{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:55:35Z","timestamp":1787766935093,"version":"build-2784847793"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.yebeh.2022.108877","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T11:57:52Z","timestamp":1660737472000},"page":"108877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Irritability and its relationship with psychosocial symptoms and quality of life in adolescents with epilepsy receiving levetiracetam therapy: A case-control study"],"prefix":"10.1016","volume":"135","author":[{"given":"U\u011fur","family":"Tekin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halit Necmi","family":"U\u00e7ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2022.108877_b0005","article-title":"Behavioral issues in pediatric epilepsy","author":"Dunn","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.108877_b0010","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1469-8749.2003.tb00398.x","article-title":"A population survey of mental health problems in children with epilepsy","volume":"45","author":"Davies","year":"2003","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.yebeh.2022.108877_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1684\/epd.2009.0238","article-title":"Antiepileptic drugs and psychopathology of epilepsy: an update","volume":"11","author":"Mula","year":"2009","journal-title":"Epileptic Disorders"},{"issue":"11","key":"10.1016\/j.yebeh.2022.108877_b0020","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s40263-016-0384-x","article-title":"Synaptic vesicle glycoprotein 2A ligands in the treatment of epilepsy and beyond","volume":"30","author":"L\u00f6scher","year":"2016","journal-title":"CNS drugs"},{"issue":"11","key":"10.1016\/j.yebeh.2022.108877_b0025","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2165\/00003088-200443110-00002","article-title":"Clinical pharmacokinetics of levetiracetam","volume":"43","author":"Patsalos","year":"2004","journal-title":"Clin Pharmacokinet"},{"issue":"9","key":"10.1016\/j.yebeh.2022.108877_b0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.seizure.2014.06.004","article-title":"Behavioral side-effects of levetiracetam in children with epilepsy: a systematic review","volume":"23","author":"Halma","year":"2014","journal-title":"Seizure"},{"issue":"6","key":"10.1016\/j.yebeh.2022.108877_b0035","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1176\/appi.ajp.2016.16070839","article-title":"Irritability in youths: a translational model","volume":"174","author":"Brotman","year":"2017","journal-title":"Am J Psychiatry"},{"issue":"2","key":"10.1016\/j.yebeh.2022.108877_b0040","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00787-010-0150-4","article-title":"Irritability in children and adolescents: a challenge for DSM-5","volume":"20","author":"Stringaris","year":"2011","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"4","key":"10.1016\/j.yebeh.2022.108877_b0045","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tics.2017.02.002","article-title":"Pediatric irritability: a systems neuroscience approach","volume":"21","author":"Leibenluft","year":"2017","journal-title":"Trends Cogn Sci"},{"issue":"7","key":"10.1016\/j.yebeh.2022.108877_b0050","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jaac.2016.04.014","article-title":"The status of irritability in psychiatry: a conceptual and quantitative review","volume":"55","author":"Vidal-Ribas","year":"2016","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108877_b0055","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1124\/pr.115.012021","article-title":"Epilepsy, antiepileptic drugs, and aggression: an evidence-based review","volume":"68","author":"Brodie","year":"2016","journal-title":"Pharmacol Rev"},{"issue":"11","key":"10.1016\/j.yebeh.2022.108877_b0060","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1469-7610.2012.02561.x","article-title":"The Affective Reactivity Index: a concise irritability scale for clinical and research settings","volume":"53","author":"Stringaris","year":"2012","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.yebeh.2022.108877_b0065","series-title":"Irritability in children and adolescents: Validity and reliability of Turkish version of Affective Reactivity Index (specialization thesis)","author":"Kocael","year":"2016"},{"issue":"11","key":"10.1016\/j.yebeh.2022.108877_b0070","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/00004583-200111000-00015","article-title":"Psychometric properties of the strengths and difficulties questionnaire","volume":"40","author":"Goodman","year":"2001","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.yebeh.2022.108877_b0075","first-page":"65","article-title":"G\u00fc\u00e7ler ve g\u00fc\u00e7l\u00fckler anketi'nin (gga) T\u00fcrk\u00e7e uyarlamasinin psikometrik \u00f6zellikleri","volume":"15","author":"G\u00fcvenir","year":"2008","journal-title":"Turkish J Child Adolescent Mental Health"},{"issue":"2","key":"10.1016\/j.yebeh.2022.108877_b0080","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00005650-199902000-00003","article-title":"The PedsQL\u2122: measurement model for the