{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:15:29Z","timestamp":1792804529987,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.yebeh.2022.108646","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T17:53:25Z","timestamp":1647280405000},"page":"108646","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Safety and efficacy of responsive neurostimulation in the pediatric population: Evidence from institutional review and patient-level meta-analysis"],"prefix":"10.1016","volume":"129","author":[{"given":"Panagiotis","family":"Kerezoudis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyrios","family":"Gyftopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Yohan","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donnie","family":"Keith Starnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine C.","family":"Nickels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Worrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine C.","family":"Wirrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian N.","family":"Lundstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie J.","family":"Van Gompel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"31","key":"10.1016\/j.yebeh.2022.108646_b0005","doi-asserted-by":"crossref","first-page":"821","DOI":"10.15585\/mmwr.mm6631a1","article-title":"National and state estimates of the numbers of adults and children with active epilepsy \u2014 United States, 2015","volume":"66","author":"Zack","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"17","key":"10.1016\/j.yebeh.2022.108646_b0010","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.0000000000011839","article-title":"Incidence and prevalence of drug-resistant epilepsy: a systematic review and meta-analysis","volume":"96","author":"Sultana","year":"2021","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.yebeh.2022.108646_b0015","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108646_b0020","doi-asserted-by":"crossref","first-page":"106479","DOI":"10.1016\/j.yebeh.2019.106479","article-title":"Resective epilepsy surgery involving eloquent cortex in the age of responsive neurostimulation: a value-based decision-making framework","volume":"99","author":"Yan","year":"2019","journal-title":"Epilepsy Behav"},{"issue":"13","key":"10.1016\/j.yebeh.2022.108646_b0025","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1212\/WNL.0b013e3182302056","article-title":"Responsive cortical stimulation for the treatment of medically intractable partial epilepsy","volume":"77","author":"Morrell","year":"2011","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108646_b0030","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/epi.12534","article-title":"Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial","volume":"55","author":"Heck","year":"2014","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2022.108646_b0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3171\/2020.5.PEDS20118","article-title":"Safety of responsive neurostimulation in pediatric patients with medically refractory epilepsy","volume":"26","author":"Panov","year":"2020","journal-title":"J Neurosurg Pediatr"},{"key":"10.1016\/j.yebeh.2022.108646_b0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebcr.2018.02.002","article-title":"Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy","volume":"10","author":"Singhal","year":"2018","journal-title":"Epilepsy Behav Case Rep"},{"issue":"5","key":"10.1016\/j.yebeh.2022.108646_b0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int J Surg"},{"key":"10.1016\/j.yebeh.2022.108646_b0050","doi-asserted-by":"crossref","unstructured":"Mortazavi A, Elliott RJS, Phan TN, Schreiber J, Gaillard WD, Oluigbo CO. Responsive neurostimulation for the treatment of medically refractory epilepsy in pediatric patients: strategies, outcomes, and technical considerations. J Neurosurg Pediatr. Published online April 30, 2021:1-8.","DOI":"10.3171\/2020.11.PEDS20660"},{"key":"10.1016\/j.yebeh.2022.108646_b0055","doi-asserted-by":"crossref","first-page":"107389","DOI":"10.1016\/j.yebeh.2020.107389","article-title":"Responsive neurostimulation for refractory epilepsy in the pediatric population: a single-center experience","volume":"112","author":"Bercu","year":"2020","journal-title":"Epilepsy Behav"},{"issue":"6","key":"10.1016\/j.yebeh.2022.108646_b0060","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1684\/epd.2020.1224","article-title":"Improved seizure burden and cognitive performance in a child treated with responsive neurostimulation (RNS) following febrile infection related epilepsy syndrome (FIRES)","volume":"22","author":"Theroux","year":"2020","journal-title":"Epileptic Disord"},{"issue":"4","key":"10.1016\/j.yebeh.2022.108646_b0065","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3171\/2017.10.PEDS17353","article-title":"Treatment of medically refractory seizures with responsive neurostimulation: 2 pediatric cases","volume":"21","author":"Kokoszka","year":"2018","journal-title":"J Neurosurg Pediatr"},{"key":"10.1016\/j.yebeh.2022.108646_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.656585","article-title":"Case report: responsive neurostimulation of the centromedian thalamic nucleus for the detection and treatment of seizures in pediatric primary generalized epilepsy","volume":"12","author":"Welch","year":"2021","journal-title":"Front Neurol"},{"issue":"10","key":"10.1016\/j.yebeh.2022.108646_b0075","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1002\/acn3.51173","article-title":"Centromedian thalamic responsive neurostimulation for Lennox-Gastaut epilepsy and autism","volume":"7","author":"Kwon","year":"2020","journal-title":"Ann Clin Transl Neurol"},{"issue":"6","key":"10.1016\/j.yebeh.2022.108646_b0080","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/neuros\/nyab343","article-title":"Real-world preliminary experience with responsive neurostimulation in pediatric epilepsy: a multicenter retrospective observational