{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:08:32Z","timestamp":1782302912189,"version":"3.54.5"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.yebeh.2024.110028","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T01:11:57Z","timestamp":1725153117000},"page":"110028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Aprepitant\u2019s roles in abating seizures, behavioral, and cognitive deficits in mice model of epilepsy"],"prefix":"10.1016","volume":"159","author":[{"given":"Heba","family":"A. Hassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Al-Saraireh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2024.110028_b0005","doi-asserted-by":"crossref","unstructured":"C. E. Stafstrom and L. Carmant, \u201cSeizures and epilepsy: an overview for neuroscientists.,\u201d Cold Spring Harb. Perspect. Med., vol. 5, no. 6, Jun. 2015, doi: 10.1101\/cshperspect.a022426.","DOI":"10.1101\/cshperspect.a022426"},{"key":"10.1016\/j.yebeh.2024.110028_b0010","doi-asserted-by":"crossref","unstructured":"S. Chakraborty, R. Parayil, S. Mishra, U. Nongthomba, and J. P. Clement, \u201cEpilepsy Characteristics in Neurodevelopmental Disorders: Research from Patient Cohorts and Animal Models Focusing on Autism Spectrum Disorder,\u201d Int. J. Mol. Sci., vol. 23, no. 18, 2022, doi: 10.3390\/ijms231810807.","DOI":"10.3390\/ijms231810807"},{"issue":"7","key":"10.1016\/j.yebeh.2024.110028_b0015","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.3390\/ph3072090","article-title":"Difficulties in treatment and management of epilepsy and challenges in new drug development","volume":"3","author":"Wahab","year":"2010","journal-title":"Pharmaceut. (Basel)"},{"issue":"9","key":"10.1016\/j.yebeh.2024.110028_b0020","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s40263-021-00827-8","article-title":"The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond","volume":"35","author":"L\u00f6scher","year":"2021","journal-title":"CNS Drugs"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/bja\/aep125","article-title":"Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting","volume":"103","author":"Diemunsch","year":"2009","journal-title":"Br. J. Anaesth."},{"issue":"5","key":"10.1016\/j.yebeh.2024.110028_b0030","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bjan.2020.04.005","article-title":"Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis","volume":"70","author":"Murakami","year":"2020","journal-title":"Braz. J. Anesthesiol."},{"issue":"7","key":"10.1016\/j.yebeh.2024.110028_b0035","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1007\/s12325-020-01377-z","article-title":"Best practice approach to successful conversion of fosaprepitant to aprepitant IV in a large multisite community oncology infusion center: a retrospective analysis","volume":"37","author":"Burns","year":"2020","journal-title":"Adv. Ther."},{"key":"10.1016\/j.yebeh.2024.110028_b0040","unstructured":"M. JAVED Naim et al., \u201cA review on pharmacological profile of Morpholine derivatives,\u201d Artic. Int. J. Pharmacol. Pharm. Sci., vol. 3, no. 1, pp. 40\u201351, 2015, [Online]. Available: https:\/\/www.researchgate.net\/publication\/331480489."},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0045","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2013","article-title":"Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease","volume":"94","author":"Steinhoff","year":"2014","journal-title":"Physiol. Rev."},{"issue":"44","key":"10.1016\/j.yebeh.2024.110028_b0050","doi-asserted-by":"crossref","first-page":"78225","DOI":"10.18632\/oncotarget.20606","article-title":"The role of substance P in epilepsy and seizure disorders","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0055","article-title":"Biological and Pharmacological Aspects of the NK1-Receptor","volume":"2015","author":"Garcia-Recio","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.yebeh.2024.110028_b0060","doi-asserted-by":"crossref","unstructured":"A. T. Berg, \u201cEpilepsy, cognition, and behavior: The clinical picture.,\u201d Epilepsia, vol. 52 Suppl 1, no. Suppl 1, pp. 7\u201312, Jan. 2011, doi: 10.1111\/j.1528-1167.2010.02905.x.","DOI":"10.1111\/j.1528-1167.2010.02905.x"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0065","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.eplepsyres.2011.08.006","article-title":"Increased neurokinin-1 receptor availability in temporal lobe epilepsy: A positron emission tomography study using [11C]GR205171","volume":"97","author":"Danfors","year":"2011","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.yebeh.2024.110028_b0070","doi-asserted-by":"crossref","unstructured":"T.-S. Chen, T.-H. Huang, M.-C. Lai, and C.