{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:21:43Z","timestamp":1789906903134,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.yebeh.2020.107279","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T17:45:34Z","timestamp":1595094334000},"page":"107279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A single episode of early-life status epilepticus impacts neonatal ultrasonic vocalization behavior in the Fmr1 knockout mouse"],"prefix":"10.1016","volume":"111","author":[{"given":"Jessica L.","family":"Huebschman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha L.","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conner D.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne O.","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin N.","family":"Lugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2020.107279_bb0005","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1172\/JCI63141","article-title":"Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics","volume":"122","author":"Bagni","year":"2012","journal-title":"J Clin Investig"},{"key":"10.1016\/j.yebeh.2020.107279_bb0010","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","article-title":"Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome","volume":"65","author":"Verkerk","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.yebeh.2020.107279_bb0015","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2011.06.013","article-title":"FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism","volume":"146","author":"Darnell Jennifer","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.yebeh.2020.107279_bb0020","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1523\/JNEUROSCI.0054-07.2007","article-title":"Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation","volume":"27","author":"Pfeiffer","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2020.107279_bb0025","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1044\/1058-0360(2006\/033)","article-title":"Communication in young children with fragile X syndrome: a qualitative study of mothers' perspectives","volume":"15","author":"Brady","year":"2006","journal-title":"Am J Speech Lang Pathol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/TLD.0b013e3181a72016","article-title":"Language development in individuals with fragile X syndrome","volume":"29","author":"Finestack","year":"2009","journal-title":"Top Lang Disord"},{"key":"10.1016\/j.yebeh.2020.107279_bb0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1044\/0161-1461(2003\/026)","article-title":"Early intervention practices and communication intervention strategies for young males with fragile X syndrome","volume":"34","author":"Mirrett","year":"2003","journal-title":"Lang Speech Hear Serv Sch"},{"key":"10.1016\/j.yebeh.2020.107279_bb0040","doi-asserted-by":"crossref","first-page":"13.12.1","DOI":"10.1002\/0471140856.tx1312s30","article-title":"Analysis of ultrasonic vocalizations emitted by infant rodents","volume":"30","author":"Branchi","year":"2006","journal-title":"Curr Protoc Toxicol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0045","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/BF00632534","article-title":"Ultraschall-Laute bei jungen M\u00e4usen (Ultrasonic vocalization in infant mice)","volume":"43","author":"Zippelius","year":"1956","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.yebeh.2020.107279_bb0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0031-9384(85)90331-2","article-title":"Differences in patterns of pup care in mice V\u2014pup ultrasonic emissions and pup care behavior","volume":"35","author":"Cohen-Salmon","year":"1985","journal-title":"Physiol Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0091-6773(74)91026-8","article-title":"Maternal responses to infant vocalizations and olfactory cues in rats and mice","volume":"12","author":"Smotherman","year":"1974","journal-title":"Behav Biol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030386","article-title":"Ultrasonic songs of male mice","volume":"3","author":"Holy","year":"2005","journal-title":"PLoS Biol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0065","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1601-183X.2010.00623.x","article-title":"Unusual repertoire of vocalizations in adult BTBR T+tf\/J mice during three types of social encounters","volume":"10","author":"Scattoni","year":"2011","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0070","doi-asserted-by":"crossref","first-page":"e44816","DOI":"10.1371\/journal.pone.0044816","article-title":"Comprehensive analysis of ultrasonic vocalizations in a mouse model of fragile X syndrome reveals limited, call type specific deficits","volume":"7","author":"Roy","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.yebeh.2020.107279_bb0075","doi-asserted-by":"crossref","first-page":"e3067","DOI":"10.1371\/journal.pone.0003067","article-title":"Unusual repertoire of vocalizations in the BTBR T+tf\/J mouse model of autism","volume":"3","author":"Scattoni","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.yebeh.2020.107279_bb0080","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/epi.13450","article-title":"The effect of early life status epilepticus on ultrasonic vocalizations in mice","volume":"57","author":"Reynolds","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107279_bb0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yebeh.2017.04.025","article-title":"Early-life status epilepticus acutely impacts select quantitative and qualitative features of neonatal vocalization behavior: spectrographic and temporal characterizations in C57BL\/6 mice","volume":"72","author":"Reynolds","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0090","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbr.2017.05.052","article-title":"Spectral and temporal properties of calls reveal deficits in ultrasonic vocalizations of adult Fmr1 knockout mice","volume":"332","author":"Hodges","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2020.107279_bb0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbr.2013.10.049","article-title":"Temporal