{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:06:48Z","timestamp":1792591608301,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.yebeh.2022.109029","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T05:10:14Z","timestamp":1670649014000},"page":"109029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Determinants of medication adherence in people with epilepsy: A multicenter, cross-sectional survey"],"prefix":"10.1016","volume":"138","author":[{"given":"F.","family":"Narducci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lanzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Marrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Piccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boscarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sancetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Di Lazzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tombini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Assenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2022.109029_b0005","first-page":"45","article-title":"Partial medication compliance: the enigma in poor medical outcomes","volume":"1","author":"Cramer","year":"1995","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.yebeh.2022.109029_b0010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF02850081","article-title":"Medication adherence and persistence: A comprehensive review","volume":"22","author":"Krueger","year":"2005","journal-title":"Adv Therapy"},{"key":"10.1016\/j.yebeh.2022.109029_b0015","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.seizure.2005.07.010","article-title":"Frequency of provocative factors in epileptic patients admitted for seizures: a prospective study in Singapore","volume":"14","author":"Tan","year":"2005","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2022.109029_b0020","unstructured":"Sabat\u00e9 E, World Health Organization, editors. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003."},{"key":"10.1016\/j.yebeh.2022.109029_b0025","first-page":"369","article-title":"Compliance, adherence and the therapeutic alliance: steps in the development of self-care","volume":"12","author":"Barofsky","year":"1978","journal-title":"Soc Sci Med"},{"key":"10.1016\/j.yebeh.2022.109029_b0030","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1528-1157.1997.tb01128.x","article-title":"Quality of life of people with epilepsy: a European study","volume":"38","author":"Baker","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109029_b0035","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1111\/epi.12801","article-title":"Nonadherence to treatment causing acute hospitalizations in people with epilepsy: An observational, prospective study","volume":"55","author":"Samsonsen","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109029_b0040","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S1525-5050(02)00037-9","article-title":"The relationship between poor medication compliance and seizures","volume":"3","author":"Cramer","year":"2002","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109029_b0045","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1007\/s10072-020-04990-6","article-title":"Epilepsy and quality of life: what does really matter?","volume":"42","author":"Tombini","year":"2021","journal-title":"Neurol Sci"},{"key":"10.1016\/j.yebeh.2022.109029_b0050","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1751-7176.2008.07572.x","article-title":"Predictive Validity of a Medication Adherence Measure in an Outpatient Setting","volume":"10","author":"Morisky","year":"2008","journal-title":"J Clin Hypertension"},{"issue":"4","key":"10.1016\/j.yebeh.2022.109029_b0060","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.seizure.2014.01.003","article-title":"Validation of Chinese version of the Morisky Medication Adherence Scale in patients with epilepsy","volume":"23","author":"Yang","year":"2014","journal-title":"Seizure"},{"issue":"11","key":"10.1016\/j.yebeh.2022.109029_b0065","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s10072-013-1438-1","article-title":"Adherence to anti-Parkinson drug therapy in the \u201cREASON\u201d sample of Italian patients with Parkinson\u2019s disease: the linguistic validation of the Italian version of the \u201cMorisky Medical Adherence Scale-8 items\u201d","volume":"34","author":"Fabbrini","year":"2013","journal-title":"Neurol Sci"},{"key":"10.1016\/j.yebeh.2022.109029_b0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00005650-198601000-00007","article-title":"Concurrent and predictive validity of a self-reported measure of medication adherence","volume":"24","author":"Morisky","year":"1986","journal-title":"Med Care"},{"key":"10.1016\/j.yebeh.2022.109029_b0075","unstructured":"Vickrey BG, Perrine K, Hays RD, Hermann B, Cramer J, Meador K, et al. Quality of life in epilepsy QOLIE-31 scoring manual (version 1.0); 1993."