{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:29:32Z","timestamp":1788370172523,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016879","name":"UCB Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016879","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.yebeh.2023.109562","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T05:13:45Z","timestamp":1702098825000},"page":"109562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Favorable combinations of antiseizure medication with vagus nerve stimulation to improve health-related quality of life in patients with epilepsy"],"prefix":"10.1016","volume":"150","author":[{"given":"Victoria","family":"Sauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Ellwardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assel","family":"Saryyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim K.","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Ringel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiu","family":"Groppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslav","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.yebeh.2023.109562_b0005","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.0000000000011839","article-title":"Incidence and prevalence of drug-resistant epilepsy: a systematic review and meta-analysis","volume":"96","author":"Sultana","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109562_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.108524","article-title":"Ethical considerations in the surgical and neuromodulatory treatment of epilepsy","volume":"127","author":"Shlobin","year":"2022","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109562_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109182","article-title":"Neuro-stimulation in focal epilepsy: a systematic review and meta-analysis","volume":"142","author":"Skrehot","year":"2023","journal-title":"Epilepsy Behav"},{"issue":"6","key":"10.1016\/j.yebeh.2023.109562_b0020","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/jamaneurol.2023.0066","article-title":"Focal cortex stimulation with a novel implantable device and antiseizure outcomes in 2 prospective multicenter single-arm trials","volume":"80","author":"Schulze-Bonhage","year":"2023","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.yebeh.2023.109562_b0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.seizure.2020.09.027","article-title":"Learnings from 30 years of reported efficacy and safety of vagus nerve stimulation (VNS) for epilepsy treatment: a critical review","volume":"83","author":"Toffa","year":"2020","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2023.109562_b0030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.seizure.2022.01.017","article-title":"Long-term outcome of vagus nerve stimulation for drug-resistant epilepsy using continuous assessment, with a note on mortality","volume":"96","author":"Polkey","year":"2022","journal-title":"Seizure"},{"issue":"6","key":"10.1016\/j.yebeh.2023.109562_b0035","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1007\/s00415-022-10967-6","article-title":"Efficacy and safety of VNS therapy or continued medication management for treatment of adults with drug-resistant epilepsy: systematic review and meta-analysis","volume":"269","author":"Batson","year":"2022","journal-title":"J Neurol"},{"issue":"6","key":"10.1016\/j.yebeh.2023.109562_b0040","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s40263-022-00922-4","article-title":"Current principles in the management of drug-resistant epilepsy","volume":"36","author":"Shlobin","year":"2022","journal-title":"CNS Drugs"},{"issue":"2","key":"10.1016\/j.yebeh.2023.109562_b0045","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/epi.17153","article-title":"Association between antiseizure medications and quality of life in epilepsy: a mediation analysis","volume":"63","author":"Wang","year":"2022","journal-title":"Epilepsia"},{"issue":"10","key":"10.1016\/j.yebeh.2023.109562_b0050","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1007\/s00415-023-11825-9","article-title":"Synergistic effects of vagus nerve stimulation and antiseizure medication","volume":"270","author":"Winter","year":"2023","journal-title":"J Neurol"},{"issue":"4","key":"10.1016\/j.yebeh.2023.109562_b0055","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jval.2016.03.1860","article-title":"Comparing generic and condition-specific preference-based measures in epilepsy: EQ-5D-3L and NEWQOL-6D","volume":"20","author":"Mulhern","year":"2017","journal-title":"Value Health"},{"issue":"6","key":"10.1016\/j.yebeh.2023.109562_b0060","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1528-1157.1996.tb00612.x","article-title":"A brief questionnaire to screen for quality of life in epilepsy: the QOLIE-10","volume":"37","author":"Cramer","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109562_b0065","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00115-006-2098-7","article-title":"Reliability and validity of the Revised Beck Depression Inventory (BDI-II). Results from German samples","volume":"78","author":"K\u00fchner","year":"2007","journal-title":"Nervenarzt"},{"key":"10.1016\/j.yebeh.2023.109562_b0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.yebeh.2017.12.037","article-title":"Health-related quality of life in patients with poststroke epilepsy","volume":"80","author":"Winter","year":"2018","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109562_b0075","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.seizure.2022.07.003","article-title":"Efficacy and safety of antiseizure medication in post-stroke epilepsy","volume":"100","author":"Winter","year":"2022","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2023.109562_b0080","article-title":"The role of vagus nerve stimulation in the treatment of refractory epilepsy: clinical outcomes and impact on quality of life","author":"Martorell-Llobregat","year":"2019","journal-title":"Neurologia (Engl Ed)"},{"key":"10.1016\/j.yebeh.2023.109562_b0085","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.seizure.2019.02.010","article-title":"Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy","volume":"66","author":"Wang","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2023.109562_b0090","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.yebeh.2016.02.019","article-title":"Factors affecting quality of life in adults with epilepsy in Taiwan: a cross-sectional, correlational study","volume":"58","author":"Chen","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109562_b0095","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","article-title":"The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)","volume":"289","author":"Kessler","year":"2003","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.yebeh.2023.109562_b0100","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: a population-based analysis","volume":"48","author":"Tellez\u2010Zenteno","year":"2007","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2023.109562_b0105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1535-7597.2005.05106.x","article-title":"Depression in epilepsy: a neurobiologic perspective","volume":"5","author":"Kanner","year":"2005","journal-title":"Epilepsy Curr"},{"issue":"1-2","key":"10.1016\/j.yebeh.2023.109562_b0110","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jns.2009.04.012","article-title":"Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy","volume":"284","author":"Wang","year":"2009","journal-title":"J Neurol Sci"},{"issue":"9","key":"10.1016\/j.yebeh.2023.109562_b0115","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/00001756-200307010-00017","article-title":"Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices","volume":"14","author":"Niespodziany","year":"2003","journal-title":"Neuroreport"},{"issue":"4","key":"10.1016\/j.yebeh.2023.109562_b0120","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/phrs.2000.0689","article-title":"Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs","volume":"42","author":"Georg Margineanu","year":"2000","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.yebeh.2023.109562_b0125","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/epi.13340","article-title":"Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment","volume":"57","author":"Klitgaard","year":"2016","journal-title":"Epilepsia"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550502300481X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550502300481X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T13:15:40Z","timestamp":1736428540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152550502300481X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":25,"alternative-id":["S152550502300481X"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109562","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Favorable combinations of antiseizure medication with vagus nerve stimulation to improve health-related quality of life in patients with epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109562"}}