-W. Huang, \u201cThe Role of Glutamate Receptors in Epilepsy.,\u201d Biomedicines, vol. 11, no. 3, Mar. 2023, doi: 10.3390\/biomedicines11030783.","DOI":"10.3390\/biomedicines11030783"},{"issue":"4","key":"10.1016\/j.yebeh.2024.110028_b0075","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/receptors2040016","article-title":"Evidence for the Involvement of the Tachykinin NK1 Receptor in Acute Inflammation of the Central Nervous System","volume":"2","author":"Turner","year":"2023","journal-title":"Receptors"},{"issue":"3","key":"10.1016\/j.yebeh.2024.110028_b0080","first-page":"99","article-title":"Substance P and its receptors - A potential target for novel medicines in malignant brain tumour therapies (mini-review)","volume":"45","author":"\u0141azarczyk","year":"2007","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.yebeh.2024.110028_b0085","doi-asserted-by":"crossref","unstructured":"A. Garnier, \u201cNeurokinin-1 receptor as a therapeutic target in hepatoblastoma,\u201d 2016.","DOI":"10.1055\/s-0035-1550262"},{"key":"10.1016\/j.yebeh.2024.110028_b0090","doi-asserted-by":"crossref","unstructured":"Y. Chen et al., \u201cNeuroinflammatory mediators in acquired epilepsy: an update.,\u201d Inflamm. Res. Off. J. Eur. Histamine Res. Soc. ... [et al.], vol. 72, no. 4, pp. 683\u2013701, Apr. 2023, doi: 10.1007\/s00011-023-01700-8.","DOI":"10.1007\/s00011-023-01700-8"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneumeth.2008.04.019","article-title":"The pilocarpine model of temporal lobe epilepsy","volume":"172","author":"Curia","year":"2008","journal-title":"J. Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0105","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0091-3057(99)00264-6","article-title":"Pentylenetetrazol-kindling modulates stimulated dopamine release in the nucleus accumbens of rats","volume":"66","author":"Becker","year":"2000","journal-title":"Pharmacol. Biochem. Behav"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0920-1211(01)00272-8","article-title":"Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy","volume":"46","author":"Glien","year":"2001","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.yebeh.2024.110028_b0115","doi-asserted-by":"crossref","unstructured":"M. L. Seibenhener and M. C. Wooten, \u201cUse of the Open Field Maze to measure locomotor and anxiety-like behavior in mice.,\u201d J. Vis. Exp., no. 96, p. e52434, Feb. 2015, doi: 10.3791\/52434.","DOI":"10.3791\/52434-v"},{"issue":"April","key":"10.1016\/j.yebeh.2024.110028_b0120","article-title":"Exposure to a glyphosate-based herbicide during pregnancy and lactation induces neurobehavioral alterations in rat offspring","volume":"53","author":"Gallegos","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.yebeh.2024.110028_b0125","doi-asserted-by":"crossref","unstructured":"K. Takao and T. Miyakawa, \u201cLight\/dark transition test for mice.,\u201d J. Vis. Exp., no. 1, p. 104, Nov. 2006, doi: 10.3791\/104.","DOI":"10.3791\/104"},{"key":"10.1016\/j.yebeh.2024.110028_b0130","doi-asserted-by":"crossref","unstructured":"R. M. J. Deacon, \u201cMeasuring motor coordination in mice.,\u201d J. Vis. Exp., no. 75, 2013, doi: 10.3791\/2609.","DOI":"10.3791\/2609-v"},{"key":"10.1016\/j.yebeh.2024.110028_b0135","doi-asserted-by":"crossref","unstructured":"R. d\u2019Isa, G. Comi, and L. Leocani, \u201cApparatus design and behavioural testing protocol for the evaluation of spatial working memory in mice through the spontaneous alternation T-maze.,\u201d Sci. Rep., vol. 11, no. 1, p. 21177, Oct. 2021, doi: 10.1038\/s41598-021-00402-7.","DOI":"10.1038\/s41598-021-00402-7"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0140","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0169-328X(98)00191-0","article-title":"A tachykinin NK1 receptor antagonist, CP-122,721\u20131, attenuates kainic acid-induced seizure activity","volume":"60","author":"Zachrisson","year":"1998","journal-title":"Mol. Brain Res."},{"issue":"10","key":"10.1016\/j.yebeh.2024.110028_b0145","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1046\/j.1460-9568.2002.02266.x","article-title":"Neurokinin-receptor-mediated depolarization of cortical neurons elicits an increase in glutamate release at excitatory synapses","volume":"16","author":"Stacey","year":"2002","journal-title":"Eur. J. Neurosci."},{"issue":"May","key":"10.1016\/j.yebeh.2024.110028_b0150","first-page":"1","article-title":"Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures","volume":"13","author":"Khalife","year":"2022","journal-title":"Front. Neurol."},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1684\/epd.2015.0739","article-title":"Cognitive impairment in epilepsy: the role of network abnormalities","volume":"17","author":"Holmes","year":"2015","journal-title":"Epileptic Disord."