{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:56:23Z","timestamp":1761504983626,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.yebeh.2022.108601","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T20:50:19Z","timestamp":1645563019000},"page":"108601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Motor and behavioral phenotype of Dravet syndrome in adulthood"],"prefix":"10.1016","volume":"129","author":[{"given":"Peter","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"K\u00fcmmerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2022.108601_b0005","doi-asserted-by":"crossref","unstructured":"Rubinstein M, Han S, Tai C, Westenbroek RE, Hunker A, Scheuer T, et al. Dissecting the phenotypes of Dravet syndrome by gene deletion. Brain. 2015; 138:2219-33. https:\/\/doi:10.1093\/brain\/awv142.","DOI":"10.1093\/brain\/awv142"},{"key":"10.1016\/j.yebeh.2022.108601_b0010","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1152\/jn.00824.2015","article-title":"Model systems for studying cellular mechanisms of SCN1A-related epilepsy","volume":"115","author":"Schutte","year":"2016","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.yebeh.2022.108601_b0015","doi-asserted-by":"crossref","unstructured":"Jiang TJ, Shen YS, Chen H, Yuan Z, Mao S, Gao F. Clinical and molecular analysis of epilepsy-related genes in patients with Dravet syndrome. Medicine. 2018; 97:50(e13565). https:\/\/doi: 10.1097\/MD.0000000000013565.","DOI":"10.1097\/MD.0000000000013565"},{"key":"10.1016\/j.yebeh.2022.108601_b0020","doi-asserted-by":"crossref","first-page":"E139","DOI":"10.1073\/pnas.1411131111","article-title":"Impaired excitability of parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome","volume":"111","author":"Tai","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.yebeh.2022.108601_b0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/epi4.12062","article-title":"Interneuronopathies and their role in early life epilepsies and neurodevelopmental disorders","volume":"2","author":"Katsarou","year":"2017","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.yebeh.2022.108601_b0030","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/humu.22782","article-title":"The SCN1A mutation database: updating information and analysis of the relationships among genotype, functional alteration, and phenotype","volume":"36","author":"Meng","year":"2015","journal-title":"Hum Mutat"},{"key":"10.1016\/j.yebeh.2022.108601_b0035","doi-asserted-by":"crossref","first-page":"10288","DOI":"10.1038\/s41598-020-67215-y","article-title":"A study among the genotype, functional alterations, and phenotype of 9 SCN1A mutations in epilepsy patients","author":"Kluckova","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.yebeh.2022.108601_b0040","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.seizure.2011.06.014","article-title":"Variable expressivity of a novel mutation in the SCN1A gene leading to an autosomal dominant seizure disorder","volume":"20","author":"Mhanni","year":"2011","journal-title":"Seizure"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2022.108601_b0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1167.2011.02994.x","article-title":"The core Dravet syndrome phenotype","volume":"52","author":"Dravet","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108601_b0050","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1093\/brain\/awr129","article-title":"Dravet syndrome as epileptic encephalopathy: evidence from long-term course and neuropathology","volume":"134","author":"Catarino","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2022.108601_b0055","doi-asserted-by":"crossref","unstructured":"Jansson JS, Hallb\u00f6\u00f6k T, Reilly C. Intellectual functioning and behavior in Dravet syndrome: a systematic review. Epilepsy Behav. 2020; 108: 107079. https:\/\/doi:10.1016\/j.yebeh.2020.107079.","DOI":"10.1016\/j.yebeh.2020.107079"},{"key":"10.1016\/j.yebeh.2022.108601_b0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.yebeh.2011.04.060","article-title":"Autism in Dravet syndrome: prevalence, features, and relationship to the clinical characteristics of epilepsy and mental retardation","volume":"21","author":"Li","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108601_b0065","doi-asserted-by":"crossref","unstructured":"Nabbout R, Chemaly N, Chipaux M, Barica G, Bouis C, Dubouch C. Encephalopathy in children with Dravet syndrome is not a pure consequence of epilepsy. Orphanet J Rare Dis. 2013; 8: 176. https:\/\/doi:10.1186\/1750-1172-8-176.","DOI":"10.1186\/1750-1172-8-176"},{"key":"10.1016\/j.yebeh.2022.108601_b0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yebeh.2015.04.057","article-title":"Autism and behavior in adult patients with Dravet syndrome (DS)","volume":"47","author":"Berkvens","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108601_b0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/epi4.12281","article-title":"Autism spectrum disorder and cognitive profile in children with Dravet syndrome: Delineation of a specific phenotype","volume":"4","author":"Ouss","year":"2019","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.yebeh.2022.108601_b0080","doi-asserted-by":"crossref","unstructured":"Thurm A, Farmer C, Salzman E, Lord C, Bishop S. Bishop State of the field: Differentiating intellectual disability from autism spectrum disorder. Front Psychiatry. 