{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:30:38Z","timestamp":1792197038735,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"am","delay-in-days":262,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.yebeh.2020.107229","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T17:35:05Z","timestamp":1592674505000},"page":"107229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma carboxylesterase knockout mice"],"prefix":"10.1016","volume":"111","author":[{"given":"Brenda M.","family":"Marrero-Rosado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"de Araujo Furtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica R.","family":"Kundrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie A.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline R.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna A.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucille A.","family":"Lumley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.yebeh.2020.107229_bb0005","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.1523\/JNEUROSCI.17-19-07532.1997","article-title":"Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors","volume":"17","author":"Kapur","year":"1997","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"10.1016\/j.yebeh.2020.107229_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0006-8993(98)01080-4","article-title":"Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus","volume":"814","author":"Mazarati","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2020.107229_bb0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ntt.2014.06.002","article-title":"Caramiphen edisylate as adjunct to standard therapy attenuates soman-induced seizures and cognitive deficits in rats","volume":"44","author":"Schultz","year":"2014","journal-title":"Neurotoxicol Teratol"},{"issue":"12","key":"10.1016\/j.yebeh.2020.107229_bb0020","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1111\/epi.14582","article-title":"Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam","volume":"59","author":"Marrero-Rosado","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107229_bb0025","doi-asserted-by":"crossref","first-page":"104629","DOI":"10.1016\/j.dib.2019.104629","article-title":"Dataset of EEG power integral, spontaneous recurrent seizure and behavioral responses following combination drug therapy in soman-exposed rats","volume":"27","author":"Lumley","year":"2019","journal-title":"Data Brief"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107229_bb0030","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/epi4.12344","article-title":"Neurosteroid and benzodiazepine combination therapy reduces status epilepticus and long-term effects of whole-body sarin exposure in rats","volume":"4","author":"Lumley","year":"2019","journal-title":"Epilepsia Open"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107229_bb0035","first-page":"86","article-title":"Anticonvulsants for soman-induced seizure activity","volume":"6","author":"Shih","year":"1999","journal-title":"J Biomed Sci"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107229_bb0040","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/epi.12989","article-title":"Midazolam as an anticonvulsant antidote for organophosphate intoxication\u2014a pharmacotherapeutic appraisal","volume":"56","author":"Reddy","year":"2015","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107229_bb0045","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJMoa1107494","article-title":"Intramuscular versus intravenous therapy for prehospital status epilepticus","volume":"366","author":"Silbergleit","year":"2012","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107229_bb0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1212\/CPJ.0000000000000641","article-title":"Therapy for acute nerve agent poisoning: an update","volume":"9","author":"Newmark","year":"2019","journal-title":"Neurol Clin Pract"},{"issue":"Pt B","key":"10.1016\/j.yebeh.2020.107229_bb0055","doi-asserted-by":"crossref","first-page":"106367","DOI":"10.1016\/j.yebeh.2019.06.011","article-title":"Early polytherapy for benzodiazepine-refractory status epilepticus","volume":"101","author":"Niquet","year":"2019","journal-title":"Epilepsy Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107229_bb0060","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/nyas.13147","article-title":"Benzodiazepine-refractory status epilepticus: pathophysiology and principles of treatment","volume":"1378","author":"Niquet","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.yebeh.2020.107229_bb0065","doi-asserted-by":"crossref","first-page":"104537","DOI":"10.1016\/j.nbd.2019.104537","article-title":"Rational polytherapy in the treatment of cholinergic seizures","volume":"133","author":"Niquet","year":"2020","journal-title":"Neurobiol Dis"},{"issue":"5","key":"10.1016\/j.yebeh.2020.107229_bb0070","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/14737175.2017.1288099","article-title":"Ketamine for the treatment of (super) refractory status epilepticus? Not quite yet","volume":"17","author":"Dorandeu","year":"2017","journal-title":"Expert Rev Neurother"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107229_bb0075","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cbi.2012.09.013","article-title":"Ketamine combinations for the field treatment of soman-induced self-sustaining status epilepticus. Review of current data and perspectives","volume":"203","author":"Dorandeu","year":"2013","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.yebeh.2020.107229_bb0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.seizure.2018.08.004","article-title":"Novel