{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:08:41Z","timestamp":1776467321904,"version":"3.51.2"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004079","name":"Konrad-Adenauer-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004079","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004350","name":"Studienstiftung des Deutschen Volkes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.yebeh.2023.109189","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T11:06:07Z","timestamp":1680951967000},"page":"109189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia"],"prefix":"10.1016","volume":"142","author":[{"given":"Bj\u00f6rn","family":"Welzel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Johne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"L\u00f6scher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2023.109189_b0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5409\/wjcp.v5.i1.67","article-title":"Short and long term prognosis in perinatal asphyxia: An update","volume":"5","author":"Ahearne","year":"2016","journal-title":"World J Clin Pediatr"},{"key":"10.1016\/j.yebeh.2023.109189_b0010","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/epi.16790","article-title":"A physiologically-validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia","volume":"62","author":"Ala-Kurikka","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0015","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1038\/nprot.2006.275","article-title":"Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice","volume":"1","author":"Alamed","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.yebeh.2023.109189_b0020","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrn2335","article-title":"The hippocampus and memory: insights from spatial processing","volume":"9","author":"Bird","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.yebeh.2023.109189_b0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2009.11.067","article-title":"Seizures are associated with brain injury severity in a neonatal model of hypoxia-ischemia","volume":"166","author":"Bj\u00f6rkman","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2023.109189_b0030","first-page":"81","article-title":"Une nouvelle methode simple pour explorer l'action 'tranquillisante': le test de la cheminee","volume":"3","author":"Boissier","year":"1960","journal-title":"Med Exp"},{"key":"10.1016\/j.yebeh.2023.109189_b0035","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1523\/JNEUROSCI.0633-10.2010","article-title":"Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy","volume":"30","author":"Brandt","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2023.109189_b0040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.neuropharm.2018.09.025","article-title":"Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy","volume":"143","author":"Brandt","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2023.109189_b0045","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3389\/fneur.2018.01023","article-title":"Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?","volume":"9","author":"Cavarsan","year":"2018","journal-title":"Front Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0050","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1460-9568.2012.08140.x","article-title":"Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette","volume":"35","author":"Chapman","year":"2012","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.yebeh.2023.109189_b0055","doi-asserted-by":"crossref","first-page":"e57148","DOI":"10.1371\/journal.pone.0057148","article-title":"Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures","volume":"8","author":"Cleary","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2023.109189_b0060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0149-7634(85)90030-2","article-title":"Exploratory behavior models of anxiety in mice","volume":"9","author":"Crawley","year":"1985","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.yebeh.2023.109189_b0065","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/jcbfm.1983.35","article-title":"Regional brain blood flow, blood volume, and haematocrit values in the adult rat","volume":"3","author":"Cremer","year":"1983","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.yebeh.2023.109189_b0070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1042\/BST20150028","article-title":"Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection","volume":"43","author":"Da Pozzo","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.yebeh.2023.109189_b0075","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/s41390-019-0319-6","article-title":"Evaluating anti-epileptic drugs in the era of therapeutic hypothermia","volume":"85","author":"Davidson","year":"2019","journal-title":"Pediatr Res"},{"key":"10.1016\/j.yebeh.2023.109189_b0080","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1467-7687.2006.00499.x","article-title":"Brain and cognitive-behavioural development after asphyxia at term birth","volume":"9","author":"de Haan","year":"2006","journal-title":"Dev Sci"},{"key":"10.1016\/j.yebeh.2023.109189_b0085","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/j.1476-5381.2011.01733.x","article-title":"Role of neurosteroids in the anticonvulsant activity of midazolam","volume":"165","author":"Dhir","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.yebeh.2023.109189_b0090","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3390\/cells9040870","article-title":"Diagnostic and Therapeutic Potential of TSPO Studies Regarding Neurodegenerative Diseases, Psychiatric Disorders, Alcohol Use Disorders, Traumatic Brain Injury, and Stroke: An Update","volume":"9","author":"Dimitrova-Shumkovska","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.yebeh.2023.109189_b0095","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s40265-016-0554-7","article-title":"Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives","volume":"76","author":"Donovan","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.yebeh.2023.109189_b0100","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1006\/cbir.1999.0397","article-title":"'Non-synaptic' mechanisms in seizures and epileptogenesis","volume":"22","author":"Dudek","year":"1998","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.yebeh.2023.109189_b0105","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/1531-8249(200010)48:4<632::AID-ANA10>3.0.CO;2-3","article-title":"Seizures accelerate anoxia-induced neuronal death in the neonatal rat hippocampus","volume":"48","author":"Dzhala","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0110","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nm1301","article-title":"NKCC1 transporter facilitates seizures in the developing brain","volume":"11","author":"Dzhala","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.yebeh.2023.109189_b0115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ana.21229","article-title":"Bumetanide enhances