{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:35:19Z","timestamp":1793795719822,"version":"4.6.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.yebeh.2019.106862","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T23:40:23Z","timestamp":1578354023000},"page":"106862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"PA","title":["Exploring the ameliorative role of \u03b17 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice"],"prefix":"10.1016","volume":"103","author":[{"given":"Neeraj Kumar","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhdeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Kumar","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.yebeh.2019.106862_bb0005","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","article-title":"Global, regional, and national burden of neurological disorders during 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"16","author":"Feigin","year":"2017","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.1016\/j.yebeh.2019.106862_bb0010","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrd4126","article-title":"New avenues for anti-epileptic drug discovery and development","volume":"12","author":"L\u00f6scher","year":"2013","journal-title":"Nat Rev Drug Discov"},{"issue":"12","key":"10.1016\/j.yebeh.2019.106862_bb0015","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: a population-based analysis","volume":"48","author":"Tellez-Zenteno","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2019.106862_bb0020","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/bph.12052","article-title":"Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder?","author":"Cardamone","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.yebeh.2019.106862_bb0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fphar.2013.00045","article-title":"Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved","volume":"4","author":"Renoir","year":"2013","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.yebeh.2019.106862_bb0030","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fphar.2017.00057","article-title":"Nicotine elicits convulsive seizures by activating amygdalar neurons","volume":"8","author":"Iha","year":"2017","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.yebeh.2019.106862_bb0035","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bcp.2015.06.005","article-title":"The \u03b17 nicotinic acetylcholine receptor: a mediator of pathogenesis and therapeutic target in autism spectrum disorders and Down syndrome","volume":"97","author":"Deutsch","year":"2015","journal-title":"Biochem Pharmacol"},{"issue":"7","key":"10.1016\/j.yebeh.2019.106862_bb0040","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1177\/0269881108091587","article-title":"Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests","volume":"23","author":"Andreasen","year":"2009","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.yebeh.2019.106862_bb0045","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.fct.2017.09.050","article-title":"Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2\/NF-\u03baB transcriptional pathway","volume":"109","author":"Zhao","year":"2017","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.yebeh.2019.106862_bb0050","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1523\/JNEUROSCI.18-12-04461.1998","article-title":"Identification of four classes of brain nicotinic receptors using \u03b22 mutant mice","volume":"18","author":"Zoli","year":"1998","journal-title":"J Neurosci"},{"issue":"7","key":"10.1016\/j.yebeh.2019.106862_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002612","article-title":"Rational engineering of enzyme allosteric regulation through sequence evolution analysis","volume":"8","author":"Yang","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.yebeh.2019.106862_bb0060","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1124\/mol.116.104240","article-title":"Understanding the bases of function and modulation of \u03b17 nicotinic receptors: implications for drug discovery","volume":"90","author":"Corradi","year":"2016","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.yebeh.2019.106862_bb0065","first-page":"37","article-title":"\u03b17 nicotinic receptor agonists: potential therapeutic drugs for treatment of cognitive impairments in schizophrenia and Alzheimer's disease","volume":"4","author":"Toyohara","year":"2010","journal-title":"Open Med Chem J"},{"issue":"1","key":"10.1016\/j.yebeh.2019.106862_bb0070","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuropharm.2008.08.025","article-title":"The selective nicotinic acetylcholine receptor \u03b17 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain","volume":"56","author":"Feuerbach","year":"2009","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.yebeh.2019.106862_bb0075","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1152\/jn.01030.2012","article-title":"\u03b17-Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability","volume":"110","author":"Pidoplichko","year":"2013","journal-title":"J Neurophysiol"},{"issue":"2","key":"10.1016\/j.yebeh.2019.106862_bb0080","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuroscience.2008.03.083","article-title":"The selective \u03b17 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: differential effects in the juvenile and adult rat","volume":"154","author":"Thomsen","year":"2008","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.yebeh.2019.106862_bb0085","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/bcpt.12275","article-title":"Adjuvant anticholinesterase therapy for the management of epilepsy-induced memory deficit: a critical pre-clinical study","volume":"115","author":"Mishra","year":"2014","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"4","key":"10.1016\/j.yebeh.2019.106862_bb0090","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s11011-015-9650-8","article-title":"Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: search for add on therapy","volume":"30","author":"Mishra","year":"2015","journal-title":"Metab Brain Dis"},{"issue":"3","key":"10.1016\/j.yebeh.2019.106862_bb0095","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.yebeh.2019.106862_bb0100","article-title":"Sucrose preference test to measure anhedonic behaviour in mice","volume":"6","author":"Serchov","year":"2016","journal-title":"BioProtocol"},{"issue":"2","key":"10.1016\/j.yebeh.2019.106862_bb0105","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"issue":"2","key":"10.1016\/j.yebeh.2019.106862_bb0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.35652\/IGJPS.2012.15","article-title":"Behavior & pharmacological animal models for the evaluation of learning & memory condition","volume":"2","author":"Narwal","year":"2012","journal-title":"Indo Global J Pharm Sci"},{"issue":"1","key":"10.1016\/j.yebeh.2019.106862_bb0115","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2466\/pr0.1967.21.1.221","article-title":"An improved one-trial passive avoidance learning situation","volume":"21","author":"Jarvik","year":"1967","journal-title":"Psychol Rep"},{"key":"10.1016\/j.yebeh.2019.106862_bb0120","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jep.2015.09.025","article-title":"Pharmacological validation of in-silico guided novel nootropic potential of Achyranthes aspera L","volume":"175","author":"Gawande","year":"2015","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10.1016\/j.yebeh.2019.106862_bb0125","doi-asserted-by":"crossref","first-page":"7-4","DOI":"10.1002\/0471142301.ns0704s48","article-title":"Detection and quantification of neurotransmitters in dialysates","volume":"48","author":"Zapata","year":"2009","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.yebeh.2019.106862_bb0130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2013.02.012","article-title":"Ameliorative effect of curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice","volume":"704","author":"Choudhary","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2019.106862_bb0135","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2016.05.019","article-title":"Adjuvant indoleamine 2, 3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression","volume":"784","author":"Singh","year":"2016","journal-title":"Eur J Pharmacol"},{"issue":"136","key":"10.1016\/j.yebeh.2019.106862_bb0140","article-title":"Pentylenetetrazole-induced kindling mouse model","author":"Shimada","year":"2018","journal-title":"JoVE (J Vis Exp)"},{"issue":"1","key":"10.1016\/j.yebeh.2019.106862_bb0145","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1423-0127-19-56","article-title":"The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats","volume":"19","author":"Rajabzadeh","year":"2012","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.yebeh.2019.106862_bb0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fnbeh.2017.00203","article-title":"Neuronal nitric oxide synthase contributes to PTZ kindling-induced cognitive impairment and depressive-like behavior","volume":"11","author":"Zhu","year":"2017","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.yebeh.2019.106862_bb0155","series-title":"Models of seizures and epilepsy","first-page":"1091","article-title":"Models of depression","author":"Mazarati","year":"2017"},{"key":"10.1016\/j.yebeh.2019.106862_bb0160","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.biopha.2017.01.009","article-title":"A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice","volume":"88","author":"Abdel-Zaher","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.yebeh.2019.106862_bb0165","first-page":"287","article-title":"Anti-oxidant strategies","volume":"vol. 12, no. 4","author":"Buonocore","year":"2007"},{"key":"10.1016\/j.yebeh.2019.106862_bb0170","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2019.03.053","article-title":"Nicotinic acetylcholine receptor \u03b17 subunit maybe a risk factor of seizure susceptibility","volume":"704","author":"Chen","year":"2019","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2019.106862_bb0175","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.biopha.2018.09.137","article-title":"Protective effect of \u03b1-asarone against nicotine-induced seizures in mice, but not by its interaction with nicotinic acetylcholine receptors","volume":"108","author":"Chellian","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"10.1016\/j.yebeh.2019.106862_bb0180","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am J Psychiatry"},{"issue":"2","key":"10.1016\/j.yebeh.2019.106862_bb0185","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.yebeh.2005.06.003","article-title":"New facets of the neuropathology and molecular profile of human temporal lobe epilepsy","volume":"7","author":"de Lanerolle","year":"2005","journal-title":"Epilepsy Behav"},{"issue":"7","key":"10.1016\/j.yebeh.2019.106862_bb0190","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/jcbfm.2013.54","article-title":"Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice","volume":"33","author":"Smeland","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"10.1016\/j.yebeh.2019.106862_bb0195","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1385\/JMN:20:1:53","article-title":"CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons","volume":"20","author":"Mir","year":"2003","journal-title":"J Mol Neurosci"},{"issue":"2","key":"10.1016\/j.yebeh.2019.106862_bb0200","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/0975-7406.111818","article-title":"Stress: neurobiology, consequences and management","volume":"5","author":"Kumar","year":"2013","journal-title":"J Pharm Bioallied Sci"},{"key":"10.1016\/j.yebeh.2019.106862_bb0205","series-title":"Psychoneuroimmunology","first-page":"322","article-title":"Aging, neuroinflammation and behavior","volume":"vol. 4","author":"Ader","year":"2009"},{"issue":"3","key":"10.1016\/j.yebeh.2019.106862_bb0210","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ncl.2006.03.010","article-title":"Age and neuroinflammation: a lifetime of psychoneuroimmune consequences","volume":"24","author":"Godbout","year":"2006","journal-title":"Neurol Clin"},{"issue":"5\u20138","key":"10.1016\/j.yebeh.2019.106862_bb0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03402177","article-title":"The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation","volume":"9","author":"Pavlov","year":"2003","journal-title":"Mol Med"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505019308716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505019308716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:32:06Z","timestamp":1761503526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505019308716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":43,"alternative-id":["S1525505019308716"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2019.106862","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the ameliorative role of \u03b17 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2019.106862","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106862"}}