{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:52:36Z","timestamp":1784260356723,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.yebeh.2024.110258","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T08:30:59Z","timestamp":1737189059000},"page":"110258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Association between glymphatic system function and cognitive impairment in elderly patients with late-onset epilepsy"],"prefix":"10.1016","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9648-9987","authenticated-orcid":false,"given":"Long","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Cang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.yebeh.2024.110258_b0005","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/epi.17494","article-title":"The epidemiology of epilepsy in older adults: A narrative review by the ILAE Task Force on Epilepsy in the Elderly","volume":"64","author":"Beghi","year":"2023","journal-title":"Epilepsia"},{"issue":"11","key":"10.1016\/j.yebeh.2024.110258_b0010","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jamaneurol.2018.1935","article-title":"Association Between Midlife Risk Factors and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study","volume":"75","author":"Johnson","year":"2018","journal-title":"JAMA Neurol"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110258_b0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1684\/epd.2021.1360","article-title":"Prevalence of various risk factors associated with new-onset epilepsy after the age of 50: a retrospective population-based study","volume":"24","author":"Cvetkovska","year":"2022","journal-title":"Epileptic disorders : international epilepsy journal with videotape"},{"key":"10.1016\/j.yebeh.2024.110258_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.851897","article-title":"Clinical and Instrumental Characterization of Patients With Late-Onset Epilepsy","volume":"13","author":"DiFrancesco","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.yebeh.2024.110258_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.109723","article-title":"Bidirectional relationship between late-onset epilepsy (LOE) and dementia: A systematic review and meta-analysis of cohort studies","volume":"153","author":"Tan","year":"2024","journal-title":"Epilepsy & behavior : E&B"},{"issue":"8","key":"10.1016\/j.yebeh.2024.110258_b0030","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41582-021-00505-9","article-title":"Amyloid-beta: a potential link between epilepsy and cognitive decline","volume":"17","author":"Romoli","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.yebeh.2024.110258_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1138769","article-title":"Glymphatic system: an emerging therapeutic approach for neurological disorders","volume":"16","author":"Gao","year":"2023","journal-title":"Front Mol Neurosci"},{"issue":"11","key":"10.1016\/j.yebeh.2024.110258_b0040","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S1474-4422(18)30318-1","article-title":"The glymphatic pathway in neurological disorders","volume":"17","author":"Rasmussen","year":"2018","journal-title":"The Lancet Neurology"},{"issue":"37","key":"10.1016\/j.yebeh.2024.110258_b0045","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1523\/JNEUROSCI.0619-21.2021","article-title":"The Glymphatic System: A Novel Component of Fundamental Neurobiology","volume":"41","author":"Hablitz","year":"2021","journal-title":"J Neurosci"},{"issue":"7717","key":"10.1016\/j.yebeh.2024.110258_b0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","article-title":"Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease","volume":"560","author":"Da Mesquita","year":"2018","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.yebeh.2024.110258_b0055","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/brain\/awaa179","article-title":"Impaired glymphatic function and clearance of tau in an Alzheimer's disease model","volume":"143","author":"Harrison","year":"2020","journal-title":"Brain J Neurol"},{"key":"10.1016\/j.yebeh.2024.110258_b0060","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3389\/fneur.2020.00707","article-title":"Omega-3 Polyunsaturated Fatty Acids Alleviate Traumatic Brain Injury by Regulating the Glymphatic Pathway in Mice","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Neurol"},{"issue":"17","key":"10.1016\/j.yebeh.2024.110258_b0065","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.151835","article-title":"Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus","volume":"6","author":"Liu","year":"2021","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.yebeh.2024.110258_b0070","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.brs.2020.03.012","article-title":"Clinically-derived vagus nerve stimulation enhances cerebrospinal fluid penetrance","volume":"13","author":"Cheng","year":"2020","journal-title":"Brain Stimul"},{"issue":"4","key":"10.1016\/j.yebeh.2024.110258_b0075","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn J