{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:07:37Z","timestamp":1760123257318,"version":"3.32.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.yebeh.2023.109535","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T12:39:52Z","timestamp":1702989592000},"page":"109535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Evaluating the efficacy of a ketogenic diet in managing drug resistant paediatric DEDPC5-related epilepsy"],"prefix":"10.1016","volume":"150","author":[{"given":"Anna","family":"Winczewska-Wiktor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Braszka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Harada-Laszlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Badura-Stronka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Kaczmarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Starczewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Wencel-Warot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Steinborn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksander","family":"Jamsheer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.yebeh.2023.109535_b0005","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41436-018-0060-2","article-title":"The landscape of epilepsy-related GATOR1 variants","volume":"21","author":"Baldassari","year":"2019","journal-title":"Genet Med"},{"issue":"23","key":"10.1016\/j.yebeh.2023.109535_b0010","doi-asserted-by":"crossref","first-page":"14484","DOI":"10.1074\/jbc.273.23.14484","article-title":"Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism","volume":"273","author":"Hara","year":"1998","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.yebeh.2023.109535_b0015","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.yebeh.2023.109535_b0020","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuroscience.2016.11.017","article-title":"Molecular neurobiology of mTOR","volume":"341","author":"Switon","year":"2017","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.yebeh.2023.109535_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111278","article-title":"DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting","volume":"40","author":"Yuskaitis","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.yebeh.2023.109535_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108678","article-title":"DEPDC5-related epilepsy: A comprehensive review","volume":"130","author":"Samanta","year":"2022","journal-title":"Epilepsy Behav"},{"issue":"5","key":"10.1016\/j.yebeh.2023.109535_b0035","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/ng.2599","article-title":"Mutations in DEPDC5 cause familial focal epilepsy with variable foci","volume":"45","author":"Dibbens","year":"2013","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.yebeh.2023.109535_b0040","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ng.2601","article-title":"Mutations of DEPDC5 cause autosomal dominant focal epilepsies","volume":"45","author":"Ishida","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.yebeh.2023.109535_b0045","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00401-011-0920-1","article-title":"Neuropathologic measurements in focal cortical dysplasias: validation of the ILAE 2011 classification system and diagnostic implications for MRI","volume":"123","author":"M\u00fchlebner","year":"2012","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.yebeh.2023.109535_b0050","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3389\/fnins.2020.00821","article-title":"DEPDC5 variants associated malformations of cortical development and focal epilepsy with febrile seizure plus\/febrile seizures: the role of molecular sub-regional effect","volume":"14","author":"Liu","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.yebeh.2023.109535_b0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/bs.pbr.2016.04.013","article-title":"mTOR signaling pathway genes in focal epilepsies","volume":"226","author":"Baulac","year":"2016","journal-title":"Prog Brain Res"},{"issue":"2","key":"10.1016\/j.yebeh.2023.109535_b0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/epi4.12225","article-title":"Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group","volume":"3","author":"Kossoff","year":"2018","journal-title":"Epilepsia Open"},{"year":"2010","series-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","author":"Kwan","key":"10.1016\/j.yebeh.2023.109535_b0065"},{"issue":"9","key":"10.1016\/j.yebeh.2023.109535_b0070","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1469-8749.2007.00707.x","article-title":"GLUT1 deficiency syndrome\u20132007 update","volume":"49","author":"Klepper","year":"2007","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.yebeh.2023.109535_b0075","doi-asserted-by":"crossref","unstructured":"Sofou K, Dahlin M, Hallb\u00f6\u00f6k T, Lindefeldt M, Viggedal G, Darin N. Ketogenic diet in pyruvate dehydrogenase complex deficiency: short\u2010and long\u2010term outcomes. Journal of Inherited Metabolic Disease: Official Journal of the Society for the Study of Inborn Errors of Metabolism. 