phenobarbital efficacy in a neonatal seizure model","volume":"63","author":"Dzhala","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0120","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.yebeh.2023.109189_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.544431","article-title":"TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells","volume":"14","author":"Feng","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.yebeh.2023.109189_b0130","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1111\/epi.17050","article-title":"Long-term outcome in a noninvasive rat model of birth asphyxia with neonatal seizures: Cognitive impairment, anxiety, epilepsy, and structural brain alterations","volume":"62","author":"Gailus","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0135","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jpeds.2009.03.040","article-title":"Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury","volume":"155","author":"Glass","year":"2009","journal-title":"J Pediatr"},{"key":"10.1016\/j.yebeh.2023.109189_b0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pediatrneurol.2017.04.016","article-title":"Seizures in Preterm Neonates: A Multicenter Observational Cohort Study","volume":"72","author":"Glass","year":"2017","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.spen.2019.08.004","article-title":"Acute Symptomatic Seizures in Neonates","volume":"32","author":"Glass","year":"2019","journal-title":"Semin Pediatr Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0150","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.nbd.2019.01.024","article-title":"Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water","volume":"125","author":"Glykys","year":"2019","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.yebeh.2023.109189_b0155","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1152\/jn.00944.2004","article-title":"Furosemide and mannitol suppression of epileptic activity in the human brain","volume":"94","author":"Haglund","year":"2005","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.yebeh.2023.109189_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107616","article-title":"The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain","volume":"114","author":"Hampel","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109189_b0165","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000242982","article-title":"Cerebral blood volumes in young rats with and without in situ saline flushing of cerebral vasculature. Implications for in vivo studies of brain substance uptake","volume":"56","author":"Hansen","year":"1989","journal-title":"Biol Neonate"},{"key":"10.1016\/j.yebeh.2023.109189_b0170","unstructured":"Heyser CJ. Assessment of developmental milestones in rodents. Curr Protoc Neurosci. Chapter 8, Unit 8.18; 2004."},{"key":"10.1016\/j.yebeh.2023.109189_b0175","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.270.5233.99","article-title":"Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity","volume":"270","author":"Hochman","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2023.109189_b0180","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.clp.2009.07.012","article-title":"The long-term effects of neonatal seizures","volume":"36","author":"Holmes","year":"2009","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.yebeh.2023.109189_b0185","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.intimp.2018.11.050","article-title":"Midazolam suppresses the lipopolysaccharide-stimulated immune responses of human macrophages via translocator protein signaling","volume":"66","author":"Horiguchi","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.yebeh.2023.109189_b0190","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF00401402","article-title":"Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse","volume":"13","author":"Irwin","year":"1968","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.yebeh.2023.109189_b0195","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1126\/science.1248725","article-title":"Structure of the mitochondrial translocator protein in complex with a diagnostic ligand","volume":"343","author":"Jaremko","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2023.109189_b0200","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/epi.16778","article-title":"Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective","volume":"62","author":"Johne","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0205","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/epi.16912","article-title":"A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia","volume":"62","author":"Johne","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/FOC\/2008\/25\/9\/E22","article-title":"The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures","volume":"25","author":"Kahle","year":"2008","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.yebeh.2023.109189_b0215","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/epi.17279","article-title":"Bumetanide for neonatal seizures: No light in the pharmacokinetic\/dynamic tunnel","volume":"63","author":"Kaila","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0220","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fncel.2015.00173","article-title":"Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters","volume":"9","author":"Kang","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.yebeh.2023.109189_b0225","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fped.2015.00101","article-title":"Neonatal Seizures: Impact on Neurodevelopmental Outcomes","volume":"3","author":"Kang","year":"2015","journal-title":"Front Pediatr"},{"key":"10.1016\/j.yebeh.2023.109189_b0230","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fnins.2019.00310","article-title":"Off-Label Use of Bumetanide for Brain Disorders: An Overview","volume":"13","author":"Kharod","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.yebeh.2023.109189_b0235","doi-asserted-by":"crossref","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1016\/j.yebeh.2023.109189_b0240","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eplepsyres.2015.11.003","article-title":"Network pharmacology for antiepileptogenesis: tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice","volume":"118","author":"Klee","year":"2015","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2023.109189_b0245","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.eplepsyres.2014.10.002","article-title":"Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures","volume":"108","author":"Klein","year":"2014","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2023.109189_b0250","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/ALN.0b013e31829e4b05","article-title":"Bumetanide, an inhibitor of cation-chloride cotransporter isoform 1, inhibits \u00ce3-aminobutyric acidergic excitatory actions and enhances sedative actions of midazolam in neonatal rats","volume":"119","author":"Koyama","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.yebeh.2023.109189_b0255","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF02246454","article-title":"Pharmacokinetics and bioavailability of midazolam after intravenous, subcutaneous, intraperitoneal and oral administration under a chronic food-limited regimen: relating DRL performance to pharmacokinetics","volume":"126","author":"Lau","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.yebeh.2023.109189_b0260","unstructured":"Lehmann EL. Nonparametrics: Statistical Methods Based on Ranks. Heidelberg: Springer; 2006."