{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:50:06Z","timestamp":1774381806536,"version":"3.50.1"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"am","delay-in-days":296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015515","name":"Roy J. and Lucille A. Carver College of Medicine, University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31 NS125955"],"award-info":[{"award-number":["F31 NS125955"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS095842"],"award-info":[{"award-number":["R01 NS095842"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS129722"],"award-info":[{"award-number":["NS129722"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.yebeh.2025.110385","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T10:19:15Z","timestamp":1742897955000},"page":"110385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["MK-212 precipitates seizure-induced death in amygdala-kindled mice via a non-5-HT2C receptor-mediated mechanism"],"prefix":"10.1016","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2949-6105","authenticated-orcid":false,"given":"Katelyn G.","family":"Joyal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole A.","family":"Boodhoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2371-4455","authenticated-orcid":false,"given":"Gordon F.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2025.110385_b0010","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1056\/NEJM200002033420503","article-title":"Early identification of refractory epilepsy","volume":"342","author":"Kwan","year":"2000","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110385_b0015","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/jamaneurol.2017.3949","article-title":"treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: A 30-year longitudinal cohort study","volume":"75","author":"Chen","year":"2018","journal-title":"JAMA Neurol"},{"issue":"10","key":"10.1016\/j.yebeh.2025.110385_b0020","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S1474-4422(16)30158-2","article-title":"Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention","volume":"15","author":"Devinsky","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2025.110385_b0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.expneurol.2019.113145","article-title":"Serotonin and sudden unexpected death in epilepsy","volume":"325","author":"Petrucci","year":"2020","journal-title":"Exp Neurol"},{"issue":"Suppl 1","key":"10.1016\/j.yebeh.2025.110385_b0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1528-1167.2010.02908.x","article-title":"The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP","volume":"52","author":"Richerson","year":"2011","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110385_b0035","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/epi.14652","article-title":"Effect of monoamine reuptake inhibition and alpha1 blockade on respiratory arrest and death following electroshock-induced seizures in mice","volume":"60","author":"Kruse","year":"2019","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.yebeh.2025.110385_b0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5698\/1535-7597-13.5.241","article-title":"Serotonin: the anti-suddendeathamine?","volume":"13","author":"Richerson","year":"2013","journal-title":"Epilepsy Curr"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1152\/jn.00213.2015","article-title":"5-HT2A receptor activation is necessary for CO2-induced arousal","volume":"114","author":"Buchanan","year":"2015","journal-title":"J Neurophysiol"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0050","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1471-4159.2006.04277.x","article-title":"Serotonin and epilepsy","volume":"100","author":"Bagdy","year":"2007","journal-title":"J Neurochem"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0055","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/epi.17521","volume":"64","author":"Faingold","year":"2023","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110385_b0060","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/exnr.1998.6901","article-title":"Global increases in seizure susceptibility in mice lacking 5-HT2C receptors: a behavioral analysis","volume":"154","author":"Applegate","year":"1998","journal-title":"Exp Neurol"},{"issue":"6522","key":"10.1016\/j.yebeh.2025.110385_b0065","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/374542a0","article-title":"Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors","volume":"374","author":"Tecott","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.yebeh.2025.110385_b0070","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2011.08.043","article-title":"Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA\/2 vs. DBA\/1 mice","volume":"1418","author":"Faingold","year":"2011","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0075","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ng0897-387","article-title":"Sound-induced seizures in serotonin 5-HT2c receptor mutant mice","volume":"16","author":"Brennan","year":"1997","journal-title":"Nat Genet"},{"issue":"8","key":"10.1016\/j.yebeh.2025.110385_b0080","doi-asserted-by":"crossref","first-page":"e0136494","DOI":"10.1371\/journal.pone.0136494","article-title":"Social behavioral deficits coincide with the onset of seizure susceptibility in mice lacking serotonin receptor 2c","volume":"10","author":"S\u00e9journ\u00e9","year":"2015","journal-title":"PLoS One"},{"issue":"Pt B","key":"10.1016\/j.yebeh.2025.110385_b0085","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.yebeh.2015.06.008","article-title":"Abnormalities of serotonergic neurotransmission in animal models of SUDEP","volume":"71","author":"Feng","year":"2017","journal-title":"Epilepsy Behav"},{"issue":"2\u20133","key":"10.1016\/j.yebeh.2025.110385_b0090","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.eplepsyres.2009.11.004","article-title":"Abnormal serotonin receptor expression in DBA\/2 mice associated with susceptibility to sudden death due to respiratory arrest","volume":"88","author":"Uteshev","year":"2010","journal-title":"Epilepsy