Radiol"},{"issue":"8","key":"10.1016\/j.yebeh.2024.110258_b0080","doi-asserted-by":"crossref","first-page":"e829","DOI":"10.1212\/WNL.0000000000013215","article-title":"Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults","volume":"98","author":"Siow","year":"2022","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.yebeh.2024.110258_b0085","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/svn-2022-002191","article-title":"Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study","volume":"8","author":"Tian","year":"2023","journal-title":"Stroke and vascular neurology"},{"key":"10.1016\/j.yebeh.2024.110258_b0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2023.04.004","article-title":"Association of Cognition and Brain Reserve in Aging and Glymphatic Function Using Diffusion Tensor Image-along the Perivascular Space (DTI-ALPS)","volume":"524","author":"Hsiao","year":"2023","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110258_b0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11604-021-01187-5","article-title":"Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study","volume":"40","author":"Taoka","year":"2022","journal-title":"Jpn J Radiol"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110258_b0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jmri.26892","article-title":"Glymphatic imaging using MRI","volume":"51","author":"Taoka","year":"2020","journal-title":"Journal of magnetic resonance imaging : JMRI"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110258_b0105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/cns.13984","article-title":"Diffusion along perivascular spaces provides evidence interlinking compromised glymphatic function with aging in Parkinson's disease","volume":"29","author":"Cai","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.yebeh.2024.110258_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1173221","article-title":"Age- and time-of-day dependence of glymphatic function in the human brain measured via two diffusion MRI methods","volume":"15","author":"Han","year":"2023","journal-title":"Front Aging Neurosci"},{"issue":"7","key":"10.1016\/j.yebeh.2024.110258_b0115","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afad107","article-title":"Glymphatic function plays a protective role in ageing-related cognitive decline","volume":"52","author":"Wang","year":"2023","journal-title":"Age Ageing"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110258_b0120","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3233\/JAD-230932","article-title":"Plasma Amyloid-beta, Total Tau, and Neurofilament Light Chain Across the Alzheimer's Disease Clinical Spectrum: A Population-Based Study","volume":"96","author":"Dong","year":"2023","journal-title":"J Alzheimers Dis"},{"issue":"13","key":"10.1016\/j.yebeh.2024.110258_b0125","first-page":"e1319","article-title":"Association of Plasma Abeta(42)\/Abeta(40) Ratio and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study","volume":"101","author":"Johnson","year":"2023","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.yebeh.2024.110258_b0130","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/jon.12837","article-title":"Assessment of the DTI-ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia","volume":"31","author":"Steward","year":"2021","journal-title":"J Neuroimag Official J Am Soc Neuroimag"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110258_b0135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00415-023-12004-6","article-title":"Correlation of glymphatic system abnormalities with Parkinson's disease progression: a clinical study based on non-invasive fMRI","volume":"271","author":"Meng","year":"2024","journal-title":"J Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2024.110258_b0140","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ana.26710","article-title":"Frontotemporal Lobar Degeneration Neuroimaging I: Regional Glymphatic Abnormality in Behavioral Variant Frontotemporal Dementia","volume":"94","author":"Jiang","year":"2023","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2024.110258_b0145","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41582-024-00932-4","article-title":"Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums","volume":"20","author":"Kamondi","year":"2024","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"10.1016\/j.yebeh.2024.110258_b0150","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1093\/brain\/awy162","article-title":"Late onset epilepsy and Alzheimer's disease: exploring the dual pathogenic role of amyloid-beta","volume":"141","author":"Costa","year":"2018","journal-title":"Brain J Neurol"},{"issue":"10225","key":"10.1016\/j.yebeh.2024.110258_b0155","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(19)33064-8","article-title":"Epilepsy in older people","volume":"395","author":"Sen","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110258_b0160","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.25267","article-title":"The cerebral lymphatic drainage system and its implications in epilepsy","volume":"102","author":"Peng","year":"2024","journal-title":"J Neurosci Res"},{"issue":"12","key":"10.1016\/j.yebeh.2024.110258_b0165","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s00234-022-03018-4","article-title":"Glymphatic system impairment in patients with status