{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:57:31Z","timestamp":1761505051070,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.yebeh.2024.109688","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T18:01:04Z","timestamp":1709229664000},"page":"109688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Tuberous sclerosis complex in adulthood: focus on epilepsy prognosis"],"prefix":"10.1016","volume":"153","author":[{"given":"Laura","family":"Licchetta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Bruschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Stipa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Maria Beatrice","family":"Belotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Mostacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Vignatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Minardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Di Vito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Muccioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Boni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Tinuper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bisulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2024.109688_b0005","doi-asserted-by":"crossref","unstructured":"Henske EP, J\u00f3\u017awiak S, Kingswood JC, Sampson JR, Thiele EA. Tuberous sclerosis complex. Nat Rev Dis Primers. 2016;2:16035. Published 2016 May 26. doi:10.1038\/nrdp.2016.35.","DOI":"10.1038\/nrdp.2016.35"},{"key":"10.1016\/j.yebeh.2024.109688_b0010","unstructured":"Northrup H, Koenig MK, Pearson DA, Au KS. Tuberous Sclerosis Complex. In: Adam MP, Feldman J, Mirzaa GM, et al., eds.GeneReviews\u00ae. Seattle (WA): University of Washington, Seattle; July 13, 1999. Last Revision: December 9, 2021."},{"key":"10.1016\/j.yebeh.2024.109688_b0015","doi-asserted-by":"crossref","unstructured":"Kwiatkowski DJ, Manning BD. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet. 2005;14 Spec No. 2:R251-R258. doi:10.1093\/hmg\/ddi260.","DOI":"10.1093\/hmg\/ddi260"},{"issue":"9","key":"10.1016\/j.yebeh.2024.109688_b0020","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1177\/08830738040190091301","article-title":"Molecular pathogenesis of tuber formation in tuberous sclerosis complex","volume":"19","author":"Crino","year":"2004","journal-title":"J Child Neurol"},{"issue":"12","key":"10.1016\/j.yebeh.2024.109688_b0025","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/jnen\/63.12.1236","article-title":"Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation","volume":"63","author":"Chan","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.yebeh.2024.109688_b0030","doi-asserted-by":"crossref","unstructured":"Caban C, Khan N, Hasbani DM, Crino PB. Genetics of tuberous sclerosis complex: implications for clinical practice. Appl Clin Genet. 2016;10:1-8. Published 2016 Dec 21. doi:10.2147\/TACG.S90262.","DOI":"10.2147\/TACG.S90262"},{"key":"10.1016\/j.yebeh.2024.109688_b0035","doi-asserted-by":"crossref","unstructured":"Specchio N, Nabbout R, Aronica E, et al. Updated clinical recommendations for the management of tuberous sclerosis complex associated epilepsy [published online ahead of print, 2023 Aug 30]. Eur J Paediatr Neurol. 2023;47:25-34. doi:10.1016\/j.ejpn.2023.08.005.","DOI":"10.1016\/j.ejpn.2023.08.005"},{"key":"10.1016\/j.yebeh.2024.109688_b0040","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pediatrneurol.2021.07.011","article-title":"Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations","volume":"123","author":"Northrup","year":"2021","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.yebeh.2024.109688_b0045","first-page":"1","article-title":"Zur Diagnostik der tuberosen sklerose","volume":"2","author":"Vogt","year":"1908","journal-title":"Z Erforsch Behandl Jugeudl Schwachsinns"},{"key":"10.1016\/j.yebeh.2024.109688_b0050","doi-asserted-by":"crossref","unstructured":"Nabbout R, Belousova E, Benedik MP, et al. Epilepsy in tuberous sclerosis complex: Findings from the TOSCA Study.Epilepsia Open. 2018;4(1):73-84. Published 2018 Dec 21. doi:10.1002\/epi4.12286.","DOI":"10.1002\/epi4.12286"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109688_b0055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jaad.2007.05.004","article-title":"Tuberous sclerosis complex: advances in diagnosis, genetics, and management","volume":"57","author":"Schwartz","year":"2007","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109688_b0060","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1542\/peds.2010-0192","article-title":"Tuberous sclerosis complex: diagnostic challenges, presenting symptoms, and commonly missed signs","volume":"127","author":"Staley","year":"2011","journal-title":"Pediatrics"},{"issue":"12","key":"10.1016\/j.yebeh.2024.109688_b0065","doi-asserted-by":"crossref","first-page":"806","DOI":"10.7326\/0003-4819-154-12-201106210-00008","article-title":"Recognition of tuberous sclerosis in adult women: delayed presentation with life-threatening consequences","volume":"154","author":"Seibert","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.yebeh.2024.109688_b0070","doi-asserted-by":"crossref","unstructured":"De Sautu De Borb\u00f3n EC, Guerra Vales JM, Lumbreras Bermejo C, et al. Clinical, genetic and quality-of-life study of a cohort of adult patients with tuberous sclerosis. Orphanet J Rare Dis. 2021;16(1):243. Published 2021 May 