{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:16:49Z","timestamp":1786652209816,"version":"build-2736575974"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T00:00:00Z","timestamp":1733616000000},"content-version":"vor","delay-in-days":342,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.yebeh.2023.109565","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T22:50:42Z","timestamp":1702075842000},"page":"109565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Epileptogenesis and drug-resistant in focal cortical dysplasias: Update on clinical, cellular, and molecular markers"],"prefix":"10.1016","volume":"150","author":[{"given":"Daniel","family":"Rodrigo Marinowic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Bottega Pazzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Prates da Cunha de Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pinzetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Victor Machado de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Tonon Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales","family":"Thor Ramos Previato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio","family":"Jean Varella de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaderson","family":"Costa Da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2023.109565_b0005","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1111\/epi.17301","article-title":"The ILAE consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the ILAE diagnostic methods commission","volume":"63","author":"Najm","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0010","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1056\/NEJMoa1703784","article-title":"Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery","volume":"377","author":"Blumcke","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yebeh.2023.109565_b0015","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1528-1167.2010.02777.x","article-title":"The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission","volume":"52","author":"Bl\u00fcmcke","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40478-023-01532-x","article-title":"An integrated genetic analysis of epileptogenic brain malformed lesions","volume":"11","author":"Fujita","year":"2023","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.yebeh.2023.109565_b0025","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/epi.13200","article-title":"Diagnostic methods and treatment options for focal cortical dysplasia","volume":"56","author":"Guerrini","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0030","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/jnnp.34.4.369","article-title":"Focal dysplasia of the cerebral cortex in epilepsy","volume":"34","author":"Taylor","year":"1971","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.yebeh.2023.109565_b0035","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1212\/01.WNL.0000114507.30388.7E","article-title":"Terminology and classification of the cortical dysplasias","volume":"62","author":"Palmini","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109565_b0040","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","article-title":"Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005\u20132009","volume":"51","author":"Berg","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1684\/epd.2010.0327","article-title":"Type I focal cortical dysplasia: surgical outcome is related to histopathology","volume":"12","author":"Tassi","year":"2010","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.yebeh.2023.109565_b0050","first-page":"326","article-title":"Focal Cortical Dysplasia. Encyclopedia of the","author":"Thom","year":"2014","journal-title":"Neurol Sci"},{"key":"10.1016\/j.yebeh.2023.109565_b0055","doi-asserted-by":"crossref","first-page":"13321","DOI":"10.1038\/s41598-023-40240-3","article-title":"Identifying cellular markers of focal cortical dysplasia type II with cell-type deconvolution and single-cell signatures","volume":"13","author":"Galv\u00e3o","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.yebeh.2023.109565_b0060","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/epi.15612","article-title":"Recommendations for the use of structural magnetic resonance imaging in the care of patients with epilepsy: A consensus report from the International League Against Epilepsy Neuroimaging Task Force","volume":"60","author":"Bernasconi","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0065","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1212\/WNL.0000000000011413","article-title":"7T Epilepsy Task Force Consensus Recommendations on the Use of 7T MRI in Clinical Practice","volume":"96","author":"Opheim","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109565_b0070","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s12031-020-01492-0","article-title":"Differential Expression Hallmarks of Interneurons in Different Types of Focal Cortical Dysplasia","volume":"70","author":"Liang","year":"2020","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.yebeh.2023.109565_b0075","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/j.1528-1167.2011.03158.x","article-title":"Focal cortical dysplasia type IIb: Completeness of cortical, not subcortical, resection is necessary for seizure freedom","volume":"52","author":"Wagner","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0080","first-page":"15","article-title":"Bridging Development and Disruption: Comprehensive Insights into Focal Cortical Dysplasia and Epileptic Management","author":"Mohsin","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.yebeh.2023.109565_b0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s42494-023-00131-6","article-title":"Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report","volume":"5","author":"S\u00e1nchez-Boluarte","year":"2023","journal-title":"Acta