},{"key":"10.1016\/j.yebeh.2023.109189_b0265","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1111\/epi.12378","article-title":"AMPA receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures","volume":"54","author":"Lippman-Bell","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0920-1211(91)90041-D","article-title":"The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. IV. Protective indices","volume":"9","author":"L\u00f6scher","year":"1991","journal-title":"Epilepsy Res"},{"issue":"Suppl 8","key":"10.1016\/j.yebeh.2023.109189_b0275","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/epi.12025","article-title":"How theories evolved concerning the mechanism of action of barbiturates","volume":"53","author":"L\u00f6scher","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0280","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/epi.16866","article-title":"Reply to the commentary by Ben-Ari and Delpire: Bumetanide and neonatal seizures: Fiction versus reality","volume":"62","author":"L\u00f6scher","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0285","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s40263-021-00827-8","article-title":"The pharmacology and clinical efficacy of antiseizure medications: From bromide salts to cenobamate and beyond","volume":"35","author":"L\u00f6scher","year":"2021","journal-title":"CNS Drugs"},{"key":"10.1016\/j.yebeh.2023.109189_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108910","article-title":"CNS pharmacology of NKCC1 inhibitors","volume":"205","author":"L\u00f6scher","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2023.109189_b0295","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1212\/WNL.55.4.506","article-title":"Electrographic seizures in neonates correlate with poor neurodevelopmental outcome","volume":"55","author":"McBride","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109189_b0300","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fncel.2017.00078","article-title":"Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges","volume":"11","author":"Millar","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.yebeh.2023.109189_b0305","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1212\/WNL.58.4.542","article-title":"Seizure-associated brain injury in term newborns with perinatal asphyxia","volume":"58","author":"Miller","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109189_b0310","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fped.2019.00489","article-title":"A Global View of Neonatal Asphyxia and Resuscitation","volume":"7","author":"Moshiro","year":"2019","journal-title":"Front Pediatr"},{"key":"10.1016\/j.yebeh.2023.109189_b0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0773.1977.tb03209.x","article-title":"The pharmacology of bumetanide","volume":"41","author":"Olsen","year":"1977","journal-title":"Acta Pharmacol. Toxicol. (Copenh)"},{"key":"10.1016\/j.yebeh.2023.109189_b0320","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM199908123410704","article-title":"Phenobarbital compared with phenytoin for the treatment of neonatal seizures","volume":"341","author":"Painter","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yebeh.2023.109189_b0325","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tips.2006.06.005","article-title":"Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function","volume":"27","author":"Papadopoulos","year":"2006","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.yebeh.2023.109189_b0330","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.yebeh.2023.109189_b0335","doi-asserted-by":"crossref","first-page":"e13467","DOI":"10.1111\/apha.13467","article-title":"Endogenous bain-sparing responses in brain pH and PO2 in a rodent model of birth asphyxia","volume":"229","author":"Pospelov","year":"2020","journal-title":"Acta Physiol"},{"key":"10.1016\/j.yebeh.2023.109189_b0340","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1111\/epi.16963","article-title":"Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia","volume":"62","author":"Pospelov","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0345","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1474-4422(14)70303-5","article-title":"Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1\/2 trial","volume":"14","author":"Pressler","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107854","article-title":"Why we urgently need improved seizure and epilepsy therapies for children and neonates","volume":"170","author":"Pressler","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2023.109189_b0355","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/epi.16815","article-title":"The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures","volume":"62","author":"Pressler","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0360","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/epi.12620","article-title":"Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures","volume":"55","author":"Puskarjov","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0365","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pbb.2015.10.005","article-title":"Translocator protein mediates the anxiolytic and antidepressant effects of midazolam","volume":"139","author":"Qiu","year":"2015","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.yebeh.2023.109189_b0370","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroenceph Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2023.109189_b0375","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1528-1167.2011.02992.x","article-title":"Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures","volume":"52","author":"Rakhade","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0380","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.tips.2008.07.005","article-title":"Animal models of anxiety: do I need multiple tests?","volume":"29","author":"Ramos","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.yebeh.2023.109189_b0390","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022780","article-title":"Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet","volume":"6","author":"Rogawski","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.yebeh.2023.109189_b0400","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1172\/JCI134793","article-title":"Preventing neuronal edema increases network excitability after traumatic brain