pediatric quality of life inventory","volume":"37","author":"Varni","year":"1999","journal-title":"Med Care"},{"key":"10.1016\/j.yebeh.2022.108877_b0085","first-page":"353","article-title":"The validity and reliability of the Turkish Pediatric Quality of Life Inventory for children 13\u201318 years old","volume":"18","author":"Memik","year":"2007","journal-title":"Turk Psikiyatri Dergisi"},{"key":"10.1016\/j.yebeh.2022.108877_b0090","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.seizure.2015.07.004","article-title":"The adverse event profile of levetiracetam: a meta-analysis on children and adults","volume":"31","author":"Verrotti","year":"2015","journal-title":"Seizure"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108877_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149686","article-title":"Safety of levetiracetam in paediatrics: a systematic review","volume":"11","author":"Egunsola","year":"2016","journal-title":"PLoS ONE"},{"issue":"10","key":"10.1016\/j.yebeh.2022.108877_b0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1177\/0883073819846804","article-title":"Effectiveness of levetiracetam monotherapy in pediatric patients with epilepsy","volume":"34","author":"Mazur","year":"2019","journal-title":"J Child Neurol"},{"key":"10.1016\/j.yebeh.2022.108877_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.107939","article-title":"Behavioral adverse events with brivaracetam, levetiracetam, perampanel, and topiramate: a systematic review","volume":"118","author":"Steinhoff","year":"2021","journal-title":"Epilepsy Behav"},{"issue":"8","key":"10.1016\/j.yebeh.2022.108877_b0110","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jaac.2015.05.008","article-title":"Normative irritability in youth: developmental findings from the Great Smoky Mountains Study","volume":"54","author":"Copeland","year":"2015","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"s184","key":"10.1016\/j.yebeh.2022.108877_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0404.2006.00666.x","article-title":"Role of valproate across the ages. Treatment of epilepsy in children","volume":"114","author":"Aldenkamp","year":"2006","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2022.108877_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.107989","article-title":"Pediatric adverse reactions to antiseizure medications\u2013an analysis of data from the Italian spontaneous reporting system (2001\u20132019)","volume":"119","author":"Franco","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108877_b0125","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yebeh.2017.08.039","article-title":"Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy","volume":"76","author":"Chen","year":"2017","journal-title":"Epilepsy Behav"},{"issue":"5","key":"10.1016\/j.yebeh.2022.108877_b0130","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00787-018-1234-9","article-title":"Suicidal behaviors and irritability in children and adolescents: a systematic review of the nature and mechanisms of the association","volume":"28","author":"Benarous","year":"2019","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"9","key":"10.1016\/j.yebeh.2022.108877_b0135","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1176\/appi.ajp.2009.08121849","article-title":"Adult outcomes of youth irritability: a 20-year prospective community-based study","volume":"166","author":"Stringaris","year":"2009","journal-title":"Am J Psychiatry"},{"issue":"1_suppl","key":"10.1016\/j.yebeh.2022.108877_b0140","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1177\/08830738020170010201","article-title":"Update on the epidemiology and prognosis of pediatric epilepsy","volume":"17","author":"Shinnar","year":"2002","journal-title":"J Child Neurol"},{"key":"10.1016\/j.yebeh.2022.108877_b0145","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1528-1167.2005.463010.x","article-title":"Antiepileptic drugs and the regulation of mood and quality of life (QOL): the evidence from epilepsy","volume":"46","author":"Selai","year":"2005","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.yebeh.2022.108877_b0150","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.yebeh.2008.03.009","article-title":"Association of non-adherence to antiepileptic drugs and seizures, quality of life, and productivity: survey of patients with epilepsy and physicians","volume":"13","author":"Hovinga","year":"2008","journal-title":"Epilepsy Behav"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022003262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022003262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:49:36Z","timestamp":1761504576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505022003262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":30,"alternative-id":["S1525505022003262"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108877","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Irritability and its relationship with psychosocial symptoms and quality of life in adolescents with epilepsy receiving levetiracetam therapy: A case-control study","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108877"}}