Epileptol"},{"key":"10.1016\/j.yebeh.2023.109565_b0090","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00401-011-0920-1","article-title":"Neuropathologic measurements in focal cortical dysplasias: validation of the ILAE 2011 classification system and diagnostic implications for MRI","volume":"123","author":"M\u00fchlebner","year":"2012","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.yebeh.2023.109565_b0095","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yebeh.2006.05.012","article-title":"Epileptogenesis in pediatric cortical dysplasia: The dysmature cerebral developmental hypothesis","volume":"9","author":"Cepeda","year":"2006","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109565_b0100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00401-010-0714-x","article-title":"Focal Cortical Dysplasias: clinical implication of neuropathological classification systems","volume":"120","author":"Spreafico","year":"2010","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.yebeh.2023.109565_b0105","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00401-005-1005-9","article-title":"Aberrant neuronal-glial differentiation in Taylor-type focal cortical dysplasia (type IIA\/B)","volume":"109","author":"Englund","year":"2005","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.yebeh.2023.109565_b0110","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1093\/brain\/awm175","article-title":"Developmental lineage of cell types in cortical dysplasia with balloon cells","volume":"130","author":"Lamparello","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2023.109565_b0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/2051-5960-2-45","article-title":"Layer-specific gene expression in epileptogenic type II focal cortical dysplasia: normal-looking neurons reveal the presence of a hidden laminar organization","volume":"2","author":"Rossini","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.yebeh.2023.109565_b0120","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/epi.13319","article-title":"International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods","volume":"57","author":"Bl\u00fcmcke","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0125","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/ana.410370410","article-title":"Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results","volume":"37","author":"Palmini","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.yebeh.2017.02.031","article-title":"Surgical outcomes in two different age groups with Focal Cortical Dysplasia type II: Any real difference?","volume":"70","author":"Ram\u00edrez-Molina","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109565_b0135","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jocn.2015.04.022","article-title":"Clinical characteristics and post-surgical outcomes of focal cortical dysplasia subtypes","volume":"23","author":"Xue","year":"2016","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.yebeh.2023.109565_b0140","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1080\/14737175.2021.1915135","article-title":"Focal cortical dysplasia: an update on diagnosis and treatment","volume":"21","author":"Guerrini","year":"2021","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.yebeh.2023.109565_b0145","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/brain\/aws019","article-title":"A developmental and genetic classification for malformations of cortical development: update 2012","volume":"135","author":"Barkovich","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2023.109565_b0150","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.molmed.2011.07.008","article-title":"mTOR: A pathogenic signaling pathway in developmental brain malformations","volume":"17","author":"Crino","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.yebeh.2023.109565_b0155","first-page":"1558","article-title":"Whole Transcriptome Screening Reveals Myelination Deficits in Dysplastic Human Temporal Neocortex","volume":"27","author":"Donkels","year":"2017","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.yebeh.2023.109565_b0160","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/brain\/awl001","article-title":"Large-scale expression study of human mesial temporal lobe epilepsy: evidence for dysregulation of the neurotransmission and complement systems in the entorhinal cortex","volume":"129","author":"Jamali","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2023.109565_b0165","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.seizure.2012.01.009","article-title":"A study of drug-resistant childhood epilepsy testing the new ILAE criteria","volume":"21","author":"Ramos-Lizana","year":"2012","journal-title":"Seizure - Eur J Epilepsy"},{"key":"10.1016\/j.yebeh.2023.109565_b0170","article-title":"Detection of brain somatic mutations in focal cortical dysplasia during epilepsy presurgical workup","author":"Checri","year":"20235174","journal-title":"Brain Commun"},{"key":"10.1016\/j.yebeh.2023.109565_b0175","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/s-0035-1552617","article-title":"Focal Cortical Dysplasia","volume":"35","author":"Crino","year":"2015","journal-title":"Semin Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-005-1016-6","article-title":"Neuropathological spectrum of cortical dysplasia in children with severe focal epilepsies","volume":"110","author":"Hildebrandt","year":"2005","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.yebeh.2023.109565_b0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1528-1167.2008.01682.x","article-title":"Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II","volume":"50","author":"Krsek","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0190","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0404.2005.00555.x","article-title":"Focal