{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:53:21Z","timestamp":1782978801334,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.yebeh.2020.107634","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T06:00:33Z","timestamp":1608098433000},"page":"107634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Late-onset epilepsy predicts stroke: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-3481","authenticated-orcid":false,"given":"Jasmine","family":"Wall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-1660","authenticated-orcid":false,"given":"Jo","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedley C.A.","family":"Emsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2020.107634_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.seizure.2014.02.007","article-title":"Patients with epilepsy are at an increased risk of subsequent stroke: a population-based cohort study","author":"Chang","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107634_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.seizure.2017.05.010","article-title":"Pre-stroke seizures: a nationwide register-based investigation","author":"Zelano","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107634_b0015","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yebeh.2015.03.026","article-title":"Epilepsy & behavior","volume":"48","author":"Trinka","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107634_b0020","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awy022","article-title":"Cognition and dementia in older patients with epilepsy","author":"Sen","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2020.107634_b0025","doi-asserted-by":"crossref","DOI":"10.1136\/svn-2016-000035","article-title":"Update on cerebral small vessel disease: a dynamic whole-brain disease","author":"Shi","year":"2016","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.yebeh.2020.107634_b0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yebeh.2013.11.003","article-title":"Late-onset seizures and risk of subsequent stroke: a systematic review","volume":"31","author":"Brigo","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107634_b0035","unstructured":"The Nordic Cochrane Centre. Review Manager (RevMan). Cochrane Collab 2014."},{"key":"10.1016\/j.yebeh.2020.107634_b0040","doi-asserted-by":"crossref","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107634_b0045","doi-asserted-by":"crossref","DOI":"10.1111\/epi.13266","article-title":"Towards a clinically informed, data-driven definition of elderly onset epilepsy","author":"Josephson","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107634_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2014.10.012","article-title":"Epilepsy associated with Leukoaraiosis mainly affects temporal lobe: a casual or causal relationship?","author":"Gasparini","year":"2015","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2020.107634_b0055","doi-asserted-by":"crossref","DOI":"10.1177\/1535759718822041","article-title":"Seize the day for a day with no seizures: modifiable midlife risk factors identified","author":"Koubeissi","year":"2019","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.yebeh.2020.107634_b0060","article-title":"Hypertension and the risk of new-onset unprovoked seizures","author":"Ng","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107634_b0065","doi-asserted-by":"crossref","DOI":"10.1007\/s10072-019-03913-4","article-title":"Hypertension, seizures, and epilepsy: a review on pathophysiology and management","author":"Gasparini","year":"2019","journal-title":"Neurol Sci"},{"key":"10.1016\/j.yebeh.2020.107634_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.05.005","article-title":"Increased risk of stroke and myocardial infarction in patients with epilepsy: A systematic review of population-based cohort studies","volume":"104","author":"Brigo","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107634_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2018.09.006","article-title":"Alzheimer\u2019s disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology","author":"Costa","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.yebeh.2020.107634_b0080","doi-asserted-by":"crossref","DOI":"10.1001\/archneurol.2011.830","article-title":"Incidence of new-onset seizures in mild to moderate Alzheimer disease","author":"Irizarry","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1016\/j.yebeh.2020.107634_b0085","doi-asserted-by":"crossref","DOI":"10.1111\/j.1528-1157.1991.tb04664.x","article-title":"Magnetic resonance imaging and late onset epilepsy","author":"Kilpatrick","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107634_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.06.039","article-title":"Seizures in the context of occult cerebrovascular disease","volume":"104","author":"Emsley","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107634_b0095","doi-asserted-by":"crossref","first-page":"E988","DOI":"10.1212\/WNL.0000000000007010","article-title":"Association between white matter hyperintensities, cortical volumes, and late-onset epilepsy","volume":"92","author":"Johnson","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107634_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2012.07.009","article-title":"Prevalence and subtypes of radiological cerebrovascular disease in late-onset isolated seizures and epilepsy","author":"Maxwell","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.yebeh.2020.107634_b0105","doi-asserted-by":"crossref","DOI":"10.1159\/000488673","article-title":"Small hyperintensities in the area of the perforating arteries in patients with seizure","author":"Izutsu","year":"2018","journal-title":"Eur Neurol"},{"key":"10.1016\/j.yebeh.2020.107634_b0110","doi-asserted-by":"crossref","DOI":"10.1007\/s00234-018-2019-z","article-title":"Brain morphological and microstructural features in cryptogenic late-onset temporal lobe epilepsy: a structural and diffusion MRI study","author":"Sone","year":"2018","journal-title":"Neuroradiology"},{"key":"10.1016\/j.yebeh.2020.107634_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(04)15946-1","article-title":"Late-onset seizures as a predictor of subsequent stroke","author":"Cleary","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.yebeh.2020.107634_b0120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yebeh.2014.11.028","article-title":"Stroke after adult-onset epilepsy: a population-based retrospective cohort study","volume":"43","author":"Wannamaker","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107634_b0125","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.i2648","article-title":"Biases in detection of apparent \u201cweekend effect\u201d on outcome with administrative coding data: Population based study of stroke","author":"Li","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.yebeh.2020.107634_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.seizure.2019.02.004","article-title":"Cerebrovascular disease burden in late-onset non-lesional focal epilepsy","author":"Abraira","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107634_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.seizure.2014.05.011","article-title":"The effects of antiepileptic drugs on vascular risk factors: a narrative review","author":"Katsiki","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107634_b0140","article-title":"Effects of epilepsy and selected antiepileptic drugs on risk of myocardial infarction, stroke, and death in patients with or without previous stroke: a nationwide cohort study","author":"Olesen","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.yebeh.2020.107634_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(87)90701-X","article-title":"The frequency of epilepsy preceding stroke. Case-control study in 230 patients","author":"Shinton","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.yebeh.2020.107634_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","author":"Moher","year":"2009","journal-title":"PLoS Med"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020308143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020308143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:41:17Z","timestamp":1761504077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505020308143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":30,"alternative-id":["S1525505020308143"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107634","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Late-onset epilepsy predicts stroke: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107634","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107634"}}