{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:26:11Z","timestamp":1792877171869,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901330"],"award-info":[{"award-number":["81901330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071458"],"award-info":[{"award-number":["82071458"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2020jcyj-bshX0055"],"award-info":[{"award-number":["cstc2020jcyj-bshX0055"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.yebeh.2022.109064","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T05:37:06Z","timestamp":1673501826000},"page":"109064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Clinical characteristics and risk factors of cerebral cavernous malformation-related epilepsy"],"prefix":"10.1016","volume":"139","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxue","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxian","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangmei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.yebeh.2022.109064_b0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrneurol.2009.177","article-title":"Cavernous malformations: natural history, diagnosis and treatment","volume":"5","author":"Batra","year":"2009","journal-title":"Nat Rev Neurol"},{"issue":"9","key":"10.1016\/j.yebeh.2022.109064_b0010","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.mayocp.2019.11.005","article-title":"Cerebral Cavernous Malformation: What a Practicing Clinician Should Know","volume":"95","author":"Flemming","year":"2020","journal-title":"Mayo Clin Proc"},{"issue":"12","key":"10.1016\/j.yebeh.2022.109064_b0015","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1111\/epi.12402","article-title":"Cavernoma-related epilepsy: review and recommendations for management\u2013report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies","volume":"54","author":"Rosenow","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0020","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1528-1167.2012.03405.x","article-title":"Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions","volume":"53","author":"Raabe","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/svn-2018-000195","article-title":"CCM3 and cerebral cavernous malformation disease","volume":"4","author":"Wang","year":"2019","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.yebeh.2022.109064_b0030","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3390\/ijms21020675","article-title":"Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation","volume":"21","author":"Wei","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.yebeh.2022.109064_b0035","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1046\/j.1528-1157.2003.23603.x","article-title":"Physiology of human cortical neurons adjacent to cavernous malformations and tumors","volume":"44","author":"Williamson","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0040","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1212\/WNL.0b013e3182190f37","article-title":"Seizure risk from cavernous or arteriovenous malformations: prospective population-based study","volume":"76","author":"Josephson","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2022.109064_b0045","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1111\/epi.12327","article-title":"Surgical management and long-term seizure outcome after epilepsy surgery for different types of epilepsy associated with cerebral cavernous malformations","volume":"54","author":"von der Brelie","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106649","article-title":"Comparison of psychiatric comorbidities and impact on quality of life in patients with epilepsy or psychogenic nonepileptic spells","volume":"102","author":"Abe","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109064_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107443","article-title":"Screening for suicidality and its relation to undiagnosed psychiatric comorbidities in children and youth with epilepsy","volume":"113","author":"Dagar","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109064_b0060","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/ene.14546","article-title":"Health-related quality of life in patients with untreated cavernous malformations of the central nervous system","volume":"28","author":"Herten","year":"2021","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.yebeh.2022.109064_b0065","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1111\/epi.16665","article-title":"Self-reported quality of life and degree of youth-parent agreement: A long-term follow-up of childhood-onset epilepsy","volume":"61","author":"Puka","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.108241","article-title":"Long-term mood, quality of life, and seizure freedom in intracranial EEG epilepsy surgery","volume":"123","author":"Swarup","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2022.109064_b0075","doi-asserted-by":"crossref","first-page":"e2595","DOI":"10.1002\/brb3.2595","article-title":"Quality of life and mood assessment in conservatively treated cavernous malformation-related epilepsy","volume":"12","author":"Rauschenbach","year":"2022","journal-title":"Brain Behav"},{"key":"10.1016\/j.yebeh.2022.109064_b0080","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","article-title":"Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)","volume":"46","author":"Fisher","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0085","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/epi.13671","article-title":"Instruction manual for the ILAE 2017 operational classification of seizure types","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0090","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0095","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0100","first-page":"3222","article-title":"Hemorrhage from cavernous malformations of the brain: definition and reporting standards","volume":"39","author":"Al-Shahi Salman","year":"2008","journal-title":"Angioma Alliance Sci Adv Board Stroke"},{"key":"10.1016\/j.yebeh.2022.109064_b0105","doi-asserted-by":"crossref","unstructured":"Hosmer Jr DW, Lemeshow S, Sturdivant RX. Applied logistic regression. 3rd ed. New York. New York: John Wiley & Sons Inc.; 2013.","DOI":"10.1002\/9781118548387"},{"key":"10.1016\/j.yebeh.2022.109064_b0110","unstructured":"Chatterjee S, Hadi AS. Regression analysis by example. 5th ed. New York. New York: John Wiley & Sons, Inc.; 2012."