{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:48:02Z","timestamp":1794008882750,"version":"4.8.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.yebeh.2024.109987","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T15:26:03Z","timestamp":1724426763000},"page":"109987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Treatment of prolonged seizure with diazepam nasal spray: An exploratory post hoc cohort analysis"],"prefix":"10.1016","volume":"159","author":[{"given":"Randa","family":"Jarrar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-8055","authenticated-orcid":false,"given":"Danielle A.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-0606","authenticated-orcid":false,"given":"Adrian L.","family":"Rabinowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8788-0722","authenticated-orcid":false,"given":"Enrique","family":"Carrazana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.yebeh.2024.109987_b0005","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/epi.17492","article-title":"Duration of epileptic seizure types: a data-driven approach","volume":"64","author":"Meritam Larsen","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109987_b0010","article-title":"The unmet need for rapid epileptic seizure termination (REST)","volume":"15","author":"Asnis-Alibozek","year":"2021","journal-title":"Epilepsy Behav Rep"},{"key":"10.1016\/j.yebeh.2024.109987_b0015","doi-asserted-by":"crossref","unstructured":"Haut SR, Nabbout R. Recognizing seizure clusters in the community: The path to uniformity and individualization in nomenclature and definition. Epilepsia 2022;63 Suppl 1(suppl):S6-S13. 10.1111\/epi.17346.","DOI":"10.1111\/epi.17346"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109987_b0020","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5698\/1535-7597-16.1.48","article-title":"Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the guideline committee of the American Epilepsy Society","volume":"16","author":"Glauser","year":"2016","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.yebeh.2024.109987_b0025","doi-asserted-by":"crossref","DOI":"10.1002\/epd2.20243","article-title":"Outpatient management of prolonged seizures and seizure clusters to prevent progression to a higher-level emergency: Consensus recommendations of an expert working group","author":"Pina-Garza","year":"2024","journal-title":"Epileptic Disord"},{"issue":"suppl 1","key":"10.1016\/j.yebeh.2024.109987_b0030","first-page":"S14","article-title":"Consequences: bench to home","volume":"63","author":"Kapur","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109987_b0035","unstructured":"Bausch Health US, LLC. Diastat\u00ae C-IV (diazepam rectal gel). Full Prescribing Information. Bridgewater, NJ: Bausch Health US, LLC; 2023."},{"key":"10.1016\/j.yebeh.2024.109987_b0040","unstructured":"Neurelis, Inc. VALTOCO\u00ae (diazepam nasal spray). Full Prescribing Information. San Diego, CA: Neurelis, Inc.; 2023."},{"key":"10.1016\/j.yebeh.2024.109987_b0045","unstructured":"UCB, Inc. Nayzilam\u00ae (midazolam nasal spray). Full Prescribing Information. Smyrna, GA: UCB, Inc.; 2023."},{"key":"10.1016\/j.yebeh.2024.109987_b0050","unstructured":"Aquestive Therapeutics. Libervant (diazepam buccal film). Full Prescribing Information. Warren, NJ: Aquestive Therapeutics; April 2024."},{"key":"10.1016\/j.yebeh.2024.109987_b0055","unstructured":"Laboratorios Lesvi SL. Buccolam summary of product characteristics (midazolam hydrochloride oromucosal solution). Summary of Product Characteristics. Laboratorios Lesvi, S.L.; 2023."},{"key":"10.1016\/j.yebeh.2024.109987_b0060","unstructured":"Electronic Medicines Compendium. Buccolam 2.5 mg oromucosal solution, https:\/\/www.medicines.org.uk\/emc\/product\/2768\/smpc; 2021 [accessed September 7, 2021]."},{"key":"10.1016\/j.yebeh.2024.109987_b0065","unstructured":"European Medicines Agency. Nasolam and associated names, https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/nasolam-associated-names; 2022 [accessed May 25, 2023]."},{"issue":"10","key":"10.1016\/j.yebeh.2024.109987_b0070","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1111\/epi.17041","article-title":"Final results from a phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy","volume":"62","author":"Wheless","year":"2021","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.yebeh.2024.109987_b0075","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s40120-023-00568-4","article-title":"Rapid rescue treatment with diazepam nasal spray leads to faster seizure cluster termination in epilepsy: an exploratory post hoc cohort analysis","volume":"13","author":"Misra","year":"2024","journal-title":"Neurol Ther"},{"key":"10.1016\/j.yebeh.2024.109987_b0080","doi-asserted-by":"crossref","DOI":"10.1111\/epi.17911","article-title":"Analysis of seizure-cluster circadian periodicity from a long-term, open-label safety study of diazepam nasal spray","author":"Fountain","year":"2024","journal-title":"Epilepsia"},{"issue":"7624","key":"10.1016\/j.yebeh.2024.109987_b0085","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"von Elm","year":"2007","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.yebeh.2024.109987_b0090","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/epi.17177","article-title":"Use of second doses of Valtoco\u00ae (diazepam nasal spray) across 24 hours after the initial dose for out-of-hospital seizure clusters: results from a phase 3, open-label, repeat-dose safety study","volume":"63","author":"Sperling","year":"2022","journal-title":"Epilepsia"},{"issue":"Pt A","key":"10.1016\/j.yebeh.2024.109987_b0095","article-title":"Examining the patient and caregiver experience with diazepam nasal spray for seizure clusters: results from an exit survey of a phase 3, open-label, repeat-dose safety study","volume":"121","author":"Penovich","year":"2021","journal-title":"Epilepsy Behav"},{"issue":"10","key":"10.1016\/j.yebeh.2024.109987_b0100","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/epi.17385","article-title":"Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters","volume":"63","author":"Misra","year":"2022","journal-title":"Epilepsia"},{"issue":"10","key":"10.1016\/j.yebeh.2024.109987_b0105","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus-report of the ILAE task force on classification of status epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"issue":"9153","key":"10.1016\/j.yebeh.2024.109987_b0110","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0140-6736(98)06425-3","article-title":"Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial","volume":"353","author":"Scott","year":"1999","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.yebeh.2024.109987_b0115","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/epi.17441","article-title":"A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato(R) alprazolam for rapid seizure termination","volume":"64","author":"French","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2024.109987_b0120","doi-asserted-by":"crossref","DOI":"10.1007\/s12028-024-01971-x","article-title":"Efficacy and tolerability of intranasal midazolam administration for antiseizure treatment in adults: a systematic review","author":"Dittrich","year":"2024","journal-title":"Neurocrit Care"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109987_b0125","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41582-022-00664-3","article-title":"Why won't it stop? the dynamics of benzodiazepine resistance in status epilepticus","volume":"18","author":"Burman","year":"2022","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.yebeh.2024.109987_b0130","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.2147\/NDT.S376104","article-title":"Implications of seizure-cluster treatment on healthcare utilization: use of approved rescue medications","volume":"18","author":"Rabinowicz","year":"2022","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"7","key":"10.1016\/j.yebeh.2024.109987_b0135","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1111\/epi.17249","article-title":"Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: a population analysis","volume":"63","author":"Cascino","year":"2022","journal-title":"Epilepsia"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024003688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024003688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:15:30Z","timestamp":1726359330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505024003688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":27,"alternative-id":["S1525505024003688"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.109987","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of prolonged seizure with diazepam nasal spray: An exploratory post hoc cohort analysis","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.109987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109987"}}