Res"},{"issue":"n\/a","key":"10.1016\/j.yebeh.2025.110385_b0095","article-title":"Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function","volume":"n\/a","author":"Kouchi","year":"2024","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110385_b0100","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuropharm.2016.04.016","article-title":"Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures","volume":"108","author":"Venzi","year":"2016","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0105","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0014-2999(98)00621-9","article-title":"Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents","volume":"359","author":"Upton","year":"1998","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0110","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.neuint.2006.12.008","article-title":"Concerted action of antiepileptic and antidepressant agents to depress spinal neurotransmission: possible use in the therapy of spasticity and chronic pain","volume":"50","author":"Than","year":"2007","journal-title":"Neurochem Int"},{"key":"10.1016\/j.yebeh.2025.110385_b0115","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.8b00739","article-title":"Evaluation of selective 5-HT2C agonists in acute seizure models","author":"Silenieks","year":"2019","journal-title":"ACS Chem Neurosci"},{"issue":"7","key":"10.1016\/j.yebeh.2025.110385_b0120","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1007\/s11064-017-2227-7","article-title":"Validation of a preclinical drug screening platform for pharmacoresistant epilepsy","volume":"42","author":"Barker-Haliski","year":"2017","journal-title":"Neurochem Res"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110385_b0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s002130051122","article-title":"Serotonin2C receptors appear to mediate genetic sensitivity to cocaine-induced convulsions","volume":"146","author":"O\u2019Dell","year":"1999","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2005.07.049","article-title":"Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities","volume":"1057","author":"Morita","year":"2005","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0135","first-page":"53","article-title":"Effect of dotarizine on electroconvulsive shock or pentylenetetrazol-induced amnesia and on seizure reactivity in rats","volume":"17","author":"Lazarova","year":"1995","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2025.110385_b0140","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2022.983211","article-title":"The role of sleep state and time of day in modulating breathing in epilepsy: Implications for SUDEP","author":"Joyal","year":"2022","journal-title":"Front Neural Circuits"},{"issue":"6","key":"10.1016\/j.yebeh.2025.110385_b0145","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/ana.410100613","article-title":"Systemic and pulmonary vascular pressures during generalized seizures in sheep","volume":"10","author":"Bayne","year":"1981","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2025.110385_b0150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.seizure.2015.02.023","article-title":"Pulmonary edema following generalized tonic clonic seizures is directly associated with seizure duration","volume":"27","author":"Kennedy","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2025.110385_b0155","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0450-23.2023","article-title":"Seizures cause prolonged impairment of ventilation, CO2 chemoreception and thermoregulation","author":"Teran","year":"2023","journal-title":"J Neurosci"},{"issue":"Pt 12","key":"10.1016\/j.yebeh.2025.110385_b0160","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1093\/brain\/awn277","article-title":"Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors","volume":"131","author":"Bateman","year":"2008","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.yebeh.2025.110385_b0165","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/j.1528-1167.2009.02518.x","article-title":"Respiratory changes with seizures in localization-related epilepsy: Analysis of periictal hypercapnia and airflow patterns","volume":"51","author":"Seyal","year":"2010","journal-title":"Epilepsia"},{"issue":"10","key":"10.1016\/j.yebeh.2025.110385_b0170","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S1474-4422(13)70214-X","article-title":"Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study","volume":"12","author":"Ryvlin","year":"2013","journal-title":"Lancet Neurol"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110385_b0175","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1172\/JCI94999","article-title":"Severe peri-ictal respiratory dysfunction is common in Dravet syndrome","volume":"128","author":"Kim","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yebeh.2025.110385_b0180","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.nbd.2019.04.006","article-title":"Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy","volume":"127","author":"Dhaibar","year":"2019","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0185","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0028-3908(99)00086-6","article-title":"Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS","volume":"39","author":"Clemett","year":"2000","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110385_b0190","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.resp.2010.03.006","article-title":"Medullary serotonin neurons and their roles in central respiratory chemoreception","volume":"173","author":"Hodges","year":"2010","journal-title":"Respir Physiol Neurobiol"},{"issue":"7","key":"10.1016\/j.yebeh.2025.110385_b0195","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1164\/rccm.200312-1674OC","article-title":"Systemic administration of serotonin 2A\/2C agonist improves upper airway stability in zucker rats","volume":"170","author":"Ogasa","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0200","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tins.2019.02.002","article-title":"Impaired CO2-induced arousal in SIDS and SUDEP","volume":"42","author":"Buchanan","year":"2019","journal-title":"Trends Neurosci"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110385_b0205","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.resp.2013.05.010","article-title":"Sudden unexpected death in epilepsy: fatal post-ictal respiratory and arousal mechanisms","volume":"189","author":"Sowers","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.yebeh.2025.110385_b0210","unstructured":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. (2011) Guide for the Care and Use of Laboratory Animals. 8 Ed. Washington D.C.: National Academies Press (US). Print."