{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T14:16:49Z","timestamp":1792937809969,"version":"4.5.0"},"reference-count":139,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Provincial Medical Research Foundation","doi-asserted-by":"publisher","award":["A2022203"],"award-info":[{"award-number":["A2022203"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022A1515012615"],"award-info":[{"award-number":["2022A1515012615"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017290","name":"Technology Bureau of Zhanjiang Municipality","doi-asserted-by":"publisher","award":["2021A05051"],"award-info":[{"award-number":["2021A05051"]}],"id":[{"id":"10.13039\/501100017290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001368"],"award-info":[{"award-number":["82001368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.yebeh.2024.109849","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T18:03:16Z","timestamp":1717092196000},"page":"109849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Alzheimer\u2019s disease and epilepsy: Research hotspots for comorbidity in the era of global aging"],"prefix":"10.1016","volume":"157","author":[{"given":"Xu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-5987","authenticated-orcid":false,"given":"Hua","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2024.109849_b0005","doi-asserted-by":"crossref","first-page":"1333781","DOI":"10.1016\/j.jclepro.2022.133781","article-title":"Spatiotemporal heterogeneity in associations of national population ageing with socioeconomic and environmental factors at the global scale","volume":"373","author":"Wan","year":"2022","journal-title":"J Clean Prod"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1684\/epd.2016.0808","article-title":"From here to epilepsy: the risk of seizure in patients with Alzheimer's disease","volume":"18","author":"Nicastro","year":"2016","journal-title":"Epileptic Disord"},{"issue":"9","key":"10.1016\/j.yebeh.2024.109849_b0015","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1212\/WNL.0000000000003048","article-title":"Seizures in dominantly inherited Alzheimer disease","volume":"87","author":"Zarea","year":"2016","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0020","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.0013-9580.2005.02104.x","article-title":"Cognitive functioning in community dwelling older adults with chronic partial epilepsy","volume":"46","author":"Martin","year":"2005","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.yebeh.2005.09.004","article-title":"Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairment","volume":"8","author":"Griffith","year":"2006","journal-title":"Epilepsy Behav"},{"issue":"5","key":"10.1016\/j.yebeh.2024.109849_b0030","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/BF00294177","article-title":"Senile plaques in temporal lobe epilepsy","volume":"87","author":"Mackenzie","year":"1994","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.yebeh.2024.109849_b0035","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.eplepsyres.2017.09.006","article-title":"Brain glucose metabolism and its relation to amyloid load in middle-aged adults with childhood-onset epilepsy","volume":"137","author":"Joutsa","year":"2017","journal-title":"Epilepsy Res"},{"issue":"11","key":"10.1016\/j.yebeh.2024.109849_b0040","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2174\/1570159X20666220507020635","article-title":"Epilepsy and Alzheimer's disease: current concepts and treatment perspective on two closely related pathologies","volume":"20","author":"Leo","year":"2022","journal-title":"Curr Neuropharmacol"},{"issue":"12","key":"10.1016\/j.yebeh.2024.109849_b0045","article-title":"Treatment of epilepsy for people with Alzheimer's disease","volume":"12","author":"Liu","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"10.1016\/j.yebeh.2024.109849_b0050","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1080\/14656566.2018.1496237","article-title":"Pharmacotherapeutic strategies for treating epilepsy in patients with Alzheimer's disease","volume":"19","author":"Cretin","year":"2018","journal-title":"Expert Opin Pharmacother"},{"issue":"8","key":"10.1016\/j.yebeh.2024.109849_b0055","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s11064-021-03332-y","article-title":"Alzheimer's disease and epilepsy: a perspective on the opportunities for overlapping therapeutic innovation","volume":"46","author":"Lehmann","year":"2021","journal-title":"Neurochem Res"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0060","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1590\/S1980-57642014DN81000010","article-title":"Epilepsy in patients with Alzheimer's disease: a systematic review","volume":"8","author":"Miranda","year":"2014","journal-title":"Dement Neuropsychol"},{"issue":"11","key":"10.1016\/j.yebeh.2024.109849_b0065","doi-asserted-by":"crossref","first-page":"e3221","DOI":"10.1002\/brb3.3221","article-title":"The bidirectional relationship between Alzheimer's disease (AD) and epilepsy: a Mendelian randomization study","volume":"13","author":"Xu","year":"2023","journal-title":"Brain Behav"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0070","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2217\/fnl.12.8","article-title":"Alzheimer's disease and epilepsy: insight from animal models","volume":"7","author":"Scharfman","year":"2012","journal-title":"Future Neurol"},{"key":"10.1016\/j.yebeh.2024.109849_b0075","article-title":"Amyloid-\u03b2 plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation","volume":"24","author":"Zhuohao","year":"2017","journal-title":"Nat