and spectral differences in the ultrasonic vocalizations of fragile X knock out mice during postnatal development","volume":"259","author":"Lai","year":"2014","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2020.107279_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12611","article-title":"High-throughput analysis of vocalizations reveals sex-specific changes in Fmr1 mutant pups","volume":"19","author":"Nolan","year":"2020","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0105","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1469-8749.2002.tb00277.x","article-title":"Epilepsy in fragile X syndrome","volume":"44","author":"Berry-Kravis","year":"2002","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0110","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1352\/1944-7558-115.6.461","article-title":"Seizures in fragile X syndrome: characteristics and comorbid diagnoses","volume":"115","author":"Berry-Kravis","year":"2010","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.yebeh.2020.107279_bb0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.expneurol.2014.09.018","article-title":"Early life seizures: evidence for chronic deficits linked to autism and intellectual disability across species and models","volume":"263","author":"Bernard","year":"2015","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0120","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yebeh.2015.01.006","article-title":"Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype","volume":"44","author":"Bernard","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0125","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.expneurol.2014.03.014","article-title":"Early-life seizures result in deficits in social behavior and learning","volume":"256","author":"Lugo","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0135","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.yebeh.2004.06.005","article-title":"Febrile convulsions affect ultrasonic vocalizations in the rat pup","volume":"5","author":"Keller","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0140","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.yebeh.2013.10.006","article-title":"Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup","volume":"31","author":"L\u00f3pez-Meraz","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yebeh.2017.04.025","article-title":"Early-life status epilepticus acutely impacts select quantitative and qualitative features of neonatal vocalization behavior: spectrographic and temporal characterizations in C57BL\/6 mice","volume":"72","author":"Reynolds","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022093","article-title":"A role for strain differences in waveforms of ultrasonic vocalizations during male\u2013female interaction","volume":"6","author":"Sugimoto","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2020.107279_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199929","article-title":"The temporal organization of mouse ultrasonic vocalizations","volume":"13","author":"Castellucci","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2020.107279_bb0160","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1097\/WNR.0000000000000701","article-title":"Sex-specific and genotype-specific differences in vocalization development in FMR1 knockout mice","volume":"27","author":"Reynolds","year":"2016","journal-title":"Neuroreport"},{"key":"10.1016\/j.yebeh.2020.107279_bb0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.yebeh.2019.03.037","article-title":"High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL\/6J mice","volume":"95","author":"Nolan","year":"2019","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107279_bb0170","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1037\/h0077287","article-title":"Responses of adult mice to models of infant calls","volume":"90","author":"Smith","year":"1976","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.yebeh.2020.107279_bb0175","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/mp.2015.190","article-title":"Structure and function of neonatal social communication in a genetic mouse model of autism","volume":"21","author":"Takahashi","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.yebeh.2020.107279_bb0180","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2016.04.016","article-title":"Characterization of ultrasonic vocalizations of fragile X mice","volume":"310","author":"Belagodu","year":"2016","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2020.107279_bb0185","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.0013-9580.2004.69103.x","article-title":"NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury","volume":"45","author":"Koh","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107279_bb0190","doi-asserted-by":"crossref","first-page":"106193","DOI":"10.1016\/j.eplepsyres.2019.106193","article-title":"A single early-life seizure results in long-term behavioral changes in the adult Fmr1 knockout mouse","volume":"157","author":"Hodges","year":"2019","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2020.107279_bb0195","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.nbd.2019.01.006","article-title":"A two-hit story: seizures and genetic mutation interaction sets phenotype severity in SCN1A epilepsies","volume":"125","author":"Salgueiro-Pereira","year":"2019","journal-title":"Neurobiol Dis"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020304583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020304583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:39:36Z","timestamp":1761503976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505020304583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":39,"alternative-id":["S1525505020304583"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107279","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A single episode of early-life status epilepticus impacts neonatal ultrasonic vocalization behavior in the Fmr1 knockout mouse","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107279"}}