epilepticus","volume":"64","author":"Lee","year":"2022","journal-title":"Neuroradiology"},{"key":"10.1016\/j.yebeh.2024.110258_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.698036","article-title":"Glymphatic System in the Central Nervous System, a Novel Therapeutic Direction Against Brain Edema After Stroke","volume":"13","author":"Zhou","year":"2021","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"10.1016\/j.yebeh.2024.110258_b0175","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14669","article-title":"Fingolimod improves diffuse brain injury by promoting AQP4 polarization and functional recovery of the glymphatic system","volume":"30","author":"Feng","year":"2024","journal-title":"CNS Neurosci Ther"},{"issue":"8002","key":"10.1016\/j.yebeh.2024.110258_b0180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-024-07132-6","article-title":"Multisensory gamma stimulation promotes glymphatic clearance of amyloid","volume":"627","author":"Murdock","year":"2024","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.yebeh.2024.110258_b0185","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s12035-023-03636-w","article-title":"TGN-020 Alleviate Inflammation and Apoptosis After Cerebral Ischemia-Reperfusion Injury in Mice Through Glymphatic and ERK1\/2 Signaling Pathway","volume":"61","author":"Li","year":"2024","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.yebeh.2024.110258_b0190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jare.2023.03.004","article-title":"Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson's disease","volume":"56","author":"Si","year":"2024","journal-title":"J Adv Res"},{"issue":"5","key":"10.1016\/j.yebeh.2024.110258_b0195","article-title":"Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor","volume":"15","author":"Debacker","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2024.110258_b0200","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.mri.2018.10.007","article-title":"A novel MRI phantom to study interstitial fluid transport in the glymphatic system","volume":"56","author":"Komlosh","year":"2019","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.yebeh.2024.110258_b0205","series-title":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","article-title":"Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method","author":"Taoka","year":"2024"},{"issue":"4","key":"10.1016\/j.yebeh.2024.110258_b0210","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s00415-021-10799-w","article-title":"Glymphatic system dysfunction in patients with juvenile myoclonic epilepsy","volume":"269","author":"Lee","year":"2022","journal-title":"J Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2024.110258_b0215","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/jon.13083","article-title":"Glymphatic system dysfunction in patients with occipital lobe epilepsy","volume":"33","author":"Kim","year":"2023","journal-title":"Journal of neuroimaging : official journal of the American Society of Neuroimaging"},{"issue":"6","key":"10.1016\/j.yebeh.2024.110258_b0220","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.neurad.2023.05.009","article-title":"The asymmetry of glymphatic system dysfunction in patients with temporal lobe epilepsy: A DTI-ALPS study","volume":"50","author":"Zhao","year":"2023","journal-title":"Journal of neuroradiology = Journal de neuroradiologie"},{"issue":"1","key":"10.1016\/j.yebeh.2024.110258_b0225","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16097","article-title":"Anti-seizure medication response and the glymphatic system in patients with focal epilepsy","volume":"31","author":"Kim","year":"2024","journal-title":"Eur J Neurol"},{"issue":"9","key":"10.1016\/j.yebeh.2024.110258_b0230","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1007\/s00330-023-09588-y","article-title":"Recovery of glymphatic system function in patients with temporal lobe epilepsy after surgery","volume":"33","author":"Zhang","year":"2023","journal-title":"Eur Radiol"},{"key":"10.1016\/j.yebeh.2024.110258_b0235","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbi.2020.07.022","article-title":"Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems","volume":"89","author":"Liu","year":"2020","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.yebeh.2024.110258_b0240","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.sleep.2022.11.012","article-title":"The impact of sleep components, quality and patterns on glymphatic system functioning in healthy adults: A systematic review","volume":"101","author":"Sangalli","year":"2023","journal-title":"Sleep Med"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024006401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505024006401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T23:16:37Z","timestamp":1740698197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505024006401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":48,"alternative-id":["S1525505024006401"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.110258","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between glymphatic system function and cognitive impairment in elderly patients with late-onset epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2024.110258","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110258"}}