Med"},{"issue":"21","key":"10.1016\/j.yebeh.2024.109849_b0080","doi-asserted-by":"crossref","first-page":"8266","DOI":"10.1073\/pnas.85.21.8266","article-title":"Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21","volume":"85","author":"Patterson","year":"1988","journal-title":"PNAS"},{"key":"10.1016\/j.yebeh.2024.109849_b0085","doi-asserted-by":"crossref","unstructured":"R W M, O E S, R J M. Prevalence and associated features of epilepsy in adults with Down's syndrome. Br J Psychiatry 1994;164.","DOI":"10.1192\/bjp.164.4.528"},{"key":"10.1016\/j.yebeh.2024.109849_b0090","doi-asserted-by":"crossref","unstructured":"R A C, S A C. Epilepsy in adults with Down's syndrome. Br J Psychiatry 1994;165.","DOI":"10.1192\/bjp.165.1.117a"},{"key":"10.1016\/j.yebeh.2024.109849_b0095","article-title":"Phenotype associated with APP duplication in five families","volume":"129","author":"Lucie","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2024.109849_b0100","article-title":"Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy","volume":"29","author":"Rimante","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2024.109849_b0105","article-title":"Genetic analyses of early-onset Alzheimer's disease using next generation sequencing","volume":"9","author":"Vo Van","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.yebeh.2024.109849_b0110","article-title":"Tau oligomerization on microtubules in health and disease","volume":"81","author":"Kassandra","year":"2023","journal-title":"Cytoskeleton (Hoboken)"},{"key":"10.1016\/j.yebeh.2024.109849_b0115","article-title":"Microtubules gate tau condensation to spatially regulate microtubule functions","volume":"21","author":"Ruensern","year":"2019","journal-title":"Nat Cell Biol"},{"issue":"9","key":"10.1016\/j.yebeh.2024.109849_b0120","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.neurobiolaging.2013.03.015","article-title":"Tau phosphorylation affects its axonal transport and degradation","volume":"34","author":"Rodr\u00edguez-Mart\u00edn","year":"2013","journal-title":"Neurobiol Aging"},{"issue":"9","key":"10.1016\/j.yebeh.2024.109849_b0125","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1096\/fj.08-109181","article-title":"Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin","volume":"22","author":"Cuchillo-Ibanez","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.yebeh.2024.109849_b0130","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","article-title":"Neurodegenerative tauopathies","volume":"24","author":"Lee","year":"2001","journal-title":"Annu Rev Neurosci"},{"issue":"5825","key":"10.1016\/j.yebeh.2024.109849_b0135","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science (New York, NY)"},{"issue":"6","key":"10.1016\/j.yebeh.2024.109849_b0140","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.ajpath.2012.08.012","article-title":"Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP\/PS1 mice","volume":"181","author":"Leroy","year":"2012","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0145","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.nbd.2011.12.005","article-title":"Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models","volume":"45","author":"Jones","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.yebeh.2024.109849_b0150","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/brain\/aww116","article-title":"Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau","volume":"139","author":"Liu","year":"2016","journal-title":"Brain J Neurol"},{"key":"10.1016\/j.yebeh.2024.109849_b0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.seizure.2021.06.028","article-title":"Brain concentrations of glutamate and GABA in human epilepsy: a review","volume":"91","author":"Sarlo","year":"2021","journal-title":"Seizure"},{"issue":"12","key":"10.1016\/j.yebeh.2024.109849_b0160","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1134\/S0006297923120027","article-title":"Changes in the glutamate\/GABA system in the hippocampus of rats with age and during alzheimer's disease signs development","volume":"88","author":"Burnyasheva","year":"2023","journal-title":"Biochem Biokhimiia"},{"issue":"5","key":"10.1016\/j.yebeh.2024.109849_b0165","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"issue":"22","key":"10.1016\/j.yebeh.2024.109849_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228704","article-title":"Impaired expression of GABA signaling components in the Alzheimer's disease middle temporal gyrus","volume":"21","author":"Govindpani","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.yebeh.2024.109849_b0175","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/archneur.1982.00510230035010","article-title":"Decreased CSF concentrations of homovanillic acid and gamma-aminobutyric acid in Alzheimer's disease. Age- or disease-related modifications?","volume":"39","author":"Bareggi","year":"1982","journal-title":"Arch Neurol"},{"issue":"10","key":"10.1016\/j.yebeh.2024.109849_b0180","first-page":"e30195","article-title":"The association between Alzheimer's disease and epilepsy: a narrative review","volume":"14","author":"Purushotham","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.yebeh.2024.109849_b0185","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/neuro.05.028.2009","article-title":"Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques","volume":"3","author":"Garcia-Marin","year":"2009","journal-title":"Front Neuroanat"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0190","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12964-024-01528-7","article-title":"Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer's disease","volume":"22","author":"Mao","year":"2024","journal-title":"Cell Commun Signal"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109849_b0195","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1111\/epi.16918","article-title":"Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease","volume":"62","author":"Dejakaisaya","year":"2021","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0200","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1046\/j.1471-4159.2001.00322.x","article-title":"Transfer of glutamine between astrocytes and neurons","volume":"77","author":"Br\u00f6er","year":"2001","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0205","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1471-4159.2003.02330.x","article-title":"Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease","volume":"89","author":"Hynd","year":"2004","journal-title":"J Neurochem"},{"issue":"8","key":"10.1016\/j.yebeh.2024.109849_b0210","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022863","article-title":"Glutamatergic mechanisms associated with seizures and epilepsy","volume":"5","author":"Barker-Haliski","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.yebeh.2024.109849_b0215","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer's disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0220","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-007-0312-8","article-title":"Alzheimer disease models and human neuropathology: similarities and differences","volume":"115","author":"Duyckaerts","year":"2008","journal-title":"Acta Neuropathol"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0225","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nm838","article-title":"Adult mouse astrocytes degrade amyloid-beta in vitro and in situ","volume":"9","author":"Wyss-Coray","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.yebeh.2024.109849_b0230","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.nbd.2016.08.001","article-title":"Astrocytes from old Alzheimer's disease mice are impaired in A\u03b2 uptake and in neuroprotection","volume":"96","author":"Iram","year":"2016","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0235","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.yebeh.2024.109849_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27061816","article-title":"Role of cholinergic signaling in Alzheimer's disease","volume":"27","author":"Chen","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.yebeh.2024.109849_b0245","article-title":"Review: cholinesterase inhibitors have a modest effect on neuropsychiatric and functional outcomes in Alzheimer's disease","volume":"6","author":"Debomoy","year":"2003","journal-title":"Evid Based Ment Health"},{"key":"10.1016\/j.yebeh.2024.109849_b0250","article-title":"Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis","volume":"289","author":"Nhi-Ha","year":"2003","journal-title":"J Am Med Assoc"},{"issue":"Pt 3","key":"10.1016\/j.yebeh.2024.109849_b0255","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/brain\/awm322","article-title":"EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up","volume":"131","author":"Bonanni","year":"2008","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.yebeh.2024.109849_b0260","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.clinph.2005.07.007","article-title":"Human EEG gamma oscillations in neuropsychiatric disorders","volume":"116","author":"Herrmann","year":"2005","journal-title":"Clin Neurophysiol"},{"issue":"38","key":"10.1016\/j.yebeh.2024.109849_b0265","doi-asserted-by":"crossref","first-page":"13264","DOI":"10.1523\/JNEUROSCI.5086-11.2012","article-title":"Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy","volume":"32","author":"Levesque","year":"2012","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0270","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ana.22548","article-title":"High-frequency oscillations as a new biomarker in epilepsy","volume":"71","author":"Zijlmans","year":"2012","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0275","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/epi.17462","article-title":"High-frequency oscillations (250\u2013500 Hz) in animal models of Alzheimer's disease and two animal models of epilepsy","volume":"64","author":"Lisgaras","year":"2023","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0280","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0426-17.2018","article-title":"Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease","volume":"5","author":"Brown","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.yebeh.2024.109849_b0285","doi-asserted-by":"crossref","first-page":"20119","DOI":"10.1038\/srep20119","article-title":"Interictal spikes during sleep are an early defect in the Tg2576 mouse model of beta-amyloid neuropathology","volume":"6","author":"Kam","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.yebeh.2024.109849_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106294","article-title":"Interictal spikes in Alzheimer's disease: preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum","volume":"187","author":"Lisgaras","year":"2023","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0295","doi-asserted-by":"crossref","first-page":"11851","DOI":"10.1038\/s41598-020-68845-y","article-title":"Response of spike-wave discharges in aged APP\/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs","volume":"10","author":"Jin","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.yebeh.2024.109849_b0300","doi-asserted-by":"crossref","first-page":"1277613","DOI":"10.3389\/fneur.2024.1277613","article-title":"Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies","volume":"15","author":"Vicente","year":"2024","journal-title":"Front