{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:00:14Z","timestamp":1787065214001,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.yebeh.2020.107400","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T01:12:08Z","timestamp":1599527528000},"page":"107400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Statins in primary prevention of poststroke seizures and epilepsy: A systematic review"],"prefix":"10.1016","volume":"112","author":[{"given":"Bruna","family":"Nucera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Nardone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Lattanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Brigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.yebeh.2020.107400_bb0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/archneur.59.2.195","article-title":"Poststroke seizures","volume":"59","author":"Silverman","year":"2002","journal-title":"Arch Neurol"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107400_bb0010","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/01616412.2018.1455014","article-title":"Pathogenesis of epileptic seizures and epilepsy after stroke","volume":"40","author":"Yang","year":"2018","journal-title":"Neurol Res"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107400_bb0015","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1528-1167.2009.02285.x","article-title":"Recommendation for a definition of acute symptomatic seizure","volume":"51","author":"Beghi","year":"2010","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2020.107400_bb0020","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/j.1528-1167.2008.01945.x","article-title":"Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure","volume":"50","author":"Hesdorffer","year":"2009","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107400_bb0025","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107400_bb0030","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1212\/WNL.60.3.400","article-title":"Early and late seizures after cryptogenic ischemic stroke in young adults","volume":"60","author":"Lamy","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107400_bb0035","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1528-1167.2005.57904.x","article-title":"Poststroke epilepsy: occurrence and predictors\u2014a long-term prospective controlled study (Akershus Stroke Study)","volume":"46","author":"Lossius","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107400_bb0040","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/pgmj.2005.041426","article-title":"Post-stroke seizure and post-stroke epilepsy","volume":"82","author":"Myint","year":"2006","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.yebeh.2020.107400_bb0045","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1159\/000348704","article-title":"Complications of acute stroke and the occurrence of early seizures","volume":"35","author":"Pezzini","year":"2013","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.yebeh.2020.107400_bb0050","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.eplepsyres.2012.06.003","article-title":"The incidence rate of post-stroke epilepsy: a 5-year follow-up study in Taiwan","volume":"102","author":"Chen","year":"2012","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2020.107400_bb0055","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/STROKEAHA.111.000220","article-title":"Incidence and associations of poststroke epilepsy: the prospective South London Stroke Register","volume":"44","author":"Graham","year":"2013","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107400_bb0060","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1684\/epd.2020.1159","article-title":"How to diagnose and treat post-stroke seizures and epilepsy","volume":"22","author":"Zelano","year":"2020","journal-title":"Epileptic Disord"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2020.107400_bb0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1528-1167.2007.01063.x","article-title":"Epileptogenesis in experimental models","volume":"48","author":"Pitk\u00e4nen","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107400_bb0070","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1212\/WNL.57.2.200","article-title":"Prevalence and predictors of early seizure and status epilepticus after first stroke","volume":"57","author":"Labovitz","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107400_bb0075","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1212\/WNL.0b013e3182364878","article-title":"Incidence and predictors of acute symptomatic seizures after stroke","volume":"77","author":"Beghi","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107400_bb0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000338374","article-title":"Seizures in acute stroke: incidence, risk factors and prognosis","volume":"39","author":"Procaccianti","year":"2012","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.yebeh.2020.107400_bb0085","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1212\/WNL.0b013e31823648a6","article-title":"Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome","volume":"77","author":"De Herdt","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107400_bb0090","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/jnnp-2015-311849","article-title":"The prognosis of acute symptomatic seizures after ischaemic stroke","volume":"88","author":"Leung","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107400_bb0095","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/STR.0000000000000158","volume":"49","author":"Powers","year":"2018","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107400_bb0100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/2396987317705536","article-title":"European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy","volume":"2","author":"Holtkamp","year":"2017","journal-title":"Eur Stroke J"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107400_bb0105","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.eplepsyres.2011.04.002","article-title":"Are post intracerebral hemorrhage seizures prevented by anti-epileptic treatment?","volume":"95","author":"Gilad","year":"2011","journal-title":"Epilepsy Res"},{"issue":"12","key":"10.1016\/j.yebeh.2020.107400_bb0110","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1161\/STROKEAHA.115.010875","article-title":"Prophylactic antiepileptic drug use and outcome in the ethnic\/racial variations of intracerebral hemorrhage study","volume":"46","author":"Sheth","year":"2015","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107400_bb0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pneurobio.2009.02.002","article-title":"Statins: mechanisms of neuroprotection","volume":"88","author":"van der Most","year":"2009","journal-title":"Prog Neurobiol"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107400_bb0120","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.yebeh.2012.02.001","article-title":"Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide","volume":"23","author":"Moezi","year":"2012","journal-title":"Epilepsy Behav"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107400_bb0125","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1472-8206.2012.01038.x","article-title":"Anticonvulsive effect of atorvastatin on pentylenetetrazole-induced seizures in mice: the role of nitric oxide pathway","volume":"27","author":"Moazzami","year":"2013","journal-title":"Fundam Clin Pharmacol"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107400_bb0130","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s40263-018-0501-0","article-title":"Effect of statin intensity on the risk of epilepsy after ischaemic stroke: real-world evidence from population-based health claims","volume":"32","author":"Lin","year":"2018","journal-title":"CNS