{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:27:08Z","timestamp":1786998428646,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.yebeh.2023.109141","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T12:34:35Z","timestamp":1677846875000},"page":"109141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Detect, predict, and prevent acute seizures and status epilepticus"],"prefix":"10.1016","volume":"141","author":[{"given":"Tobias","family":"Loddenkemper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9531","key":"10.1016\/j.yebeh.2023.109141_b0005","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0140-6736(06)69043-0","article-title":"Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study","volume":"368","author":"Chin","year":"2006","journal-title":"Lancet Lond Engl"},{"issue":"3","key":"10.1016\/j.yebeh.2023.109141_b0010","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1212\/WNL.50.3.735","article-title":"Incidence of status epilepticus in Rochester, Minnesota, 1965\u20131984","volume":"50","author":"Hesdorffer","year":"1998","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.yebeh.2023.109141_b0015","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1212\/WNL.0b013e3181d0cca2","article-title":"Prospective study of new-onset seizures presenting as status epilepticus in childhood","volume":"74","author":"Singh","year":"2010","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.yebeh.2023.109141_b0020","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/jamaneurol.2017.4382","article-title":"Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus","volume":"75","author":"Ga\u00ednza-Lein","year":"2018","journal-title":"JAMA Neurol"},{"issue":"Suppl 2","key":"10.1016\/j.yebeh.2023.109141_b0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/epi.14515","article-title":"Long-term outcomes of status epilepticus: A critical assessment","volume":"59","author":"Sculier","year":"2018","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.yebeh.2023.109141_b0030","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/jamaneurol.2017.4382","article-title":"Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus","volume":"75","author":"Ga\u00ednza-Lein","year":"2018","journal-title":"JAMA Neurol"},{"issue":"10","key":"10.1016\/j.yebeh.2023.109141_b0035","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1111\/epi.16646","article-title":"The burden of decisional uncertainty in the treatment of status epilepticus","volume":"61","author":"S\u00e1nchez Fern\u00e1ndez","year":"2020","journal-title":"Epilepsia"},{"issue":"5 Suppl 2","key":"10.1016\/j.yebeh.2023.109141_b0040","first-page":"13","article-title":"The biochemical basis and pathophysiology of status epilepticus","volume":"40","author":"Lothman","year":"1990","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.yebeh.2023.109141_b0045","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus\u2013Report of the ILAE Task Force on Classification of Status Epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.yebeh.2023.109141_b0050","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41582-022-00664-3","article-title":"Why won\u2019t it stop? The dynamics of benzodiazepine resistance in status epilepticus","volume":"18","author":"Burman","year":"2022","journal-title":"Nat Rev Neurol"},{"issue":"Suppl Suppl 2","key":"10.1016\/j.yebeh.2023.109141_b0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/epi4.12270","article-title":"Role of NMDA receptors in the pathophysiology and treatment of status epilepticus","volume":"3","author":"Kapur","year":"2018","journal-title":"Epilepsia Open"},{"issue":"Suppl 6","key":"10.1016\/j.yebeh.2023.109141_b0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/epi.12266","article-title":"Receptor trafficking hypothesis revisited: plasticity of AMPA receptors during established status epilepticus","volume":"54","author":"Rajasekaran","year":"2013","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.yebeh.2023.109141_b0065","first-page":"S23","article-title":"Status epilepticus: risk factors and complications","volume":"41","author":"Fountain","year":"2000","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2023.109141_b0070","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11910-014-0444-x","article-title":"Stigma in epilepsy","volume":"14","author":"Fiest","year":"2014","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"Pt B","key":"10.1016\/j.yebeh.2023.109141_b0075","article-title":"Stigma reduction interventions for epilepsy: A systematized literature review","volume":"114","author":"Chakraborty","year":"2021","journal-title":"Epilepsy Behav EB"},{"issue":"1","key":"10.1016\/j.yebeh.2023.109141_b0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10549-020-05538-0","article-title":"Healthcare system distrust and the breast cancer continuum of care","volume":"180","author":"Mouslim","year":"2020","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"10.1016\/j.yebeh.2023.109141_b0085","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1440-1754.2009.01642.x","article-title":"Sleep habits and disturbances in Malaysian children with epilepsy","volume":"46","author":"Ong","year":"2010","journal-title":"J Paediatr Child Health"},{"issue":"3","key":"10.1016\/j.yebeh.2023.109141_b0090","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.seizure.2008.08.007","article-title":"Detecting nocturnal convulsions: efficacy of the MP5 monitor","volume":"18","author":"Carlson","year":"2009","journal-title":"Seizure"},{"issue":"4","key":"10.1016\/j.yebeh.2023.109141_b0095","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yebeh.2005.02.012","article-title":"\u201cSeizure-alert dogs\u201d: observations from an inpatient video\/EEG unit","volume":"6","author":"Ortiz","year":"2005","journal-title":"Epilepsy