},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0160","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.1186\/s12974-022-02558-z","article-title":"Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R\/PKC\u03b4 pathway in a mouse model of intracerebral hemorrhage","volume":"19","author":"Jin","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0165","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/WCO.0b013e3283292401","article-title":"Cognitive abilities and behaviour of children exposed to antiepileptic drugs in utero","volume":"22","author":"Bromley","year":"2009","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.yebeh.2024.110028_b0170","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.reprotox.2013.06.001","article-title":"Developmental outcomes at preschool age after fetal exposure to valproic acid and lamotrigine: Cognitive, motor, sensory and behavioral function","volume":"41","author":"Rihtman","year":"2013","journal-title":"Reprod. Toxicol."},{"issue":"43","key":"10.1016\/j.yebeh.2024.110028_b0175","doi-asserted-by":"crossref","first-page":"38269","DOI":"10.1021\/acsomega.2c00163","article-title":"Neuroprotective effects of natural antioxidants against branched-chain fatty acid-induced oxidative stress in cerebral cortex and cerebellum regions of the rat brain","volume":"7","author":"Chaudhary","year":"2022","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbr.2011.11.035","article-title":"Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression","volume":"228","author":"Roche","year":"2012","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0185","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.1186\/s41983-022-00479-5","article-title":"Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case\u2013control study","volume":"58","author":"Shehta","year":"2022","journal-title":"Egypt J. Neurol. Psychiatry Neurosurg."},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0190","article-title":"Seizure-induced oxidative stress in temporal lobe epilepsy","volume":"2015","author":"Puttachary","year":"2015","journal-title":"Biomed Res. Int."},{"issue":"8","key":"10.1016\/j.yebeh.2024.110028_b0195","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022863","article-title":"Glutamatergic mechanisms associated with seizures and epilepsy","volume":"5","author":"Barker-Haliski","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.yebeh.2024.110028_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.851394","article-title":"The function of NF-Kappa B during epilepsy, a potential therapeutic target","volume":"16","author":"Cai","year":"2022","journal-title":"Front. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.yebeh.2024.110028_b0205","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.eplepsyres.2006.05.017","article-title":"Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems","volume":"71","author":"Zhu","year":"2006","journal-title":"Epilepsy Res."},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0210","first-page":"pp","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.yebeh.2024.110028_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106058","article-title":"Astrocyte-neuron circuits in epilepsy","volume":"179","author":"Purnell","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0220","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.1186\/s42494-023-00137-0","article-title":"Biomolecular mechanisms of epileptic seizures and epilepsy: a review","volume":"5","author":"Sumadewi","year":"2023","journal-title":"Acta Epileptol"},{"issue":"9","key":"10.1016\/j.yebeh.2024.110028_b0225","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1073\/pnas.96.9.5286","article-title":"Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus","volume":"96","author":"Liu","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0230","first-page":"74","article-title":"Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury","volume":"7","author":"Vink","year":"2010","journal-title":"Neurother. J. Am. Soc. Exp. Neurother."},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0235","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1570159X15666170504122410","article-title":"Substance P regulation in epilepsy","volume":"16","author":"Chi","year":"2017","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.yebeh.2024.110028_b0240","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1523\/JNEUROSCI.10-03-00741.1990","article-title":"Chronic naltrexone treatment increases expression of preproenkephalin and preprotachykinin mRNA in discrete brain regions","volume":"10","author":"Tempel","year":"1990","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0245","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0306-4522(00)00383-3","article-title":"Patterns of status epilepticus-induced substance P expression during