{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:12:58Z","timestamp":1768925578096,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.yebeh.2020.107652","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T18:39:56Z","timestamp":1607625596000},"page":"107652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"PA","title":["Modulation of locomotor behaviors by location-specific epileptic spiking and seizures"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-4893","authenticated-orcid":false,"given":"Joseph R.","family":"Geraghty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Senador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9869-1801","authenticated-orcid":false,"given":"Biswajit","family":"Maharathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell P.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepshika","family":"Sudhakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-6957","authenticated-orcid":false,"given":"Rachael A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-6377","authenticated-orcid":false,"given":"Jeffrey A.","family":"Loeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.yebeh.2020.107652_b0005","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ncl.2016.06.015","article-title":"The epidemiology of global epilepsy","volume":"34","author":"Singh","year":"2016","journal-title":"Neurol Clin"},{"issue":"10","key":"10.1016\/j.yebeh.2020.107652_b0010","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMra1004418","article-title":"Drug-resistant epilepsy","volume":"365","author":"Kwan","year":"2011","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107652_b0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.eplepsyres.2009.03.003","article-title":"The descriptive epidemiology of epilepsy \u2013 a review","volume":"85","author":"Banerjee","year":"2009","journal-title":"Epilepsy Res"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107652_b0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1528-1157.1970.tb03903.x","article-title":"Factors related to the occurrence of typical paroxysmal abnormalities in the EEG records of epileptic patients","volume":"11","author":"Marsan","year":"1970","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107652_b0025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00004691-198907000-00001","article-title":"The significance of the interictal spike discharge: a review","volume":"6","author":"Hughes","year":"1989","journal-title":"J Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107652_b0030","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1177\/1073858405278239","article-title":"Do interictal spikes drive epileptogenesis?","volume":"11","author":"Staley","year":"2005","journal-title":"Neuroscientist"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107652_b0035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1528-1167.2009.02339.x","article-title":"EEG spike activity precedes epilepsy after kainite-induced status epilepticus","volume":"51","author":"White","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107652_b0040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yebeh.2016.01.001","article-title":"Interictal epileptiform discharge effects on neuropsychological assessment and epilepsy surgical planning","volume":"56","author":"Drane","year":"2016","journal-title":"Epilepsy Behav"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107652_b0045","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1046\/j.1528-1157.2003.38902.x","article-title":"Quantitative interictal subdural EEG analyses in children with neocortical epilepsy","volume":"44","author":"Asano","year":"2003","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107652_b0050","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.clinph.2017.03.033","article-title":"Interictal ripples nested in epileptiform discharge help to identify the epileptogenic zone in neocortical epilepsy","volume":"128","author":"Wang","year":"2017","journal-title":"Clin Neurophysiol"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107652_b0055","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1528-1167.2009.02386.x","article-title":"Psychiatric comorbidity and suicidal behavior in epilepsy: a community-based case-control study","volume":"51","author":"Stefanello","year":"2010","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.yebeh.2020.107652_b0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1167.2006.00679.x","article-title":"The evaluation of behavioral disturbances in epilepsy","volume":"47","author":"Krishnamoorthy","year":"2006","journal-title":"Epilepsia"},{"issue":"Pt B","key":"10.1016\/j.yebeh.2020.107652_b0065","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.yebeh.2018.11.028","article-title":"Psychiatric comorbidities go untreated in patients with epilepsy: Ignorance or denial?","volume":"98","author":"Bermeo-Ovalle","year":"2019","journal-title":"Epilepsy Behav"},{"issue":"Pt B","key":"10.1016\/j.yebeh.2020.107652_b0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.yebeh.2019.03.013","article-title":"Obstacles in the treatment of common psychiatric comorbidities in patients with epilepsy: What is wrong with this picture?","volume":"98","author":"Kanner","year":"2019","journal-title":"Epilepsy Behav"},{"issue":"8","key":"10.1016\/j.yebeh.2020.107652_b0075","first-page":"358","article-title":"EEG abnormalities in patients with atypical panic attacks","volume":"56","author":"Weilburg","year":"1995","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107652_b0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/155005949602700106","article-title":"A