cortical dysplasia: prevalence, clinical presentation and epilepsy in children and adults","volume":"113","author":"Bast","year":"2006","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2023.109565_b0195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/epi.12179","article-title":"Predicting pharmacoresistance in pediatric epilepsy","volume":"54","author":"Wirrell","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0200","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/ana.21398","article-title":"Different features of histopathological subtypes of pediatric focal cortical dysplasia","volume":"63","author":"Krsek","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0205","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1111\/j.1528-1167.2011.03394.x","article-title":"Efficacy of the ketogenic diet: Which epilepsies respond?","volume":"53","author":"Thammongkol","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0210","doi-asserted-by":"crossref","first-page":"e330","DOI":"10.1542\/peds.2008-0012","article-title":"Long-Term Outcome of the Ketogenic Diet for Intractable Childhood Epilepsy With Focal Malformation of Cortical Development","volume":"122","author":"Jung","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.yebeh.2023.109565_b0215","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S1474-4422(20)30220-9","article-title":"Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study","volume":"19","author":"Lamberink","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0220","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1212\/WNL.53.4.715","article-title":"Clinical and imaging features of cortical malformations in childhood","volume":"53","author":"Leventer","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2023.109565_b0225","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/ana.24368","article-title":"Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations","volume":"77","author":"Baulac","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0230","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1161\/STROKEAHA.117.019202","article-title":"Vagus Nerve Stimulation Enhances Stable Plasticity and Generalization of Stroke Recovery","volume":"49","author":"Meyers","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.yebeh.2023.109565_b0235","doi-asserted-by":"crossref","first-page":"eaal1641","DOI":"10.1126\/science.aal1641","article-title":"Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network","volume":"356","author":"McConnell","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2023.109565_b0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nicl.2017.04.017","article-title":"Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI","volume":"15","author":"Adler","year":"2017","journal-title":"NeuroImage Clin"},{"key":"10.1016\/j.yebeh.2023.109565_b0245","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nm.3824","article-title":"Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy","volume":"21","author":"Lim","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.yebeh.2023.109565_b0250","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/ijlh.12426","article-title":"Comparison between different D-Dimer cutoff values to assess the individual risk of recurrent venous thromboembolism: analysis of results obtained in the DULCIS study","volume":"38","author":"Palareti","year":"2016","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.yebeh.2023.109565_b0255","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/neup.12242","article-title":"Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia","volume":"36","author":"Patil","year":"2016","journal-title":"Neuropathology"},{"key":"10.1016\/j.yebeh.2023.109565_b0260","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/01.jnen.0000171651.32460.19","article-title":"Distinct Allelic Variants of TSC1 and TSC2 in Epilepsy-Associated Cortical Malformations Without Balloon Cells","volume":"64","author":"Majores","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ana.10251","article-title":"Focal cortical dysplasia of Taylor\u2019s balloon cell type: Mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis","volume":"52","author":"Becker","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0270","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1111\/j.1528-1167.2008.01979.x","article-title":"Focal cortical dysplasia: A genotype\u2013phenotype analysis of polymorphisms and mutations in the TSC genes","volume":"50","author":"Gumbinger","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0275","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1001\/jamaneurol.2016.0363","article-title":"Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism","volume":"73","author":"Mirzaa","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2012.08.005","article-title":"Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes","volume":"161","author":"Giudicessi","year":"2013","journal-title":"Transl Res"},{"key":"10.1016\/j.yebeh.2023.109565_b0285","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev-pathol-052016-100138","article-title":"Focal Cortical Dysplasia: Gene Mutations, Cell Signaling, and Therapeutic Implications","volume":"12","author":"Iffland","year":"2017","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"10.1016\/j.yebeh.2023.109565_b0290","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1523\/JNEUROSCI.5685-08.2009","article-title":"Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice","volume":"29","author":"Zhou","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2023.109565_b0295","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.yebeh.2018.05.014","article-title":"MTOR pathway in focal cortical dysplasia type 