Drugs"},{"issue":"8","key":"10.1016\/j.yebeh.2020.107400_bb0135","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1212\/WNL.0000000000001814","article-title":"Statin treatment reduces the risk of poststroke seizures","volume":"85","author":"Guo","year":"2015","journal-title":"Neurology"},{"issue":"17","key":"10.1016\/j.yebeh.2020.107400_bb0140","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1212\/WNL.0b013e3181f96253","article-title":"Statin use and risk of epilepsy: a nested case\u2013control study","volume":"75","author":"Etminan","year":"2010","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107400_bb0145","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1532-5415.2008.02124.x","article-title":"New-onset epilepsy risk factors in older veterans","volume":"57","author":"Pugh","year":"2009","journal-title":"J Am Geriatr Soc"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107400_bb0150","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107400_bb0155","doi-asserted-by":"crossref","first-page":"A12","DOI":"10.7326\/ACPJC-1995-123-3-A12","article-title":"The well-built clinical question: a key to evidence-based decisions","volume":"123","author":"Richardson","year":"1995","journal-title":"ACP J Club"},{"key":"10.1016\/j.yebeh.2020.107400_bb0160","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"issue":"7650","key":"10.1016\/j.yebeh.2020.107400_bb0165","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107400_bb0170","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1038\/s41598-020-58652-w","article-title":"Statin treatment can reduce incidence of early seizure in acute ischemic stroke: a propensity score analysis","volume":"10","author":"Matsubara","year":"2020","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.yebeh.2020.107400_bb0175","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/01616412.2020.1735821","article-title":"Statin effects on post-stroke epilepsy and mortality \u2014 Taiwan population-based study","volume":"42","author":"Hsieh","year":"2020","journal-title":"Neurol Res"},{"key":"10.1016\/j.yebeh.2020.107400_bb0180","series-title":"The effect of statin treatment on the occurrence of poststroke seizures","author":"Lee","year":"2016"},{"issue":"9","key":"10.1016\/j.yebeh.2020.107400_bb0185","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1111\/bcp.13626","article-title":"Statin use associated with lower risk of epilepsy after intracranial haemorrhage: a population-based cohort study","volume":"84","author":"Lin","year":"2018","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2020.107400_bb0190","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.seizure.2019.07.010","article-title":"Efficacy of statin therapy in post-stroke seizure prophylaxis: clues from an observational study of routine secondary prevention treatment","volume":"71","author":"Li","year":"2019","journal-title":"Seizure"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107400_bb0195","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s10072-020-04298-5","article-title":"The influence of statins on the risk of post-stroke epilepsy","volume":"41","author":"Vitturi","year":"2020","journal-title":"Neurol Sci"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107400_bb0200","doi-asserted-by":"crossref","first-page":"747","DOI":"10.2174\/1389450116666150330114850","article-title":"Statins and epilepsy: preclinical studies, clinical trials and statin\u2013anticonvulsant drug interactions","volume":"16","author":"Scicchitano","year":"2015","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.yebeh.2020.107400_bb0205","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1100\/tsw.2009.141","article-title":"Statins in neurological disorders: mechanisms and therapeutic value","volume":"9","author":"Reiss","year":"2009","journal-title":"Sci World J"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107400_bb0210","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.pharep.2014.02.026","article-title":"Statins \u2014 are they anticonvulsant?","volume":"66","author":"Banach","year":"2014","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.yebeh.2020.107400_bb0215","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/epi.13448","article-title":"Epilepsy in cerebrovascular diseases: review of experimental and clinical data with meta-analysis of risk factors","volume":"57","author":"Ferlazzo","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107400_bb0220","doi-asserted-by":"crossref","first-page":"106540","DOI":"10.1016\/j.yebeh.2019.106540","article-title":"Younger age at stroke onset but not thrombolytic treatment predicts poststroke epilepsy: an updated meta-analysis","volume":"104","author":"Gasparini","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107400_bb0225","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1161\/STROKEAHA.112.655894","article-title":"Statin therapy and the risk of intracerebral hemorrhage: a meta-analysis of 31 randomized controlled trials","volume":"43","author":"McKinney","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.yebeh.2020.107400_bb0230","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/ane.12540","article-title":"High-dose statin therapy and risk of intracerebral hemorrhage: a meta-analysis","volume":"134","author":"Pandit","year":"2016","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2020.107400_bb0235","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1528-1167.2012.03671.x","article-title":"Enzyme induction with antiepileptic drugs: cause for concern?","volume":"54","author":"Brodie","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107400_bb0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/ane.13249","article-title":"Drug treatments in patients with cardiac diseases and epilepsy","volume":"142","author":"Zaccara","year":"2020","journal-title":"Acta Neurol Scand"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107400_bb0245","first-page":"CD008710","article-title":"Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage","volume":"2013","author":"Marigold","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107400_bb0250","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/WCO.0000000000000067","article-title":"Antiepileptogenesis in humans: disappointing clinical evidence and ways to move forward","volume":"27","author":"Trinka","year":"2014","journal-title":"Curr Opin Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107400_bb0255","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neulet.2011.03.010","article-title":"Human clinical trails in antiepileptogenesis","volume":"497","author":"Mani","year":"2011","journal-title":"Neurosci Lett"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107400_bb0260","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1474-4422(17)30404-0","article-title":"Prediction of late seizures after ischaemic stroke with a novel prognostic model (the SeLECT score): a multivariable prediction model development and validation study","volume":"17","author":"Galovic","year":"2018","journal-title":"Lancet Neurol"},{"issue":"11","key":"10.1016\/j.yebeh.2020.107400_bb0265","doi-asserted-by":"crossref","first-page":"20607","DOI":"10.3390\/ijms151120607","article-title":"Molecular mechanisms underlying the effects of statins in the central nervous system","volume":"15","author":"McFarland","year":"2014","journal-title":"Int J Mol Sci"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020305795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020305795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:41:59Z","timestamp":1761504119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505020305795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":53,"alternative-id":["S1525505020305795"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107400","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Statins in primary prevention of poststroke seizures and epilepsy: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107400"}}