{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:34:58Z","timestamp":1761503698018,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.yebeh.2020.106960","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T18:40:21Z","timestamp":1582310421000},"page":"106960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine"],"prefix":"10.1016","volume":"105","author":[{"given":"Vivek","family":"Sabharwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mugilan","family":"Poongkunran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murad","family":"Talahma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifeanyi O.","family":"Iwuchukwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Ciccotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namir","family":"Khandker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"McGrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2020.106960_bb0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1528-1167.2009.02323.x","article-title":"Refractory status epilepticus: a prospective observational study","volume":"51","author":"Novy","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.106960_bb0010","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.conb.2010.06.001","article-title":"The cell biology of synaptic inhibition in health and disease","volume":"20","author":"Smith","year":"2010","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.yebeh.2020.106960_bb0015","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11910-015-0589-2","article-title":"Treatment of super-refractory status epilepticus","volume":"15","author":"Bayrlee","year":"2015","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"Suppl","key":"10.1016\/j.yebeh.2020.106960_bb0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1528-1167.2011.03238.x","article-title":"Super-refractory status epilepticus: an approach to therapy in this difficult clinical situation","volume":"52","author":"Shorvon","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.106960_bb0025","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1001\/archneur.62.9.1428","article-title":"A \u201cmalignant\u201d variant of status epilepticus","volume":"62","author":"Holtkamp","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.yebeh.2020.106960_bb0030","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1523\/JNEUROSCI.0900-05.2005","article-title":"Status epilepticus increases the intracellular accumulation of GABAA receptors","volume":"25","author":"Goodkin","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2020.106960_bb0035","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/epi.12247","article-title":"Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study","volume":"54","author":"Gaspard","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.106960_bb0040","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3171\/jns.1998.88.2.0349","article-title":"Rapid termination of intraoperative stimulation-evoked seizures with application of cold Ringer's lactate to the cortex. Technical note","volume":"88","author":"Sartorius","year":"1998","journal-title":"J Neurosurg"},{"key":"10.1016\/j.yebeh.2020.106960_bb0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clineuro.2014.08.032","article-title":"Therapeutic hypothermia for status: a report, historical perspective, and review","volume":"126","author":"Bennett","year":"2014","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.yebeh.2020.106960_bb0050","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fneur.2014.00286","article-title":"Management of super-refractory status epilepticus with isoflurane and hypothermia","volume":"5","author":"Zhumadilov","year":"2015","journal-title":"Front Neurol"},{"key":"10.1016\/j.yebeh.2020.106960_bb0055","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.yebeh.2015.06.028","article-title":"Deep hypothermia for the treatment of refractory status epilepticus","volume":"49","author":"Niquet","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.106960_bb0060","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.injury.2012.11.026","article-title":"The effect of admission spontaneous hypothermia on patients with severe traumatic brain injury","volume":"44","author":"Rubiano","year":"2013","journal-title":"Injury"},{"key":"10.1016\/j.yebeh.2020.106960_bb0065","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3171\/2014.7.JNS132470","article-title":"The epidemiology of spontaneous fever and hypothermia on admission of brain injury patients to intensive care units: a multicenter cohort study","volume":"121","author":"Rincon","year":"2014","journal-title":"J Neurosurg"},{"key":"10.1016\/j.yebeh.2020.106960_bb0070","first-page":"921","article-title":"Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol","volume":"88","author":"Ikeda","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1016\/j.yebeh.2020.106960_bb0075","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1476-5381.1973.tb08243.x","article-title":"Role of 5-hydroxytryptamine in ketamine-induced hypothermia in the rat","volume":"48","author":"Fahim","year":"1973","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.yebeh.2020.106960_bb0080","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/0974-2700.185276","article-title":"Hypothermia as a predictor for mortality in trauma patients at admittance to the intensive care unit","volume":"9","author":"Balvers","year":"2016","journal-title":"J Emerg Trauma Shock"},{"key":"10.1016\/j.yebeh.2020.106960_bb0085","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/0885066614555491","article-title":"Hypothermia in adult ICUs: changing incidence but persistent risk factor for mortality","volume":"31","author":"Niven","year":"2016","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.yebeh.2020.106960_bb0090","doi-asserted-by":"crossref","first-page":"430A","DOI":"10.1378\/chest.1703424","article-title":"Incidence, associated factors, and outcome of hypothermia among patients admitted to medical intensive care unit","volume":"144","author":"Choudhary","year":"2013","journal-title":"Chest J"},{"key":"10.1016\/j.yebeh.2020.106960_bb0095","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2006.10.034","article-title":"Temperature regulation is compromised in experimental limbic status epilepticus","volume":"1127","author":"Holtkamp","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2020.106960_bb0100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12028-011-9668-7","article-title":"Early ketamine to treat refractory status epilepticus","volume":"16","author":"Kramer","year":"2012","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.yebeh.2020.106960_bb0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12028-010-9445-z","article-title":"A randomized trial for the treatment of refractory status epilepticus","volume":"14","author":"Rossetti","year":"2011","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.yebeh.2020.106960_bb0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.eplepsyres.2013.01.007","article-title":"Ketamine use in the treatment of refractory status epilepticus","volume":"105","author":"Synowiec","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2020.106960_bb0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0006-8993(93)91185-U","article-title":"Effect of temperature on kainic acid-induced seizures","volume":"631","author":"Liu","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2020.106960_bb0120","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1056\/NEJMoa1608193","article-title":"Hypothermia for neuroprotection in convulsive status epilepticus","volume":"375","author":"Legriel","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yebeh.2020.106960_bb0125","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1017\/cjn.2015.31","article-title":"Therapeutic hypothermia for refractory status epilepticus","volume":"42","author":"Zeiler","year":"2015","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.yebeh.2020.106960_bb0130","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1097\/01.CCM.0000165965.31895.80","article-title":"Admission hypothermia and outcome after major trauma","volume":"33","author":"Wang","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.yebeh.2020.106960_bb0135","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1186\/cc9077","article-title":"Spontaneous hypothermia on intensive care unit admission is a predictor of unfavorable neurological outcome in patients after resuscitation: an observational cohort study","volume":"14","author":"den Hartog","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.yebeh.2020.106960_bb0140","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00134-004-2166-z","article-title":"Body temperature alterations in the critically ill","volume":"30","author":"Peres Bota","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.yebeh.2020.106960_bb0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/CCM.0b013e31822f061d","article-title":"Determinants of temperature abnormalities and influence on outcome of critical illness","volume":"40","author":"Laupland","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.yebeh.2020.106960_bb0150","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.brainres.2005.12.031","article-title":"Activation of 5-HT1A receptors in rostral medullary raph\u00e9 inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits","volume":"1073\u20131074","author":"Ootsuka","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2020.106960_bb0155","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2004.03.058","article-title":"Spinal 5-HT2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4-methylenedioxymethamphetamine,\u201cecstasy\u201d) and its reversal by clozapine","volume":"1014","author":"Ootsuka","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2020.106960_bb0160","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2005.10.062","article-title":"Thermogenesis in brown adipose tissue: increase by 5-HT2A receptor activation and decrease by 5-HT1A receptor activation in conscious rats","volume":"395","author":"Ootsuka","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2020.106960_bb0165","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/00000542-199505000-00012","article-title":"Propofol linearly reduces the vasoconstriction and shivering thresholds","volume":"82","author":"Matsukawa","year":"1995","journal-title":"Anesthesiology"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020301359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020301359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:32:00Z","timestamp":1761503520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505020301359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":33,"alternative-id":["S1525505020301359"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.106960","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.106960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106960"}}