{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:30:07Z","timestamp":1777591807462,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.yebeh.2024.109726","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T22:43:40Z","timestamp":1710974620000},"page":"109726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Understanding neurodevelopmental trajectories and behavioral profiles in SCN1A-related epilepsy syndromes"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6282-4985","authenticated-orcid":false,"given":"Amber","family":"Postma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crista A.","family":"Minderhoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim M.","family":"Otte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floor E.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.B.","family":"Gunning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith S.","family":"Verhoeven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian J.","family":"Jongmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneke R.","family":"Zinkstok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva H.","family":"Brilstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2024.109726_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yebeh.2022.108661","article-title":"The clinical, economic, and humanistic burden of dravet syndrome \u2013 a systematic literature review","volume":"130","author":"Sullivan","year":"2022","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2024.109726_b0010","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.yebeh.2018.09.041","article-title":"Outcomes and comorbidities of SCN1A-related seizure disorders","volume":"90","author":"de Lange","year":"2019","journal-title":"Epilepsy Behav"},{"issue":"S3","key":"10.1016\/j.yebeh.2024.109726_b0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/epi.16386","article-title":"SCN1A-related phenotypes: epilepsy and beyond","volume":"60","author":"Scheffer","year":"2019","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109726_b0020","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0b013e31820c309b","article-title":"Genotype-phenotype associations in SCN1A-related epilepsies","volume":"76","author":"Zuberi","year":"2011","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.yebeh.2024.109726_b0025","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1177\/0883073808314162","article-title":"Coping with a child with dravet syndrome: insights from families","volume":"23","author":"Nolan","year":"2008","journal-title":"J Child Neurol"},{"key":"10.1016\/j.yebeh.2024.109726_b0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.yebeh.2017.06.012","article-title":"Life impact of caregiving for severe childhood epilepsy: results of expert panels and caregiver focus groups","volume":"74","author":"Jensen","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2024.109726_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108978","article-title":"Challenging behavior in children and adolescents with dravet syndrome: exploring the lived experiences of parents","volume":"138","author":"Postma","year":"2023","journal-title":"Epilepsy Behav"},{"issue":"76","key":"10.1016\/j.yebeh.2024.109726_b0040","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pediatrneurol.2017.06.008","article-title":"Parental perception of comorbidities in children with dravet syndrome","volume":"2017","author":"Knupp","year":"2017","journal-title":"Pediatr Neurol"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109726_b0045","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejpn.2018.09.012","article-title":"More daytime sleepiness and worse quality of sleep in patients with dravet syndrome compared to other epilepsy patients","volume":"23","author":"Schoonjans","year":"2019","journal-title":"Eur J Paediatr Neurol"},{"issue":"8","key":"10.1016\/j.yebeh.2024.109726_b0050","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/j.1528-1167.2011.03129.x","article-title":"Comorbidities and predictors of health-related quality of life in dravet syndrome","volume":"52","author":"Brunklaus","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109726_b0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.yebeh.2018.11.029","article-title":"Behavior problems and health-related quality of life in dravet syndrome","volume":"90","author":"Sinoo","year":"2019","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2024.109726_b0060","article-title":"Long-term predictors of developmental outcome and disease burden in SCN1A-positive dravet syndrome","author":"Feng","year":"202461004","journal-title":"Brain Commun"},{"key":"10.1016\/j.yebeh.2024.109726_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yebeh.2023.109193","article-title":"Emotional experiences of family caregivers of children with dravet syndrome","volume":"142","author":"Domaradzki","year":"2023","journal-title":"Epilepsy Behav"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109726_b0070","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/epi.17531","article-title":"Comorbidities and predictors of health-related quality of life in dravet syndrome: a 10-year, prospective follow-up study","volume":"64","author":"Makiello","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109726_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yebeh.2020.107079","article-title":"Intellectual functioning and behavior in dravet syndrome: a systematic review","volume":"108","author":"Jansson","year":"2020","journal-title":"Epilepsy Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109726_b0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/dmcn.13591","article-title":"Quality of life and comorbidities associated with dravet syndrome severity: a multinational cohort survey","volume":"60","author":"Lagae","year":"2018","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.yebeh.2024.109726_b0085","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1093\/brain\/aws151","article-title":"Prognostic, clinical and demographic features in SCN1A mutation-positive dravet syndrome","volume":"135","author":"Brunklaus","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2024.109726_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109361","article-title":"Gastrointestinal and eating problems in SCN1A-related seizure disorders","volume":"146","author":"Minderhoud","year":"2023","journal-title":"Epilepsy Behav"},{"issue":"5","key":"10.1016\/j.yebeh.2024.109726_b0095","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the american College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.yebeh.2024.109726_b0100","unstructured":"Stichting Dravetsyndroom Nederland\/Vlaanderen [Internet]. 2014. Available from: https:\/\/www.dravetsyndroom.eu\/."},{"key":"10.1016\/j.yebeh.2024.109726_b0105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pediatrneurol.2017.01.025","article-title":"Optimizing the diagnosis and Management of Dravet Syndrome: recommendations from a north american consensus panel","volume":"68","author":"Wirrell","year":"2017","journal-title":"Pediatr Neurol"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109726_b0110","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/epi.17274","article-title":"International consensus on diagnosis and management of dravet syndrome","volume":"63","author":"Wirrell","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109726_b0115","unstructured":"Achenbach TM, Leslie A. Rescorla. Manual for the ASEBA preschool forms and profiles. In: Journal of Child and Family Studies. 