Neurol"},{"key":"10.1016\/j.yebeh.2024.109849_b0305","doi-asserted-by":"crossref","first-page":"1277613","DOI":"10.3389\/fneur.2024.1277613","article-title":"Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies","volume":"15","author":"Vicente","year":"2024","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0310","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1515\/revneuro-2017-0064","article-title":"Cracking novel shared targets between epilepsy and Alzheimer's disease: need of the hour","volume":"29","author":"Garg","year":"2018","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.yebeh.2024.109849_b0315","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainresbull.2020.04.009","article-title":"Epilepsy and Alzheimer's disease: potential mechanisms for an association","volume":"160","author":"Giorgi","year":"2020","journal-title":"Brain Res Bull"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109849_b0320","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1111\/epi.16918","article-title":"Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease","volume":"62","author":"Dejakaisaya","year":"2021","journal-title":"Epilepsia"},{"issue":"s1","key":"10.1016\/j.yebeh.2024.109849_b0325","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.3233\/JAD-230059","article-title":"Neuroinflammation: a common pathway in Alzheimer's disease and epilepsy","volume":"94","author":"Liew","year":"2023","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0330","doi-asserted-by":"crossref","first-page":"e018292","DOI":"10.1136\/bmjopen-2017-018292","article-title":"Prevalence of physical conditions and multimorbidity in a cohort of adults with intellectual disabilities with and without Down syndrome: cross-sectional study","volume":"8","author":"Kinnear","year":"2018","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0335","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.ridd.2014.01.022","article-title":"Multimorbidity in older adults with intellectual disabilities","volume":"35","author":"Hermans","year":"2014","journal-title":"Res Dev Disabil"},{"issue":"13","key":"10.1016\/j.yebeh.2024.109849_b0340","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10132776","article-title":"Epilepsy in down syndrome: a highly prevalent comorbidity","volume":"10","author":"Altuna","year":"2021","journal-title":"J Clin Med"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109849_b0345","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1742-1241.2001.tb11087.x","article-title":"Age of seizure onset in adults with Down's syndrome","volume":"55","author":"Puri","year":"2001","journal-title":"Int J Clin Pract"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0350","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1192\/bjp.164.4.528","article-title":"Prevalence and associated features of epilepsy in adults with Down's syndrome","volume":"164","author":"McVicker","year":"1994","journal-title":"Br J Psychiatry J Ment Sci"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0355","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1059-1311(05)80175-X","article-title":"The diversity of epilepsy in adults with severe developmental disabilities: age at seizure onset and other prognostic factors","volume":"3","author":"Brodtkorb","year":"1994","journal-title":"Seizure"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0360","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/seiz.2000.0500","article-title":"Late-onset myoclonic epilepsy in Down's syndrome (LOMEDS)","volume":"10","author":"M\u00f6ller","year":"2001","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2024.109849_b0365","doi-asserted-by":"crossref","first-page":"1119326","DOI":"10.3389\/fneur.2023.1119326","article-title":"Clinical and genetic characteristics in a central-southern Chinese cohort of early-onset Alzheimer's disease","volume":"14","author":"Liang","year":"2023","journal-title":"Front Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0370","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S1474-4422(10)70306-9","article-title":"Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE \u025b4 allele","volume":"10","author":"van der Flier","year":"2011","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0375","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yebeh.2011.03.022","article-title":"Presenilin-1 mutation Alzheimer's disease: a genetic epilepsy syndrome?","volume":"21","author":"Larner","year":"2011","journal-title":"Epilepsy Behav"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109849_b0380","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.0013-9580.2004.55403.x","article-title":"CA1 hippocampal neuronal loss in familial Alzheimer's disease presenilin-1 E280A mutation is related to epilepsy","volume":"45","author":"Velez-Pardo","year":"2004","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0385","doi-asserted-by":"crossref","first-page":"e12155","DOI":"10.1002\/dad2.12155","article-title":"Insight into the genetic etiology of Alzheimer's disease: a comprehensive review of the role of rare variants","volume":"13","author":"Hoogmartens","year":"2021","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1016\/j.yebeh.2024.109849_b0390","article-title":"Non-familial Alzheimer's disease is mainly due to genetic factors","volume":"4","author":"Wesson","year":"2002","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0395","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.eplepsyres.2010.05.007","article-title":"ApoE