{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:58:35Z","timestamp":1792429115824,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-15-00430"],"award-info":[{"award-number":["21-15-00430"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.yebeh.2023.109391","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:49:21Z","timestamp":1692686961000},"page":"109391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Refinement of the Barnes and Morris water maze protocols improves characterization of spatial cognitive deficits in the lithium-pilocarpine rat model of epilepsy"],"prefix":"10.1016","volume":"147","author":[{"given":"Alexandra V.","family":"Dyomina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya V.","family":"Smolensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4503-0647","authenticated-orcid":false,"given":"Aleksey V.","family":"Zaitsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2023.109391_b0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0165-0173(01)00058-3","article-title":"Varieties of human spatial memory: a meta-analysis on the effects of hippocampal lesions","volume":"35","author":"Kessels","year":"2001","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.yebeh.2023.109391_b0010","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.lfs.2010.09.004","article-title":"Assessment of spatial memory in mice","volume":"87","author":"Sharma","year":"2010","journal-title":"Life Sci"},{"key":"10.1016\/j.yebeh.2023.109391_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112310","article-title":"Potential causes of cognitive alterations in temporal lobe epilepsy","volume":"378","author":"Chauvi\u00e8re","year":"2020","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106595","article-title":"Life and death in the hippocampus: what\u2019s bad?","volume":"121","author":"Santos","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109391_b0025","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneumeth.2008.04.019","article-title":"The pilocarpine model of temporal lobe epilepsy","volume":"172","author":"Curia","year":"2008","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.yebeh.2023.109391_b0030","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1523\/JNEUROSCI.4699-08.2009","article-title":"Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy","volume":"29","author":"Chauviere","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2023.109391_b0035","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1134\/S0022093022010100","article-title":"Ethosuximide improves cognitive flexibility during reversal learning in WAG\/Rij rats with absence epilepsy and comorbid depression","volume":"58","author":"Fedosova","year":"2022","journal-title":"J Evol Biochem Phys"},{"key":"10.1016\/j.yebeh.2023.109391_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112044","article-title":"Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy","volume":"372","author":"Smolensky","year":"2019","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0045","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/epi.12549","article-title":"Attention and executive functions in a rat model of chronic epilepsy","volume":"55","author":"Faure","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109391_b0050","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1111\/bph.12603","article-title":"Modelling cognitive affective biases in major depressive disorder using rodents: Rodent models of cognitive affective biases","volume":"171","author":"Hales","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.yebeh.2023.109391_b0055","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.yebeh.2005.03.005","article-title":"Convulsive and nonconvulsive epilepsy in rats: effects on behavioral response to novelty stress","volume":"6","author":"Midzyanovskaya","year":"2005","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109391_b0060","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1007\/s12035-016-0012-2","article-title":"Nicotine significantly improves chronic stress-induced impairments of cognition and synaptic plasticity in mice","volume":"54","author":"Shang","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.yebeh.2023.109391_b0065","doi-asserted-by":"crossref","first-page":"R785","DOI":"10.1016\/S0960-9822(00)00763-6","article-title":"Hippocampus: mapping or memory?","volume":"10","author":"Eichenbaum","year":"2000","journal-title":"Curr Biol"},{"key":"10.1016\/j.yebeh.2023.109391_b0070","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0028-3932(99)00099-8","article-title":"A comparison of egocentric and allocentric spatial memory in a patient with selective hippocampal damage","volume":"38","author":"Holdstock","year":"2000","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.yebeh.2023.109391_b0075","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3390\/biology11091365","article-title":"A mouse model of neurodegeneration induced by blade penetrating stab wound to the hippocampus","volume":"11","author":"He","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.yebeh.2023.109391_b0080","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.yebeh.2023.109391_b0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbr.2009.05.022","article-title":"Spatial memory: theoretical basis and comparative review on experimental methods in rodents","volume":"203","author":"Paul","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0090","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbr.2008.10.015","article-title":"Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks","volume":"198","author":"Harrison","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0095","doi-asserted-by":"crossref","first-page":"7809","DOI":"10.1523\/JNEUROSCI.22-17-07809.2002","article-title":"Conceptual, spatial, and cue learning in the Morris water maze in fast or slow kindling rats: attention deficit comorbidity","volume":"22","author":"Anisman","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2023.109391_b0100","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1134\/S0022093021020113","article-title":"Possibilities and prospects of the behavioral test \u201cMorris Water Maze\u201d","volume":"57","author":"Chernyuk","year":"2021","journal-title":"J Evol Biochem Phys"},{"key":"10.1016\/j.yebeh.2023.109391_b0105","doi-asserted-by":"crossref","first-page":"e78238","DOI":"10.1371\/journal.pone.0078238","article-title":"5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze","volume":"8","author":"Karabeg","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2023.109391_b0110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00441-013-1668-9","article-title":"Spatial memory tasks in rodents: what do they model?","volume":"354","author":"Morellini","year":"2013","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0115","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s11064-018-2610-z","article-title":"The Barnes maze task reveals specific impairment of spatial learning strategy in the intrahippocampal kainic acid model for temporal lobe epilepsy","volume":"44","author":"Van Den Herrewegen","year":"2019","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0120","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1111\/epi.16291","article-title":"Cognitive deficits in a rat model of temporal lobe epilepsy using touchscreen-based translational tools","volume":"60","author":"Carron","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109391_b0125","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/npp.2015.202","article-title":"Estradiol and progesterone have opposing roles in the regulation of fear extinction in female rats","volume":"41","author":"Graham","year":"2016","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.yebeh.2023.109391_b0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3390\/ijms23010497","article-title":"MTEP, a selective mGluR5 antagonist, had a neuroprotective effect but did not prevent the development of spontaneous recurrent seizures and behavioral comorbidities in the rat lithium-pilocarpine model of