{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:38:46Z","timestamp":1761503926452,"version":"build-2065373602"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001605","name":"Epilepsy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.yebeh.2020.107741","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T12:30:33Z","timestamp":1611318633000},"page":"107741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Coffee and cigarette smoking interactions with lamotrigine"],"prefix":"10.1016","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9588-0714","authenticated-orcid":false,"given":"Timothy E.","family":"Welty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry E.","family":"Gidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-5975","authenticated-orcid":false,"given":"Michael D.","family":"Privitera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel J.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Krebill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-6627","authenticated-orcid":false,"given":"Jerzy","family":"Szaflarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-228X","authenticated-orcid":false,"given":"Francisco J.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.yebeh.2020.107741_b0005","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0022-3565(25)11424-9","article-title":"In vitro N-glucuronidation of a novel antiepileptic drug, lamotrigine, by human liver microsomes","volume":"260","author":"Magdalou","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107741_b0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0090-9556(25)07072-2","article-title":"Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine","volume":"19","author":"Sinz","year":"1991","journal-title":"Drug Metab Dispos"},{"issue":"9","key":"10.1016\/j.yebeh.2020.107741_b0015","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1124\/dmd.109.028225","article-title":"Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltranserase 1A1, 1A6, 1A9, 2B7, and 2B10","volume":"37","author":"Kerdpin","year":"2009","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107741_b0020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/FTD.0b013e3181ceecc6","article-title":"UGT2B7_-1661C>T polymorphism is associated with lamotrigine concentration-to-dose ration in a multivariate study","volume":"32","author":"Bianca","year":"2010","journal-title":"Ther Drug Monit"},{"issue":"8","key":"10.1016\/j.yebeh.2020.107741_b0025","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.neuropharm.2008.08.032","article-title":"Several major antiepileptic drugs are substrates for human P-glycoprotein","volume":"55","author":"Luna-Tort\u00f3s","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2020.107741_b0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuropharm.2015.01.015","article-title":"The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2)","volume":"93","author":"R\u04e7mmermann","year":"2015","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.yebeh.2020.107741_b0035","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/157015910792246254","article-title":"Antiepileptic drug interactions - principles and clinical implications","volume":"8","author":"Johannessen","year":"2010","journal-title":"Curr Neuropharmacol."},{"key":"10.1016\/j.yebeh.2020.107741_b0040","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1053\/j.gastro.2010.06.048","article-title":"Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach","volume":"139","author":"Kalthoff","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yebeh.2020.107741_b0045","doi-asserted-by":"crossref","unstructured":"Isshiki M, Umezawa K, Tamura. Coffee induces breast cancer resistance protein expression in Caco-2 cells. Biol Pharm Bull. 2011;34(10):1624-27.","DOI":"10.1248\/bpb.34.1624"},{"key":"10.1016\/j.yebeh.2020.107741_b0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0002-8223(99)00051-6","article-title":"Characteristics and occurrence of phenolic phytochemicals","volume":"99","author":"King","year":"1999","journal-title":"J Am Diet Assoc"},{"issue":"2","key":"10.1016\/j.yebeh.2020.107741_b0055","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1600-0773.1998.tb01401.x","article-title":"Effect of cigarette smoke on UDP-glucuronosyltransferase activity and cytochrome P450 content in liver, lung and kidney microsomes in mice","volume":"82","author":"Villard","year":"1998","journal-title":"Pharmacol Toxicol"},{"issue":"7","key":"10.1016\/j.yebeh.2020.107741_b0060","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.seizure.2008.05.009","article-title":"Smoking reduces serum levels of lamotrigine","volume":"17","author":"Reinsberger","year":"2008","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2020.107741_b0065","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/bcp.12984","article-title":"Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: influence of polymorphism of UDP-glucuronosyltransferases and drug transporters","volume":"82","author":"Milosheska","year":"2016","journal-title":"B J Clin Pharmacol"},{"issue":"4","key":"10.1016\/j.yebeh.2020.107741_b0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1474-4422(16)00014-4","article-title":"Generic-to-generic lamotrigine switches in people with epilepsy: the randomized controlled EQUIGEN trial","volume":"15","author":"Privitera","year":"2016","journal-title":"Lancet Neurol"},{"issue":"12","key":"10.1016\/j.yebeh.2020.107741_b0075","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s40262-013-0103-4","article-title":"Random-effects linear modeling and sample size tables for two special crossover designs of average bioequivalence studies: the four-period, two-sequence, two-formulation and six-period, three-sequence, three-formulation designs","volume":"52","author":"Diaz","year":"2013","journal-title":"Clin Pharmacokin"},{"key":"10.1016\/j.yebeh.2020.107741_b0080","doi-asserted-by":"crossref","unstructured":"Botts S, Diaz F J, Santoro V, Muscatello MR, Cogollo M, Castro FE et al. (2008). Estimating the effects of co-medications on plasma olanzapine concentrations by using a mixed model. Prog Neuro-Psychopharmacol Biol Psychiatry. 2008; 32(6): 1453-58.","DOI":"10.1016\/j.pnpbp.2008.04.018"},{"issue":"1","key":"10.1016\/j.yebeh.2020.107741_b0085","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1734-1140(11)70394-2","article-title":"Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data","volume":"63","author":"Chro\u015bci\u0144ska-Krawczyk","year":"2011","journal-title":"Pharmacol Rep"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020309215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505020309215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:36:33Z","timestamp":1761503793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505020309215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":17,"alternative-id":["S1525505020309215"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107741","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coffee and cigarette smoking interactions with lamotrigine","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2020.107741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107741"}}