2019; 10:526. https:\/\/10:3389\/fpsyt.2019.00526.","DOI":"10.3389\/fpsyt.2019.00526"},{"key":"10.1016\/j.yebeh.2022.108601_b0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.braindev.2009.09.014","article-title":"Dravet syndrome: early clinical manifestations and cognitive outcome in 37 Italian patients","volume":"32","author":"Ragona","year":"2010","journal-title":"Brain Dev"},{"key":"10.1016\/j.yebeh.2022.108601_b0090","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.yebeh.2015.09.013","article-title":"Hallucinations and delusions are frequently reported in individuals with Dravet syndrome","volume":"52","author":"Martin","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"Suppl 2","key":"10.1016\/j.yebeh.2022.108601_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-8749.2011.03964.x","article-title":"Dravet syndrome history","volume":"53","author":"Dravet","year":"2011","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.yebeh.2022.108601_b0100","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archneurol.2011.3275","article-title":"Progressive gait deterioration in adolescents with Dravet syndrome","volume":"69","author":"Rodda","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1016\/j.yebeh.2022.108601_b0105","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1528-1167.2012.03583.x","article-title":"Dravet syndrome: seizure control and gait in adults with different SCN1A mutations","volume":"53","author":"Rilstone","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108601_b0110","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1212\/WNL.0000000000002859","article-title":"Motor neuropathy contributes to crouching in patients with Dravet syndrome","volume":"87","author":"Gitiaux","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108601_b0115","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1212\/WNL.0000000000008171","article-title":"Dravet syndrome and Parkinsonism","author":"Deuel","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108601_b0120","first-page":"e44","article-title":"Adult motor phenotype differentiates Dravet syndrome from Lennox-Gastaut syndrome and links SCN1A to early onset parkinsonian features","author":"Aljaafari","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108601_b0125","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1212\/WNL.0000000000000521","article-title":"Antecollis and levodopa-responsive Parkinsonism are late features of Dravet syndrome","author":"Fasano","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108601_b0130","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nbt0410-322","article-title":"A global map of human gene expression","volume":"28","author":"Lukk","year":"2010","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.yebeh.2022.108601_b0135","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1212\/WNL.0000000000003635","article-title":"Dysarthria and broader motor speech deficits in Dravet syndrome","volume":"88","author":"Turner","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108601_b0140","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000326746","article-title":"Severe myoclonic epilepsy of infancy \u2013 adult phenotype with bradykinesia, hypomimia, and perseverative behavior: report of five cases","volume":"1","author":"Martin","year":"2010","journal-title":"Mol Syndromol"},{"key":"10.1016\/j.yebeh.2022.108601_b0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/neurosurgery\/31.CN_suppl_1.9","article-title":"Honored guest presentation: abulia minor vs. agitated behavior","volume":"31","author":"Fisher","year":"1983","journal-title":"Clin Neurosurg"},{"year":"1995","series-title":"Matson evaluation of social skills for individuals with severe retardation","author":"Matson","key":"10.1016\/j.yebeh.2022.108601_b0150"},{"key":"10.1016\/j.yebeh.2022.108601_b0155","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0891-4222(98)00020-1","article-title":"The convergent validity of the Matson Evaluation of Social Skills for individuals with Severe Retardation (MESSIER)","volume":"19","author":"Matson","year":"1998","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.yebeh.2022.108601_b0160","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1177\/0145445599234008","article-title":"Reliability of the Matson Evaluation of Social Skills in Individuals with Severe Retardation (MESSIER)","volume":"23","author":"Matson","year":"1999","journal-title":"Behav Modif"},{"key":"10.1016\/j.yebeh.2022.108601_b0165","doi-asserted-by":"crossref","unstructured":"Matson JL, Boisjoli JA. Cutoff scores for the Matson Evaluation of Social Skills for Individuals with Severe Retardation (MESSIER) for adults with intellectual disability. Behav Modif. 