epilepsy","volume":"23","author":"Dyomina","year":"2022","journal-title":"IJMS"},{"key":"10.1016\/j.yebeh.2023.109391_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0013-4694(75)90204-7","article-title":"Modification of seizure activity by electrical stimulation: Cortical areas","volume":"38","author":"Racine","year":"1975","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.yebeh.2023.109391_b0140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0920-1211(01)00272-8","article-title":"Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy","volume":"46","author":"Glien","year":"2001","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0145","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"D\u2019Hooge","year":"2001","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.yebeh.2023.109391_b0150","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/neu.2015.3970","article-title":"Altered neuroinflammation and behavior after traumatic brain injury in a mouse model of Alzheimer\u2019s disease","volume":"33","author":"Kokiko-Cochran","year":"2016","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.yebeh.2023.109391_b0155","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1037\/h0077579","article-title":"Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat","volume":"93","author":"Barnes","year":"1979","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.yebeh.2023.109391_b0160","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.brs.2019.01.005","article-title":"Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats","volume":"12","author":"Izadi","year":"2019","journal-title":"Brain Stimul"},{"key":"10.1016\/j.yebeh.2023.109391_b0165","doi-asserted-by":"crossref","first-page":"12224","DOI":"10.3390\/ijms232012224","article-title":"Prolonged febrile seizures impair synaptic plasticity and alter developmental pattern of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in the hippocampus of young rats","volume":"23","author":"Griflyuk","year":"2022","journal-title":"IJMS"},{"key":"10.1016\/j.yebeh.2023.109391_b0170","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1212\/01.WNL.0000113763.11862.26","article-title":"Prevalence and clinical characteristics of postictal psychiatric symptoms in partial epilepsy","volume":"62","author":"Kanner","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109391_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/ph10030075","article-title":"Behavioral and neurochemical consequences of pentylenetetrazol-induced kindling in young and middle-aged rats","volume":"10","author":"Hoeller","year":"2017","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.yebeh.2023.109391_b0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2005.07.024","article-title":"Behavioral characteristics of WAG\/Rij rats susceptible and non-susceptible to audiogenic seizures","volume":"166","author":"Sarkisova","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0185","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1093\/brain\/awu100","article-title":"Differential influence of hippocampal subfields to memory formation: insights from patients with temporal lobe epilepsy","volume":"137","author":"Coras","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2023.109391_b0190","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/epi.12220","article-title":"International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a task force report from the ILAE commission on diagnostic methods","volume":"54","author":"Bl\u00fcmcke","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109391_b0195","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yebeh.2015.12.001","article-title":"Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy","volume":"55","author":"Lopes","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109391_b0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022372","article-title":"Hippocampal-dependent spatial memory in the water maze is preserved in an experimental model of temporal lobe epilepsy in rats","volume":"6","author":"Inostroza","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2023.109391_b0205","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuropharm.2006.05.021","article-title":"Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats","volume":"51","author":"Brandt","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2023.109391_b0210","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s002130000534","article-title":"Effects of noradrenaline depletion in the brain on response to novelty in isolation-reared rats","volume":"152","author":"Lapiz","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.yebeh.2023.109391_b0215","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1744-9081-8-51","article-title":"Age-dependent decline in learning and memory performances of WAG\/Rij rat model of absence epilepsy","volume":"8","author":"Karson","year":"2012","journal-title":"Behav Brain Funct"},{"key":"10.1016\/j.yebeh.2023.109391_b0220","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/hipo.1042","article-title":"Dorsal hippocampal kindling selectively impairs spatial learning\/short-term memory","volume":"11","author":"Hannesson","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/j.yebeh.2023.109391_b0225","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1528-1167.2006.00370.x","article-title":"Open-field behaviors and water-maze learning in the F substrain of ihara epileptic rats","volume":"47","author":"Okaichi","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109391_b0230","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1111\/j.0953-816X.2004.03410.x","article-title":"Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis","volume":"19","author":"Kubov\u00e1","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.yebeh.2023.109391_b0235","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1101\/lm.334306","article-title":"Spatial and nonspatial escape strategies in the Barnes maze","volume":"13","author":"Harrison","year":"2006","journal-title":"Learn Mem"},{"key":"10.1016\/j.yebeh.2023.109391_b0240","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bbr.2008.10.029","article-title":"Evaluation of spatial memory of C57BL\/6J and CD1 mice in the Barnes maze, the Multiple T-maze and in the Morris water maze","volume":"198","author":"Patil","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0245","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/jnr.24393","article-title":"Differential impacts on multiple forms of spatial and contextual memory in diazepam binding inhibitor knockout mice","volume":"97","author":"Ujjainwala","year":"2019","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.yebeh.2023.109391_b0250","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.yebeh.2019.05.025","article-title":"Subchronic cerebrolysin treatment alleviates cognitive impairments and dendritic arborization alterations of granular neurons in the hippocampal dentate gyrus of rats with temporal lobe epilepsy","volume":"97","author":"Zamudio","year":"2019","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109391_b0255","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.physbeh.2015.03.004","article-title":"Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL\/6 mice","volume":"143","author":"Oliveira","year":"2015","journal-title":"Physiol Behav"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023003104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023003104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:52:35Z","timestamp":1761504755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505023003104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":51,"alternative-id":["S1525505023003104"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109391","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Refinement of the Barnes and Morris water maze protocols improves characterization of spatial cognitive deficits in the lithium-pilocarpine rat model of epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109391","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109391"}}