{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:24:25Z","timestamp":1786998265026,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001771","name":"Tuberous Sclerosis Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006019","name":"Van Andel Research Institute","doi-asserted-by":"publisher","award":["U01-NS092595"],"award-info":[{"award-number":["U01-NS092595"]}],"id":[{"id":"10.13039\/100006019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20-NS080199"],"award-info":[{"award-number":["P20-NS080199"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-NS082320"],"award-info":[{"award-number":["U01-NS082320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54-NS092090"],"award-info":[{"award-number":["U54-NS092090"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1-TR000077"],"award-info":[{"award-number":["UL1-TR000077"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1-TR000124"],"award-info":[{"award-number":["UL1-TR000124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016650","name":"Rare Diseases Clinical Research Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016650","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.yebeh.2019.106844","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T09:56:59Z","timestamp":1576663019000},"page":"106844","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"PA","title":["Language predictors of autism spectrum disorder in young children with tuberous sclerosis complex"],"prefix":"10.1016","volume":"103","author":[{"given":"Alexandra","family":"Schoenberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie K.","family":"Capal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Ondracek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Weber","family":"Byars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian E.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Bebin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope","family":"Northrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Y.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy A.","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2019.106844_bb0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13023-018-0870-y","article-title":"Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national prospective surveillance study","volume":"13","author":"Ebrahimi-Fakhari","year":"2018","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.yebeh.2019.106844_bb0010","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1474-4422(15)00069-1","article-title":"Neurological and neuropsychiatric aspects of tuberous sclerosis complex","volume":"14","author":"Curatolo","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2019.106844_bb0015","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1017\/S0033291702007092","article-title":"Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex","volume":"33","author":"Joinson","year":"2003","journal-title":"Psychol Med"},{"key":"10.1016\/j.yebeh.2019.106844_bb0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1212\/01.wnl.0000250330.44291.54","article-title":"Cognitive prognosis of patients with tuberous sclerosis complex","volume":"68","author":"Winterkorn","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2019.106844_bb0025","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00787-004-0383-1","article-title":"A prospective longitudinal study of early cognitive development in tuberous sclerosis \u2014 a clinic based study","volume":"13","author":"Humphrey","year":"2004","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.yebeh.2019.106844_bb0030","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/0883073807309788","article-title":"Characterization of autism in young children with tuberous sclerosis complex","volume":"23","author":"Jeste","year":"2008","journal-title":"J Child Neurol"},{"key":"10.1016\/j.yebeh.2019.106844_bb0035","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1212\/WNL.0000000000000568","article-title":"Early developmental trajectories associated with ASD in infants with tuberous sclerosis complex","volume":"83","author":"Jeste","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2019.106844_bb0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yebeh.2011.10.005","article-title":"Cognitive and adaptive development of patients with tuberous sclerosis complex: a retrospective, longitudinal investigation","volume":"23","author":"van Eeghen","year":"2012","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2019.106844_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6503a1","article-title":"Prevalence and characteristics of autism spectrum disorder among children aged 8\u202fyears\u2014autism and developmental disabilities monitoring network, 11 Sites, United States, 2012","volume":"65","author":"Christensen","year":"2016","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.yebeh.2019.106844_bb0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yebeh.2017.02.007","article-title":"Influence of seizures on early development in tuberous sclerosis complex","volume":"70","author":"Capal","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2019.106844_bb0055","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1528-1167.2009.02474.x","article-title":"The natural history of epilepsy in tuberous sclerosis complex","volume":"51","author":"Chu-Shore","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.106844_bb0060","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1212\/01.wnl.0000280579.04974.c0","article-title":"Cognitive impairment in tuberous sclerosis complex is a multifactorial condition","volume":"70","author":"Jansen","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2019.106844_bb0065","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1017\/S0033291715000264","article-title":"Intellectual abilities in tuberous sclerosis complex: risk factors and correlates from the Tuberous Sclerosis 2000 Study","volume":"45","author":"Bolton","year":"2015","journal-title":"Psychol Med"},{"key":"10.1016\/j.yebeh.2019.106844_bb0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ejpn.2004.08.005","article-title":"Autism in tuberous sclerosis","volume":"8","author":"Curatolo","year":"2004","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.yebeh.2019.106844_bb0075","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13023-015-0371-1","article-title":"Autism spectrum disorder in tuberous sclerosis complex: searching for risk markers","volume":"10","author":"Vignoli","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.yebeh.2019.106844_bb0080","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/1362361307075706","article-title":"Language development among the siblings of children with autistic spectrum disorder","volume":"11","author":"Chuthapisith","year":"2007","journal-title":"Autism"},{"key":"10.1016\/j.yebeh.2019.106844_bb0085","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s10803-009-0727-2","article-title":"Developmental trajectories in siblings of children with autism: cognition and language from 4\u202fmonths to 7\u202fyears","volume":"39","author":"Gamliel","year":"2009","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.yebeh.2019.106844_bb0090","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1037\/amp0000436","article-title":"Impacting development in infants with tuberous sclerosis complex: multidisciplinary research collaboration","volume":"74","author":"Williams","year":"2019","journal-title":"Am Psychol"},{"key":"10.1016\/j.yebeh.2019.106844_bb0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2013.08.001","article-title":"Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference","volume":"49","author":"Northrup","year":"2013","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.yebeh.2019.106844_bb0100","series-title":"Mullen Scales of Early Learning","author":"Mullen","year":"1995"},{"key":"10.1016\/j.yebeh.2019.106844_bb0105","series-title":"Vineland Adaptive Behavior Scales: second edition (Vineland II), survey interview form\/caregiver rating form","author":"Sparrow","year":"2005"},{"key":"10.1016\/j.yebeh.2019.106844_bb0110","series-title":"Preschool Language Scale, fifth edition (PLS-5)","author":"Zimmerman","year":"2011"},{"key":"10.1016\/j.yebeh.2019.106844_bb0115","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1528-1167.2010.02542.x","article-title":"The new ILAE classification","volume":"51","author":"Shinnar","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.106844_bb0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13023-016-0553-5","article-title":"TuberOus SClerosis registry to increase disease awareness (TOSCA) \u2014 baseline data on 2093 patients","volume":"12","author":"Kingswood","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.yebeh.2019.106844_bb0125","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/adc.2011.211995","article-title":"The Tuberous Sclerosis 2000 Study: presentation initial assessments and implications for diagnosis and management","volume":"96","author":"Yates","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.yebeh.2019.106844_bb0130","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.rasd.2012.03.009","article-title":"Early language milestones predict later language, but not autism symptoms in higher functioning children with autism spectrum disorders","volume":"6","author":"Kenworthy","year":"2012","journal-title":"Res Autism Spectr Disord"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505019309151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505019309151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:29:13Z","timestamp":1761503353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505019309151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":26,"alternative-id":["S1525505019309151"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2019.106844","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Language predictors of autism spectrum disorder in young children with tuberous sclerosis complex","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2019.106844","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106844"}}