{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:03:11Z","timestamp":1780300991023,"version":"3.54.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005707","name":"Akademie fur Tiergesundheit eV","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014903","name":"Osteo Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007537","name":"Freie Universitat Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.yebeh.2025.110694","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:26:18Z","timestamp":1757100378000},"page":"110694","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Reactive astrogliosis and microgliosis in animal models of focally induced seizures: A systematic review and multivariate multilevel meta-analysis"],"prefix":"10.1016","volume":"172","author":[{"given":"Asya","family":"Egilmez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Fang","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pauletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-6586","authenticated-orcid":false,"given":"Sonja","family":"Br\u00f6er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2025.110694_bib211","series-title":"Epilepsy: a public health imperative","year":"2019"},{"issue":"6","key":"10.1016\/j.yebeh.2025.110694_b0065","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1055\/s-0040-1718719","article-title":"Epilepsy-definition, classification, pathophysiology, and epidemiology","volume":"40","author":"Falco-Walter","year":"2020","journal-title":"Semin Neurol"},{"key":"10.1016\/j.yebeh.2025.110694_b0015","doi-asserted-by":"crossref","DOI":"10.1111\/epi.18338","article-title":"Updated classification of epileptic seizures: position paper of the international league against epilepsy","author":"Beniczky","year":"2025","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110694_b0155","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110694_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.870868","article-title":"Molecular mechanisms in the genesis of seizures and epilepsy associated with viral infection","volume":"15","author":"L\u00f6scher","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"s2","key":"10.1016\/j.yebeh.2025.110694_b0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1528-1167.2007.01063.x","article-title":"Epileptogenesis in experimental models","volume":"48","author":"Pitk\u00e4nen","year":"2007","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.yebeh.2025.110694_b0145","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1528-1167.2007.01063.x","article-title":"Epileptogenesis in experimental models","volume":"48","author":"Pitkanen","year":"2007","journal-title":"Epilepsia"},{"issue":"11","key":"10.1016\/j.yebeh.2025.110694_b0190","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/j.1528-1167.2005.00298.x","article-title":"Brain inflammation in epilepsy: experimental and clinical evidence","volume":"46","author":"Vezzani","year":"2005","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110694_b0195","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022699","article-title":"Immunity and inflammation in epilepsy","volume":"6","author":"Vezzani","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.yebeh.2025.110694_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1404022","article-title":"Microglia and infiltrating macrophages in ictogenesis and epileptogenesis","volume":"17","author":"Br\u00f6er","year":"2024","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110694_b0035","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tins.2012.11.008","article-title":"Glia and epilepsy: excitability and inflammation","volume":"36","author":"Devinsky","year":"2013","journal-title":"Trends Neurosci"},{"issue":"8","key":"10.1016\/j.yebeh.2025.110694_b0040","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/epi.16956","article-title":"Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages","volume":"62","author":"Di Nunzio","year":"2021","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.yebeh.2025.110694_b0130","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/glia.22288","article-title":"Artifact versus reality\u2013how astrocytes contribute to synaptic events","volume":"60","author":"Nedergaard","year":"2012","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110694_b0180","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.brainres.2005.02.058","article-title":"Might astrocytes play a role in maintaining the seizure-prone state?","volume":"1044","author":"Vessal","year":"2005","journal-title":"Brain Res"},{"issue":"5","key":"10.1016\/j.yebeh.2025.110694_b0100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","article-title":"Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs","volume":"20","author":"L\u00f6scher","year":"2011","journal-title":"Seizure"},{"issue":"8","key":"10.1016\/j.yebeh.2025.110694_b0185","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","article-title":"Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy","volume":"15","author":"Vezzani","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.yebeh.2025.110694_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.105016","article-title":"Advanced methods and implementations for the meta-analyses of animal models: current practices and future recommendations","volume":"146","author":"Yang","year":"2023","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"10.1016\/j.yebeh.2025.110694_b0010","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/nan.12451","article-title":"Review: animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis","volume":"44","author":"Becker","year":"2018","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"9","key":"10.1016\/j.yebeh.2025.110694_b0115","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3390\/cells12091233","article-title":"Animal