2017;40(2):237-45.","DOI":"10.1007\/s10545-016-0011-5"},{"issue":"10","key":"10.1016\/j.yebeh.2023.109535_b0080","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1528-1167.2005.00266.x","article-title":"Tuberous sclerosis complex and the ketogenic diet","volume":"46","author":"Kossoff","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109535_b0085","doi-asserted-by":"crossref","unstructured":"Coppola G, Klepper J, Ammendola E, Fiorillo M, della Corte R, Capano G, et al. The effects of the ketogenic diet in refractory partial seizures with reference to tuberous sclerosis. European Journal of Paediatric Neurology. 2006;10(3):148-51.","DOI":"10.1016\/j.ejpn.2006.03.001"},{"issue":"6","key":"10.1016\/j.yebeh.2023.109535_b0090","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.pediatrneurol.2007.01.013","article-title":"Home-guided use of the ketogenic diet in a patient for more than 20 years","volume":"36","author":"Kossoff","year":"2007","journal-title":"Pediatr Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2023.109535_b0095","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cmet.2017.08.005","article-title":"A ketogenic diet extends longevity and healthspan in adult mice","volume":"26","author":"Roberts","year":"2017","journal-title":"Cell Metab"},{"issue":"17","key":"10.1016\/j.yebeh.2023.109535_b0100","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1093\/hmg\/ddz123","article-title":"Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice","volume":"28","author":"Yuskaitis","year":"2019","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1016\/j.yebeh.2023.109535_b0105","doi-asserted-by":"crossref","first-page":"226","DOI":"10.5694\/mja17.00951","article-title":"The management of epilepsy in children and adults","volume":"208","author":"Perucca","year":"2018","journal-title":"Med J Aust"},{"key":"10.1016\/j.yebeh.2023.109535_b0110","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.nbd.2018.02.013","article-title":"DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons","volume":"114","author":"Iffland","year":"2018","journal-title":"Neurobiol Dis"},{"issue":"6136","key":"10.1016\/j.yebeh.2023.109535_b0115","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1126\/science.1232044","article-title":"A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1","volume":"340","author":"Bar-Peled","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2023.109535_b0120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/B978-0-444-63326-2.00007-7","article-title":"Genetics advances in autosomal dominant focal epilepsies: focus on DEPDC5","volume":"213","author":"Baulac","year":"2014","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.yebeh.2023.109535_b0125","doi-asserted-by":"crossref","unstructured":"Schubert-Bast S, Strzelczyk A. Review of the treatment options for epilepsy in tuberous sclerosis complex: towards precision medicine. Therapeutic Advances in Neurological Disorders. 2021;14:17562864211031100.","DOI":"10.1177\/17562864211031100"},{"key":"10.1016\/j.yebeh.2023.109535_b0130","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fnmol.2014.00018","article-title":"Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation","volume":"7","author":"LaSarge","year":"2014","journal-title":"Front Mol Neurosci"},{"issue":"7","key":"10.1016\/j.yebeh.2023.109535_b0135","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrneurol.2016.81","article-title":"The mTOR signalling cascade: paving new roads to cure neurological disease","volume":"12","author":"Crino","year":"2016","journal-title":"Nat Rev Neurol"},{"issue":"20","key":"10.1016\/j.yebeh.2023.109535_b0140","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1242\/jcs.051011","article-title":"mTOR signaling at a glance","volume":"122","author":"Laplante","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.yebeh.2023.109535_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2020.106348","article-title":"Long-term outcomes of ketogenic diet in patients with tuberous sclerosis complex-derived epilepsy","volume":"164","author":"Youn","year":"2020","journal-title":"Epilepsy Res"},{"issue":"1","key":"10.1016\/j.yebeh.2023.109535_b0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.14581\/jer.17008","article-title":"Ketogenic diet for the management of epilepsy associated with tuberous sclerosis complex in children","volume":"7","author":"Park","year":"2017","journal-title":"J Epilepsy Res"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023004547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023004547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T13:06:35Z","timestamp":1736427995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505023004547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":30,"alternative-id":["S1525505023004547"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109535","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the efficacy of a ketogenic diet in managing drug resistant paediatric DEDPC5-related epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109535"}}