review of the usefulness of the standard EEG in psychiatry","volume":"27","author":"Hughes","year":"1996","journal-title":"Clin Electroencephalogr"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107652_b0085","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/archneur.1987.00520150056022","article-title":"Epileptiform abnormalities discovered on electroencephalographic screening of psychiatric inpatients","volume":"44","author":"Bridgers","year":"1987","journal-title":"Arch Neurol"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107652_b0090","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1528-1167.2006.00434.x","article-title":"Absence of seizures despite high prevalence of epileptiform EEG abnormalities in children with autism monitored in a tertiary care center","volume":"47","author":"Kim","year":"2006","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107652_b0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0887-8994(01)00370-8","article-title":"Epileptiform abnormalities in children with attention-deficit-hyperactivity disorder","volume":"26","author":"Richer","year":"2002","journal-title":"Pediatr Neurol"},{"issue":"9","key":"10.1016\/j.yebeh.2020.107652_b0100","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1046\/j.1528-1157.2003.13403.x","article-title":"Increased frequency of rolandic spikes in ADHD children","volume":"44","author":"Holtmann","year":"2003","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2020.107652_b0105","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1177\/0883073815604223","article-title":"Clinical impact of epileptiform discharge in children with attention-deficit\/hyperactivity disorder (ADHD)","volume":"31","author":"Lee","year":"2016","journal-title":"J Child Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107652_b0110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.yebeh.2010.08.005","article-title":"Epileptiform abnormalities in children diagnosed with attention deficit\/hyperactivity disorder","volume":"19","author":"Socanski","year":"2010","journal-title":"Epilepsy Behav"},{"issue":"2\u20133","key":"10.1016\/j.yebeh.2020.107652_b0115","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.eplepsyres.2007.05.007","article-title":"Ictal and interictal EEG abnormalities in ADHD children recorded over night by video-polysomnography","volume":"75","author":"Silvestri","year":"2007","journal-title":"Epilepsy Res"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107652_b0120","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.yebeh.2005.11.014","article-title":"Role of interictal epileptiform abnormalities in cognitive impairment","volume":"8","author":"Holmes","year":"2006","journal-title":"Epilepsy Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107652_b0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1212\/WNL.0b013e318297ee50","article-title":"Hippocampal interictal epileptiform activity disrupts cognition in humans","volume":"81","author":"Kleen","year":"2013","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107652_b0130","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jpeds.2004.08.084","article-title":"Treatment of interictal epileptiform discharges can improve behavior in children with behavioral problems and epilepsy","volume":"146","author":"Pressler","year":"2005","journal-title":"J Pediatr"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107652_b0135","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/155005940904000405","article-title":"An animal model to study the clinical significance of interictal spiking","volume":"40","author":"Barkmeier","year":"2009","journal-title":"Clin EEG Neurosci"},{"key":"10.1016\/j.yebeh.2020.107652_b0140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.nbd.2012.03.026","article-title":"Electrical, molecular, and behavioral effects of interictal spiking in the rat","volume":"47","author":"Barkmeier","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.yebeh.2020.107652_b0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1460-9568.1991.tb00810.x","article-title":"Chronic epileptic foci in neocortex: in vivo and in vitro effects of tetanus toxin","volume":"3","author":"Brener","year":"1991","journal-title":"Eur J Neurosci"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107652_b0150","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/jnnp.40.4.404","article-title":"Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus","volume":"40","author":"Mellanby","year":"1977","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.yebeh.2020.107652_b0155","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1113\/jphysiol.1985.sp015861","article-title":"Long-term changes in hippocampal physiology and learning ability of rats after intrahippocampal tetanus toxin","volume":"368","author":"Brace","year":"1985","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107652_b0160","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/0013-4694(90)90141-6","article-title":"Chronic focal epilepsy induced by microinjection of tetanus toxin into the cat motor cortex","volume":"75","author":"Louis","year":"1990","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107652_b0165","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"issue":"Suppl. 4","key":"10.1016\/j.yebeh.2020.107652_b0170","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/epi.13903","article-title":"Methodological standards and interpretation of video-electroencephalography in adult control rodents. A TASKI-WG1 report of the AES\/ILAE Translational Task Force of the ILAE","volume":"58","author":"Kadam","year":"2017","journal-title":"Epilepsia"},{"issue":"Suppl. 