{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:14:54Z","timestamp":1778818494392,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/11361-4"],"award-info":[{"award-number":["2013\/11361-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308968\/2015-8"],"award-info":[{"award-number":["308968\/2015-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.yebeh.2021.107854","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T19:21:47Z","timestamp":1614194507000},"page":"107854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-4099","authenticated-orcid":false,"given":"Silvia","family":"Vincentiis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana A.","family":"Alcantara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Rzezak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner F.","family":"Gattaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Helio","family":"van der Linden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Chaim-Avancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio H.","family":"Serpa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo F.","family":"Busatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruda","family":"Alessi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Demarque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-0809","authenticated-orcid":false,"given":"Kette D.","family":"Valente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2021.107854_b0005","unstructured":"Engel J Jr, Williamson P, Wieser HG. Mesial temporal lobe epilepsy. In: Engel J Jr, Pedley TA, eds. Epilepsy, a comprehensive textbook. New York, NY: Raven Press;1997:2417-26."},{"key":"10.1016\/j.yebeh.2021.107854_b0010","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1528-1167.2007.01395.x","article-title":"Epilepsy and mood disorders","volume":"48","author":"Kanner","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2021.107854_b0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yebeh.2014.01.001","article-title":"Do certain signal transduction mechanisms explain the comorbidity of epilepsy and mood disorders?","volume":"38","author":"Rocha","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2021.107854_b0020","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.yebeh.2016.03.022","article-title":"Most antidepressant drugs are safe for patients with epilepsy at therapeutic doses: A review of the evidence","volume":"61","author":"Kanner","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2021.107854_b0025","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0006-3223(03)00469-4","article-title":"Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment","volume":"54","author":"Kanner","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.yebeh.2021.107854_b0030","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1111\/j.1528-1157.1999.tb00883.x","article-title":"Behavioral, psychotic, and anxiety disorders in epilepsy: etiology, clinical features, and therapeutic implications","volume":"40","author":"Torta","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2021.107854_b0035","first-page":"369","article-title":"Mood disorders in patients with epilepsy","volume":"59","author":"Dudra-Jastrzebska","year":"2007","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.yebeh.2021.107854_b0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fphar.2015.00046","article-title":"Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?","volume":"6","author":"Guiard","year":"2015","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.yebeh.2021.107854_b0045","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuropharm.2016.04.016","article-title":"Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures","volume":"108","author":"Venzi","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2021.107854_b0050","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1471-4159.2006.04277.x","article-title":"Serotonin and epilepsy","volume":"100","author":"Bagdy","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2021.107854_b0055","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1093\/brain\/awn194","article-title":"Comorbidity between temporal lobe epilepsy and depression: a [18F] MPPF PET study","volume":"131","author":"Lothe","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2021.107854_b0060","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1046\/j.1471-4159.1996.66062621.x","article-title":"Allelic variation of human serotonin transporter gene expression","volume":"66","author":"Heils","year":"1996","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2021.107854_b0065","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF01276434","article-title":"Organization of the human serotonin transporter gene","volume":"95","author":"Lesch","year":"1994","journal-title":"J Neural Transm Gen"},{"key":"10.1016\/j.yebeh.2021.107854_b0070","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.ALC.0000150008.68473.62","article-title":"An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk","volume":"29","author":"Hu","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.yebeh.2021.107854_b0075","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0140-6736(96)90079-3","article-title":"Polymorphism in serotonin transporter gene associated with susceptibility to major depression","volume":"347","author":"Ogilvie","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.yebeh.2021.107854_b0080","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1460-9568.2003.02446.x","article-title":"The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit","volume":"17","author":"Lovejoy","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.yebeh.2021.107854_b0085","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neulet.2007.05.022","article-title":"Serotonin transporter gene (5-Htt): association analysis with temporal lobe