{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:01:44Z","timestamp":1781780504683,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/21103-3"],"award-info":[{"award-number":["2017\/21103-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.yebeh.2022.108962","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T16:19:00Z","timestamp":1667837940000},"page":"108962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"PA","title":["Alteration of hippocampal Egr3, GABA A receptors, Il-1\u03b2, Il6 and Ccl3 expression in audiogenic tremor mice after seizure"],"prefix":"10.1016","volume":"137","author":[{"given":"Mariana","family":"de Souza Aranha Garcia-Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Kenzo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Maria Gomes","family":"Massironi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orfa Yineth","family":"Galvis-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mejia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis Albert","family":"Zanatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Regina","family":"Alexandre-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Madalena Cabrera","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2022.108962_b0005","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","article-title":"Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy","volume":"15","author":"Vezzani","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.yebeh.2022.108962_b0010","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1007\/s12035-022-02725-6","article-title":"Neuroinflammation and proinflammatory cytokines in epileptogenesis","volume":"59","author":"Soltani Khaboushan","year":"2022","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.yebeh.2022.108962_b0015","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neulet.2015.04.046","article-title":"Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and brain-derived neurotrophic factor following audiogenic seizures","volume":"597","author":"de Souza Bernardino","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2022.108962_b0020","first-page":"267","article-title":"Role of cytokines during epileptogenesis and in the transition from the interictal to the ictal state in the epileptic mutant EL mouse","volume":"2","author":"Murashima","year":"2008","journal-title":"Gene Regul Syst Bio"},{"key":"10.1016\/j.yebeh.2022.108962_b0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejphar.2014.03.008","article-title":"The role of interleukin-1\u03b2 in the pentylenetetrazole-induced kindling of seizures, in the rat hippocampus","volume":"731","author":"Ko\u0142osowska","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2022.108962_b0030","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneuroim.2010.05.016","article-title":"The emerging role for chemokines in epilepsy","volume":"224","author":"Fabene","year":"2010","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.yebeh.2022.108962_b0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.eplepsyres.2017.07.016","article-title":"Chemokines as new inflammatory players in the pathogenesis of epilepsy","volume":"136","author":"Cerri","year":"2017","journal-title":"Epilepsy Res"},{"issue":"1-2","key":"10.1016\/j.yebeh.2022.108962_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2119\/2006-00079.Lee","article-title":"Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes","volume":"13","author":"Lee","year":"2007","journal-title":"Mol Med"},{"key":"10.1016\/j.yebeh.2022.108962_b0045","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.nbd.2015.07.003","article-title":"GABAA currents are decreased by IL-1\u03b2 in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis","volume":"82","author":"Roseti","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.yebeh.2022.108962_b0050","doi-asserted-by":"crossref","unstructured":"Brooks-Kayal AR, Russek SJ. Regulation of GABAA Receptor Gene Expression and Epilepsy. Jasper\u2019s Basic Mech. Epilepsies. 4th ed., National Center for Biotechnology Information (US); 2012.","DOI":"10.1093\/med\/9780199746545.003.0044"},{"key":"10.1016\/j.yebeh.2022.108962_b0055","doi-asserted-by":"crossref","first-page":"106945","DOI":"10.1016\/j.yebeh.2020.106945","article-title":"Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures","volume":"105","author":"Garcia-Gomes","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108962_b0060","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s11011-021-00823-3","article-title":"PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability","volume":"36","author":"Singh","year":"2021","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.yebeh.2022.108962_b0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.eplepsyres.2015.06.003","article-title":"Validation of the 6 Hz refractory seizure mouse model for intracerebroventricularly administered compounds","volume":"115","author":"Walrave","year":"2015","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2022.108962_b0070","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jneumeth.2015.03.025","article-title":"Which insights have we gained from the kindling and post-status epilepticus models?","volume":"260","author":"Gorter","year":"2016","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.yebeh.2022.108962_b0075","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0014-4886(87)90290-1","article-title":"Kindling of audiogenic seizures in Wistar rats: an EEG study","volume":"97","author":"Marescaux","year":"1987","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2022.108962_b0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0920-1211(96)00050-2","article-title":"Neuroethological