4","key":"10.1016\/j.yebeh.2020.107652_b0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/epi.13909","article-title":"Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASKI-WG5 report of the AES\/ILAE Translational Task Force of the ILAE","volume":"58","author":"Moyer","year":"2017","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107652_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WNP.0b013e3182784729","article-title":"American Clinical Neurophysiology Society\u2019s standardized critical care EEG terminology: 2012 version","volume":"30","author":"Hirsch","year":"2013","journal-title":"J Clin Neurophysiol"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107652_b0185","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107652_b0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150095","article-title":"Retigabine, a Kv7.2\/Kv7.3-channel opener, attenuates drug-induced seizures in knock-in mice harboring Kcnq2 mutations","volume":"11","author":"Ihara","year":"2016","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107652_b0195","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.clinph.2011.09.023","article-title":"High inter-reviewer variability of spike detection on intracranial EEG addressed by an automated multi-channel algorithm","volume":"123","author":"Barkmeier","year":"2012","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107652_b0200","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.clinph.2018.11.025","article-title":"Interictal spike connectivity in human epileptic neocortex","volume":"130","author":"Maharathi","year":"2019","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107652_b0205","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ana.21896","article-title":"Hippocampal interictal spikes disrupt cognition in rats","volume":"67","author":"Kleen","year":"2010","journal-title":"Ann Neurol"},{"issue":"Suppl 2","key":"10.1016\/j.yebeh.2020.107652_b0210","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/epi.12186","article-title":"EEG abnormalities as a biomarker for cognitive comorbidities in pharmacoresistant epilepsy","volume":"54","author":"Holmes","year":"2013","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107652_b0215","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.nbd.2010.05.002","article-title":"Interictal spikes in developing rats cause long-standing cognitive deficits","volume":"39","author":"Khan","year":"2010","journal-title":"Neurobiol Dis"},{"issue":"Spec No 1","key":"10.1016\/j.yebeh.2020.107652_b0220","first-page":"S12","article-title":"What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data?","volume":"16","author":"Holmes","year":"2014","journal-title":"Epileptic Disord"},{"issue":"Suppl 1","key":"10.1016\/j.yebeh.2020.107652_b0225","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/epi4.12236","article-title":"A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE\/AES Joint Translational Task Force","volume":"3","author":"Mazarati","year":"2018","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.yebeh.2020.107652_b0230","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1528-1157.1959.tb04288.x","article-title":"Secondary epileptogenic lesions","volume":"1","author":"Morrel","year":"1960","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.yebeh.2020.107652_b0235","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S1059-1311(03)00069-4","article-title":"Clinical differences in patients with unilateral hippocampal sclerosis and unitemporal or bitemporal epileptiform discharges","volume":"12","author":"Janszky","year":"2003","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107652_b0240","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1113\/jphysiol.1993.sp019695","article-title":"Synaptic inhibition in primary and secondary chronic epileptic foci induced by intrahippocampal tetanus toxin in the rat","volume":"465","author":"Empson","year":"1993","journal-title":"J Physiol"},{"issue":"Pt 2","key":"10.1016\/j.yebeh.2020.107652_b0245","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/brain\/awu350","article-title":"Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering","volume":"138","author":"Dachet","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2020.107652_b0250","doi-asserted-by":"crossref","unstructured":"Kirchner A, Bagla S, Dachet F, Loeb JA. DUSP4 appears to be a highly localized endogenous inhibitor of epileptic signaling in human neocortex. Neurobiol Dis 2020 Sep 2 [Epub ahead of print].","DOI":"10.1016\/j.nbd.2020.105073"},{"key":"10.1016\/j.yebeh.2020.107652_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107757","article-title":"Identifying targets for preventing epilepsy using systems biology of the human brain","volume":"168","author":"Kirchner","year":"2020","journal-title":"Neuropharmacology"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020308325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020308325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:35:38Z","timestamp":1761503738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505020308325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":51,"alternative-id":["S1525505020308325"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107652","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of locomotor behaviors by location-specific epileptic spiking and seizures","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107652"}}