{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:21:24Z","timestamp":1774538484920,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.yebeh.2022.108671","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T18:06:04Z","timestamp":1648922764000},"page":"108671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Evaluation of one-year effectiveness of clobazam as an add-on therapy to anticonvulsant monotherapy in participants with epilepsy having uncontrolled seizure episodes: An Indian experience"],"prefix":"10.1016","volume":"130","author":[{"given":"Parthasarathy","family":"Satishchandra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaturbhuj","family":"Rathore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirudha","family":"Apte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amlan","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dushyant","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagadish","family":"Agadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayanti","family":"Gurumukhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Asokan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Venkateshwarlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokesh","family":"Lingappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagarjunakonda Venkata","family":"Sundaracharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir K.","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Ravat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"VK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddhartha","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir Vadilal","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundaram","family":"Alagesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil","family":"Razdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Padhy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay Kumar","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindu","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujatha","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Chodankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"S5","key":"10.1016\/j.yebeh.2022.108671_b0005","first-page":"S2","article-title":"Staged approach to epilepsy management","volume":"58","author":"Brodie","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108671_b0010","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/jamaneurol.2017.3949","article-title":"Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: A 30-Year longitudinal cohort study","volume":"75","author":"Chen","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.yebeh.2022.108671_b0015","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(07)60461-9","article-title":"The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: An unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.yebeh.2022.108671_b0020","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(07)60460-7","article-title":"The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: An unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.yebeh.2022.108671_b0025","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/jnnp-2011-300376","article-title":"KOMET: An unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy","volume":"84","author":"Trinka","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.yebeh.2022.108671_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2003.09.007","article-title":"Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: A multicentre, randomized, pragmatic controlled trial","volume":"57","author":"Beghi","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2022.108671_b0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0920-1211(98)00095-3","article-title":"Monotherapy trials with the new antiepileptic drugs: study designs, practical relevance and ethical implications","volume":"33","author":"Perucca","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2022.108671_b0040","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1517\/14656566.2012.647686","article-title":"Clobazam for treatment of epilepsy","volume":"13","author":"Giarratano","year":"2012","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.yebeh.2022.108671_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088456","article-title":"Clobazam and its active metabolite N desmethylclobazam display significantly greater affinities for \u03b1\u2082-versus \u03b11-GABA(A)-receptor complexes","volume":"9","author":"Jensen","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.yebeh.2022.108671_b0050","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0883073812463609","article-title":"Clobazam: A newly approved but well-established drug for the treatment of intractable epilepsy syndromes","volume":"28","author":"Wheless","year":"2013","journal-title":"J Child Neurol"},{"key":"10.1016\/j.yebeh.2022.108671_b0055","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S1059-1311(02)00287-X","article-title":"Use of clobazam for the treatment of refractory complex partial seizures","volume":"12","author":"Shimizu","year":"2003","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2022.108671_b0060","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1528-1157.2001.31600.x","article-title":"Efficacy of clobazam as add-on therapy in patients with refractory partial epilepsy","volume":"42","author":"Montenegro","year":"2001","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2022.108671_b0065","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/j.1528-1167.2008.01935.x","article-title":"Clobazam in the treatment of Lennox-Gastaut syndrome","volume":"50","author":"Conry","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108671_b0070","first-page":"209","article-title":"Effect of clobazam as add-on antiepileptic drug in patients with epilepsy","volume":"140","author":"Joshi","year":"2014","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.yebeh.2022.108671_b0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1006\/ebeh.2000.0141","article-title":"On being seizure-free","volume":"2","author":"Satishchandra","year":"2001","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108671_b0080","unstructured":"National Institute for Health and Care Excellence (NICE) Epilepsies: Diagnosis and management Clinical guideline. Published: 11 January 2012. https:\/\/www.nice.org.uk\/guidance\/cg137\/resources\/epilepsies-diagnosis-and-management-35109515407813 [Accessed 31 August 2021]."},{"key":"10.1016\/j.yebeh.2022.108671_b0085","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1212\/WNL.0000000000005755","volume":"91","author":"Kanner","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108671_b0090","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108671_b0095","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.108671_b0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1212\/WNL.0000000000005756","volume":"91","author":"Kanner","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108671_b0105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0920-1211(96)01007-8","article-title":"Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group","volume":"26","author":"Brodie","year":"1997","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2022.108671_b0110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.yebeh.2018.01.001","article-title":"Efficacy and tolerability of perampanel and levetiracetam as first add-on therapy in patients with epilepsy: A retrospective single center study","volume":"80","author":"Liguori","year":"2018","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108671_b0115","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/cns.12399","article-title":"Clobazam: a safe, efficacious, and newly rediscovered therapeutic for epilepsy","volume":"21","author":"Gauthier","year":"2015","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.yebeh.2022.108671_b0120","first-page":"284","article-title":"Long-term use of clobazam in the management of intractable epilepsy: A prospective study","volume":"46","author":"Satishchandra","year":"1998","journal-title":"Neurol India"},{"key":"10.1016\/j.yebeh.2022.108671_b0125","doi-asserted-by":"crossref","unstructured":"Bresnahan R, Martin-McGill KJ, Williamson J, Michael BD, Marson AG. Clobazam add-on therapy for drug-resistant epilepsy. Cochrane Database Syst Rev. 2019;10:CD004154. 10.1002\/14651858.CD004154.pub5. Online ahead of print.","DOI":"10.1002\/14651858.CD004154.pub5"},{"key":"10.1016\/j.yebeh.2022.108671_b0130","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.yebeh.2013.05.038","article-title":"Alternative monotherapy or add-on therapy in patients with epilepsy whose seizures do not respond to the first monotherapy: An Italian multicenter prospective observational study","volume":"28","author":"Millul","year":"2013","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108671_b0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.seizure.2018.11.018","article-title":"Substitution has better efficacy than add-on therapy for patients with focal epilepsy after their first antiepileptic drug treatments fail","volume":"64","author":"Wang","year":"2019","journal-title":"Seizure"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108671_b0140","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/epi.12074","article-title":"ILAE Subcommission on AED Guidelines. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes","volume":"54","author":"Glauser","year":"2013","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.yebeh.2022.108671_b0145","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.yebeh.2012.09.039","article-title":"Long-term safety and efficacy of clobazam for Lennox-Gastaut syndrome: interim results of an open-label extension study","volume":"25","author":"Ng","year":"2012","journal-title":"Epilepsy Behav"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022001202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022001202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:45:37Z","timestamp":1761504337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505022001202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":29,"alternative-id":["S1525505022001202"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108671","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of one-year effectiveness of clobazam as an add-on therapy to anticonvulsant monotherapy in participants with epilepsy having uncontrolled seizure episodes: An Indian experience","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108671"}}