drugs and early polypharmacotherapy in status epilepticus","volume":"68","author":"Amengual-Gual","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107229_bb0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuro.2018.08.011","article-title":"Addition of ketamine to standard-of-care countermeasures for acute organophosphate poisoning improves neurobiological outcomes","volume":"69","author":"Lewine","year":"2018","journal-title":"Neurotoxicology"},{"issue":"9","key":"10.1016\/j.yebeh.2020.107229_bb0090","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1111\/epi.13480","article-title":"Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits","volume":"57","author":"Niquet","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107229_bb0095","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2017.04.019","article-title":"Simultaneous triple therapy for the treatment of status epilepticus","volume":"104","author":"Niquet","year":"2017","journal-title":"Neurobiol Dis"},{"issue":"11","key":"10.1016\/j.yebeh.2020.107229_bb0100","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1021\/tx200237a","article-title":"Production of ES1 plasma carboxylesterase knockout mice for toxicity studies","volume":"24","author":"Duysen","year":"2011","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.yebeh.2020.107229_bb0105","doi-asserted-by":"crossref","DOI":"10.1111\/nyas.14311","article-title":"Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice","author":"Kundrick","year":"2020","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.yebeh.2020.107229_bb0110","series-title":"Guide for the care and use of laboratory animals","author":"Council NR","year":"2010"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107229_bb0115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107229_bb0120","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/hipo.1044","article-title":"Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?","volume":"11","author":"Nissinen","year":"2001","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107229_bb0125","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jneumeth.2009.07.020","article-title":"Analyzing large data sets acquired through telemetry from rats exposed to organophosphorous compounds: an EEG study","volume":"184","author":"de Araujo","year":"2009","journal-title":"J Neurosci Methods"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107229_bb0130","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"J Histochem Cytochem"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107229_bb0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainresprot.2004.09.003","article-title":"Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionator","volume":"14","author":"Bonthius","year":"2004","journal-title":"Brain Res Brain Res Protoc"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107229_bb0140","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/2347-8659.139719","article-title":"A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining: cell body to cell size ratio","volume":"1","author":"Hovens","year":"2014","journal-title":"Neuroimmunol Neuroinflammation"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107229_bb0145","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.bbi.2010.02.001","article-title":"Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions","volume":"24","author":"Tynan","year":"2010","journal-title":"Brain Behav Immun"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107229_bb0150","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.taap.2012.01.017","article-title":"The anticholinergic and antiglutamatergic drug caramiphen reduces seizure duration in soman-exposed rats: synergism with the benzodiazepine diazepam","volume":"259","author":"Schultz","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107229_bb0155","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.pbb.2011.09.011","article-title":"Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: increased startle reactivity and perseverative behavior","volume":"100","author":"Langston","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107229_bb0160","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pbb.2010.11.022","article-title":"Impaired auditory and contextual fear conditioning in soman-exposed rats","volume":"98","author":"Moffett","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107229_bb0165","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1528-1167.2007.01384.x","article-title":"A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation","volume":"49","author":"Martin","year":"2008","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107229_bb0170","first-page":"381","article-title":"Neural lesions in the rat and their relationship to EEG delta activity following seizures induced by the nerve agent soman","volume":"19","author":"McDonough","year":"1998","journal-title":"Neurotoxicology"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107229_bb0175","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0091-3057(92)90019-C","article-title":"Behavioral performance, brain histology, and EEG sequela after immediate combined atropine\/diazepam treatment of soman-intoxicated rats","volume":"42","author":"Philippens","year":"1992","journal-title":"Pharmacol Biochem Behav"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107229_bb0180","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1162\/jocn.2009.21305","article-title":"Ketamine modulates theta and gamma oscillations","volume":"22","author":"Lazarewicz","year":"2010","journal-title":"J Cogn Neurosci"},{"issue":"Suppl. 