study","volume":"89","author":"Nagahama","year":"2021","journal-title":"Neurosurgery"},{"issue":"5","key":"10.1016\/j.yebeh.2022.108646_b0085","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000479288","article-title":"Infection and erosion rates in trials of a cranially implanted neurostimulator do not increase with subsequent neurostimulator placements","volume":"95","author":"Weber","year":"2017","journal-title":"Stereotact Funct Neurosurg"},{"issue":"9","key":"10.1016\/j.yebeh.2022.108646_b0090","doi-asserted-by":"crossref","first-page":"e1244","DOI":"10.1212\/WNL.0000000000010154","article-title":"Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy","volume":"95","author":"Nair","year":"2020","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108646_b0095","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3171\/jns.2003.99.3.0500","article-title":"Complications of chronic vagus nerve stimulation for epilepsy in children","volume":"99","author":"Smyth","year":"2003","journal-title":"J Neurosurg"},{"issue":"2","key":"10.1016\/j.yebeh.2022.108646_b0100","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1227\/01.neu.0000316002.03765.33","article-title":"Deep brain stimulator hardware-related infections: incidence and management in a large series","volume":"62","author":"Sillay","year":"2008","journal-title":"Neurosurgery"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108646_b0105","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nec.2020.03.009","article-title":"Neuromodulation of epilepsy networks","volume":"31","author":"Sisterson","year":"2020","journal-title":"Neurosurg Clin N Am"},{"issue":"8","key":"10.1016\/j.yebeh.2022.108646_b0110","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1212\/WNL.0000000000001280","article-title":"Long-term treatment with responsive brain stimulation in adults with refractory partial seizures","volume":"84","author":"Bergey","year":"2015","journal-title":"Neurology"},{"issue":"16 Supplement","key":"10.1016\/j.yebeh.2022.108646_b0115","article-title":"Long-term safety and efficacy of responsive brain stimulation in adults with medically intractable partial onset seizures (S21.004)","volume":"88","author":"Nair","year":"2017","journal-title":"Neurology"},{"issue":"608","key":"10.1016\/j.yebeh.2022.108646_b0120","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf6588","article-title":"Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy","volume":"13","author":"Khambhati","year":"2021","journal-title":"Sci Transl Med"},{"issue":"10","key":"10.1016\/j.yebeh.2022.108646_b0125","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1212\/WNL.0000000000001334","article-title":"Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy","volume":"84","author":"Salanova","year":"2015","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.yebeh.2022.108646_b0130","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/j.1528-1157.2000.tb00325.x","article-title":"Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures","volume":"41","author":"DeGiorgio","year":"2000","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.yebeh.2022.108646_b0135","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/epi.13739","article-title":"Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas","volume":"58","author":"Jobst","year":"2017","journal-title":"Epilepsia"},{"issue":"17","key":"10.1016\/j.yebeh.2022.108646_b0140","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1056\/NEJMoa1703784","article-title":"Histopathological findings in brain tissue obtained during epilepsy surgery","volume":"377","author":"Blumcke","year":"2017","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.yebeh.2022.108646_b0145","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1002\/acn3.50858","article-title":"Responsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy","volume":"6","author":"Herlopian","year":"2019","journal-title":"Ann Clin Transl Neurol"},{"issue":"5","key":"10.1016\/j.yebeh.2022.108646_b0150","doi-asserted-by":"crossref","first-page":"E578","DOI":"10.1093\/neuros\/nyaa001","article-title":"Responsive neurostimulation of the thalamus improves seizure control in idiopathic generalized epilepsy: a case report","volume":"87","author":"Kokkinos","year":"2020","journal-title":"Neurosurgery"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108646_b0155","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/epi4.12524","article-title":"Brain-responsive corticothalamic stimulation in the pulvinar nucleus for the treatment of regional neocortical epilepsy: a case series","volume":"6","author":"Burdette","year":"2021","journal-title":"Epilepsia Open"},{"issue":"7","key":"10.1016\/j.yebeh.2022.108646_b0160","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/jamaneurol.2019.0658","article-title":"Association of closed-loop brain stimulation neurophysiological features with seizure control among patients with focal epilepsy","volume":"76","author":"Kokkinos","year":"2019","journal-title":"JAMA Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108646_b0165","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/epi.16442","article-title":"Mesial temporal resection following long-term ambulatory intracranial EEG monitoring with a direct brain-responsive neurostimulation system","volume":"61","author":"Hirsch","year":"2020","journal-title":"Epilepsia"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022000956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022000956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:45:37Z","timestamp":1761504337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505022000956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":33,"alternative-id":["S1525505022000956"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108646","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of responsive neurostimulation in the pediatric population: Evidence from institutional review and patient-level meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108646","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108646"}}