},{"key":"10.1016\/j.yebeh.2022.109029_b0080","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.yebeh.2022.109029_b0085","series-title":"Manual for the Beck Depression Inventory, (BDI-II) San Antonio","author":"Beck","year":"1996"},{"key":"10.1016\/j.yebeh.2022.109029_b0090","doi-asserted-by":"crossref","unstructured":"K\u00fchner C, B\u00fcrger C, Keller F, Hautzinger M. [Reliability and validity of the Revised Beck Depression Inventory (BDI-II). Results from German samples]. Nervenarzt 2007;78:651\u20136. https:\/\/doi.org\/10.1007\/s00115-006-2098-7.","DOI":"10.1007\/s00115-006-2098-7"},{"key":"10.1016\/j.yebeh.2022.109029_b0095","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1590\/1516-4446-2012-1048","article-title":"Psychometric properties of the Beck Depression Inventory-II: a comprehensive review","volume":"35","author":"Wang","year":"2013","journal-title":"Rev Bras Psiquiatr"},{"key":"10.1016\/j.yebeh.2022.109029_b0100","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s10862-016-9571-9","article-title":"Psychometric Properties of the Generalized Anxiety Disorder Scale-7 (GAD-7) in Outpatients with Anxiety and Mood Disorders","volume":"39","author":"Rutter","year":"2017","journal-title":"J Psychopathol Behav Assess"},{"key":"10.1016\/j.yebeh.2022.109029_b0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s10194-015-0583-8","article-title":"Validation of the Generalized Anxiety Disorder-7 (GAD-7) and GAD-2 in patients with migraine","volume":"16","author":"Seo","year":"2015","journal-title":"J Headache Pain"},{"key":"10.1016\/j.yebeh.2022.109029_b0110","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.yebeh.2022.109029_b0115","first-page":"165","article-title":"Development and psychometric evaluation of the Resilience Scale","volume":"1","author":"Wagnild","year":"1993","journal-title":"J Nurs Meas"},{"key":"10.1016\/j.yebeh.2022.109029_b0120","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2147\/PRBM.S115657","article-title":"Reliability and validity of the Italian version of the 14-item Resilience Scale","volume":"9","author":"Callegari","year":"2016","journal-title":"Psychol Res Behav Manag"},{"key":"10.1016\/j.yebeh.2022.109029_b0125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-7525-9-8","article-title":"A methodological review of resilience measurement scales","volume":"9","author":"Windle","year":"2011","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.yebeh.2022.109029_b0130","unstructured":"Wagnild G. (2009) The Resilience Scale User\u2019s Guide for the US English Version of the Resilience Scale and the 14-Item Resilience Scale (RS-14). The Resilience Center, USA. - References - Scientific Research Publishing n.d. https:\/\/www.scirp.org\/(S(i43dyn45teexjx455qlt3d2q))\/reference\/ReferencesPapers.aspx?ReferenceID=1604067 [accessed February 27, 2022]."},{"key":"10.1016\/j.yebeh.2022.109029_b0135","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1528-1167.2011.03355.x","article-title":"Revising the \u201cRule of Three\u201d for inferring seizure freedom","volume":"53","author":"Westover","year":"2012","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.yebeh.2022.109029_b0140","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109029_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v028.i05","article-title":"Building Predictive Models in R Using the caret Package","volume":"28","author":"Kuhn","year":"2008","journal-title":"J Stat Softw"},{"key":"10.1016\/j.yebeh.2022.109029_b0150","first-page":"1413","article-title":"Unbiased variable importance for random forests","volume":"51","author":"Loecher","year":"2022","journal-title":"Null"},{"key":"10.1016\/j.yebeh.2022.109029_b0160","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.seizure.2013.02.006","article-title":"Factors associated with treatment nonadherence in patients with epilepsy in Brazil","volume":"22","author":"Ferrari","year":"2013","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2022.109029_b0165","first-page":"46","article-title":"Compliance with treatment of adult epileptics in a rural district of Thailand","volume":"86","author":"Asawavichienjinda","year":"2003","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.yebeh.2022.109029_b0170","first-page":"110","article-title":"Predictors of medication noncompliance in a sample of older adults","volume":"16","author":"Coons","year":"1994","journal-title":"Clin Ther"},{"key":"10.1016\/j.yebeh.2022.109029_b0175","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1111\/j.1572-0241.2001.04683.x","article-title":"Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis","volume":"96","author":"Kane","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.yebeh.2022.109029_b0180","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1059-1311(97)80060-X","article-title":"Factors influencing compliance with antiepileptic drug regimes","volume":"6","author":"Buck","year":"1997","journal-title":"Seizure"},{"issue":"3","key":"10.1016\/j.yebeh.2022.109029_b0185","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.yebeh.2011.04.011","article-title":"Self-reported medication adherence and