2: What do we know?","volume":"85","author":"Majolo","year":"2018","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2023.109565_b0300","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The Phosphoinositide 3-Kinase Pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2023.109565_b0305","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00401-019-02061-5","article-title":"Dissecting the genetic basis of focal cortical dysplasia: a large cohort study","volume":"138","author":"Baldassari","year":"2019","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.yebeh.2023.109565_b0310","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/WCO.0000000000000175","article-title":"Epilepsy and malformations of cortical development: new developments","volume":"28","author":"Kuzniecky","year":"2015","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.yebeh.2023.109565_b0315","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroscience.2019.03.025","article-title":"Migration and Synaptic Aspects of Neurons Derived from Human Induced Pluripotent Stem Cells from Patients with Focal Cortical Dysplasia II","volume":"408","author":"Majolo","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2023.109565_b0320","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3892\/mmr.2017.6264","article-title":"Induced pluripotent stem cells from patients with focal cortical dysplasia and refractory epilepsy","volume":"15","author":"Marinowic","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.yebeh.2023.109565_b0325","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1172\/JCI127032","article-title":"Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy","volume":"129","author":"Kim","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yebeh.2023.109565_b0330","doi-asserted-by":"crossref","unstructured":"Majolo F, Marinowic D r., Machado D c., Da Costa J c. Notch signaling in human iPS-derived neuronal progenitor lines from Focal Cortical Dysplasia patients. Int J Dev Neurosci 2018;69:112\u20138. https:\/\/doi.org\/10.1016\/j.ijdevneu.2018.07.006.","DOI":"10.1016\/j.ijdevneu.2018.07.006"},{"key":"10.1016\/j.yebeh.2023.109565_b0335","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.brainresbull.2019.11.016","article-title":"Analysis of genes involved in cell proliferation, adhesion, and control of apoptosis during embryonic neurogenesis in Induced Pluripotent Stem Cells (iPSCs) from patients with Focal Cortical Dysplasia","volume":"155","author":"Marinowic","year":"2020","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.yebeh.2023.109565_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2020.151523","article-title":"mTOR pathway activation in focal cortical dysplasia","volume":"46","author":"Kumari","year":"2020","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.yebeh.2023.109565_b0345","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2017.01.012","article-title":"Epigenetics in epilepsy","volume":"667","author":"Kobow","year":"2018","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2023.109565_b0350","article-title":"Epigenetics and Epilepsy","volume":"5","author":"Henshall","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.yebeh.2023.109565_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105179","article-title":"Epigenetic principles underlying epileptogenesis and epilepsy syndromes","volume":"148","author":"Conboy","year":"2021","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.yebeh.2023.109565_b0360","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/1073858417705840","article-title":"The Epigenetics of Epilepsy and Its Progression","volume":"24","author":"Hauser","year":"2018","journal-title":"Neuroscientist"},{"key":"10.1016\/j.yebeh.2023.109565_b0365","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.eplepsyres.2014.01.005","article-title":"miRNA expression analysis in cortical dysplasia: Regulation of mTOR and LIS1 pathway","volume":"108","author":"Lee","year":"2014","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2023.109565_b0370","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.yebeh.2023.109565_b0375","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.yebeh.2023.109565_b0380","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/epi.14934","article-title":"Genomic DNA methylation distinguishes subtypes of human focal cortical dysplasia","volume":"60","author":"Kobow","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2023.109565_b0385","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00401-013-1168-8","article-title":"Deep sequencing reveals increased DNA methylation in chronic rat epilepsy","volume":"126","author":"Kobow","year":"2013","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.yebeh.2023.109565_b0390","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1111\/epi.13913","article-title":"Seizures, syndromes, and etiologies in childhood epilepsy: The International League Against Epilepsy 1981, 1989, and 2017 classifications used in a population-based cohort","volume":"58","author":"Aaberg","year":"2017","journal-title":"Epilepsia"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023004845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505023004845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T13:16:35Z","timestamp":1736428595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505023004845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":78,"alternative-id":["S1525505023004845"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109565","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epileptogenesis and drug-resistant in focal cortical dysplasias: Update on clinical, cellular, and molecular markers","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2023.109565","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109565"}}