development","volume":"101","author":"Liu","year":"2000","journal-title":"Neuroscience"},{"issue":"5965","key":"10.1016\/j.yebeh.2024.110028_b0250","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/309261a0","article-title":"Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones","volume":"309","author":"Mayer","year":"1984","journal-title":"Nature"},{"issue":"6019","key":"10.1016\/j.yebeh.2024.110028_b0255","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/315498a0","article-title":"Substance P raises neuronal membrane excitability by reducing inward rectification","volume":"315","author":"Stanfield","year":"1985","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.yebeh.2024.110028_b0260","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/j.1471-4159.1993.tb03242.x","article-title":"Tachykinins potentiate N-methyl-D-aspartate responses in acutely isolated neurons from the dorsal horn","volume":"60","author":"Rusin","year":"1993","journal-title":"J. Neurochem."},{"issue":"6369","key":"10.1016\/j.yebeh.2024.110028_b0265","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/356521a0","article-title":"Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation","volume":"356","author":"Chen","year":"1992","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110028_b0270","first-page":"43","article-title":"Substance P Regulation in Epilepsy","volume":"16","author":"Chi","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"10","key":"10.1016\/j.yebeh.2024.110028_b0275","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/jpp\/rgab088","article-title":"Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties","volume":"73","author":"Kose","year":"2021","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.yebeh.2024.110028_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103940","article-title":"Aprepitant exerts anti-fibrotic effect via inhibition of TGF-\u03b2\/Smad3 pathway in bleomycin-induced pulmonary fibrosis in rats","volume":"95","author":"Mohamed","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.yebeh.2024.110028_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173168","article-title":"A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity","volume":"880","author":"Un","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0290","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3892\/etm.2020.8802","article-title":"Effect of valproic acid on oxidative stress parameters of glutamate-induced excitotoxicity in SH-SY5Y cells","volume":"20","author":"Terzio\u011flu Bebito\u011flu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.yebeh.2024.110028_b0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2018.11.002","article-title":"Systematic review and meta-analysis of experimental studies evaluating the organ protective effects of histone deacetylase inhibitors","volume":"205","author":"Yusoff","year":"2019","journal-title":"Transl. Res."},{"issue":"4","key":"10.1016\/j.yebeh.2024.110028_b0300","doi-asserted-by":"crossref","first-page":"504","DOI":"10.5607\/en.2019.28.4.504","article-title":"HDAC inhibition by valproic acid induces neuroprotection and improvement of PD-like behaviors in LRRK2 R1441G transgenic mice","volume":"28","author":"Kim","year":"2019","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.yebeh.2024.110028_b0305","doi-asserted-by":"crossref","unstructured":"J. Christian Machado Ximenes, E. Cris\u00f3stomo Lima Verde, M. da Gra\u00e7a Naffah-Mazzacoratti, and G. Socorro de Barros Viana, \u201cValproic Acid, a Drug with Multiple Molecular Targets Related to Its Potential Neuroprotective Action,\u201d Neurosci. Med., vol. 03, no. 01, pp. 107\u2013123, 2012, doi: 10.4236\/nm.2012.31016.","DOI":"10.4236\/nm.2012.31016"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110028_b0310","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.3390\/antiox13020244","article-title":"NMDA receptors regulate oxidative damage in keratinocytes during complex regional pain syndrome in HaCaT cells and male rats","volume":"13","author":"Wen","year":"2024","journal-title":"Antioxidants"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024004104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024004104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T04:16:40Z","timestamp":1726373800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505024004104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":62,"alternative-id":["S1525505024004104"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.110028","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aprepitant\u2019s roles in abating seizures, behavioral, and cognitive deficits in mice model of epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.110028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110028"}}