{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:43:44Z","timestamp":1761504224492,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.yebeh.2020.107730","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:54:59Z","timestamp":1611363299000},"page":"107730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Absolute spike frequency and different comorbidities in temporal lobe epilepsy"],"prefix":"10.1016","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-9425","authenticated-orcid":false,"given":"Cayetano E.","family":"Napolitano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Magunacelaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Orriols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2020.107730_b0005","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1528-1157.1999.tb00856.x","article-title":"Interictal epileptiform discharges in temporal lobe epilepsy due to hippocampal sclerosis versus medial temporal lobe tumors","volume":"40","author":"Hamer","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0010","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/epi.12186","article-title":"EEG abnormalities as a biomarker for cognitive comorbidities in pharmacoresistant epilepsy","volume":"54","author":"Holmes","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0015","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1093\/brain\/awz269","article-title":"Interictal epileptiform discharges shape large-scale intercortical communication","volume":"142","author":"Dahal","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2020.107730_b0020","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1093\/brain\/awu214","article-title":"Resilience of developing brain networks to interictal epileptiform discharges is associated with cognitive outcome","volume":"137","author":"Ibrahim","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2020.107730_b0025","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/brain\/awx178","article-title":"The nociferous influence of interictal discharges on memory","volume":"140","author":"Kleen","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2020.107730_b0030","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/j.1528-1167.2012.03533.x","article-title":"Widespread epileptic networks in focal epilepsies: EEG-fMRI study","volume":"53","author":"Fahoum","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068038","article-title":"Epileptic discharges affect the default mode network-fMRI and intracerebral EEG evidence","volume":"8","author":"Fahoum","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2020.107730_b0040","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1093\/brain\/awx143","article-title":"Interictal epileptiform activity outside the seizure onset zone impacts cognition","volume":"140","author":"Ung","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2020.107730_b0045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.eplepsyres.2012.02.010","article-title":"Connectivity disruptions in resting-state functional brain networks in children with temporal lobe epilepsy","volume":"100","author":"Mankinen","year":"2012","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2020.107730_b0050","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1212\/WNL.0000000000002674","article-title":"Long-term outcome of mild mesial temporal lobe epilepsy: A prospective longitudinal cohort study","volume":"86","author":"Labate","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107730_b0055","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1212\/WNL.0b013e31826c1b55","article-title":"Age at onset of epilepsy, pharmacoresistance, and cognitive outcome","volume":"79","author":"Berg","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107730_b0060","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1535-7511.2006.00125.x","article-title":"Depression and epilepsy: a new perspective on two closely related disorders","volume":"6","author":"Kanner","year":"2006","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.yebeh.2020.107730_b0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.seizure.2017.02.017","article-title":"Epilepsy and cognition \u2013 A bidirectional relationship?","volume":"49","author":"Helmstaedter","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107730_b0070","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.seizure.2017.11.008","article-title":"Relationships of depression and anxiety symptoms with seizure frequency: Results from a multicenter follow-up study","volume":"53","author":"Dehn","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107730_b0075","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.eplepsyres.2003.10.017","article-title":"Spikes on the postoperative EEG are related to preoperative spike frequency and postoperative seizures","volume":"57","author":"Janszky","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2020.107730_b0080","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1017\/S031716710003273X","article-title":"Relationships between interictal spiking and seizures: human and experimental evidence","volume":"18","author":"Gotman","year":"1991","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.yebeh.2020.107730_b0085","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1684\/j.1950-6945.2005.tb00139.x","article-title":"Spike frequency is dependent on epilepsy duration and seizure frequency in temporal lobe epilepsy","volume":"7","author":"Janszky","year":"2005","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.yebeh.2020.107730_b0090","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/01.wnl.0000310775.87331.90","article-title":"Absolute spike frequency predicts surgical out come in TLE with unilateral hippocampal atrophy","volume":"71","author":"Krendl","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107730_b0095","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1212\/01.WNL.0000058761.12715.0E","article-title":"Intractable temporal lobe epilepsy with rare spikes is less severe than with frequent spikes","volume":"60","author":"Rosati","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107730_b0100","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/WNP.0b013e3181eaaa0e","article-title":"Graduated and sequential propagation in mesial temporal epilepsy: analysis with scalp ictal EEG","volume":"27","author":"Napolitano","year":"2010","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2020.107730_b0105","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizures types by the International League Agains Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0110","series-title":"Neurosurgical management of the epilepsies","first-page":"59","article-title":"Contributions of electroencephalography and electrocorticography to the neurosurgical treatment of the epilepsies","author":"Gloor","year":"1975"},{"key":"10.1016\/j.yebeh.2020.107730_b0115","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1212\/WNL.0000000000009439","article-title":"Criteria for defining interictal epileptiform discharges in EEG: A clinical validation study","volume":"94","author":"Kural","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107730_b0120","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cnp.2017.07.002","article-title":"A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. Revision 2017","volume":"2","author":"Kane","year":"2017","journal-title":"Clin Neurophysiol Pract"},{"issue":"6","key":"10.1016\/j.yebeh.2020.107730_b0125","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies)","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0130","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory event in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events","volume":"8","author":"Berry","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.yebeh.2020.107730_b0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.seizure.2017.03.008","article-title":"Absolute spike frequency as a predictor of surgical outcome in temporal lobe epilepsy","volume":"47","author":"Ngo","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107730_b0140","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.clinph.2014.02.013","article-title":"Is interictal EEG activity a biomarker for mood disorders in temporal lobe epilepsy?","volume":"125","author":"Bragatti","year":"2014","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2020.107730_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107100","article-title":"Electroencephalogram alterations associated with psychiatric disorders in temporal lobe epilepsy with mesial sclerosis: A systematic review","volume":"108","author":"de Barros Louren\u00e7o","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2020.107730_b0150","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/j.1528-1157.1998.tb01329.x","article-title":"Interictal spiking increases with sleep Deph in temporal lobe epilepsy","volume":"39","author":"Malow","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0155","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/epi.13958","article-title":"Brain regions and epileptogenicity influence epileptic interictal spike production and propagation during NREM sleep in comparison with wakefulness","volume":"59","author":"Lambert","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0160","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1111\/j.1528-1157.1999.tb00886.x","article-title":"Forced normalization: clinical and therapeutic relevance","volume":"40","author":"Krishnamoorthy","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0165","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1111\/epi.16276","article-title":"Forced normalization: A systematic review","volume":"60","author":"Calle\u2010L\u00f3pez","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2020.107730_b0170","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.seizure.2013.05.008","article-title":"Severity of depressive symptomatology and functional impairment in children and adolescents with temporal lobe epilepsy","volume":"22","author":"Pereira","year":"2013","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107730_b0175","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.seizure.2014.06.013","article-title":"The influence of seizure frequency on anterograde and remote memory in mesial temporal lobe epilepsy","volume":"23","author":"Voltzenlogel","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107730_b0180","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1212\/WNL.0b013e318297ee50","article-title":"Hippocampal interictal epileptiform activity disrupts cognition in humans","volume":"81","author":"Kleen","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2020.107730_b0185","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nm.4084","article-title":"Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy","volume":"22","author":"Gelinas","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.yebeh.2020.107730_b0190","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1528-1167.2006.00427.x","article-title":"Temporal and extratemporal BOLD responses to temporal lobe interictal spikes","volume":"47","author":"Kobayashi","year":"2006","journal-title":"Epilepsia"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020309100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020309100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:38:11Z","timestamp":1761503891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505020309100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":38,"alternative-id":["S1525505020309100"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107730","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Absolute spike frequency and different comorbidities in temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107730"}}