2008; 32:109-20. https:\/\/doi:10.1177\/0145445507307466.","DOI":"10.1177\/0145445507307466"},{"key":"10.1016\/j.yebeh.2022.108601_b0170","first-page":"485","article-title":"The aberrant behavior checklist: a behavior rating scale for the assessment of treatment effects","volume":"89","author":"Aman","year":"1985","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.yebeh.2022.108601_b0175","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.ridd.2011.07.017","article-title":"Psychometric properties and norms of the German ABC-Community and PAS-ADD Checklist","volume":"32","author":"Zeilinger","year":"2011","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.yebeh.2022.108601_b0180","series-title":"Recent developments in Parkinson\u2019s disease","first-page":"153","article-title":"Unified Parkinson\u2019s disease rating scale","author":"Fahn","year":"1987"},{"key":"10.1016\/j.yebeh.2022.108601_b0185","first-page":"24","article-title":"Adult norms for the Nine Hole Peg Test of finger dexterity","volume":"5","author":"Mathiowetz","year":"1985","journal-title":"OTJR"},{"key":"10.1016\/j.yebeh.2022.108601_b0190","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1212\/01.wnl.0000249312.73155.7d","article-title":"Severe myoclonic epilepsy in infancy (Dravet syndrome): recognition and diagnosis in adults","volume":"67","author":"Jansen","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108601_b0195","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0387-7604(01)00276-5","article-title":"Severe myoclonic epilepsy in infants-a review based on the Tokyo Women\u2019s Medical University series of 84 cases","volume":"23","author":"Oguni","year":"2001","journal-title":"Brain Dev"},{"key":"10.1016\/j.yebeh.2022.108601_b0200","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.1528-1167.2009.02466.x","article-title":"A long-term follow up study of Dravet syndrome up to adulthood","volume":"51","author":"Akiyama","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108601_b0205","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/epi.12532","article-title":"Long-term course of Dravet syndrome: a study from an epilepsy center in Japan","volume":"55","author":"Takayama","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108601_b0210","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1212\/WNL.0000000000008171","article-title":"Dravet syndrome and parkinsonism. A case report investigating the dopaminergic system","volume":"93","author":"Deuel","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108601_b0215","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1212\/WNL.0000000000002859","article-title":"Motor neuropathy contributes to crouching in patients with Dravet syndrome","volume":"87","author":"Gitiaux","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108601_b0220","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.yebeh.2013.11.021","article-title":"Cognitive and adaptive evaluation of 21 consecutive patients with Dravet syndrome","volume":"31","author":"Villeneuve","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108601_b0225","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.47.3.626","article-title":"Reversible parkinsonian and cognitive impairment with chronic valproate use","volume":"47","author":"Armon","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108601_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.903250102","article-title":"Topography and collateralization of the dopaminergic projections to motor and lateral prefrontal cortex in owl monkeys","volume":"325","author":"Gaspar","year":"1992","journal-title":"J Comp Neurol"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022000506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022000506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:48:55Z","timestamp":1761504535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505022000506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":46,"alternative-id":["S1525505022000506"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108601","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Motor and behavioral phenotype of Dravet syndrome in adulthood","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108601","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108601"}}