epsilon4 genotype and the age at onset of temporal lobe epilepsy: a case-control study and meta-analysis","volume":"90","author":"Kauffman","year":"2010","journal-title":"Epilepsy Res"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0400","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1038\/s41598-019-44848-2","article-title":"Genetic analyses of early-onset Alzheimer's disease using next generation sequencing","volume":"9","author":"Giau","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.yebeh.2024.109849_b0405","article-title":"Alzheimer's disease risk genes and mechanisms of disease pathogenesis","volume":"77","author":"Celeste","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.yebeh.2024.109849_b0410","article-title":"Analysis of shared genetic regulatory networks for Alzheimer's disease and epilepsy","volume":"2021","author":"Xiao-Dan","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.yebeh.2024.109849_b0415","doi-asserted-by":"crossref","first-page":"6692974","DOI":"10.1155\/2021\/6692974","article-title":"Analysis of shared genetic regulatory networks for Alzheimer's disease and epilepsy","volume":"2021","author":"Wang","year":"2021","journal-title":"Biomed Res Int"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0420","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/archneurol.2011.830","article-title":"Incidence of new-onset seizures in mild to moderate Alzheimer disease","volume":"69","author":"Irizarry","year":"2012","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0425","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3233\/JAD-2011-110896","article-title":"Seizures can precede cognitive symptoms in late-onset Alzheimer's disease","volume":"27","author":"Picco","year":"2011","journal-title":"J Alzheimer's Dis: JAD"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0430","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1176\/appi.neuropsych.15060143","article-title":"Clinical and neurophysiologic characteristics of unprovoked seizures in patients diagnosed with dementia","volume":"28","author":"Sarkis","year":"2016","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0435","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.18632\/aging.202299","article-title":"Late-onset epilepsy and subsequent increased risk of dementia","volume":"13","author":"Tsai","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.yebeh.2024.109849_b0440","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jocn.2021.01.030","article-title":"Ten year cumulative incidence of dementia after late onset epilepsy of unknown etiology","volume":"86","author":"Ophir","year":"2021","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.yebeh.2024.109849_b0445","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neurobiolaging.2018.09.006","article-title":"Alzheimer's disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology","volume":"73","author":"Costa","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.yebeh.2024.109849_b0450","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fnagi.2017.00071","article-title":"Early-onset network hyperexcitability in presymptomatic Alzheimer's disease transgenic mice is suppressed by passive immunization with anti-human APP\/Abeta antibody and by mGluR5 blockade","volume":"9","author":"Kazim","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.yebeh.2024.109849_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108609","article-title":"On the relationships between epilepsy, sleep, and Alzheimer's disease: a narrative review","volume":"129","author":"Hanke","year":"2022","journal-title":"Epilepsy Behav: E&B"},{"issue":"9","key":"10.1016\/j.yebeh.2024.109849_b0460","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and epileptiform activity in the early stages of Alzheimer disease","volume":"70","author":"Vossel","year":"2013","journal-title":"JAMA Neurol"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0465","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic activity in Alzheimer's disease: causes and clinical relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0470","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.arr.2012.04.003","article-title":"Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: focus on the role of hypocretin and melatonin","volume":"12","author":"Slats","year":"2013","journal-title":"Ageing Res Rev"},{"issue":"6","key":"10.1016\/j.yebeh.2024.109849_b0475","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/1535759720964775","article-title":"Night watch on the titanic: detecting early signs of epileptogenesis in Alzheimer disease","volume":"20","author":"Lam","year":"2020","journal-title":"Epilepsy Curr"},{"issue":"13","key":"10.1016\/j.yebeh.2024.109849_b0480","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1084\/jem.20141788","article-title":"Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease","volume":"211","author":"Roh","year":"2014","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0485","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1532-5415.2010.03288.x","article-title":"Greater risk of Alzheimer's disease in older adults with insomnia","volume":"59","author":"Osorio","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.yebeh.2024.109849_b0490","article-title":"The whats and whens of sleep-dependent memory consolidation","volume":"13","author":"Susanne","year":"2009","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.yebeh.2024.109849_b0495","article-title":"Boosting slow oscillations during sleep potentiates memory","volume":"444","author":"Lisa","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.yebeh.2024.109849_b0500","article-title":"Slow wave sleep is a promising intervention target for Alzheimer's disease","volume":"14","author":"Yee Fun","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.yebeh.2024.109849_b0505","article-title":"Slow wave sleep and accelerated forgetting","volume":"84","author":"Kathryn","year":"2016","journal-title":"Cortex"},{"key":"10.1016\/j.yebeh.2024.109849_b0510","doi-asserted-by":"crossref","unstructured":"C R B, A Z Z. Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment. Brain 2008;131.","DOI":"10.1093\/brain\/awn127"},{"key":"10.1016\/j.yebeh.2024.109849_b0515","doi-asserted-by":"crossref","unstructured":"M J M, B R B, G W F. Epileptic seizures in elderly patients with dementia. Epilepsia 1992;33.","DOI":"10.1111\/j.1528-1157.1992.tb02343.x"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0520","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.yebeh.2010.01.015","article-title":"Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease","volume":"17","author":"Cumbo","year":"2010","journal-title":"Epilepsy Behav: E&B"},{"key":"10.1016\/j.yebeh.2024.109849_b0525","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s007020050059","article-title":"Antiglutamatergic therapy in Alzheimer's disease\u2013effects of lamotrigine. Short communication","volume":"105","author":"Tekin","year":"1998","journal-title":"J Neural Transm (Vienna, 1996)"},{"key":"10.1016\/j.yebeh.2024.109849_b0530","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.seizure.2020.01.021","article-title":"Perampanel effect on sleep architecture in patients with epilepsy","volume":"76","author":"Rocamora","year":"2020","journal-title":"Seizure"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0535","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3233\/JAD-181145","article-title":"Long-term trazodone use and cognition: a potential therapeutic role for slow-wave sleep enhancers","volume":"67","author":"La","year":"2019","journal-title":"J Alzheimer's Dis: JAD"},{"issue":"30","key":"10.1016\/j.yebeh.2024.109849_b0540","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1523\/JNEUROSCI.0260-17.2017","article-title":"Promoting sleep oscillations and their functional coupling by transcranial stimulation enhances memory consolidation in mild cognitive impairment","volume":"37","author":"Ladenbauer","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2024.109849_b0545","article-title":"Insights on the use of transgenic mice models in Alzheimer's disease research","volume":"25","author":"Mafalda Soares","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0550","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1002\/cpns.81","article-title":"Overview of transgenic mouse models for Alzheimer's disease","volume":"89","author":"Myers","year":"2019","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.yebeh.2024.109849_b0555","unstructured":"A A, K P P, F J A, Y D, D V. Anticonvulsant effect of amiloride in pentetrazole-induced status epilepticus in mice. Pharmacol Rep 2006;58."},{"key":"10.1016\/j.yebeh.2024.109849_b0560","article-title":"The pilocarpine model of mesial temporal lobe epilepsy: over one decade later, with more rodent species and new investigative approaches","volume":"130","author":"Maxime","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.yebeh.2024.109849_b0565","article-title":"The Kainic acid models of temporal lobe epilepsy","volume":"8","author":"Evgeniia","year":"2021","journal-title":"eNeuro"},{"key":"10.1016\/j.yebeh.2024.109849_b0570","article-title":"Postictal alterations induced by intrahippocampal injection of pilocarpine in C57BL\/6 mice","volume":"64","author":"Isabel Vieira de Assis","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2024.109849_b0575","article-title":"Variable electrobehavioral patterns during focal nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid","volume":"55","author":"Salvatore","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109849_b0580","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease","volume":"55","author":"Jorge","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.yebeh.2024.109849_b0585","article-title":"Chronic seizures induce sex-specific cognitive deficits with loss of presenilin 2 function","volume":"361","author":"Kevin","year":"2023","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2024.109849_b0590","article-title":"Early onset of hypersynchronous network activity and expression of a marker of chronic seizures in the Tg2576 mouse model of Alzheimer's disease","volume":"10","author":"Charlotte","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.yebeh.2024.109849_b0595","doi-asserted-by":"crossref","first-page":"e48782","DOI":"10.1371\/journal.pone.0048782","article-title":"Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3xTg-AD mice","volume":"7","author":"Yan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2024.109849_b0600","unstructured":"Dodart JC, May P. Overview on rodent models of Alzheimer's disease. Curr Protoc Neurosci 2005;Chapter 9:Unit 9 22."