Behav EB"},{"key":"10.1016\/j.yebeh.2023.109141_b0100","doi-asserted-by":"crossref","first-page":"e2737","DOI":"10.1002\/brb3.2737","article-title":"Automated detection of nocturnal motor seizures using an audio-video system","author":"Armand Larsen","year":"2022","journal-title":"Brain Behav"},{"key":"10.1016\/j.yebeh.2023.109141_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.724904","article-title":"Prospective Study of a Multimodal Convulsive Seizure Detection Wearable System on Pediatric and Adult Patients in the Epilepsy Monitoring Unit","volume":"12","author":"Onorati","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.yebeh.2023.109141_b0110","first-page":"4415","article-title":"Continuous monitoring of electrodermal activity during epileptic seizures using a wearable sensor","volume":"2010","author":"Poh","year":"2010","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Int Conf"},{"issue":"9","key":"10.1016\/j.yebeh.2023.109141_b0115","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/epi.13083","article-title":"Electromyography-based seizure detector: Preliminary results comparing a generalized tonic-clonic seizure detection algorithm to video-EEG recordings","volume":"56","author":"Szab\u00f3","year":"2015","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.yebeh.2023.109141_b0120","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.clinph.2020.01.007","article-title":"Electrocardiographic changes associated with epilepsy beyond heart rate and their utilization in future seizure detection and forecasting methods","volume":"131","author":"Ufongene","year":"2020","journal-title":"Clin Neurophysiol Off J Int Fed Clin Neurophysiol"},{"issue":"13","key":"10.1016\/j.yebeh.2023.109141_b0125","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1212\/WNL.0b013e3182302056","article-title":"RNS System in Epilepsy Study Group. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy","volume":"77","author":"Morrell","year":"2011","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.yebeh.2023.109141_b0130","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1111\/epi.16630","article-title":"A new era in electroencephalographic monitoring? Subscalp devices for ultra-long-term recordings","volume":"61","author":"Duun-Henriksen","year":"2020","journal-title":"Epilepsia"},{"issue":"11","key":"10.1016\/j.yebeh.2023.109141_b0135","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/epi.13899","article-title":"Multicenter clinical assessment of improved wearable multimodal convulsive seizure detectors","volume":"58","author":"Onorati","year":"2017","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2023.109141_b0140","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1111\/j.1528-1167.2012.03444.x","article-title":"Convulsive seizure detection using a wrist-worn electrodermal activity and accelerometry biosensor","volume":"53","author":"Poh","year":"2012","journal-title":"Epilepsia"},{"issue":"Suppl 1","key":"10.1016\/j.yebeh.2023.109141_b0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/epi.14048","article-title":"Detection of convulsive seizures using surface electromyography","volume":"59","author":"Beniczky","year":"2018","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.yebeh.2023.109141_b0150","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/WCO.0000000000000658","article-title":"Non-electroencephalography-based seizure detection","volume":"32","author":"Beniczky","year":"2019","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.yebeh.2023.109141_b0155","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.yebeh.2014.06.023","article-title":"Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy","volume":"37","author":"Ramgopal","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"36","key":"10.1016\/j.yebeh.2023.109141_b0160","doi-asserted-by":"crossref","first-page":"e2107099","DOI":"10.1002\/smll.202107099","article-title":"Drawn-on-Skin Sensors from Fully Biocompatible Inks toward High-Quality Electrophysiology","volume":"18","author":"Patel","year":"2022","journal-title":"Small Weinh Bergstr Ger"},{"key":"10.1016\/j.yebeh.2023.109141_b0165","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3762\/bjnano.12.54","article-title":"Nanogenerator-based self-powered sensors for data collection","volume":"12","author":"Shao","year":"2021","journal-title":"Beilstein J Nanotechnol"},{"issue":"3","key":"10.1016\/j.yebeh.2023.109141_b0170","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/epi.12526","article-title":"Emergency management of febrile status epilepticus: results of the FEBSTAT study","volume":"55","author":"Seinfeld","year":"2014","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.yebeh.2023.109141_b0175","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.yebeh.2003.12.012","article-title":"Time to treatment in prolonged seizure episodes","volume":"5","author":"Pellock","year":"2004","journal-title":"Epilepsy Behav EB"},{"issue":"23","key":"10.1016\/j.yebeh.2023.109141_b0180","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1212\/WNL.0000000000001673","article-title":"Time from convulsive status epilepticus onset to anticonvulsant administration in children","volume":"84","author":"S\u00e1nchez Fern\u00e1ndez","year":"2015","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.yebeh.2023.109141_b0185","doi-asserted-by":"crossref","first-page":"e1222","DOI":"10.1212\/WNL.0000000000010174","article-title":"Association of guideline publication and delays to treatment in pediatric status epilepticus","volume":"95","author":"S\u00e1nchez Fern\u00e1ndez","year":"2020","journal-title":"Neurology"},{"issue":"19","key":"10.1016\/j.yebeh.2023.109141_b0190","doi-asserted-by":"crossref","first-page":"e1692","DOI":"10.1212\/WNL.0000000000005488","article-title":"Factors