{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:07:50Z","timestamp":1778620070772,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["P-SV-24\\u201327"],"award-info":[{"award-number":["P-SV-24\\u201327"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["S-SV-24\\u201398"],"award-info":[{"award-number":["S-SV-24\\u201398"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.yebeh.2025.110480","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:55:08Z","timestamp":1747630508000},"page":"110480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Determinants of fatigue among adults with epilepsy: Should we focus solely on antiseizure medication effects?"],"prefix":"10.1016","volume":"170","author":[{"given":"Kristijonas","family":"Puteikis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benas","family":"Matuzevi\u010dius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u016bta","family":"Mameni\u0161kien\u0117","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2025.110480_b0005","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrneurol.2017.117","article-title":"Fatigue as a symptom or comorbidity of neurological diseases","volume":"13","author":"Penner","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.yebeh.2025.110480_b0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.seizure.2016.11.006","article-title":"Fatigue in epilepsy: a systematic review and meta-analysis","volume":"45","author":"Kwon","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2025.110480_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2024.107481","article-title":"Epilepsy core outcome set for effectiveness trials (EPSET): a systematic review of outcomes measured in registered phase III and IV clinical trials for adults with epilepsy","volume":"209","author":"Mitchell","year":"2025","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2025.110480_b0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.eplepsyres.2011.03.010","article-title":"How to measure fatigue in epilepsy? The validation of three scales for clinical use","volume":"95","author":"Hernandez-Ronquillo","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2025.110480_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108688","article-title":"Rasch analysis of fatigue severity scale in patients with epilepsy","volume":"130","author":"Syed","year":"2022","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110480_b0030","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1111\/epi.17971","article-title":"Development of an International Standard Set of Outcomes and measurement methods for routine practice for adults with epilepsy: the international consortium for health outcomes measurement consensus recommendations","volume":"65","author":"Mitchell","year":"2024","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110480_b0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s13760-020-01292-8","article-title":"Inter-ictal fatigue and antiepileptic drugs in patients with epilepsy","volume":"121","author":"\u00c7illiler","year":"2021","journal-title":"Acta Neurol Belg"},{"key":"10.1016\/j.yebeh.2025.110480_b0040","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s42399-019-00133-x","article-title":"Fatigue and its Related Factors in Patients with Epilepsy and Psychogenic Non-epileptic Seizure: a Cross-Sectional Study","volume":"1","author":"Ramezani","year":"2019","journal-title":"SN Compr Clin Med"},{"key":"10.1016\/j.yebeh.2025.110480_b0045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.yebeh.2017.04.030","article-title":"Fatigue during treatment with antiepileptic drugs: A levetiracetam-specific adverse event?","volume":"72","author":"Mula","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110480_b0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.eplepsyres.2010.07.006","article-title":"Fatigue in epilepsy: A prospective inter-ictal and post-ictal survey","volume":"91","author":"Hamelin","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2025.110480_b0055","unstructured":"Naqvi R, McLachlan R, Matijevic S, Burneo G. Fatigue is a Common Symptom in Epilepsy. American Epilepsy Society Annual Meeting Abstract number: 1.281, 2007."},{"key":"10.1016\/j.yebeh.2025.110480_b0060","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1590\/0004-282X20130075","article-title":"Fatigue in patients with epilepsy and its association with depression and sleep quality","volume":"71","author":"Neves","year":"2013","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.yebeh.2025.110480_b0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.seizure.2015.12.003","article-title":"Interictal fatigue and its predictors in epilepsy patients: A case-control study","volume":"34","author":"Kwon","year":"2016","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2025.110480_b0070","doi-asserted-by":"crossref","unstructured":"Krupp LB, Larocca NG, Muir-Nash J, Steinberg AD. The Fatigue Severity Scale Application to Patients With Multiple Sclerosis and Systemic Lupus Erythematosus. 