models of drug-resistant epilepsy as tools for deciphering the cellular and molecular mechanisms of pharmacoresistance and discovering more effective treatments","volume":"12","author":"L\u00f6scher","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110694_b0170","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/00236772211045485","article-title":"Laboratory animals search filter for different literature databases: PubMed","volume":"56","author":"van der Mierden","year":"2022","journal-title":"Embase, Web of Science and PsycINFO Lab Anim"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110694_b0025","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.yebeh.2025.110694_b0060","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/bpa.12198","article-title":"Alterations in immune cells and mediators in the brain: it\u2019s not always neuroinflammation!","volume":"24","author":"Estes","year":"2014","journal-title":"Brain Pathol"},{"issue":"2","key":"10.1016\/j.yebeh.2025.110694_b0120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/1469-0691.12494","article-title":"The effects of clinical and statistical heterogeneity on the predictive values of results from meta-analyses","volume":"20","author":"Melsen","year":"2014","journal-title":"Clin Microbiol Infect"},{"issue":"7109","key":"10.1016\/j.yebeh.2025.110694_b0045","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"S4","key":"10.1016\/j.yebeh.2025.110694_b0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/epi.13905","article-title":"Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. a TASK1-WG3 report of the AES\/ILAE Translational task Force of the ILAE","volume":"58","author":"Hernan","year":"2017","journal-title":"Epilepsia"},{"issue":"S4","key":"10.1016\/j.yebeh.2025.110694_b0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/epi.13909","article-title":"Standards for data acquisition and software\u2010based analysis of in vivo electroencephalography recordings from animals. a TASK 1\u2010 WG5 report of the AES\/ILAE Translational Task Force of the ILAE","volume":"58","author":"Moyer","year":"2017","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.yebeh.2025.110694_b0095","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/j.1528-1167.2008.01535.x","article-title":"Seizures following picornavirus infection","volume":"49","author":"Libbey","year":"2008","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.yebeh.2025.110694_b0005","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1089\/jwh.2019.8247","article-title":"Sex as a biological variable: a 5-year progress report and call to action","volume":"29","author":"Arnegard","year":"2020","journal-title":"J Women\u2019s Health"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110694_b0030","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/15357597241261463","article-title":"The promise and practicality of addressing sex as a biological variable and the ovarian cycle in preclinical epilepsy research","volume":"24","author":"Christian-Hinman","year":"2024","journal-title":"Epilepsy Currents"},{"issue":"3","key":"10.1016\/j.yebeh.2025.110694_b0050","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat Neurosci"},{"issue":"12","key":"10.1016\/j.yebeh.2025.110694_b0055","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1002\/glia.23687","article-title":"Questions and (some) answers on reactive astrocytes","volume":"67","author":"Escartin","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.yebeh.2025.110694_b0085","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fncel.2020.00198","article-title":"Overview of general and discriminating markers of differential microglia phenotypes","volume":"14","author":"Jurga","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"Suppl 4","key":"10.1016\/j.yebeh.2025.110694_b0070","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/epi.13906","article-title":"Common data elements for preclinical epilepsy research: Standards for data collection and reporting. a TASK3 report of the AES\/ILAE Translational task Force of the ILAE","volume":"58","author":"Harte-Hargrove","year":"2017","journal-title":"Epilepsia"},{"issue":"S4","key":"10.1016\/j.yebeh.2025.110694_b0160","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/epi.13908","article-title":"Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature\u2013a TASK 2 report of the AES\/ILAE Translational Task Force of the ILAE","volume":"58","author":"Simonato","year":"2017","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.yebeh.2025.110694_b0135","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"issue":"4","key":"10.1016\/j.yebeh.2025.110694_b0105","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1124\/pr.110.003046","article-title":"Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research","volume":"62","author":"L\u00f6scher","year":"2010","journal-title":"Pharmacol Rev"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505025004342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505025004342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:27:39Z","timestamp":1780298859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505025004342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":36,"alternative-id":["S1525505025004342"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2025.110694","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactive astrogliosis and microgliosis in animal models of focally induced seizures: A systematic review and multivariate multilevel meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2025.110694","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110694"}}