associated with treatment delays in pediatric refractory convulsive status epilepticus","volume":"90","author":"S\u00e1nchez Fern\u00e1ndez","year":"2018","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.yebeh.2023.109141_b0195","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S1474-4422(08)70141-8","article-title":"Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study","volume":"7","author":"Chin","year":"2008","journal-title":"Lancet Neurol"},{"issue":"8","key":"10.1016\/j.yebeh.2023.109141_b0200","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1212\/01.wnl.0000180959.31355.92","article-title":"Treatment delay and the risk of prolonged status epilepticus","volume":"65","author":"Eriksson","year":"2005","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.yebeh.2023.109141_b0205","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0887-8994(95)00044-G","article-title":"Effect of prehospital treatment on the outcome of status epilepticus in children","volume":"12","author":"Alldredge","year":"1995","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.yebeh.2023.109141_b0210","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pediatrneurol.2018.05.012","article-title":"Decreasing Seizure Treatment Time Through Quality Improvement Reduces Critical Care Utilization","volume":"85","author":"Ostendorf","year":"2018","journal-title":"Pediatr Neurol"},{"issue":"10","key":"10.1016\/j.yebeh.2023.109141_b0215","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1111\/epi.17026","article-title":"Improving time for administration of second-line antiseizure medications for children with generalized convulsive status epilepticus using quality improvement methodology","volume":"62","author":"Vidaurre","year":"2021","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.yebeh.2023.109141_b0220","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1097\/CCM.0000000000004428","article-title":"Evaluating the Clinical Impact of Rapid Response Electroencephalography: The DECIDE Multicenter Prospective Observational Clinical Study","volume":"48","author":"Vespa","year":"2020","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.yebeh.2023.109141_b0225","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/epi.13354","article-title":"Impact of an ICU EEG monitoring pathway on timeliness of therapeutic intervention and electrographic seizure termination","volume":"57","author":"Williams","year":"2016","journal-title":"Epilepsia"},{"issue":"19","key":"10.1016\/j.yebeh.2023.109141_b0230","doi-asserted-by":"crossref","first-page":"e2683","DOI":"10.1212\/WNL.0000000000010828","article-title":"First-line medication dosing in pediatric refractory status epilepticus","volume":"95","author":"Vasquez","year":"2020","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.yebeh.2023.109141_b0235","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/epi.16825","article-title":"Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial","volume":"62","author":"Sathe","year":"2021","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.yebeh.2023.109141_b0240","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/epi.13812","article-title":"Nonintravenous rescue medications for pediatric status epilepticus: A cost-effectiveness analysis","volume":"58","author":"S\u00e1nchez Fern\u00e1ndez","year":"2017","journal-title":"Epilepsia"},{"issue":"20","key":"10.1016\/j.yebeh.2023.109141_b0245","doi-asserted-by":"crossref","first-page":"e2339","DOI":"10.1212\/WNL.0000000000007503","article-title":"Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus","volume":"92","author":"S\u00e1nchez Fern\u00e1ndez","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109141_b0250","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.seizure.2018.09.013","article-title":"Status epilepticus prevention, ambulatory monitoring, early seizure detection and prediction in at-risk patients","volume":"68","author":"Amengual-Gual","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2023.109141_b0255","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.seizure.2016.06.008","article-title":"Automated seizure detection systems and their effectiveness for each type of seizure","volume":"40","author":"Ulate-Campos","year":"2016","journal-title":"Seizure"},{"issue":"2","key":"10.1016\/j.yebeh.2023.109141_b0260","first-page":"E65","article-title":"Characteristics of Future Models of Integrated Outpatient Care","volume":"7","author":"Leviton","year":"2019","journal-title":"Healthc Basel Switz"},{"issue":"2","key":"10.1016\/j.yebeh.2023.109141_b0265","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.yebeh.2013.04.014","article-title":"Visual aids to medical data and computational diagnostics: new frontiers in pediatric neurology","volume":"28","author":"Mane","year":"2013","journal-title":"Epilepsy Behav EB"},{"issue":"1","key":"10.1016\/j.yebeh.2023.109141_b0270","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5334\/ijic.5598","article-title":"Identifying Barriers to Care in the Pediatric Acute Seizure Care Pathway","volume":"22","author":"Jackson","year":"2022","journal-title":"Int J Integr Care"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023000598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023000598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:50:40Z","timestamp":1761504640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505023000598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":54,"alternative-id":["S1525505023000598"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109141","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detect, predict, and prevent acute seizures and status epilepticus","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109141"}}