injury","volume":"130","author":"Sawant-Pokam","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yebeh.2023.109189_b0405","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0920-1211(98)00058-8","article-title":"Osmolarity, ionic flux, and changes in brain excitability","volume":"32","author":"Schwartzkroin","year":"1998","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2023.109189_b0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species","volume":"106\u2013107","author":"Semple","year":"2013","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.yebeh.2023.109189_b0420","doi-asserted-by":"crossref","first-page":"e20193182","DOI":"10.1542\/peds.2019-3182","article-title":"Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial","volume":"145","author":"Sharpe","year":"2020","journal-title":"Pediatrics"},{"key":"10.1016\/j.yebeh.2023.109189_b0425","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0006-8993(88)90816-5","article-title":"Determination of rat cerebral cortical blood volume changes by capillary mean transit time analysis during hypoxia, hypercapnia and hyperventilation","volume":"454","author":"Shockley","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2023.109189_b0430","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/epi4.12619","article-title":"Acetazolamide: Old drug, new evidence?","volume":"7","author":"Shukralla","year":"2022","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.yebeh.2023.109189_b0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.107966","article-title":"Mechanisms of Action of Currently Used Antiseizure Drugs","volume":"168","author":"Sills","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2023.109189_b0440","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.siny.2018.02.002","article-title":"Acute symptomatic seizures in term neonates: Etiologies and treatments","volume":"23","author":"Soul","year":"2018","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.yebeh.2023.109189_b0445","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ana.25959","article-title":"A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures","volume":"89","author":"Soul","year":"2021","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0450","doi-asserted-by":"crossref","first-page":"495","DOI":"10.31887\/DCNS.2011.13.4\/tsteimer","article-title":"Animal models of anxiety disorders in rats and mice: some conceptual issues","volume":"13","author":"Steimer","year":"2011","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.yebeh.2023.109189_b0455","doi-asserted-by":"crossref","first-page":"e3001526","DOI":"10.1371\/journal.pbio.3001526","article-title":"The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner","volume":"20","author":"T\u00f3th","year":"2022","journal-title":"PLoS Biol"},{"key":"10.1016\/j.yebeh.2023.109189_b0460","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/ana.24124","article-title":"A novel prodrug-based strategy to increase effects of bumetanide in epilepsy","volume":"75","author":"T\u00f6llner","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0465","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1152\/jn.1989.61.5.927","article-title":"Role of extracellular space in hyperosmotic suppression of potassium-induced electrographic seizures","volume":"61","author":"Traynelis","year":"1989","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.yebeh.2023.109189_b0470","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1020202806759","article-title":"Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol","volume":"29","author":"Tuk","year":"2002","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"10.1016\/j.yebeh.2023.109189_b0475","doi-asserted-by":"crossref","first-page":"3","DOI":"10.21037\/pm.2019.11.02","article-title":"Birth asphyxia-induced brain damage: the long road to optimal reduction and prevention!","volume":"3","author":"van Bel","year":"2020","journal-title":"Pediatr Med"},{"key":"10.1016\/j.yebeh.2023.109189_b0480","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00431-007-0437-8","article-title":"Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review","volume":"166","author":"van Handel","year":"2007","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.yebeh.2023.109189_b0485","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1528-1167.2008.01894.x","article-title":"Bumetanide for neonatal seizures: Based on evidence or enthusiasm?","volume":"50","author":"Vanhatalo","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109189_b0495","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.yebeh.2023.109189_b0500","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2014.11.031","article-title":"In vivo effects of bumetanide at brain concentrations incompatible with NKCC1 inhibition on newborn DGC structure and spontaneous EEG seizures following hypoxia-induced neonatal seizures","volume":"286","author":"Wang","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2023.109189_b0505","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ana.26498","article-title":"Midazolam prevents the adverse outcome of neonatal asphyxia","volume":"93","author":"Welzel","year":"2023","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109189_b0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.109057","article-title":"The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia","volume":"139","author":"Welzel","year":"2023","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109189_b0515","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.eplepsyres.2019.02.010","article-title":"Network pharmacology for antiepileptogenesis: tolerability and neuroprotective effects of novel multitargeted combination treatments in nonepileptic vs. post-status epilepticus in mice","volume":"151","author":"Welzel","year":"2019","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2023.109189_b0520","unstructured":"WHO. Guidelines on neonatal seizures. Geneva: World Health Organization; 2011."},{"key":"10.1016\/j.yebeh.2023.109189_b0525","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1203\/00006450-200110000-00005","article-title":"Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage","volume":"50","author":"Wirrell","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.yebeh.2023.109189_b0530","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/dmcn.14610","article-title":"Combination treatments with therapeutic hypothermia for hypoxic-ischemic neuroprotection","volume":"62","author":"Zhou","year":"2020","journal-title":"Dev Med Child Neurol"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023001087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023001087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:51:01Z","timestamp":1761504661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505023001087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":102,"alternative-id":["S1525505023001087"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109189","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109189"}}