2000."},{"key":"10.1016\/j.yebeh.2024.109726_b0120","series-title":"Manual for the ASEBA school-age forms & profiles: an integrated system of multi-informant assessment Burlington","author":"Achenbach","year":"2001"},{"key":"10.1016\/j.yebeh.2024.109726_b0125","series-title":"Rescorla L a","author":"Achenbach","year":"2003"},{"key":"10.1016\/j.yebeh.2024.109726_b0130","article-title":"Achenbach system of empirically based assessment (ASEBA): development, findings, theory, and applications","author":"Achenbach","year":"2009","journal-title":"In: Encyclopedia of Autism Spectrum Disorders"},{"key":"10.1016\/j.yebeh.2024.109726_b0135","doi-asserted-by":"crossref","DOI":"10.1542\/pir.21.8.265","article-title":"The child behavior checklist and related forms for assessing behavioral\/emotional problems and competencies","author":"Achenbach","year":"2000","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.yebeh.2024.109726_b0140","series-title":"Multicultural supplement to the manual for the ASEBA Preschool Forms & Profiles","author":"Achenbach","year":"2010"},{"issue":"8","key":"10.1016\/j.yebeh.2024.109726_b0145","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/00005650-200108000-00006","article-title":"4.0: reliability and validity of the pediatric quality of life InventoryTM version 4.0 generic Core scales in healthy and patient populations","volume":"39","author":"Varni","year":"2001","journal-title":"Med Care"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109726_b0150","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0002-7138(09)60942-0","article-title":"Prevalence of sleep disorders and sleep behaviors in children and adolescents","volume":"21","author":"Simonds","year":"1982","journal-title":"J Am Acad Child Psychiatry"},{"issue":"6","key":"10.1016\/j.yebeh.2024.109726_b0155","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-2788.1996.tb00662.x","article-title":"Severe sleep disturbance and daytime challenging behaviour in children with severe learning disabilities","volume":"40","author":"Wiggs","year":"1996","journal-title":"J Intellect Disabil Res"},{"issue":"5","key":"10.1016\/j.yebeh.2024.109726_b0160","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/01241398-200409000-00011","article-title":"The functional mobility scale (FMS)","volume":"24","author":"Graham","year":"2004","journal-title":"J Pediatr Orthop"},{"issue":"394","key":"10.1016\/j.yebeh.2024.109726_b0165","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/01621459.1986.10478280","article-title":"Multiple imputation for interval estimation from simple random samples with ignorable nonresponse","volume":"81","author":"Rubin","year":"1986","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.yebeh.2024.109726_b0170","series-title":"Manual for the ASEBA school-age forms & profiles: an integrated system of multi-informant assessment Burlington, VT: University of Vermont","author":"Achenbach","year":"2001"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109726_b0175","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jfma.2011.08.022","article-title":"ADHD-related symptoms, emotional\/behavioral problems, and physical conditions in taiwanese children with epilepsy","volume":"112","author":"Tsai","year":"2013","journal-title":"J Formos Med Assoc"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109726_b0180","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.yebeh.2008.05.016","article-title":"The effect of depression on academic achievement in children with epilepsy","volume":"13","author":"Tosun","year":"2008","journal-title":"Epilepsy Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109726_b0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yebeh.2007.07.008","article-title":"Family function in cognitively normal children with epilepsy: impact on competence and problem behaviors","volume":"12","author":"Thornton","year":"2008","journal-title":"Epilepsy Behav"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109726_b0190","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3934\/Neuroscience.2022015","article-title":"Assessment of behavioural problems in preschool and school going children with epilepsy","volume":"9","author":"Shanmuganathan","year":"2022","journal-title":"AIMS Neurosci"},{"key":"10.1016\/j.yebeh.2024.109726_b0195","unstructured":"Fariba KA, Saadabadi A. Topiramate. [Updated 2023 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554530\/."},{"issue":"4","key":"10.1016\/j.yebeh.2024.109726_b0200","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.psc.2015.07.001","article-title":"The relationship between sleep disturbances and psychiatric disorders: introduction and overview","volume":"38","author":"Winokur","year":"2015","journal-title":"Psychiatr Clin North Am"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109726_b0205","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/DBP.0000000000000134","article-title":"Stability of sleep disorders from preschool to first grade and their bidirectional relationship with psychiatric symptoms","volume":"36","author":"Steinsbekk","year":"2015","journal-title":"J Dev Behav Pediatr"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109726_b0210","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1365-2788.1996.768768.x","article-title":"Population prevalence of psychopathology in children and adolescents with intellectual disability: II epidemiological findings","volume":"40","author":"Einfeld","year":"1996","journal-title":"J Intellect Disabil Res"},{"issue":"5","key":"10.1016\/j.yebeh.2024.109726_b0215","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/1039856217706820","article-title":"Psychopathology of adolescents with an intellectual disability who present to general hospital services","volume":"25","author":"Theodoratos","year":"2017","journal-title":"Australas Psychiatry"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109726_b0220","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.yebeh.2012.09.018","article-title":"Antiepileptic drug effects on mood and behavior: molecular targets","volume":"26","author":"Perucca","year":"2013","journal-title":"Epilepsy Behav"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024001070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024001070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T23:14:17Z","timestamp":1714691657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505024001070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":44,"alternative-id":["S1525505024001070"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.109726","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding neurodevelopmental trajectories and behavioral profiles in SCN1A-related epilepsy syndromes","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.109726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109726"}}