},{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0215","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.neuron.2008.09.033","article-title":"5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis","volume":"60","author":"Xu","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.yebeh.2025.110385_b0220","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuroscience.2020.11.029","article-title":"Post-ictal generalized EEG suppression is reduced by enhancing dorsal raphe serotonergic neurotransmission","volume":"453","author":"Petrucci","year":"2021","journal-title":"Neuroscience"},{"issue":"19","key":"10.1016\/j.yebeh.2025.110385_b0225","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1113\/jphysiol.2014.277574","article-title":"Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality","volume":"592","author":"Buchanan","year":"2014","journal-title":"J Physiol"},{"issue":"37","key":"10.1016\/j.yebeh.2025.110385_b0230","doi-asserted-by":"crossref","first-page":"16354","DOI":"10.1073\/pnas.1004587107","article-title":"Central serotonin neurons are required for arousal to CO2","volume":"107","author":"Buchanan","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.yebeh.2025.110385_b0235","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1152\/jn.00011.2016","article-title":"Influence of vigilance state on physiological consequences of seizures and seizure-induced death in mice","volume":"115","author":"Hajek","year":"2016","journal-title":"J Neurophysiol"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0240","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1528-1167.2008.01710.x","article-title":"Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis","volume":"50","author":"Blumenfeld","year":"2009","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110385_b0245","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"1\u20132","key":"10.1016\/j.yebeh.2025.110385_b0250","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.resp.2008.05.014","article-title":"Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects","volume":"164","author":"Hodges","year":"2008","journal-title":"Respir Physiol Neurobiol"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0255","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1542\/peds.16.1.81","article-title":"A barometric method for measuring ventilation in newborn infants","volume":"16","author":"Drorbaugh","year":"1955","journal-title":"Pediatrics"},{"key":"10.1016\/j.yebeh.2025.110385_b0260","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuroscience.2023.01.016","article-title":"Selective serotonin reuptake inhibitors and 5-HT2 receptor agonists have distinct, sleep-state dependent effects on postictal breathing in amygdala kindled mice","volume":"513","author":"Joyal","year":"2023","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110385_b0265","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0006-8993(96)01322-4","article-title":"Role of serotonin receptor subtypes in the development of amygdaloid kindling in rats","volume":"747","author":"Wada","year":"1997","journal-title":"Brain Res"},{"issue":"5","key":"10.1016\/j.yebeh.2025.110385_b0270","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s10517-006-0427-2","article-title":"Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice","volume":"142","author":"Kuznetsova","year":"2006","journal-title":"Bull Exp Biol Med"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110385_b0275","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-2999(96)00439-6","article-title":"Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212","volume":"311","author":"Hemrick-Luecke","year":"1996","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0280","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0091-3057(89)90470-X","article-title":"Selective cross-tolerance to 5-HT1A and 5-HT2 receptor-mediated temperature and corticosterone responses","volume":"33","author":"Nash","year":"1989","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0285","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/sj.npp.1300006","article-title":"Central serotonergic effects of m-Chlorophenylpiperazine (mCPP) among normal control adolescents","volume":"28","author":"Ghaziuddin","year":"2003","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0290","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2005.10.075","article-title":"Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors","volume":"1067","author":"Yamauchi","year":"2006","journal-title":"Brain Res"},{"issue":"11","key":"10.1016\/j.yebeh.2025.110385_b0295","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.tins.2017.08.004","article-title":"Stress and seizures: space, time and hippocampal circuits","volume":"40","author":"Gunn","year":"2017","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.yebeh.2025.110385_b0300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.seizure.2016.12.009","article-title":"Stress as a seizure precipitant: Identification, associated factors, and treatment options","volume":"44","author":"McKee","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2025.110385_b0305","doi-asserted-by":"crossref","unstructured":"Reddy DS, Thompson W, Calderara G. (2022) Does Stress Trigger Seizures? Evidence from Experimental Models Psychiatric and Behavioral Aspects of Epilepsy: Current Perspectives and Mechanisms. Eds. Jones NC, Kanner AM. Cham: Springer International Publishing. 41-64. Print.Published: Springer International Publishing; 2022: 41-64.","DOI":"10.1007\/7854_2020_191"},{"key":"10.1016\/j.yebeh.2025.110385_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107557","article-title":"Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish","volume":"114","author":"Canzian","year":"2021","journal-title":"Epilepsy Behav"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110385_b0315","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1460-9568.1999.00495.x","article-title":"Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state","volume":"11","author":"Karst","year":"1999","journal-title":"Eur J Neurosci"},{"issue":"7","key":"10.1016\/j.yebeh.2025.110385_b0320","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.psyneuen.2007.05.011","article-title":"The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors","volume":"32","author":"Kumar","year":"2007","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.yebeh.2025.110385_b0325","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/sj.npp.1300709","article-title":"Chronic low-dose corticosterone supplementation enhances acquired epileptogenesis in