepileptic drugs \u2014 best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies","volume":"49","author":"Patsalos","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0125","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1528-1157.2000.tb00232.x","article-title":"Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation","volume":"41","author":"Ohman","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0130","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1542\/peds.2007-3812","article-title":"Lamotrigine in breast milk and nursing infants: determination of exposure","volume":"122","author":"Newport","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0135","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/1756285615623934","article-title":"Management of epilepsy during pregnancy: an update","volume":"9","author":"Patel","year":"2016","journal-title":"Ther Adv Neurol Disord"},{"key":"10.1016\/j.yebeh.2019.04.002_bb0140","doi-asserted-by":"crossref","DOI":"10.1097\/FTD.0000000000000604","article-title":"A short communication: lamotrigine levels in milk, mothers and breast-fed infants during the 1st postnatal month","author":"Kacirova","year":"2019","journal-title":"Ther Drug Monit"},{"issue":"1","key":"10.1016\/j.yebeh.2019.04.002_bb0145","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1212\/WNL.48.1.182","article-title":"Safety and efficacy of divalproex sodium monotherapy in partial epilepsy: a double-blind, concentration\u2013response design clinical trial. Depakote Monotherapy for Partial Seizures Study Group","volume":"48","author":"Beydoun","year":"1997","journal-title":"Neurology"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505019301210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505019301210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:27:28Z","timestamp":1761503248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505019301210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":27,"alternative-id":["S1525505019301210"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2019.04.002","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2019.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}