treatment satisfaction in patients with epilepsy","volume":"21","author":"Sweileh","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109029_b0190","first-page":"13","article-title":"Epileptic patient compliance with prescribed medical treatment","volume":"59","author":"Lusi\u0107","year":"2005","journal-title":"Acta Med Croatica"},{"key":"10.1016\/j.yebeh.2022.109029_b0195","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.seizure.2005.05.003","article-title":"Drug compliance of children and adolescents with epilepsy","volume":"14","author":"Asadi-Pooya","year":"2005","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2022.109029_b0200","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0920-1211(99)00112-6","article-title":"A questionnaire survey about doctor-patient communication, compliance and locus of control among south Indian people with epilepsy","volume":"39","author":"Gopinath","year":"2000","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2022.109029_b0205","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yebeh.2019.06.026","article-title":"Epilepsy-associated stigma from the perspective of people with epilepsy and the community in Italy","volume":"98","author":"Tombini","year":"2019","journal-title":"Epilepsy Behav"},{"issue":"2","key":"10.1016\/j.yebeh.2022.109029_b0210","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.yebeh.2008.03.009","article-title":"Association of nonadherence to antiepileptic drugs and seizures, quality of life, and productivity: Survey of patients with epilepsy and physicians","volume":"13","author":"Hovinga","year":"2008","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109029_b0215","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.seizure.2006.06.003","article-title":"Adherence to treatment in patients with epilepsy: Associations with seizure control and illness beliefs","volume":"15","author":"Jones","year":"2006","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2022.109029_b0220","first-page":"135","article-title":"Determinants of compliance in epileptic patients","volume":"1","author":"Loiseau","year":"1988","journal-title":"Epilepsy Res Suppl"},{"key":"10.1016\/j.yebeh.2022.109029_b0225","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1525-5050(03)00151-3","article-title":"Postictal serum levels of antiepileptic drugs for detection of noncompliance","volume":"4","author":"Specht","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109029_b0230","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1528-1157.1982.tb05075.x","article-title":"Determinants of patient compliance with anticonvulsant therapy","volume":"23","author":"Peterson","year":"1982","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109029_b0235","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.yebeh.2012.02.002","article-title":"Effects of antiepileptic drug characteristics on medication adherence","volume":"23","author":"Bautista","year":"2012","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109029_b0240","first-page":"572","article-title":"Determinants of compliance in epileptic outpatients","volume":"15","author":"Bryant","year":"1981","journal-title":"Drug Intell Clin Pharm"},{"key":"10.1016\/j.yebeh.2022.109029_b0245","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yebeh.2014.05.011","article-title":"The relationship of depression to antiepileptic drug adherence and quality of life in epilepsy","volume":"36","author":"Ettinger","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109029_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107537","article-title":"Alexithymia and emotion dysregulation in adult patients with epilepsy","volume":"113","author":"Tombini","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109029_b0270","doi-asserted-by":"crossref","first-page":"106398","DOI":"10.1016\/j.yebeh.2019.06.041","article-title":"Resilience, quality of life, and clinical aspects of patients with epilepsy","volume":"103","author":"Tedrus","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109029_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106662","article-title":"Prevalence of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy from western China: A cross-sectional survey","volume":"104","author":"Yang","year":"2020","journal-title":"Epilepsy Behav"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022004784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022004784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:49:54Z","timestamp":1761504594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505022004784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":50,"alternative-id":["S1525505022004784"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.109029","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determinants of medication adherence in people with epilepsy: A multicenter, cross-sectional survey","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.109029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109029"}}