},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0605","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00401-016-1662-x","article-title":"Alzheimer's disease: experimental models and reality","volume":"133","author":"Drummond","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"5","key":"10.1016\/j.yebeh.2024.109849_b0610","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single App knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat Neurosci"},{"issue":"46","key":"10.1016\/j.yebeh.2024.109849_b0615","doi-asserted-by":"crossref","first-page":"10637","DOI":"10.1523\/JNEUROSCI.3279-05.2005","article-title":"Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)","volume":"25","author":"Ramsden","year":"2005","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0620","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1101\/lm.66106","article-title":"Hippocampal CA1 kindling but not long-term potentiation disrupts spatial memory performance","volume":"13","author":"Leung","year":"2006","journal-title":"Learn Mem (Cold Spring Harb)"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0625","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0306-4522(95)00384-3","article-title":"Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation","volume":"70","author":"Kokaia","year":"1996","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109849_b0630","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0006-8993(97)00054-1","article-title":"Reversal of a selective decrease in hippocampal acetylcholine release, but not of the persistence of kindling, after discontinuation of long-term pentylenetetrazol administration in rats","volume":"751","author":"Serra","year":"1997","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0635","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2217\/fnl.12.8","article-title":"Alzheimer's disease and epilepsy: insight from animal models","volume":"7","author":"Scharfman","year":"2012","journal-title":"Future Neurol"},{"issue":"6","key":"10.1016\/j.yebeh.2024.109849_b0640","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/ana.24794","article-title":"Incidence and impact of subclinical epileptiform activity in Alzheimer's disease","volume":"80","author":"Vossel","year":"2016","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109849_b0645","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ana.24188","article-title":"A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease","volume":"76","author":"Karran","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2024.109849_b0650","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106106","article-title":"Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer's disease mouse model","volume":"181","author":"Rizzello","year":"2023","journal-title":"Neurobiol Dis"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0655","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.yebeh.2010.01.015","article-title":"Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease","volume":"17","author":"Cumbo","year":"2010","journal-title":"Epilepsy Behav: E&B"},{"issue":"10","key":"10.1016\/j.yebeh.2024.109849_b0660","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1111\/epi.17355","article-title":"Higher susceptibility to 6 Hz corneal kindling and lower responsiveness to antiseizure drugs in mouse models of Alzheimer's disease","volume":"63","author":"Vande Vyver","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109849_b0665","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102233","article-title":"Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: the guardian angle","volume":"95","author":"Al-Kuraishy","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"12","key":"10.1016\/j.yebeh.2024.109849_b0670","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.4103\/1673-5374.373715","article-title":"Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP\/PS1 mice via the Nrf2\/HO-1 and NF-kappaB signaling pathways","volume":"18","author":"Jiang","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.yebeh.2024.109849_b0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112163","article-title":"Overview of cannabidiol (CBD) and its analogues: structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease","volume":"192","author":"Li","year":"2020","journal-title":"Eur J Med Chem"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109849_b0680","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/ebeh.2001.0221","article-title":"A pilot study of donepezil for memory problems in epilepsy","volume":"2","author":"Fisher","year":"2001","journal-title":"Epilepsy Behav: E&B"},{"issue":"3","key":"10.1016\/j.yebeh.2024.109849_b0685","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/brain\/awac380","article-title":"Randomized placebo-controlled crossover trial of memantine in children with epileptic encephalopathy","volume":"146","author":"Schiller","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2024.109849_b0690","doi-asserted-by":"crossref","DOI":"10.1002\/epd2.20202","article-title":"Memantine's double duty? Investigating its impact on epilepsy control in Alzheimer's disease","author":"Rayala","year":"2024","journal-title":"Epileptic Disord"},{"issue":"5","key":"10.1016\/j.yebeh.2024.109849_b0695","article-title":"Treatment of epilepsy for people with Alzheimer's disease","volume":"5","author":"Liu","year":"2021","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024002300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024002300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:45:14Z","timestamp":1762548314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505024002300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":139,"alternative-id":["S1525505024002300"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.109849","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alzheimer\u2019s disease and epilepsy: Research hotspots for comorbidity in the era of global aging","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.109849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109849"}}