{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:46:16Z","timestamp":1782499576088,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.yebeh.2023.109334","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T23:24:23Z","timestamp":1687908263000},"page":"109334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Evaluating the effect of calcifediol supplementation on seizure frequency in people with drug-resistant epilepsy"],"prefix":"10.1016","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-7815","authenticated-orcid":false,"given":"Mario","family":"Tombini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilisa","family":"Boscarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narducci","family":"Flavia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sancetta","family":"Biagio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anda Mihaela","family":"Naciu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Tabacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cesareo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Lazzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Assenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2023.109334_b0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1212\/WNL.0b013e3181beecb7","article-title":"25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services","volume":"74","author":"Buell","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109334_b0010","first-page":"67","article-title":"Serum Vitamin D and the Risk of Parkinson Disease","author":"Knekt","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.yebeh.2023.109334_b0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jns.2011.06.035","article-title":"Vitamin D: evidence for its role as a prognostic factor in multiple sclerosis","volume":"311","author":"Mowry","year":"2011","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.yebeh.2023.109334_b0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yebeh.2012.03.011","article-title":"Correction of vitamin D deficiency improves seizure control in epilepsy: a pilot study","volume":"24","author":"Holl\u00f3","year":"2012","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109334_b0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jsbmb.2017.09.008","article-title":"Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes","volume":"177","author":"Landel","year":"2018","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.yebeh.2023.109334_b0030","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/jcb.21913","article-title":"Membrane receptor-initiated signaling in 1,25(OH)2D3-stimulated calcium uptake in intestinal epithelial cells","volume":"105","author":"Khanal","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.yebeh.2023.109334_b0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchemneu.2004.08.006","article-title":"Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain","volume":"29","author":"Eyles","year":"2005","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.yebeh.2023.109334_b0040","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2007.07.002","article-title":"Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock","volume":"573","author":"Borowicz","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2023.109334_b0045","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-8993(84)91153-3","article-title":"Administration of 1,25-dihydroxyvitamin D3 results in the elevation of hippocampal seizure threshold levels in rats","volume":"298","author":"Siegel","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2023.109334_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2019.106262","article-title":"The effect of vitamin D3 and paricalcitol on penicillin-induced epileptiform activity in rats","volume":"159","author":"Sumbul","year":"2020","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2023.109334_b0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.eplepsyres.2018.11.011","article-title":"Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice","volume":"149","author":"Momeni","year":"2019","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2023.109334_b0060","first-page":"37","article-title":"Long-term anticonvulsant therapy leads to low bone mineral density\u2013evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells","volume":"108","author":"Feldkamp","year":"2000","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.yebeh.2023.109334_b0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.phrs.2003.11.011","article-title":"The effect of valproate on bone mineral density in adult epileptic patients","volume":"50","author":"Boluk","year":"2004","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.yebeh.2023.109334_b0070","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1046\/j.1528-1157.2002.13002.x","article-title":"Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine","volume":"43","author":"Verrotti","year":"2002","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.yebeh.2023.109334_b0075","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.yebeh.2003.11.030","article-title":"Fractures, epilepsy, and antiepileptic drugs","volume":"5","author":"Mattson","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109334_b0080","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/bmj.2.5913.258","article-title":"\u201cAnticonvulsant action\u201d of vitamin D in epileptic patients? A controlled pilot study","volume":"2","author":"Christiansen","year":"1974","journal-title":"Br Med J"},{"key":"10.1016\/j.yebeh.2023.109334_b0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.seizure.2018.04.008","article-title":"Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control","volume":"58","author":"Tombini","year":"2018","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2023.109334_b0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.yebeh.2019.03.001","article-title":"Safety and tolerability of Vitamin D3 5000 IU\/day in epilepsy","volume":"94","author":"DeGiorgio","year":"2019","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109334_b0095","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00198-018-4520-y","article-title":"Is calcifediol better than cholecalciferol for vitamin D supplementation?","volume":"29","author":"Quesada-Gomez","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.yebeh.2023.109334_b0100","doi-asserted-by":"crossref","first-page":"E1016","DOI":"10.3390\/nu11051016","article-title":"Hypovitaminosis D: Is It Time to Consider the Use of Calcifediol?","volume":"11","author":"Cesareo","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.yebeh.2023.109334_b0105","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109334_b0110","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1212\/01.wnl.0000210503.89488.88","article-title":"Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy","volume":"66","author":"Souverein","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109334_b0115","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1472-6890-8-12","article-title":"Derivation and internal validation of an equation for albumin-adjusted calcium","volume":"8","author":"James","year":"2008","journal-title":"BMC Clin Pathol"},{"key":"10.1016\/j.yebeh.2023.109334_b0120","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.clinbiochem.2009.07.013","article-title":"An evaluation of automated methods for measurement of serum 25-hydroxyvitamin D","volume":"42","author":"Wagner","year":"2009","journal-title":"Clin Biochem"},{"key":"10.1016\/j.yebeh.2023.109334_b0125","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3390\/nu10050546","article-title":"Italian Association of Clinical Endocrinologists (AME) and Italian Chapter of the American Association of Clinical Endocrinologists (AACE) Position Statement: Clinical Management of Vitamin D Deficiency in Adults","volume":"10","author":"Cesareo","year":"2018","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.yebeh.2023.109334_b0130","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s11154-021-09693-7","article-title":"Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?","volume":"22","author":"Bilezikian","year":"2021","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.yebeh.2023.109334_b0135","doi-asserted-by":"crossref","first-page":"262","DOI":"10.5144\/0256-4947.2022.262","article-title":"Association between serum vitamin D levels and age in patients with epilepsy: a retrospective study from an epilepsy center in Saudi Arabia","volume":"42","author":"Alhaidari","year":"2022","journal-title":"Ann Saudi Med"},{"key":"10.1016\/j.yebeh.2023.109334_b0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4274\/npa.y7089","article-title":"The Influence of Vitamin D Treatment on the Inducible Nitric Oxide Synthase (INOS) Expression in Primary Hippocampal Neurons","volume":"51","author":"Dursun","year":"2014","journal-title":"Noro Psikiyatr Ars"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023002536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023002536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:49:51Z","timestamp":1782496191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505023002536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":28,"alternative-id":["S1525505023002536"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109334","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the effect of calcifediol supplementation on seizure frequency in people with drug-resistant epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109334"}}