},{"key":"10.1016\/j.yebeh.2022.109064_b0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/B978-0-444-63640-9.00021-7","article-title":"Natural history of cerebral cavernous malformations","volume":"143","author":"Ene","year":"2017","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.yebeh.2022.109064_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.wneu.2019.05.157","article-title":"Symptomatic Cavernous Malformation Presenting with Seizure without Hemorrhage: Analysis of Factors Influencing Clinical Presentation","volume":"129","author":"Agosti","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.yebeh.2022.109064_b0125","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1227\/00006123-199305000-00005","article-title":"Factors predisposing to clinical disability in patients with cavernous malformations of the brain","volume":"32","author":"Robinson","year":"1993","journal-title":"Neurosurgery"},{"key":"10.1016\/j.yebeh.2022.109064_b0130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1227\/00006123-198602000-00008","article-title":"Cavernous angioma: a review of 126 collected and 12 new clinical cases","volume":"18","author":"Simard","year":"1986","journal-title":"Neurosurgery"},{"key":"10.1016\/j.yebeh.2022.109064_b0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00006123-199607000-00007","article-title":"Supratentorial cavernous angiomas and epileptic seizures: preoperative course and postoperative outcome","author":"Casazza","year":"1996","journal-title":"Neurosurgery"},{"key":"10.1016\/j.yebeh.2022.109064_b0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1227\/01.NEU.0000346648.03272.07","article-title":"Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations","volume":"65","author":"Chang","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.yebeh.2022.109064_b0145","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1227\/NEU.0b013e3181eb5032","article-title":"Epileptogenicity of cavernomas depends on (archi-) cortical localization","volume":"67","author":"Menzler","year":"2010","journal-title":"Neurosurgery"},{"key":"10.1016\/j.yebeh.2022.109064_b0150","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1136\/jnnp.66.5.561","article-title":"Supratentorial cavernous haemangiomas and epilepsy: a review of the literature and case series","volume":"66","author":"Moran","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.yebeh.2022.109064_b0155","first-page":"1166","article-title":"The natural history of cavernous malformations: a prospective study of 68 patients","volume":"44","author":"Moriarity","year":"1999","journal-title":"Neurosurgery"},{"key":"10.1016\/j.yebeh.2022.109064_b0160","volume":"2012","author":"T\u00e9llez-Zenteno","year":"2012","journal-title":"A review of the epidemiology of temporal lobe epilepsy. Epilepsy Res Treat"},{"key":"10.1016\/j.yebeh.2022.109064_b0165","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.neurol.2021.02.390","article-title":"An inventory of basic research in temporal lobe epilepsy","volume":"177","author":"Marissal","year":"2021","journal-title":"Rev Neurol"},{"key":"10.1016\/j.yebeh.2022.109064_b0170","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1111\/epi.17309","article-title":"Clinical characteristics and long-term outcome of cerebral cavernous malformations-related epilepsy","volume":"63","author":"Shih","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0175","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3171\/2011.7.JNS11536","article-title":"Predictors of seizure freedom in the surgical treatment of supratentorial cavernous malformations","volume":"115","author":"Englot","year":"2011","journal-title":"J Neurosurg"},{"key":"10.1016\/j.yebeh.2022.109064_b0180","doi-asserted-by":"crossref","first-page":"e659","DOI":"10.1016\/j.wneu.2017.11.067","article-title":"Surgical Management and Long-Term Seizure Outcome After Surgery for Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformations","volume":"110","author":"Yang","year":"2018","journal-title":"World Neurosurg"},{"key":"10.1016\/j.yebeh.2022.109064_b0185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0090-3019(96)00425-9","article-title":"An analysis of the natural history of cavernous malformations","volume":"48","author":"Kim","year":"1997","journal-title":"Surg Neurol"},{"key":"10.1016\/j.yebeh.2022.109064_b0190","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.12669\/pjms.295.3681","article-title":"Factors associated with epileptic seizure of cavernous malformations in the central nervous system in West China","volume":"29","author":"Huang","year":"2013","journal-title":"Pak J Med Sci"},{"key":"10.1016\/j.yebeh.2022.109064_b0195","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/STROKEAHA.117.017074","article-title":"Cranial Cavernous Malformations: Natural History and Treatment","volume":"49","author":"Stapleton","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.yebeh.2022.109064_b0200","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.96527","article-title":"Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex","volume":"200","author":"Willmore","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2022.109064_b0205","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00004691-199703000-00002","article-title":"Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: proposed role of synaptic reorganization","volume":"14","author":"Dudek","year":"1997","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2022.109064_b0210","doi-asserted-by":"crossref","first-page":"11550","DOI":"10.1523\/JNEUROSCI.3016-08.2008","article-title":"Chelation of mitochondrial iron prevents seizure-induced mitochondrial dysfunction and neuronal injury","volume":"28","author":"Liang","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2022.109064_b0215","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1528-1167.2006.00468.x","article-title":"Seizure outcome after resection of cavernous malformations is better when surrounding hemosiderin-stained brain also is removed","volume":"47","author":"Baumann","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2022.109064_b0220","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.clineuro.2014.01.013","article-title":"Seizure outcome after surgical resection of supratentorial cavernous malformations plus hemosiderin rim in patients with short duration of epilepsy","volume":"119","author":"Jin","year":"2014","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.yebeh.2022.109064_b0225","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-0038-1645871","article-title":"Surgical Treatment and Long-Term Outcome of Cerebral Cavernous Malformations-Related Epilepsy in Pediatric Patients","volume":"49","author":"Lin","year":"2018","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.yebeh.2022.109064_b0230","doi-asserted-by":"crossref","first-page":"e0136619","DOI":"10.1371\/journal.pone.0136619","article-title":"The Role of Hemosiderin Excision in Seizure Outcome in Cerebral Cavernous Malformation Surgery: A Systematic Review and Meta-Analysis","volume":"10","author":"Ruan","year":"2015","journal-title":"PLoS One"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022005133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505022005133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:49:17Z","timestamp":1761504557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505022005133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":46,"alternative-id":["S1525505022005133"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.109064","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics and risk factors of cerebral cavernous malformation-related epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2022.109064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109064"}}