{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:25:16Z","timestamp":1774869916812,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004202","name":"Ondokuz Mayis \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.yebeh.2020.107403","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T02:04:39Z","timestamp":1600308279000},"page":"107403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity"],"prefix":"10.1016","volume":"112","author":[{"given":"Yildirim","family":"Kayacan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak Elmi","family":"Ghojebeigloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnay","family":"\u00c7erit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman Emre","family":"Kocacan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Ayy\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2020.107403_bb0005","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11062-017-9611-4","article-title":"Penicillin-induced epileptiform ECoG activity in gerbils: effects of physical exercise and a diospyroskaki extract","volume":"48","author":"Kayacan","year":"2016","journal-title":"Neurophysiology"},{"key":"10.1016\/j.yebeh.2020.107403_bb0010","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ymgme.2015.11.008","article-title":"Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: a potential treatment target?","volume":"117","author":"Horvath","year":"2016","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.yebeh.2020.107403_bb0015","first-page":"68","article-title":"Theeffects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats","volume":"79","author":"Kayacan","year":"2019","journal-title":"Acta Neurobiol"},{"key":"10.1016\/j.yebeh.2020.107403_bb0020","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/s41386-019-0400-1","article-title":"Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept","volume":"44","author":"Jacobsen","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yebeh.2020.107403_bb0025","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ymben.2018.06.007","article-title":"Metabolic pathway engineering for high-level production of 5-hydroxytryptophan in Escherichia coli","volume":"48","author":"Wang","year":"2018","journal-title":"Metab Eng"},{"key":"10.1016\/j.yebeh.2020.107403_bb0030","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1007\/s00253-020-10371-y","article-title":"Enhanced production of 5-hydroxytryptophan through the regulation of L-tryptophan biosynthetic pathway","volume":"104","author":"Xu","year":"2020","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.yebeh.2020.107403_bb0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11357-015-9815-8","article-title":"The influence of physical exercise and leisure activity on neuropsychologica functioning in older adults","volume":"37","author":"Antunes","year":"2015","journal-title":"Age"},{"key":"10.1016\/j.yebeh.2020.107403_bb0040","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neuroimage.2005.05.025","article-title":"BOLD signal increase preceeds EEG spike activity\u2014a dynamic penicillin induced focal epilepsy in deep anesthesia","volume":"27","author":"M\u00e4kiranta","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.yebeh.2020.107403_bb0045","series-title":"Key topics in sports medicine, First Publs","first-page":"102","article-title":"Epilepsy and exercise","author":"Parnia","year":"2006"},{"key":"10.1016\/j.yebeh.2020.107403_bb0050","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clinthera.2017.12.004","article-title":"Role of physical activity and exercise in alleviating cognitive impairment in people with epilepsy","volume":"40","author":"Allendorfer","year":"2018","journal-title":"Clin Ther"},{"key":"10.1016\/j.yebeh.2020.107403_bb0055","first-page":"63","article-title":"Youth with epilepsy: their insight into participating in enhanced physical activity study","volume":"89","author":"Willis","year":"2018","journal-title":"Epilepsy"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107403_bb0060","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1006\/ebeh.2001.0271","article-title":"A prospective evaluation of the effects of a 12-week outpatient exercise program on clinical and behavioral outcomes in patients with epilepsy","volume":"2","author":"McAuley","year":"2001","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107403_bb0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0920-1211(99)00032-7","article-title":"Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats","volume":"37","author":"Arida","year":"1999","journal-title":"Epilepsy Res"},{"issue":"5","key":"10.1016\/j.yebeh.2020.107403_bb0070","doi-asserted-by":"crossref","first-page":"935","DOI":"10.5114\/aoms.2016.61907","article-title":"The effects of treadmill exercise on penicillin-induced epileptiform activity","volume":"12","author":"Kayacan","year":"2016","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.yebeh.2020.107403_bb0075","doi-asserted-by":"crossref","first-page":"100874","DOI":"10.1016\/j.isci.2020.100874","article-title":"Mechanical regulation underlies effects of exercise on serotonin-induced signaling in the prefrontal cortex neurons","author":"Ryu","year":"2020","journal-title":"iScience"},{"issue":"10","key":"10.1016\/j.yebeh.2020.107403_bb0080","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1177\/0269881113499209","article-title":"Tryptophan: the key to boosting brain serotonin synthesis in depressive illness","volume":"27","author":"Badawy","year":"2013","journal-title":"J Psychopharmacol"},{"issue":"5","key":"10.1016\/j.yebeh.2020.107403_bb0085","doi-asserted-by":"crossref","DOI":"10.1249\/MSS.0b013e31823ede8e","article-title":"Exercise increases tryptophan availability to the brain in older men age 57\u201370\u202fyears","volume":"44","author":"Melancon","year":"2012","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107403_bb9000","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s007260170064","article-title":"Influence of exercise on serotonergic neuromodulation in the brain","volume":"20","author":"Weicker","year":"2001","journal-title":"Amino Acids"},{"key":"10.1016\/j.yebeh.2020.107403_bb8000","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fphys.2020.00221","article-title":"The role of serotonin in the influence of intense locomotion on the behavior under uncertainty in the mollusk Lymnaea stagnalis","volume":"11","author":"Aonuma","year":"2020","journal-title":"Front Physiol"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107403_bb7000","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/00207454.2018.1557166","article-title":"The effect of serotonin on penicillin-induced epileptiform activity","volume":"129","author":"Taskiran","year":"2019","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.yebeh.2020.107403_bb6000","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF00241089","article-title":"Role of serotonin in the anticonvul- sant effect of fluoxetine in genetically epilepsy-prone rats","volume":"350","author":"Yan","year":"1994","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"10.1016\/j.yebeh.2020.107403_bb5000","first-page":"31","article-title":"Serum sero- tonin levels in patients with epileptic seizures","author":"Murugesan","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107403_bb4040","doi-asserted-by":"crossref","first-page":"a020412","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood\u2013brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.yebeh.2020.107403_bb4000","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.semcdb.2014.10.003","article-title":"Blood\u2013brain barrier dysfunction, seizures and ep- ilepsy","volume":"38","author":"Van Vliet","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.yebeh.2020.107403_bb3000","first-page":"29","article-title":"5-HT3 receptors: a potential therapeutic target for epilepsy","volume":"16","author":"Zhao","year":"2018","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.yebeh.2020.107403_bb2000","series-title":"Role of serotonin2a recep- tors in epilepsy. 5-HT2A receptors in the central nervous system","first-page":"375","author":"Crunelli","year":"2018"},{"key":"10.1016\/j.yebeh.2020.107403_bb1000","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/NDT.S33259","article-title":"5-HTP efficacy and contraindications","volume":"8","author":"Hinz","year":"2012","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.yebeh.2020.107403_bb1010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2147\/NDT.S23676","article-title":"APRESS: apical regulatory super system, serotonin, and dopamine interaction","volume":"7","author":"Hinz","year":"2011","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"5","key":"10.1016\/j.yebeh.2020.107403_bb2020","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.neubiorev.2004.06.008","article-title":"The role of norepinephrine in epilepsy: from the bench to the bedside","volume":"28","author":"Giorgi","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107403_bb3030","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/epi.13321","article-title":"Effects of selective serotonin and norepinephrine reuptake inhibitors on depressive-and impulsive-like behaviors and on monoamine transmission in experimental temporal lobe epilepsy","volume":"57","author":"Kumar","year":"2016","journal-title":"Epilepsia"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020305825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020305825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:42:45Z","timestamp":1761504165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505020305825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":30,"alternative-id":["S1525505020305825"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107403","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107403"}}