{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:12:30Z","timestamp":1778771550843,"version":"3.51.4"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1K23NS114178-01"],"award-info":[{"award-number":["1K23NS114178-01"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013410","name":"LivaNova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.yebeh.2022.108653","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T16:11:08Z","timestamp":1647447068000},"page":"108653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Concurrent brain-responsive and vagus nerve stimulation for treatment of drug-resistant focal epilepsy"],"prefix":"10.1016","volume":"129","author":[{"given":"Mesha-Gay","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Sillau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia D.","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario J.","family":"Englot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hern\u00e1n F.J.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Proleta","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Karakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Rolston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Arain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram R.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Drees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.yebeh.2022.108653_b0005","doi-asserted-by":"crossref","first-page":"e1244","DOI":"10.1212\/WNL.0000000000010154","article-title":"Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy","volume":"95","author":"Nair","year":"2020","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.yebeh.2022.108653_b0010","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/epi.16593","article-title":"Real\u2010world experience with direct brain\u2010responsive neurostimulation for focal onset seizures","volume":"61","author":"Razavi","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108653_b0015","doi-asserted-by":"crossref","unstructured":"Ernst LD, Steffan PJ, Srikanth P, Wiedrick J, Spencer DC, Datta P, et al. Electrocorticography analysis in patients with dual neurostimulators supports desynchronization as a mechanism of action for acute vagal nerve stimulator stimulation. J Clin Neurophysiol. 2021. doi: 10.1097\/WNP.0000000000000847. Epub ahead of print. PMID: 34009846.","DOI":"10.1097\/WNP.0000000000000847"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108653_b0020","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.3171\/2012.1.FOCUS11335","article-title":"Comparison of seizure control outcomes and the safety of vagus nerve, thalamic deep brain, and responsive neurostimulation: evidence from randomized controlled trials","volume":"32","author":"Rolston","year":"2012","journal-title":"Neurosurg Focus"},{"issue":"2","key":"10.1016\/j.yebeh.2022.108653_b0025","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/WCO.0000000000000534","article-title":"Neurostimulation for drug-resistant epilepsy: a systematic review of clinical evidence for efficacy, safety, contraindications and predictors for response","volume":"31","author":"Boon","year":"2018","journal-title":"Curr Opin Neurol"},{"issue":"16","key":"10.1016\/j.yebeh.2022.108653_b0030","article-title":"Effects of anterior thalamic nuclei stimulation on hippocampal activity: Chronic recording in a patient with drug-resistant focal epilepsy","volume":"30","author":"Silva","year":"2021","journal-title":"Epilepsy Behav Rep"},{"issue":"13","key":"10.1016\/j.yebeh.2022.108653_b0035","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1212\/WNL.0b013e3182302056","article-title":"Responsive cortical stimulation for the treatment of medically intractable partial epilepsy","volume":"77","author":"Morrell","year":"2011","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108653_b0040","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/epi.12534","article-title":"Two\u2010year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial","volume":"55","author":"Heck","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108653_b0045","doi-asserted-by":"crossref","first-page":"107327","DOI":"10.1016\/j.yebeh.2020.107327","article-title":"RNS modifications to eliminate stimulation-triggered signs or symptoms (STS): Case series and practical guide","volume":"112","author":"Hixon","year":"2020","journal-title":"Epilepsy Behav"},{"issue":"8","key":"10.1016\/j.yebeh.2022.108653_b0050","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1212\/WNL.0000000000001280","article-title":"Long-term treatment with responsive brain stimulation in adults with refractory partial seizures","volume":"84","author":"Bergey","year":"2015","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108653_b0055","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.yebeh.2010.12.042","article-title":"Efficacy of vagus nerve stimulation over time: review of 65 consecutive patients with treatment-resistant epilepsy treated with VNS > 10 years","volume":"20","author":"Elliott","year":"2011","journal-title":"Epilepsy Behav"},{"issue":"608","key":"10.1016\/j.yebeh.2022.108653_b0060","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf6588","article-title":"Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy","volume":"13","author":"Khambhati","year":"2021","journal-title":"Sci Transl Med"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022001020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022001020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:47:07Z","timestamp":1761504427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505022001020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":12,"alternative-id":["S1525505022001020"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108653","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concurrent brain-responsive and vagus nerve stimulation for treatment of drug-resistant focal epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108653"}}