and morphological (Neo-Timm staining) correlates of limbic recruitment during the development of audiogenic kindling in seizure susceptible Wistar rats","volume":"26","author":"Garcia-Cairasco","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2022.108962_b0085","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuroscience.2004.01.042","article-title":"Limbic epileptogenicity, cell loss and axonal reorganization induced by audiogenic and amygdala kindling in wistar audiogenic rats (WAR strain)","volume":"125","author":"Galvis-Alonso","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2022.108962_b0090","doi-asserted-by":"crossref","unstructured":"Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, D.C.: National Academies Press; 2011. doi: 10.17226\/12910.","DOI":"10.17226\/12910"},{"issue":"3","key":"10.1016\/j.yebeh.2022.108962_b0095","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001556","article-title":"Equine herpesvirus 1 elicits a strong pro-inflammatory response in the brain of mice","volume":"102","author":"Mesquita","year":"2021","journal-title":"J Gen Virol"},{"key":"10.1016\/j.yebeh.2022.108962_b0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.yebeh.2022.108962_b0105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ygeno.2009.04.008","article-title":"A powerful and flexible linear mixed model framework for the analysis of relative quantification RT-PCR data","volume":"94","author":"Steibel","year":"2009","journal-title":"Genomics"},{"key":"10.1016\/j.yebeh.2022.108962_b0110","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.expneurol.2004.03.023","article-title":"Modulation of IL-1 beta gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury","volume":"188","author":"Marini","year":"2004","journal-title":"Exp Neurol"},{"issue":"2-3","key":"10.1016\/j.yebeh.2022.108962_b0115","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tox.2007.05.032","article-title":"Prolonged inflammatory gene response following soman-induced seizures in mice","volume":"238","author":"Dhote","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.yebeh.2022.108962_b0120","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1742-2094-7-40","article-title":"The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations","volume":"7","author":"Johnson","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.yebeh.2022.108962_b0125","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.eplepsyres.2006.05.017","article-title":"Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems","volume":"71","author":"Zhu","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2022.108962_b0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0022-3565(24)35318-2","article-title":"Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons","volume":"292","author":"Wang","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2022.108962_b0135","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.yebeh.2015.12.020","article-title":"Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures","volume":"71","author":"L\u00f3pez-L\u00f3pez","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.108962_b0140","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1365-2990.2009.01022.x","article-title":"CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE)","volume":"35","author":"Xu","year":"2009","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.yebeh.2022.108962_b0145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.55782\/ane-2011-1840","article-title":"Status epilepticus evokes prolonged increase in the expression of CCL3 and CCL4 mRNA and protein in the rat brain","volume":"71","author":"Guzik-Kornacka","year":"2011","journal-title":"Acta Neurobiol Exp (Wars)"},{"issue":"1","key":"10.1016\/j.yebeh.2022.108962_b0150","first-page":"17","article-title":"Modulation of Neural Networks by Interleukin-1","volume":"7","author":"Nemeth","year":"2021","journal-title":"Brain Plast (Amsterdam, Netherlands)"},{"key":"10.1016\/j.yebeh.2022.108962_b0155","doi-asserted-by":"crossref","first-page":"134830","DOI":"10.1016\/j.neulet.2020.134830","article-title":"Inflammatory markers in the hippocampus after audiogenic kindling","volume":"721","author":"de Deus","year":"2020","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.yebeh.2022.108962_b0160","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.pbb.2004.01.012","article-title":"Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice","volume":"77","author":"De Sarro","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.yebeh.2022.108962_b0165","doi-asserted-by":"crossref","first-page":"11894","DOI":"10.1073\/pnas.0501434102","article-title":"Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression","volume":"102","author":"Roberts","year":"2005","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022004115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022004115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:47:19Z","timestamp":1761504439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505022004115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":33,"alternative-id":["S1525505022004115"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108962","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alteration of hippocampal Egr3, GABA A receptors, Il-1\u03b2, Il6 and Ccl3 expression in audiogenic tremor mice after seizure","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.108962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108962"}}