epilepsy","volume":"421","author":"Manna","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2021.107854_b0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.eplepsyres.2009.03.010","article-title":"Serotonin transporter gene variation and refractory mesial temporal epilepsy with hippocampal sclerosis","volume":"85","author":"Kauffman","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2021.107854_b0095","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.eplepsyres.2010.06.008","article-title":"Association of serotonin transporter promoter (5-HTTLPR) and intron 2 (VNTR-2) polymorphisms with treatment response in temporal lobe epilepsy","volume":"91","author":"Hecimovic","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2021.107854_b0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2010.04.060","article-title":"Epilepsy and serotonin (5HT): variations of 5HT-related genes in temporal lobe epilepsy","volume":"478","author":"Stefulj","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2021.107854_b0105","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.eplepsyres.2011.03.013","article-title":"Serotonin transporter gene (5HTT) polymorphisms and temporal lobe epilepsy","volume":"95","author":"Schenkel","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2021.107854_b0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.eplepsyres.2011.12.005","article-title":"Serotonin gene polymorphisms and psychiatry comorbidities in temporal lobe epilepsy","volume":"99","author":"Schenkel","year":"2012","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2021.107854_b0115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1468-1331.2011.03521.x","article-title":"Association study of functional polymorphisms in serotonin transporter gene with temporal lobe epilepsy in Han Chinese population","volume":"19","author":"Li","year":"2012","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.yebeh.2021.107854_b0120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.seizure.2018.07.004","article-title":"BDNF Val66Met polymorphism is not related with temporal lobe epilepsy caused by hippocampal sclerosis in Brazilian population","volume":"60","author":"Alcantara","year":"2018","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2021.107854_b0125","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/ene.13631","article-title":"Association study of functional polymorphisms of dopaminergic pathway in epilepsy-related factors of temporal lobe epilepsy in Brazilian population","volume":"25","author":"Alcantara","year":"2018","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.yebeh.2021.107854_b0130","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.yebeh.2018.03.032","article-title":"Genetic polymorphisms of the 5HT receptors are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis","volume":"83","author":"Vincentiis","year":"2018","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2021.107854_b0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.eplepsyres.2018.11.003","article-title":"Higher transcription alleles of the MAOA-uVNTR polymorphism are associated with higher seizure frequency in temporal lobe epilepsy","volume":"149","author":"Vincentiis","year":"2019","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2021.107854_b0140","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/epi.12220","article-title":"International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods","volume":"54","author":"Bl\u00fcmcke","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2021.107854_b0145","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2021.107854_b0150","unstructured":"American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Text Revision. Washington DC; 2000."},{"key":"10.1016\/j.yebeh.2021.107854_b0155","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Patient Edition (SCID-I\/P). New York, NY: Biometrics Research, New York State Psychiatric Institute; 2002."},{"key":"10.1016\/j.yebeh.2021.107854_b0160","first-page":"316","article-title":"A nontoxic and versatile protein salting-out method for isolation of DNA","volume":"17","author":"Laitinen","year":"1994","journal-title":"Biotechniques"},{"key":"10.1016\/j.yebeh.2021.107854_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017063","article-title":"The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected","volume":"6","author":"Pena","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.yebeh.2021.107854_b0170","first-page":"1270","article-title":"Association between serotonin transporter gene polymorphisms and non-lesional temporal lobe epilepsy in a Chinese Han population","volume":"5","author":"Che","year":"2010","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.yebeh.2021.107854_b0175","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1046\/j.1460-9568.2000.00126.x","article-title":"Altered expression. and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter","volume":"12","author":"Fabre","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.yebeh.2021.107854_b0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yebeh.2014.07.016","article-title":"Serotonin transporter gene \u00d7 environment and risk of depression in community-treated epilepsy","volume":"39","author":"Lacey","year":"2014","journal-title":"Epilepsy Behav"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505021000883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505021000883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:48:48Z","timestamp":1778816928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505021000883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":36,"alternative-id":["S1525505021000883"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2021.107854","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2021.107854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107854"}}