31. doi:10.1186\/s13023-021-01878-2.","DOI":"10.1186\/s13023-021-01878-2"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109688_b0075","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/epi.17159","article-title":"Adults with tuberous sclerosis complex: A distinct patient population","volume":"63","author":"Bachour","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109688_b0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pediatrneurol.2019.12.016","article-title":"Epilepsy and Neurodevelopmental Comorbidities in Tuberous Sclerosis Complex: A Natural History Study","volume":"106","author":"Gupta","year":"2020","journal-title":"Pediatr Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109688_b0085","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/dmcn.14356","article-title":"Long-term cognitive outcomes in tuberous sclerosis complex","volume":"62","author":"Tye","year":"2020","journal-title":"Dev Med Child Neurol"},{"issue":"10","key":"10.1016\/j.yebeh.2024.109688_b0090","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1177\/088307380001501003","article-title":"Usefulness of diagnostic criteria of tuberous sclerosis complex in pediatric patients","volume":"15","author":"J\u00f3zwiak","year":"2000","journal-title":"J Child Neurol"},{"issue":"6","key":"10.1016\/j.yebeh.2024.109688_b0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1017\/S0012162206001058","article-title":"Tuberous sclerosis complex: clinical features, diagnosis, and prevalence within Northern Ireland","volume":"48","author":"Devlin","year":"2006","journal-title":"Dev Med Child Neurol"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109688_b0100","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1469-8749.1996.tb12086.x","article-title":"Morbidity associated with tuberous sclerosis: a population study","volume":"38","author":"Webb","year":"1996","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.yebeh.2024.109688_b0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.seizure.2017.10.005","article-title":"Epilepsy in tuberous sclerosis patients in Sweden - Healthcare utilization, treatment, morbidity, and mortality using national register data","volume":"53","author":"Welin","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2024.109688_b0110","doi-asserted-by":"crossref","unstructured":"Kingswood JC, d'Aug\u00e8res GB, Belousova E, et al. TuberOus SClerosis registry to increase disease Awareness (TOSCA) - baseline data on 2093 patients. Orphanet J Rare Dis. 2017;12(1):2. Published 2017 Jan 5. doi:10.1186\/s13023-016-0553-5.","DOI":"10.1186\/s13023-016-0553-5"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109688_b0115","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1528-1167.2009.02474.x","article-title":"The natural history of epilepsy in tuberous sclerosis complex","volume":"51","author":"Chu-Shore","year":"2010","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.yebeh.2024.109688_b0120","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0025-6196(12)61196-3","article-title":"Causes of death in patients with tuberous sclerosis","volume":"66","author":"Shepherd","year":"1991","journal-title":"Mayo Clin Proc"},{"issue":"Suppl 3","key":"10.1016\/j.yebeh.2024.109688_b0125","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/epi.12722","article-title":"Transition into adulthood: tuberous sclerosis complex, Sturge-Weber syndrome, and Rasmussen encephalitis","volume":"55","author":"Thiele","year":"2014","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109688_b0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-4632.2010.04727.x","article-title":"Tuberous sclerosis complex: tumors and tumorigenesis","volume":"50","author":"Borkowska","year":"2011","journal-title":"Int J Dermatol"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109688_b0135","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.molmed.2010.05.001","article-title":"Tuberous sclerosis complex: linking cancer to metabolism","volume":"16","author":"Mieulet","year":"2010","journal-title":"Trends Mol Med"},{"issue":"10","key":"10.1016\/j.yebeh.2024.109688_b0140","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/sj.ki.5001853","article-title":"Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors","volume":"70","author":"Rakowski","year":"2006","journal-title":"Kidney Int"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109688_b0145","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/hmg\/ddu597","article-title":"A shower of second hit events as the cause of multifocal renal cell carcinoma in tuberous sclerosis complex","volume":"24","author":"Tyburczy","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.yebeh.2024.109688_b0150","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/ajmg.a.37644","article-title":"Do patients with tuberous sclerosis complex have an increased risk for malignancies?","volume":"170","author":"Peron","year":"2016","journal-title":"Am J Med Genet A"},{"issue":"9","key":"10.1016\/j.yebeh.2024.109688_b0155","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archneur.60.9.1286","article-title":"Seizure remission and antiepileptic drug discontinuation in children with tuberous sclerosis complex","volume":"60","author":"Sparagana","year":"2003","journal-title":"Arch Neurol"},{"issue":"12","key":"10.1016\/j.yebeh.2024.109688_b0160","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1111\/epi.12430","article-title":"Epilepsy