6","key":"10.1016\/j.yebeh.2020.107229_bb0185","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/epi.12290","article-title":"Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus","volume":"54","author":"Shekh-Ahmad","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107229_bb0190","series-title":"Medical aspects of chemical warfare","article-title":"Neuroprotection as a treatment","volume":"221","author":"Ballough","year":"2008"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107229_bb0195","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.bbadis.2017.02.003","article-title":"Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy","volume":"1863","author":"Clossen","year":"2017","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107229_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/cells7040026","article-title":"Microglia after seizures and in epilepsy","volume":"7","author":"Hiragi","year":"2018","journal-title":"Cells"},{"issue":"2\u20133","key":"10.1016\/j.yebeh.2020.107229_bb0205","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tox.2007.05.032","article-title":"Prolonged inflammatory gene response following soman-induced seizures in mice","volume":"238","author":"Dhote","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.yebeh.2020.107229_bb0210","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1742-2094-8-84","article-title":"Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin","volume":"8","author":"Spradling","year":"2011","journal-title":"J Neuroinflammation"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107229_bb0215","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tins.2012.11.008","article-title":"Glia and epilepsy: excitability and inflammation","volume":"36","author":"Devinsky","year":"2013","journal-title":"Trends Neurosci"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107229_bb0220","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.taap.2011.12.024","article-title":"Combinations of ketamine and atropine are neuroprotective and reduce neuroinflammation after a toxic status epilepticus in mice","volume":"259","author":"Dhote","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"issue":"8","key":"10.1016\/j.yebeh.2020.107229_bb0225","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/j.1528-1167.2009.02478.x","article-title":"Spontaneous recurrent seizures after status epilepticus induced by soman in Sprague\u2013Dawley rats","volume":"51","author":"de Araujo","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107229_bb0230","article-title":"Differential effects of traxoprodil and S-ketamine on quantitative EEG and auditory event-related potentials as translational biomarkers in preclinical trials in rats and mice","volume":"108072","author":"Raith","year":"2020","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107229_bb0235","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/epi.12144","article-title":"Therapeutic brain hypothermia, its mechanisms of action, and its prospects as a treatment for epilepsy","volume":"54","author":"Motamedi","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107229_bb0240","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.yebeh.2015.06.028","article-title":"Deep hypothermia for the treatment of refractory status epilepticus","volume":"49","author":"Niquet","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107229_bb0245","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/cns.12096","article-title":"Treatment of status epilepticus with ketamine, are we there yet?","volume":"19","author":"Dorandeu","year":"2013","journal-title":"CNS Neurosci Ther"},{"issue":"5","key":"10.1016\/j.yebeh.2020.107229_bb0250","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/14737175.2020.1757433","article-title":"How close is ketamine to routine use in refractory status epilepticus?","volume":"20","author":"Yan","year":"2020","journal-title":"Expert Rev Neurother"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107229_bb0255","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1111\/epi.13695","article-title":"Treatment of experimental status epilepticus with synergistic drug combinations","volume":"58","author":"Niquet","year":"2017","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107229_bb0260","doi-asserted-by":"crossref","first-page":"13","DOI":"10.55460\/CBRW-A2G1","article-title":"A triple-option analgesia plan for tactical combat casualty care: TCCC guidelines change 13-04","volume":"14","author":"Butler","year":"2014","journal-title":"J Spec Oper Med"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107229_bb0265","doi-asserted-by":"crossref","first-page":"304","DOI":"10.7205\/MILMED-D-14-00257","article-title":"Prehospital pain medication use by US forces in Afghanistan","volume":"180","author":"Shackelford","year":"2015","journal-title":"Mil Med"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550502030408X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550502030408X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:34:54Z","timestamp":1761503694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152550502030408X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":53,"alternative-id":["S152550502030408X"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107229","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma carboxylesterase knockout mice","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107229"}}