{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:54:11Z","timestamp":1787806451276,"version":"build-2784847793"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2021SF-283"],"award-info":[{"award-number":["2021SF-283"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["21YXYJ011"],"award-info":[{"award-number":["21YXYJ011"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.yebeh.2025.110718","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:05:05Z","timestamp":1761138305000},"page":"110718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Efficacy and safety of long-term combination therapy with lacosamide and oxcarbazepine for pediatric patients with focal epilepsy: real-world clinical experience"],"prefix":"10.1016","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8791-7034","authenticated-orcid":false,"given":"Xueying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaobo","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-9615","authenticated-orcid":false,"given":"Yonghui","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2025.110718_b0005","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1474-4422(18)30454-X","article-title":"Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Beghi","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2025.110718_b0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s40263-017-0441-0","article-title":"Sodium channel blockers in the treatment of epilepsy","volume":"31","author":"Brodie","year":"2017","journal-title":"CNS Drugs"},{"key":"10.1016\/j.yebeh.2025.110718_b0015","article-title":"Safety, efficacy, and tolerability of lacosamide for the treatment of epilepsy in pediatric patients in Uygur","volume":"117","author":"Zhao","year":"2021","journal-title":"China Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110718_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108781","article-title":"Efficacy and safety of lacosamide in pediatric patients with epilepsy: a systematic review and meta-analysis","volume":"134","author":"Yang","year":"2022","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110718_b0025","article-title":"Plasma lacosamide monitoring in children with epilepsy: focus on reference therapeutic range and influencing factors","volume":"10","author":"Li","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.yebeh.2025.110718_b0030","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/mol.107.039867","article-title":"The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels","volume":"73","author":"Errington","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.yebeh.2025.110718_b0035","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2165\/11587550-000000000-00000","article-title":"A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs","volume":"24","author":"Sake","year":"2010","journal-title":"CNS Drugs"},{"key":"10.1016\/j.yebeh.2025.110718_b0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yebeh.2010.10.002","article-title":"Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: a pharmacodynamic interaction?","volume":"20","author":"Novy","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110718_b0045","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.seizure.2020.04.016","article-title":"Efficacy and tolerability of treatment with lacosamide in children: postmarketing experience from the Middle East","volume":"79","author":"Hmaimess","year":"2020","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2025.110718_b0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.seizure.2023.09.011","article-title":"Efficacy and tolerability of lacosamide and controlled-release carbamazepine monotherapy in patients with newly diagnosed temporal lobe epilepsy: Post hoc analysis of a randomized, double-blind trial","volume":"112","author":"Terada","year":"2023","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2025.110718_b0055","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1111\/epi.18338","article-title":"Updated classification of epileptic seizures: position paper of the International League Against Epilepsy","volume":"66","author":"Beniczky","year":"2025","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110718_b0060","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/epi.17241","article-title":"International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: position paper by the ILAE Task Force on Nosology and Definitions","volume":"63","author":"Specchio","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110718_b0065","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110718_b0070","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE commission for classification and terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110718_b0075","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1212\/WNL.0000000000005756","volume":"91","author":"Kanner","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2025.110718_b0080","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5698\/1535-7597.18.4.269","volume":"18","author":"Kanner","year":"2018","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.yebeh.2025.110718_b0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/epi.13602","article-title":"Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na(+) channel inactivation","volume":"58","author":"Holtkamp","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110718_b0090","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/epi.17843","article-title":"A real-world comparison among third-generation antiseizure medications: results from the COMPARE study","volume":"65","author":"Roberti","year":"2024","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110718_b0095","doi-asserted-by":"crossref","first-page":"e1212","DOI":"10.1212\/WNL.0000000000008126","article-title":"Efficacy and tolerability of adjunctive lacosamide in pediatric patients with focal seizures","volume":"93","author":"Farkas","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2025.110718_b0100","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1055\/s-0042-1758366","article-title":"Use of lacosamide in children: experience of a tertiary medical care center in Brazil","volume":"80","author":"Romao","year":"2022","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.yebeh.2025.110718_b0105","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/jpc.12850","article-title":"Lacosamide as adjunctive therapy in treatment-resistant epilepsy in childhood","volume":"51","author":"Gulati","year":"2015","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.yebeh.2025.110718_b0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/epi4.12682","article-title":"Safety and tolerability of short-term infusions of intravenous lacosamide in pediatric patients with epilepsy: an open-label, phase 2\/3 trial","volume":"8","author":"Farkas","year":"2023","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.yebeh.2025.110718_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.108397","article-title":"Effectiveness of lacosamide in children and young adults previously treated with other sodium channel blockers","volume":"125","author":"Suzuki","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110718_b0120","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/epi.13466","article-title":"Lacosamide use in children with epilepsy: Retention rate and effect of concomitant sodium channel blockers in a large cohort","volume":"57","author":"McGinnis","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110718_b0125","first-page":"139","article-title":"Encephalopathy with status epilepticus during sleep (ESES) induced by oxcarbazepine in idiopathic focal epilepsy in childhood","volume":"30","author":"Pavlidis","year":"2015","journal-title":"Funct Neurol"},{"key":"10.1016\/j.yebeh.2025.110718_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.106965","article-title":"Electrical status epilepticus in sleep (ESES) \u2013 treatment pattern and EEG outcome in children with very high spike-wave index","volume":"105","author":"Wiwattanadittakul","year":"2020","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2025.110718_b0135","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.eplepsyres.2014.08.021","article-title":"Lacosamide efficacy in epileptic syndromes with continuous spike and waves during slow sleep (CSWS)","volume":"108","author":"Grosso","year":"2014","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2025.110718_b0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pediatrneurol.2019.10.009","article-title":"PCDH19-related epilepsy syndrome: a comprehensive clinical review","volume":"105","author":"Samanta","year":"2020","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.yebeh.2025.110718_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21114096","article-title":"Reactive glia inflammatory signaling pathways and epilepsy","volume":"21","author":"Sanz","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.yebeh.2025.110718_b0150","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/acn3.52004","article-title":"Efficacy and tolerability of adjunctive lacosamide in patients aged <4 years with focal seizures","volume":"11","author":"Makedonska","year":"2024","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.yebeh.2025.110718_b0155","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/epi.16828","article-title":"Symptomatology of carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy","volume":"62","author":"Berghuis","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2025.110718_b0160","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.trsl.2017.10.002","article-title":"Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications","volume":"191","author":"Auerbach","year":"2018","journal-title":"Transl Res"},{"key":"10.1016\/j.yebeh.2025.110718_b0165","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.seizure.2016.06.004","article-title":"Polytherapy with sodium channel-blocking antiepileptic drugs is associated with arrhythmogenic ST-T abnormality in patients with epilepsy","volume":"40","author":"Ishizue","year":"2016","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2025.110718_b0170","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pediatrneurol.2023.09.004","article-title":"Neonatal cardiac arrest following lacosamide treatment: a case report","volume":"149","author":"Huberman","year":"2023","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.yebeh.2025.110718_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.891368","article-title":"Evaluation of cardiovascular concerns of Intravenous lacosamide therapy in epilepsy patients","volume":"13","author":"Lu","year":"2022","journal-title":"Front Neurol"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505025004585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505025004585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:13:38Z","timestamp":1773202418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505025004585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":35,"alternative-id":["S1525505025004585"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2025.110718","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of long-term combination therapy with lacosamide and oxcarbazepine for pediatric patients with focal epilepsy: real-world clinical experience","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2025.110718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110718"}}