in TSC: certain etiology does not mean certain prognosis","volume":"54","author":"Vignoli","year":"2013","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.yebeh.2024.109688_b0165","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jcma.2018.02.001","article-title":"Trend of seizure remission in patients with tuberous sclerosis complex: A retrospective medical review","volume":"81","author":"Wei","year":"2018","journal-title":"J Chin Med Assoc"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109688_b0170","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/ane.13416","article-title":"Epilepsy in adult patients with tuberous sclerosis complex","volume":"144","author":"Vignoli","year":"2021","journal-title":"Acta Neurol Scand"},{"issue":"14","key":"10.1016\/j.yebeh.2024.109688_b0175","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1177\/0883073817737446","article-title":"Predictors of Drug-Resistant Epilepsy in Tuberous Sclerosis Complex","volume":"32","author":"Jeong","year":"2017","journal-title":"J Child Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109688_b0180","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00381-019-04066-7","article-title":"Factors affecting epilepsy prognosis in patients with tuberous sclerosis","volume":"35","author":"G\u00fcl Mert","year":"2019","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.yebeh.2024.109688_b0185","article-title":"Electro-clinical and neurodevelopmental outcome in six children with early diagnosis of tuberous sclerosis complex and role of the genetic background. Ital","author":"Savini","year":"202046136","journal-title":"J Pediatr"},{"issue":"12","key":"10.1016\/j.yebeh.2024.109688_b0190","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1212\/01.wnl.0000280579.04974.c0","article-title":"Cognitive impairment in tuberous sclerosis complex is a multifactorial condition","volume":"70","author":"Jansen","year":"2008","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109688_b0195","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1212\/01.wnl.0000250330.44291.54","article-title":"Cognitive prognosis of patients with tuberous sclerosis complex","volume":"68","author":"Winterkorn","year":"2007","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.yebeh.2024.109688_b0200","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1179\/016164107X163996","article-title":"Neurological aspects of tuberous sclerosis in relation to MRI\/MR spectroscopy findings in children with epilepsy","volume":"29","author":"Yapici","year":"2007","journal-title":"Neurol Res"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109688_b0205","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ejpn.2018.03.001","article-title":"Early predictors of clinical and mental outcome in tuberous sclerosis complex: A prospective study","volume":"22","author":"Benova","year":"2018","journal-title":"Eur J Paediatr Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109688_b0210","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4068\/cmj.2011.47.3.150","article-title":"Clinical progress of epilepsy in children with tuberous sclerosis: prognostic factors for seizure outcome","volume":"47","author":"Park","year":"2011","journal-title":"Chonnam Med J"},{"key":"10.1016\/j.yebeh.2024.109688_b0215","doi-asserted-by":"crossref","unstructured":"Wong M. The role of glia in epilepsy, intellectual disability, and other neurodevelopmental disorders in tuberous sclerosis complex.J Neurodev Disord. 2019;11(1):30. Published 2019 Dec 16. doi:10.1186\/s11689-019-9289-6.","DOI":"10.1186\/s11689-019-9289-6"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109688_b0220","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S2352-4642(18)30099-3","article-title":"Adjunctive everolimus for children and adolescents with treatment-refractory seizures associated with tuberous sclerosis complex: post-hoc analysis of the phase 3 EXIST-3 trial","volume":"2","author":"Curatolo","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"issue":"15","key":"10.1016\/j.yebeh.2024.109688_b0225","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2147\/TCRM.S145630","article-title":"Everolimus for the treatment of refractory seizures associated with tuberous sclerosis complex (TSC): current perspectives","volume":"26","author":"Overwater","year":"2019","journal-title":"Ther Clin Risk Manag"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109688_b0230","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/epi.16829","article-title":"Everolimus in adult tuberous sclerosis complex patients with epilepsy: Too late for success? A retrospective study","volume":"62","author":"Stockinger","year":"2021","journal-title":"Epilepsia"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024000696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024000696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:52:29Z","timestamp":1761504749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505024000696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":46,"alternative-id":["S1525505024000696"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.109688","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tuberous sclerosis complex in adulthood: focus on epilepsy prognosis","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.109688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109688"}}