the rat amygdala kindling model of TLE","volume":"30","author":"Taher","year":"2005","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110385_b0330","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1210\/en.2018-00767","article-title":"Circadian and ultradian variations in corticosterone level influence functioning of the male mouse basolateral amygdala","volume":"160","author":"den Boon","year":"2019","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.yebeh.2025.110385_b0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001341","article-title":"The origin of glucocorticoid hormone oscillations","volume":"10","author":"Walker","year":"2012","journal-title":"PLoS Biol"},{"key":"10.1016\/j.yebeh.2025.110385_b0340","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.936104","article-title":"Chronobiology of epilepsy and sudden unexpected death in epilepsy","volume":"16","author":"Kreitlow","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.yebeh.2025.110385_b0345","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3389\/fneur.2018.01079","article-title":"Dead in the night: sleep-wake and time-of-day influences on sudden unexpected death in epilepsy","volume":"9","author":"Purnell","year":"2018","journal-title":"Front Neurol"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0350","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1152\/japplphysiol.00211.2020","article-title":"Free-running circadian breathing rhythms are eliminated by suprachiasmatic nucleus lesion","volume":"129","author":"Purnell","year":"2020","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.yebeh.2025.110385_b0355","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.708304","article-title":"The good, the bad, and the deadly: adenosinergic mechanisms underlying sudden unexpected death in epilepsy","volume":"15","author":"Purnell","year":"2021","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110385_b0360","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0006-8993(89)91331-0","article-title":"Kindling induced changes in parvalbumin immunoreactivity in rat hippocampus and its relation to long-term decrease in GABA-immunoreactivity","volume":"479","author":"Kamphuis","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2025.110385_b0365","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0079-6123(02)35010-6","article-title":"Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits","volume":"135","author":"Kotloski","year":"2002","journal-title":"Prog Brain Res"},{"issue":"2\u20133","key":"10.1016\/j.yebeh.2025.110385_b0370","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.eplepsyres.2004.07.001","article-title":"Mechanisms of epilepsy progression: current theories and perspectives from neuroplasticity in adulthood and development","volume":"60","author":"Sutula","year":"2004","journal-title":"Epilepsy Res"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110385_b0375","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0014-4886(78)90133-4","article-title":"Experimental epileptogenesis: Kindling-induced epilepsy in rats","volume":"58","author":"Pinel","year":"1978","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2025.110385_b0380","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0301-0082(80)90006-4","article-title":"Kindling model of epilepsy: a review","volume":"15","author":"McNamara","year":"1980","journal-title":"Prog Neurobiol"},{"issue":"7","key":"10.1016\/j.yebeh.2025.110385_b0385","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1523\/JNEUROSCI.23-07-02759.2003","article-title":"Spontaneous seizures and loss of axo-axonic and axo-somatic inhibition induced by repeated brief seizures in kindled rats","volume":"23","author":"Sayin","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2025.110385_b0390","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2147\/NDT.S50371","article-title":"Animal models of epilepsy: use and limitations","volume":"10","author":"Kandratavicius","year":"2014","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110385_b0395","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab149","article-title":"X-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsy","volume":"3","author":"Massey","year":"2021","journal-title":"Brain Commun"},{"issue":"22","key":"10.1016\/j.yebeh.2025.110385_b0400","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.172423","article-title":"Failure to breathe persists without air hunger or alarm following amygdala seizures","volume":"8","author":"Harmata","year":"2023","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.yebeh.2025.110385_b0405","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134852","article-title":"A human amygdala site that inhibits respiration and elicits apnea in pediatric epilepsy","volume":"5","author":"Rhone","year":"2020","journal-title":"JCI Insight"},{"issue":"32","key":"10.1016\/j.yebeh.2025.110385_b0410","doi-asserted-by":"crossref","first-page":"14449","DOI":"10.1073\/pnas.0914381107","article-title":"Metaplasticity of amygdalar responses to the stress hormone corticosterone","volume":"107","author":"Karst","year":"2010","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110385_b0415","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00210-004-0951-4","article-title":"Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors","volume":"370","author":"Knight","year":"2004","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110385_b0420","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-2999(00)00258-2","article-title":"The effect of the acute administration of various selective 5-HT receptor antagonists on focal hippocampal seizures in freely-moving rats","volume":"398","author":"Watanabe","year":"2000","journal-title":"Eur J Pharmacol"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505025001246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505025001246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T23:00:17Z","timestamp":1745535617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505025001246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":84,"alternative-id":["S1525505025001246"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2025.110385","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MK-212 precipitates seizure-induced death in amygdala-kindled mice via a non-5-HT2C receptor-mediated mechanism","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2025.110385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110385"}}