1989.","DOI":"10.1037\/t25491-000"},{"key":"10.1016\/j.yebeh.2025.110480_b0075","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1474-4422(06)70415-X","article-title":"Rapid detection of major depression in epilepsy\u00a0: a multicentre study","volume":"5","author":"Gilliam","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2025.110480_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108913","article-title":"Psychometric properties of the Lithuanian version of the NDDI-E in persons with epilepsy and suicidal ideation","volume":"136","author":"Puteikis","year":"2022","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110480_b0085","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: The GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.yebeh.2025.110480_b0090","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.yebeh.2016.02.015","article-title":"Rapid detection of generalized anxiety disorder and major depression in epilepsy: Validation of the GAD-7 as a complementary tool to the NDDI-E in a French sample","volume":"57","author":"Micoulaud-Franchi","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110480_b0095","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1528-1167.2006.00956.x","article-title":"The Liverpool Adverse Events Profile: Relation to AED Use and Mood","volume":"48","author":"Panelli RJ","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110480_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.108371","article-title":"Tolerability of antiseizure medicines using Lithuanian version of the Liverpool Adverse Events Profile","volume":"124","author":"Jasionis","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110480_b0105","article-title":"The demographic features of fatigue in the general population worldwide: a systematic review and meta-analysis. Front","volume":"11","author":"Yoon","year":"2023","journal-title":"Public Health"},{"key":"10.1016\/j.yebeh.2025.110480_b0110","doi-asserted-by":"crossref","DOI":"10.1186\/s42494-021-00070-0","article-title":"Gender differences in prevalence and risk factors of sleep disturbances in patients with epilepsy","volume":"4","author":"Xiao","year":"2022","journal-title":"Acta Epileptologica"},{"key":"10.1016\/j.yebeh.2025.110480_b0115","first-page":"42","article-title":"Factors Influencing on Fatigue in Patients with Epilepsy","volume":"13","author":"Kwangsoo","year":"2009","journal-title":"Journal of Korean Epilepsy Society"},{"key":"10.1016\/j.yebeh.2025.110480_b0120","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/jpc.14077","article-title":"Association between seizure frequency and fatigue levels in children with epilepsy","volume":"54","author":"Kanemura","year":"2018","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.yebeh.2025.110480_b0125","author":"Ettinger","year":"1998","journal-title":"Epilepsy"},{"key":"10.1016\/j.yebeh.2025.110480_b0130","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jocn.2016.03.043","article-title":"Risk factors for fatigue in patients with epilepsy","volume":"33","author":"Yan","year":"2016","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.yebeh.2025.110480_b0135","first-page":"2233","article-title":"Validity of the Liverpool Adverse Events Profile as a Screening Tool for Detecting Comorbid Depression or Anxiety Disorder in People with Epilepsy","author":"Kwon","year":"2018","journal-title":"J Epilepsy Res"},{"key":"10.1016\/j.yebeh.2025.110480_b0140","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2013.09.013","article-title":"A review on antiepileptic drugs-dependent fatigue: pathophysiological mechanisms and incidence","volume":"718","author":"Siniscalchi","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2025.110480_b0145","doi-asserted-by":"crossref","unstructured":"Goldenholz D, Brinkmann BH, Westover MB. How accurate do self-reported seizures need to be for effective medication management in epilepsy? Epilepsia 2024;65:e104\u201312. doi: 10.1111\/epi.18019.","DOI":"10.1111\/epi.18019"},{"key":"10.1016\/j.yebeh.2025.110480_b0150","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S1474-4422(13)70075-9","article-title":"Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: A first-in-man study","volume":"12","author":"Cook","year":"2013","journal-title":"Lancet Neurol"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505025002197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505025002197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:08:49Z","timestamp":1778616529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505025002197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":30,"alternative-id":["S1525505025002197"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2025.110480","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determinants of fatigue among adults with epilepsy: Should we focus solely on antiseizure medication effects?","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2025.110480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110480"}}